Real Estate Investment Properties for Sale in Matlacha Isles, FL

Looking for investment property in Matlacha Isles, FL with high ROI ?

Explore a variety of short-term homes & houses in Matlacha Isles, FL. Invest wisely with VRBO & Matlacha Isles, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Matlacha Isles, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2709 Clyde Street MATLACHA ISLES, FL Beautifully maintained 2-bedroom, 2-bath waterfront home offering a peaceful and relaxing ...	2 beds \| 2 baths \| 1,170 sq.ft.	$575,000	Airbnb cash on cash: -0.68% Traditional cash on cash: 1.81% Airbnb Rental Income: $1164 Traditional Rental Income: $2122 Airbnb ROI: -0.68% Traditional ROI: 1.81%
4767 Pine Island Rd NW MATLACHA ISLES, FL Do not miss this one-of-a-kind Matlacha property! This 3-bedroom, 3-bath home sits on over...	N/A beds \| N/A baths \| 1,915 sq.ft.	$899,900	Airbnb cash on cash: 0.34% Traditional cash on cash: 2.76% Airbnb Rental Income: $2276 Traditional Rental Income: $3732 Airbnb ROI: 0.34% Traditional ROI: 2.76%
12304 Boat Shell Drive MATLACHA ISLES, FL HOME NEVER FLOODED! LOW FLOOD INSURANCE POLICY IS TRANSFERABLE! TURNKEY Gulf-access waterf...	3 beds \| 3 baths \| 2,137 sq.ft.	$825,000	Airbnb cash on cash: -0.62% Traditional cash on cash: 1.83% Airbnb Rental Income: $1693 Traditional Rental Income: $3106 Airbnb ROI: -0.62% Traditional ROI: 1.83%
2589 Bayshore Drive MATLACHA ISLES, FL Live Your Best Island Life in this Beautiful Direct Deep-Water Access Island Home! Surroun...	3 beds \| 2 baths \| 1,040 sq.ft.	$434,900	Airbnb cash on cash: 1.3% Traditional cash on cash: 3.74% Airbnb Rental Income: $1693 Traditional Rental Income: $2217 Airbnb ROI: 1.3% Traditional ROI: 3.74%
2574 Bayshore Drive MATLACHA ISLES, FL Waterfront living in Matlacha has a special rhythm, and this Island Harbors pool home capt...	2 beds \| 2 baths \| 1,268 sq.ft.	$625,000	Airbnb cash on cash: -0.65% Traditional cash on cash: 1.77% Airbnb Rental Income: $1164 Traditional Rental Income: $2188 Airbnb ROI: -0.65% Traditional ROI: 1.77%
2864 Triggerfish St MATLACHA ISLES, FL MATLACHA, One of the most charming waterfront communities in Florida. A very walkable town...	N/A beds \| N/A baths \| 1,205 sq.ft.	$515,000	Airbnb cash on cash: 1.58% Traditional cash on cash: 3.36% Airbnb Rental Income: $2276 Traditional Rental Income: $2568 Airbnb ROI: 1.58% Traditional ROI: 3.36%
2849 Triggerfish St MATLACHA ISLES, FL ATTENTION INVESTORS, BUILDERS AND SAVVY HOMEOWNERS! Old Florida Garden Style Duplex sited...	N/A beds \| N/A baths \| N/A	$604,900	Airbnb cash on cash: 1.23% Traditional cash on cash: 2.41% Airbnb Rental Income: $2276 Traditional Rental Income: $2371 Airbnb ROI: 1.23% Traditional ROI: 2.41%
2639 Bridgeview Street MATLACHA ISLES, FL Welcome to your dream waterfront escape in Matlacha, where tropical charm meets modern con...	2 beds \| 2 baths \| 1,076 sq.ft.	$629,000	Airbnb cash on cash: -0.46% Traditional cash on cash: 1.52% Airbnb Rental Income: $1164 Traditional Rental Income: $1949 Airbnb ROI: -0.46% Traditional ROI: 1.52%
8787 Kodiak Lane MATLACHA ISLES, FL SECOND CHANCE AT A ONE-OF-A-KIND ST. JAMES CITY PROPERTY - 2 ACRES, TURNKEY FURNISHED, HEA...	2 beds \| 2 baths \| 1,224 sq.ft.	$599,000	Airbnb cash on cash: -0.54% Traditional cash on cash: 1.85% Airbnb Rental Income: $1164 Traditional Rental Income: $2113 Airbnb ROI: -0.54% Traditional ROI: 1.85%
8500 Redwood Drive MATLACHA ISLES, FL This immaculately maintained home must be seen to be truly appreciated. Every detail has b...	4 beds \| 3 baths \| 2,792 sq.ft.	$579,000	Airbnb cash on cash: 1.5% Traditional cash on cash: 6.13% Airbnb Rental Income: $2002 Traditional Rental Income: $3986 Airbnb ROI: 1.5% Traditional ROI: 6.13%
2761 Geary Street MATLACHA ISLES, FL INCOME-PRODUCING ELEVATED WATERFRONT HOME IN MATLACHA. PRIVATE DOCK, BEAUTIFUL WATER VIEWS...	2 beds \| 2 baths \| 1,295 sq.ft.	$650,000	Airbnb cash on cash: -0.81% Traditional cash on cash: 2.19% Airbnb Rental Income: $1164 Traditional Rental Income: $2602 Airbnb ROI: -0.81% Traditional ROI: 2.19%
4931 Island Acres Court MATLACHA ISLES, FL Just over an Acre of Pure Island Serenity! Nestled at the end of the cul-da-sac for total ...	3 beds \| 3 baths \| 1,975 sq.ft.	$549,000	Airbnb cash on cash: 0.03% Traditional cash on cash: 5.24% Airbnb Rental Income: $1693 Traditional Rental Income: $3894 Airbnb ROI: 0.03% Traditional ROI: 5.24%
11306 Matlacha Ave MATLACHA ISLES, FL Just needs some love and a full rehab! **DIRECT SAILBOAT ACCESS* Deep water and less t...	N/A beds \| N/A baths \| 1,405 sq.ft.	$299,900	Airbnb cash on cash: 4.02% Traditional cash on cash: 7.51% Airbnb Rental Income: $2276 Traditional Rental Income: $2693 Airbnb ROI: 4.02% Traditional ROI: 7.51%
4278 Pine Island Road NW MATLACHA ISLES, FL MATLACHA CHARM ALERT! Sitting on the Dock of the Bay - the Best Seat in the House! Welcome...	2 beds \| 1 baths \| 587 sq.ft.	$399,900	Airbnb cash on cash: 0.55% Traditional cash on cash: 2.95% Airbnb Rental Income: $1164 Traditional Rental Income: $1681 Airbnb ROI: 0.55% Traditional ROI: 2.95%
12279 Matlacha Boulevard MATLACHA ISLES, FL Old Florida charm meets waterfront living in the heart of Matlacha Isles. Situated on a ra...	2 beds \| 2 baths \| 1,320 sq.ft.	$549,900	Airbnb cash on cash: -0.12% Traditional cash on cash: 3.17% Airbnb Rental Income: $1164 Traditional Rental Income: $2472 Airbnb ROI: -0.12% Traditional ROI: 3.17%
12065 Boat Shell Drive MATLACHA ISLES, FL AMAZING PRICE for this beautifully remodeled 3-bedroom, 2-bathroom home located in the des...	3 beds \| 2 baths \| 1,364 sq.ft.	$500,000	Airbnb cash on cash: -0.47% Traditional cash on cash: 3.02% Airbnb Rental Income: $1693 Traditional Rental Income: $2855 Airbnb ROI: -0.47% Traditional ROI: 3.02%
12088 Boat Shell Drive MATLACHA ISLES, FL Completely renovated and sold fully turnkey, this exceptional waterfront pool home in Matl...	3 beds \| 2 baths \| 1,668 sq.ft.	$849,000	Airbnb cash on cash: -0.56% Traditional cash on cash: 0.29% Airbnb Rental Income: $1693 Traditional Rental Income: $1890 Airbnb ROI: -0.56% Traditional ROI: 0.29%
2691 Geary Street MATLACHA ISLES, FL WELCOME TO YOUR MATLACHA FISHING PARADISE! Just four homes from the channel, this DIRECT G...	2 beds \| 1 baths \| 1,040 sq.ft.	$499,000	Airbnb cash on cash: -0.32% Traditional cash on cash: 6.03% Airbnb Rental Income: $1164 Traditional Rental Income: $3743 Airbnb ROI: -0.32% Traditional ROI: 6.03%
12201 Shoreview Drive MATLACHA ISLES, FL Stunning waterfront estate set on 2.24 acres in the heart of Matlacha-truly a boater's par...	5 beds \| 5 baths \| 4,021 sq.ft.	$2,598,000	Airbnb cash on cash: -0.63% Traditional cash on cash: 2.78% Airbnb Rental Income: $2972 Traditional Rental Income: $10493 Airbnb ROI: -0.63% Traditional ROI: 2.78%
2823 Janet St MATLACHA ISLES, FL Calling all renovators and bargain hunters! This fixer-upper presents a golden opportunity...	3 beds \| 3 baths \| 1,800 sq.ft.	$699,900	Airbnb cash on cash: 0.24% Traditional cash on cash: 4.11% Airbnb Rental Income: $1693 Traditional Rental Income: $3746 Airbnb ROI: 0.24% Traditional ROI: 4.11%
2652 Bridgeview St MATLACHA ISLES, FL Experience waterfront living at its finest in this charming 2-bedroom, 2-bathroom canal fr...	N/A beds \| N/A baths \| 1,158 sq.ft.	$299,900	Airbnb cash on cash: 4% Traditional cash on cash: 6.38% Airbnb Rental Income: $2276 Traditional Rental Income: $2379 Airbnb ROI: 4% Traditional ROI: 6.38%
4828 FLAMINGO Drive MATLACHA ISLES, FL Experience This Beautiful, Well-Kept 2 Bed, 2 Bath Home. This is NOT a Manufactured Home! ...	2 beds \| 2 baths \| 1,094 sq.ft.	$345,000	Airbnb cash on cash: 0.85% Traditional cash on cash: 5.48% Airbnb Rental Income: $1164 Traditional Rental Income: $2279 Airbnb ROI: 0.85% Traditional ROI: 5.48%
4819 Pine Island Road NW MATLACHA ISLES, FL Beautiful custom cottage with open water views and incredible gulf access. This is a fully...	2 beds \| 2 baths \| 1,056 sq.ft.	$640,000	Airbnb cash on cash: -0.4% Traditional cash on cash: 2.39% Airbnb Rental Income: $1164 Traditional Rental Income: $2447 Airbnb ROI: -0.4% Traditional ROI: 2.39%
2742 Bruce Street MATLACHA ISLES, FL YOUR MATLACHA WATERFRONT DREAM STARTS HERE - FULLY RENOVATED 3+DEN / 2 BATH - DIRECT GULF ...	3 beds \| 2 baths \| 1,702 sq.ft.	$464,900	Airbnb cash on cash: 0.39% Traditional cash on cash: 5.19% Airbnb Rental Income: $1693 Traditional Rental Income: $3312 Airbnb ROI: 0.39% Traditional ROI: 5.19%
2631 Bayshore Drive MATLACHA ISLES, FL Welcome to 2631 Bayshore Drive, a classic Matlacha cottage that perfectly blends Old-Flori...	3 beds \| 2 baths \| 1,326 sq.ft.	$439,000	Airbnb cash on cash: 0.01% Traditional cash on cash: 4.63% Airbnb Rental Income: $1693 Traditional Rental Income: $3120 Airbnb ROI: 0.01% Traditional ROI: 4.63%
8721 Nome Court MATLACHA ISLES, FL This 7.07-acre AG-2 zoned property with no deed restrictions has lots of potential and pri...	2 beds \| 1 baths \| 784 sq.ft.	$625,000	Airbnb cash on cash: 0.13% Traditional cash on cash: 2.29% Airbnb Rental Income: $1164 Traditional Rental Income: $2044 Airbnb ROI: 0.13% Traditional ROI: 2.29%
11242 Matlacha Avenue MATLACHA ISLES, FL Experience the Matlacha island lifestyle from this charming historic home featuring direct...	1 beds \| 1 baths \| 480 sq.ft.	$409,000	Airbnb cash on cash: -1.31% Traditional cash on cash: 2.24% Airbnb Rental Income: $680 Traditional Rental Income: $1738 Airbnb ROI: -1.31% Traditional ROI: 2.24%
8677 Whispering Pines Drive MATLACHA ISLES, FL Private and peaceful 3 bed/3 bath two-story home on 1.37 acres in St. James City with a fl...	3 beds \| 3 baths \| 1,424 sq.ft.	$449,000	Airbnb cash on cash: 0.76% Traditional cash on cash: 4.29% Airbnb Rental Income: $1693 Traditional Rental Income: $2706 Airbnb ROI: 0.76% Traditional ROI: 4.29%
2686 Clyde Street MATLACHA ISLES, FL This 2 br, 1 bth home located in a small quaint community of gulf access waterfront homes ...	2 beds \| 1 baths \| 855 sq.ft.	$349,000	Airbnb cash on cash: -0.22% Traditional cash on cash: 4.35% Airbnb Rental Income: $1164 Traditional Rental Income: $2278 Airbnb ROI: -0.22% Traditional ROI: 4.35%
4874 Pine Island Road NW MATLACHA ISLES, FL TRIPLEX fully occupied! SELLER FINANCING AVAILABLE!! Welcome to your dream waterfront esca...	4 beds \| 3 baths \| N/A	$529,000	Airbnb cash on cash: 1.11% Traditional cash on cash: 9.04% Airbnb Rental Income: $2002 Traditional Rental Income: $5401 Airbnb ROI: 1.11% Traditional ROI: 9.04%
2647 Pine Street MATLACHA ISLES, FL Discover your slice of paradise in the quiet fishing town of Matlacha Island. This charmin...	2 beds \| 1 baths \| 1,008 sq.ft.	$299,000	Airbnb cash on cash: 0.92% Traditional cash on cash: 7.12% Airbnb Rental Income: $1164 Traditional Rental Income: $2527 Airbnb ROI: 0.92% Traditional ROI: 7.12%
11476 May Street MATLACHA ISLES, FL Welcome to this opportunity in the charming and colorful fishing village of Matlacha! This...	2 beds \| 2 baths \| 951 sq.ft.	$355,000	Airbnb cash on cash: 0.09% Traditional cash on cash: 5.38% Airbnb Rental Income: $1164 Traditional Rental Income: $2544 Airbnb ROI: 0.09% Traditional ROI: 5.38%
2607 Bayshore Drive MATLACHA ISLES, FL This BEAUTIFUL island home offers direct access to the Gulf of Mexico, from your private b...	2 beds \| 2 baths \| 1,500 sq.ft.	$439,000	Airbnb cash on cash: -0.05% Traditional cash on cash: 5.5% Airbnb Rental Income: $1164 Traditional Rental Income: $3063 Airbnb ROI: -0.05% Traditional ROI: 5.5%
2701 Bruce Street MATLACHA ISLES, FL PRICE REDUCTION!!Perfect Opportunity to Customize a Well Built Matlacha Home! This home si...	3 beds \| 2 baths \| 1,596 sq.ft.	$629,000	Airbnb cash on cash: 0.12% Traditional cash on cash: 4.39% Airbnb Rental Income: $1693 Traditional Rental Income: $3727 Airbnb ROI: 0.12% Traditional ROI: 4.39%
2500 Harbor View Drive MATLACHA ISLES, FL FISHING ENTHUSIAST. DREAM ! Own a Piece of Waterfront Paradise on Matlacha Island! This is...	2 beds \| 2 baths \| 1,128 sq.ft.	$469,900	Airbnb cash on cash: -0.5% Traditional cash on cash: 4.3% Airbnb Rental Income: $1164 Traditional Rental Income: $2895 Airbnb ROI: -0.5% Traditional ROI: 4.3%
11860 Island Ave MATLACHA ISLES, FL Welcome to Your Waterfront Oasis - a modern upscale Hurricane-Resilient Home Designed for ...	2 beds \| 2 baths \| 1,935 sq.ft.	$687,500	Airbnb cash on cash: -0.37% Traditional cash on cash: 3.47% Airbnb Rental Income: $1164 Traditional Rental Income: $3240 Airbnb ROI: -0.37% Traditional ROI: 3.47%
4225-4227 Pine Island Rd NW MATLACHA ISLES, FL 4225-4227 Pine Island Rd NW, MATLACHA ISLES, FL 33993 \| Other	N/A beds \| N/A baths \| N/A	$348,500	Airbnb cash on cash: 3.05% Traditional cash on cash: 0.33% Airbnb Rental Income: $2276 Traditional Rental Income: $817 Airbnb ROI: 3.05% Traditional ROI: 0.33%
2656 Clyde St MATLACHA ISLES, FL 2656 Clyde St, MATLACHA ISLES, FL 33993 \| Other	N/A beds \| N/A baths \| N/A	$279,000	Airbnb cash on cash: 4.26% Traditional cash on cash: 4.08% Airbnb Rental Income: $2276 Traditional Rental Income: $1660 Airbnb ROI: 4.26% Traditional ROI: 4.08%
2609 Bayshore Dr MATLACHA ISLES, FL 2609 Bayshore Dr, MATLACHA ISLES, FL 33993 \| Other	N/A beds \| N/A baths \| N/A	$290,000	Airbnb cash on cash: 4.03% Traditional cash on cash: 3.85% Airbnb Rental Income: $2276 Traditional Rental Income: $1660 Airbnb ROI: 4.03% Traditional ROI: 3.85%
2650 Coco Plum Drive MATLACHA ISLES, FL This canal front residential property is located at 2650 Coco Plum Drive in Cape Coral, Fl...	1 beds \| 1 baths \| 468 sq.ft.	$349,000	Airbnb cash on cash: -0.97% Traditional cash on cash: 3.43% Airbnb Rental Income: $680 Traditional Rental Income: $1821 Airbnb ROI: -0.97% Traditional ROI: 3.43%

Real Estate investment in Matlacha-isles, FL

There are 56 properties for sale in the city of Matlacha Isles . The median list price in Matlacha Isles is $480,000 and the average price per square foot is $314. In September 2026, the average monthly cash on cash return in Matlacha Isles is 4.00%. The average monthly rental income in Matlacha Isles is $2,325.

Matlacha-isles, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 56 investment properties available for sale in Matlacha-isles.

In 2026, the best neighborhood to buy investment property is MATLACHA ISLES.

The ROI for Short-Term is higher than the Long-Term in Matlacha-isles with average rental income of $1,693.

Your search for investment property begins and ends here

Investment Property for Sale in Matlacha Isles, FL

2709 Clyde Street

MATLACHA ISLES, FL

2 beds | 2 baths | 1,170 sq.ft.

$575,000

Airbnb cash on cash: -0.68%

Traditional cash on cash: 1.81%

Airbnb Rental Income: $1164

Traditional Rental Income: $2122

Airbnb ROI: -0.68%

Traditional ROI: 1.81%

4767 Pine Island Rd NW

MATLACHA ISLES, FL

N/A beds | N/A baths | 1,915 sq.ft.

$899,900

Airbnb cash on cash: 0.34%

Traditional cash on cash: 2.76%

Airbnb Rental Income: $2276

Traditional Rental Income: $3732

Airbnb ROI: 0.34%

Traditional ROI: 2.76%

12304 Boat Shell Drive

MATLACHA ISLES, FL

3 beds | 3 baths | 2,137 sq.ft.

$825,000

Airbnb cash on cash: -0.62%

Traditional cash on cash: 1.83%

Airbnb Rental Income: $1693

Traditional Rental Income: $3106

Airbnb ROI: -0.62%

Traditional ROI: 1.83%

2589 Bayshore Drive

MATLACHA ISLES, FL

3 beds | 2 baths | 1,040 sq.ft.

$434,900

Airbnb cash on cash: 1.3%

Traditional cash on cash: 3.74%

Airbnb Rental Income: $1693

Traditional Rental Income: $2217

Airbnb ROI: 1.3%

Traditional ROI: 3.74%

2574 Bayshore Drive

MATLACHA ISLES, FL

2 beds | 2 baths | 1,268 sq.ft.

$625,000

Airbnb cash on cash: -0.65%

Traditional cash on cash: 1.77%

Airbnb Rental Income: $1164

Traditional Rental Income: $2188

Airbnb ROI: -0.65%

Traditional ROI: 1.77%

2864 Triggerfish St

MATLACHA ISLES, FL

N/A beds | N/A baths | 1,205 sq.ft.

$515,000

Airbnb cash on cash: 1.58%

Traditional cash on cash: 3.36%

Airbnb Rental Income: $2276

Traditional Rental Income: $2568

Airbnb ROI: 1.58%

Traditional ROI: 3.36%

2849 Triggerfish St

MATLACHA ISLES, FL

N/A beds | N/A baths | N/A

$604,900

Airbnb cash on cash: 1.23%

Traditional cash on cash: 2.41%

Airbnb Rental Income: $2276

Traditional Rental Income: $2371

Airbnb ROI: 1.23%

Traditional ROI: 2.41%

2639 Bridgeview Street

MATLACHA ISLES, FL

2 beds | 2 baths | 1,076 sq.ft.

$629,000

Airbnb cash on cash: -0.46%

Traditional cash on cash: 1.52%

Airbnb Rental Income: $1164

Traditional Rental Income: $1949

Airbnb ROI: -0.46%