Real Estate Investment Properties for Sale in Tuscumbia, AL

Looking for investment property in Tuscumbia, AL with high ROI ?

Explore a variety of short-term homes & houses in Tuscumbia, AL. Invest wisely with VRBO & Tuscumbia, AL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Tuscumbia, AL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
280 New Bethel Rd Tuscumbia, AL New Listing â 280 New Bethel Road, Tuscumbia Welcome home to this beautifully remodeled...	3 beds \| 2 baths \| 2,485 sq.ft.	$299,500	Airbnb cash on cash: 3.56% Traditional cash on cash: 7.39% Airbnb Rental Income: $1954 Traditional Rental Income: $2520 Airbnb ROI: 3.56% Traditional ROI: 7.39%
1085 Tennessee Ave Tuscumbia, AL Experience the peaceful, easy feeling of this charming home in Tuscumbiaâs Rain Tree Sub...	4 beds \| 3 baths \| 2,300 sq.ft.	$269,900	Airbnb cash on cash: 4.15% Traditional cash on cash: 8.88% Airbnb Rental Income: $1954 Traditional Rental Income: $2645 Airbnb ROI: 4.15% Traditional ROI: 8.88%
162 Valley Grove St Tuscumbia, AL Welcome to your dream home in the heart of Tuscumbia, Alabama! Built in 2020, this exquisi...	3 beds \| 3 baths \| 2,150 sq.ft.	$466,490	Airbnb cash on cash: 1.87% Traditional cash on cash: 4.22% Airbnb Rental Income: $1954 Traditional Rental Income: $2464 Airbnb ROI: 1.87% Traditional ROI: 4.22%
304 Maple St Tuscumbia, AL Charming 4-Bedroom Home on Expansive Lot! Welcome to 304 Maple St., a spacious 2,664 sq. f...	4 beds \| 2 baths \| 2,664 sq.ft.	$219,900	Airbnb cash on cash: 5.02% Traditional cash on cash: 10.39% Airbnb Rental Income: $1954 Traditional Rental Income: $2559 Airbnb ROI: 5.02% Traditional ROI: 10.39%
804 Volunteer Dr Tuscumbia, AL This spacious 3 bedroom 2 bath home has it all. Featuring updates throughout, a beautiful ...	3 beds \| 2 baths \| 2,094 sq.ft.	$279,000	Airbnb cash on cash: 3.64% Traditional cash on cash: 4.26% Airbnb Rental Income: $1954 Traditional Rental Income: $1601 Airbnb ROI: 3.64% Traditional ROI: 4.26%
105 Fieldwood Dr Tuscumbia, AL This beautiful 3 bedroom 2 bath home in Tuscumbia city limits. House sits on two lots on a...	4 beds \| 2 baths \| 2,193 sq.ft.	$479,900	Airbnb cash on cash: 1.61% Traditional cash on cash: 2.59% Airbnb Rental Income: $1954 Traditional Rental Income: $1881 Airbnb ROI: 1.61% Traditional ROI: 2.59%
720 S Mulberry St Tuscumbia, AL Charming 2-Bedroom Home with Strong Rental Potential ? Perfect Investment Opportunity! Dis...	2 beds \| 1 baths \| 639 sq.ft.	$100,000	Airbnb cash on cash: 7.46% Traditional cash on cash: 8.49% Airbnb Rental Income: $1380 Traditional Rental Income: $1061 Airbnb ROI: 7.46% Traditional ROI: 8.49%
202 Fame Ave Tuscumbia, AL New Construction Home for Sale. Currently under construction in the new development Sound ...	3 beds \| 3 baths \| 2,282 sq.ft.	$455,000	Airbnb cash on cash: 1.7% Traditional cash on cash: 4.51% Airbnb Rental Income: $1954 Traditional Rental Income: $2638 Airbnb ROI: 1.7% Traditional ROI: 4.51%
101 N Cave St Tuscumbia, AL Old town charm meets classical elegance in this historical home near downtown Tuscumbia. ...	5 beds \| 3 baths \| 3,459 sq.ft.	$345,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 9.43% Airbnb Rental Income: $1240 Traditional Rental Income: $3628 Airbnb ROI: 0.84% Traditional ROI: 9.43%
608 Eastman Ave Tuscumbia, AL Your going to fall in love with this spacious three bedroom, three bath home with large bo...	3 beds \| 3 baths \| 2,300 sq.ft.	$349,900	Airbnb cash on cash: 2.69% Traditional cash on cash: 6.43% Airbnb Rental Income: $1954 Traditional Rental Income: $2669 Airbnb ROI: 2.69% Traditional ROI: 6.43%
800 E 5th St Tuscumbia, AL Discover timeless charm in this stunning ranch-style home, perfectly situated just minutes...	4 beds \| 3 baths \| 2,903 sq.ft.	$314,900	Airbnb cash on cash: 3.3% Traditional cash on cash: 8.99% Airbnb Rental Income: $1954 Traditional Rental Income: $3124 Airbnb ROI: 3.3% Traditional ROI: 8.99%
409 N Jefferson St Tuscumbia, AL Great investment opportunity! Duplex in Tuscumbia, corner lot (409 Jefferson & 401 First S...	N/A beds \| N/A baths \| N/A	$156,900	Airbnb cash on cash: 7.37% Traditional cash on cash: 5.4% Airbnb Rental Income: $1954 Traditional Rental Income: $1144 Airbnb ROI: 7.37% Traditional ROI: 5.4%
302 Fame Ave Tuscumbia, AL This newly constructed 3-bedroom, 2.5-bathroom modern tudor home is designed with elegant ...	3 beds \| 3 baths \| 2,320 sq.ft.	$475,000	Airbnb cash on cash: 1.57% Traditional cash on cash: 4.23% Airbnb Rental Income: $1954 Traditional Rental Income: $2620 Airbnb ROI: 1.57% Traditional ROI: 4.23%
304 Fame Ave Tuscumbia, AL New Construction Home for Sale. Currently under construction in the new development Sound ...	3 beds \| 3 baths \| 2,282 sq.ft.	$467,900	Airbnb cash on cash: 1.61% Traditional cash on cash: 4.37% Airbnb Rental Income: $1954 Traditional Rental Income: $2647 Airbnb ROI: 1.61% Traditional ROI: 4.37%
1513 Joe Wheeler Dr Tuscumbia, AL Don't wait too long to see this charming house that has been updated inside as well as out...	2 beds \| 2 baths \| 1,600 sq.ft.	$159,900	Airbnb cash on cash: 4.39% Traditional cash on cash: 11.62% Airbnb Rental Income: $1380 Traditional Rental Income: $2065 Airbnb ROI: 4.39% Traditional ROI: 11.62%
2762 Old Hwy 20 Tuscumbia, AL Cornelius Landing! Muscle Shoals school district!! Don't miss this custom built 4 bedroom ...	4 beds \| 3 baths \| 2,280 sq.ft.	$439,000	Airbnb cash on cash: 1.91% Traditional cash on cash: 4.65% Airbnb Rental Income: $1954 Traditional Rental Income: $2563 Airbnb ROI: 1.91% Traditional ROI: 4.65%
1309 English Ln Tuscumbia, AL There is nothing missing in this nicely, updated brick house. Seller installed a sound pro...	3 beds \| 2 baths \| 1,479 sq.ft.	$214,900	Airbnb cash on cash: 5.25% Traditional cash on cash: 7.73% Airbnb Rental Income: $1954 Traditional Rental Income: $1945 Airbnb ROI: 5.25% Traditional ROI: 7.73%
1540 Woodmont Dr Tuscumbia, AL Cute & cozy home totally rebuilt with approximately 16 acres! This home was taken down to ...	3 beds \| 2 baths \| 1,132 sq.ft.	$239,900	Airbnb cash on cash: 4.71% Traditional cash on cash: 5.91% Airbnb Rental Income: $1954 Traditional Rental Income: $1713 Airbnb ROI: 4.71% Traditional ROI: 5.91%
121 Fame Ave Tuscumbia, AL Brand New Home Under Construction- Customize it Your Way! This stunning 3-bedroom 3-bathro...	3 beds \| 3 baths \| 2,282 sq.ft.	$479,900	Airbnb cash on cash: 1.54% Traditional cash on cash: 3.98% Airbnb Rental Income: $1954 Traditional Rental Income: $2534 Airbnb ROI: 1.54% Traditional ROI: 3.98%
306 Fame Ave Tuscumbia, AL New Construction Home in Sound Crossings- Muscle Shoals School District! Don?t miss this u...	5 beds \| 3 baths \| 2,889 sq.ft.	$652,000	Airbnb cash on cash: -0.21% Traditional cash on cash: 3.04% Airbnb Rental Income: $1240 Traditional Rental Income: $2823 Airbnb ROI: -0.21% Traditional ROI: 3.04%
1004 Hemlock St Tuscumbia, AL Three bedroom/2 bath home in the Belview Heights Subdivision in Tuscumbia. This split-lev...	3 beds \| 2 baths \| 2,347 sq.ft.	$239,000	Airbnb cash on cash: 4.63% Traditional cash on cash: 8.88% Airbnb Rental Income: $1954 Traditional Rental Income: $2398 Airbnb ROI: 4.63% Traditional ROI: 8.88%
205 Fame Ave Tuscumbia, AL Come be a part of Muscle Shoals' newest planned community, Sound Crossing. This home is fu...	3 beds \| 3 baths \| 2,320 sq.ft.	$475,600	Airbnb cash on cash: 1.62% Traditional cash on cash: 4.09% Airbnb Rental Income: $1954 Traditional Rental Income: $2539 Airbnb ROI: 1.62% Traditional ROI: 4.09%
311 E 6th Street Tuscumbia, AL Step into one of Tuscumbiaâs most iconic homes â the âHeflin House.â This nearly 4...	4 beds \| 3 baths \| 3,867 sq.ft.	$345,000	Airbnb cash on cash: 2.74% Traditional cash on cash: 8.11% Airbnb Rental Income: $1954 Traditional Rental Income: $3182 Airbnb ROI: 2.74% Traditional ROI: 8.11%
889 Blake Dr Tuscumbia, AL This is truly a rare gem offering 7,200 square feet of elegant and functional living space...	5 beds \| 6 baths \| 7,202 sq.ft.	$895,000	Airbnb cash on cash: -0.3% Traditional cash on cash: 6.35% Airbnb Rental Income: $1240 Traditional Rental Income: $6385 Airbnb ROI: -0.3% Traditional ROI: 6.35%
425 Cedar Hill Ln Tuscumbia, AL Listing agent is related to seller. Contingent upon Medicaid approval. Home to be sold "AS...	3 beds \| 2 baths \| 2,066 sq.ft.	$325,000	Airbnb cash on cash: 3.14% Traditional cash on cash: 5.86% Airbnb Rental Income: $1954 Traditional Rental Income: $2271 Airbnb ROI: 3.14% Traditional ROI: 5.86%
1100 Raintree Dr Tuscumbia, AL OPEN HOUSE SATURDAY SEPTEMBER 20TH FROM 11AM - 2PM! You will love this beautiful home sitt...	4 beds \| 3 baths \| 3,876 sq.ft.	$430,000	Airbnb cash on cash: 2.09% Traditional cash on cash: 5.36% Airbnb Rental Income: $1954 Traditional Rental Income: $2758 Airbnb ROI: 2.09% Traditional ROI: 5.36%
905 Old Lee Hwy Tuscumbia, AL Welcome to this fully remodeled 3-bedroom, 2-bathroom home is a must-see for anyone seekin...	3 beds \| 2 baths \| 1,010 sq.ft.	$169,900	Airbnb cash on cash: 6.94% Traditional cash on cash: 8.4% Airbnb Rental Income: $1954 Traditional Rental Income: $1675 Airbnb ROI: 6.94% Traditional ROI: 8.4%
804 E 7th St Tuscumbia, AL No stone unturned on this beautifully done remodel. Come see this charming 2 bedroom/1 bat...	2 beds \| 1 baths \| 1,088 sq.ft.	$165,000	Airbnb cash on cash: 4.22% Traditional cash on cash: 6.62% Airbnb Rental Income: $1380 Traditional Rental Income: $1339 Airbnb ROI: 4.22% Traditional ROI: 6.62%
1705 Keller Quarry Rd Tuscumbia, AL Charming 3 bedrooms, 2 bath home on 1 acre corner lot near Pickwick Lake. Freshly painted...	3 beds \| 2 baths \| 1,632 sq.ft.	$249,575	Airbnb cash on cash: 4.3% Traditional cash on cash: 6.61% Airbnb Rental Income: $1954 Traditional Rental Income: $1984 Airbnb ROI: 4.3% Traditional ROI: 6.61%
710 N High St Tuscumbia, AL Check out this well maintained home in the heart of Tuscumbia. This spacious 3 bed, 1.5 ba...	3 beds \| 2 baths \| 1,300 sq.ft.	$176,900	Airbnb cash on cash: 6.58% Traditional cash on cash: 8.49% Airbnb Rental Income: $1954 Traditional Rental Income: $1761 Airbnb ROI: 6.58% Traditional ROI: 8.49%
110 Emerald Dr Tuscumbia, AL Charming Updated Home on a Quiet Tuscumbia Street. Donât miss this beautifully updated h...	3 beds \| 2 baths \| 1,513 sq.ft.	$194,900	Airbnb cash on cash: 5.71% Traditional cash on cash: 8.75% Airbnb Rental Income: $1954 Traditional Rental Income: $2003 Airbnb ROI: 5.71% Traditional ROI: 8.75%
120 River Dr Tuscumbia, AL Here is your opportunity to live in the beautiful town of Tuscumbia. This home has been we...	3 beds \| 2 baths \| 2,425 sq.ft.	$223,900	Airbnb cash on cash: 4.94% Traditional cash on cash: 9.23% Airbnb Rental Income: $1954 Traditional Rental Income: $2349 Airbnb ROI: 4.94% Traditional ROI: 9.23%
1101 Catalpa St Tuscumbia, AL Welcome Home. Lovely 4 bedroom 2 bath house which sits on a .34 acre corner lot in a des...	4 beds \| 2 baths \| 1,835 sq.ft.	$238,900	Airbnb cash on cash: 4.61% Traditional cash on cash: 8.65% Airbnb Rental Income: $1954 Traditional Rental Income: $2352 Airbnb ROI: 4.61% Traditional ROI: 8.65%
1008 E 6th St Tuscumbia, AL Step into timeless charm at 1008 E 6th St in Historic Tuscumbia, AL! This classic two-stor...	3 beds \| 2 baths \| 2,277 sq.ft.	$229,900	Airbnb cash on cash: 4.81% Traditional cash on cash: 9.55% Airbnb Rental Income: $1954 Traditional Rental Income: $2471 Airbnb ROI: 4.81% Traditional ROI: 9.55%
1096 Raintree Dr Tuscumbia, AL This exceptional two-story home is packed with features that make it a must-see: 4 Bedroom...	4 beds \| 3 baths \| 2,064 sq.ft.	$379,900	Airbnb cash on cash: 2.75% Traditional cash on cash: 5.67% Airbnb Rental Income: $1954 Traditional Rental Income: $2482 Airbnb ROI: 2.75% Traditional ROI: 5.67%
28 Bulls Place Tuscumbia, AL DISCOVER YOUR DREAM HOME IN THE HEART OF TWIN PINES SUBDIVISION SITUATED ON THE 6TH HOLE O...	4 beds \| 3 baths \| 2,713 sq.ft.	$399,900	Airbnb cash on cash: 2.3% Traditional cash on cash: 6.05% Airbnb Rental Income: $1954 Traditional Rental Income: $2845 Airbnb ROI: 2.3% Traditional ROI: 6.05%
4885 Elledge Lane Tuscumbia, AL This 5 bd, 3 ba home offers over 3,000sqft of living space on a 2-acre lot.The updated kit...	5 beds \| 3 baths \| 3,016 sq.ft.	$265,000	Airbnb cash on cash: 1.7% Traditional cash on cash: 10.3% Airbnb Rental Income: $1240 Traditional Rental Income: $2995 Airbnb ROI: 1.7% Traditional ROI: 10.3%
707 Joe Wheeler Dr Tuscumbia, AL Welcome to this charming cottage located in Tuscumbia ! This pristine 3-bedroom, 2-bathro...	3 beds \| 2 baths \| 1,104 sq.ft.	$224,900	Airbnb cash on cash: 5.26% Traditional cash on cash: 8.24% Airbnb Rental Income: $1954 Traditional Rental Income: $2074 Airbnb ROI: 5.26% Traditional ROI: 8.24%
709 Joe Wheeler Dr Tuscumbia, AL Welcome to this charming cottage located in Tuscumbia ! This pristine 3-bedroom, 2-bathro...	3 beds \| 2 baths \| 1,104 sq.ft.	$224,900	Airbnb cash on cash: 5.26% Traditional cash on cash: 8.24% Airbnb Rental Income: $1954 Traditional Rental Income: $2074 Airbnb ROI: 5.26% Traditional ROI: 8.24%
2380 W County Farm Rd Tuscumbia, AL Three bedroom, two full bath home with new paint throughout, new flooring, new roof, new w...	3 beds \| 2 baths \| 2,779 sq.ft.	$279,000	Airbnb cash on cash: 3.89% Traditional cash on cash: 7.51% Airbnb Rental Income: $1954 Traditional Rental Income: $2390 Airbnb ROI: 3.89% Traditional ROI: 7.51%

Real Estate investment in Tuscumbia, AL

There are 60 properties for sale in the city of Tuscumbia . The median list price in Tuscumbia is $249,900 and the average price per square foot is $120. In October 2025, the average monthly cash on cash return in Tuscumbia is 7.00%. The average monthly rental income in Tuscumbia is $2,274.

Tuscumbia, AL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 60 investment properties available for sale in Tuscumbia.

In 2025, the best neighborhood to buy investment property is Tuscumbia.

The ROI for Long-Term is higher than the Short-Term in Tuscumbia with average rental income of $2,274.

Your search for investment property begins and ends here

Investment Property for Sale in Tuscumbia, AL

280 New Bethel Rd

Tuscumbia, AL

3 beds | 2 baths | 2,485 sq.ft.

$299,500

Airbnb cash on cash: 3.56%

Traditional cash on cash: 7.39%

Airbnb Rental Income: $1954

Traditional Rental Income: $2520

Airbnb ROI: 3.56%

Traditional ROI: 7.39%

1085 Tennessee Ave

Tuscumbia, AL

4 beds | 3 baths | 2,300 sq.ft.

$269,900

Airbnb cash on cash: 4.15%

Traditional cash on cash: 8.88%

Airbnb Rental Income: $1954

Traditional Rental Income: $2645

Airbnb ROI: 4.15%

Traditional ROI: 8.88%

162 Valley Grove St

Tuscumbia, AL

3 beds | 3 baths | 2,150 sq.ft.

$466,490

Airbnb cash on cash: 1.87%

Traditional cash on cash: 4.22%

Airbnb Rental Income: $1954

Traditional Rental Income: $2464

Airbnb ROI: 1.87%

Traditional ROI: 4.22%

304 Maple St

Tuscumbia, AL

4 beds | 2 baths | 2,664 sq.ft.

$219,900

Airbnb cash on cash: 5.02%

Traditional cash on cash: 10.39%

Airbnb Rental Income: $1954

Traditional Rental Income: $2559

Airbnb ROI: 5.02%

Traditional ROI: 10.39%

804 Volunteer Dr

Tuscumbia, AL

3 beds | 2 baths | 2,094 sq.ft.

$279,000

Airbnb cash on cash: 3.64%

Traditional cash on cash: 4.26%

Airbnb Rental Income: $1954

Traditional Rental Income: $1601

Airbnb ROI: 3.64%

Traditional ROI: 4.26%

105 Fieldwood Dr

Tuscumbia, AL

4 beds | 2 baths | 2,193 sq.ft.

$479,900

Airbnb cash on cash: 1.61%

Traditional cash on cash: 2.59%

Airbnb Rental Income: $1954

Traditional Rental Income: $1881

Airbnb ROI: 1.61%

Traditional ROI: 2.59%

720 S Mulberry St

Tuscumbia, AL

2 beds | 1 baths | 639 sq.ft.

$100,000

Airbnb cash on cash: 7.46%

Traditional cash on cash: 8.49%

Airbnb Rental Income: $1380

Traditional Rental Income: $1061

Airbnb ROI: 7.46%

Traditional ROI: 8.49%

202 Fame Ave

Tuscumbia, AL

3 beds | 3 baths | 2,282 sq.ft.

$455,000

Airbnb cash on cash: 1.7%

Traditional cash on cash: 4.51%

Airbnb Rental Income: $1954

Traditional Rental Income: $2638

Airbnb ROI: 1.7%