Real Estate Investment Properties for Sale in Tuscumbia, AL

Looking for investment property in Tuscumbia, AL with high ROI ?

Explore a variety of short-term homes & houses in Tuscumbia, AL. Invest wisely with VRBO & Tuscumbia, AL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Tuscumbia, AL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
185 Valley Grove St Tuscumbia, AL Charming 3BR/2.5BA home in a prime Tuscumbia location, just minutes from Hwy 72 and Wilson...	3 beds \| 3 baths \| 1,825 sq.ft.	$445,000	Airbnb cash on cash: -0.28% Traditional cash on cash: 4.12% Airbnb Rental Income: $813 Traditional Rental Income: $2323 Airbnb ROI: -0.28% Traditional ROI: 4.12%
909 Irene Ave Tuscumbia, AL This updated 3 bedroom, 1 bath- home offers a fresh interior with modern touches throughou...	3 beds \| 1 baths \| 1,392 sq.ft.	$189,500	Airbnb cash on cash: 0.87% Traditional cash on cash: 7.37% Airbnb Rental Income: $813 Traditional Rental Income: $1658 Airbnb ROI: 0.87% Traditional ROI: 7.37%
1402 Meadow Dr Tuscumbia, AL This beautifully updated 4-bedroom, 2.5-bath house with 2566 sq ft of living space is an a...	4 beds \| 3 baths \| 2,556 sq.ft.	$369,900	Airbnb cash on cash: 1.48% Traditional cash on cash: 5.95% Airbnb Rental Income: $1548 Traditional Rental Income: $2655 Airbnb ROI: 1.48% Traditional ROI: 5.95%
1009 Hemlock St Tuscumbia, AL Take a look at this beautiful 4-bedroom, 3-bath home located in the desirable Tuscumbia sc...	4 beds \| 3 baths \| 2,003 sq.ft.	$249,900	Airbnb cash on cash: 2.77% Traditional cash on cash: 6.55% Airbnb Rental Income: $1548 Traditional Rental Income: $1994 Airbnb ROI: 2.77% Traditional ROI: 6.55%
202 Fame Ave Tuscumbia, AL New Construction Home for Sale. Currently under construction in the new development Sound ...	3 beds \| 3 baths \| 2,282 sq.ft.	$379,000	Airbnb cash on cash: -0.36% Traditional cash on cash: 5.68% Airbnb Rental Income: $813 Traditional Rental Income: $2638 Airbnb ROI: -0.36% Traditional ROI: 5.68%
703 E 2nd St Tuscumbia, AL Charming 1950s brick home located in the heart of Tuscumbia! This 3 bedroom, 2 bath home b...	3 beds \| 2 baths \| 1,673 sq.ft.	$232,500	Airbnb cash on cash: 0.47% Traditional cash on cash: 7.98% Airbnb Rental Income: $813 Traditional Rental Income: $2138 Airbnb ROI: 0.47% Traditional ROI: 7.98%
608 Eastman Ave Tuscumbia, AL Take a look at this stunning and spacious home situated on a corner lot in Tuscumbia. Ther...	3 beds \| 3 baths \| 2,300 sq.ft.	$329,900	Airbnb cash on cash: -0.04% Traditional cash on cash: 6.99% Airbnb Rental Income: $813 Traditional Rental Income: $2669 Airbnb ROI: -0.04% Traditional ROI: 6.99%
304 Fame Ave Tuscumbia, AL New Construction Home for Sale. Currently under construction in the new development Sound ...	3 beds \| 3 baths \| 2,282 sq.ft.	$387,000	Airbnb cash on cash: -0.38% Traditional cash on cash: 5.56% Airbnb Rental Income: $813 Traditional Rental Income: $2647 Airbnb ROI: -0.38% Traditional ROI: 5.56%
121 Fame Ave Tuscumbia, AL Brand New Home Under Construction- Customize it Your Way! This stunning 3-bedroom 3-bathro...	3 beds \| 3 baths \| 2,282 sq.ft.	$419,900	Airbnb cash on cash: -0.46% Traditional cash on cash: 4.74% Airbnb Rental Income: $813 Traditional Rental Income: $2534 Airbnb ROI: -0.46% Traditional ROI: 4.74%
306 Fame Ave Tuscumbia, AL New Construction Home in Sound Crossings- Muscle Shoals School District! Don?t miss this u...	5 beds \| 3 baths \| 2,889 sq.ft.	$592,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.49% Airbnb Rental Income: $null Traditional Rental Income: $2823 Airbnb ROI: N/A Traditional ROI: 3.49%
205 Fame Ave Tuscumbia, AL Come be a part of Muscle Shoals' newest planned community, Sound Crossing, located just 15...	3 beds \| 3 baths \| 2,320 sq.ft.	$395,500	Airbnb cash on cash: -0.34% Traditional cash on cash: 5.19% Airbnb Rental Income: $813 Traditional Rental Income: $2539 Airbnb ROI: -0.34% Traditional ROI: 5.19%
311 E 6th St Tuscumbia, AL This historic property, known as the âHeflin House,â is located in Downtown Tuscumbia ...	4 beds \| 3 baths \| 3,867 sq.ft.	$345,000	Airbnb cash on cash: 1.66% Traditional cash on cash: 8.08% Airbnb Rental Income: $1548 Traditional Rental Income: $3182 Airbnb ROI: 1.66% Traditional ROI: 8.08%
425 Cedar Hill Ln Tuscumbia, AL Listing agent is related to seller. Contingent upon Medicaid approval. Home to be sold "AS...	3 beds \| 2 baths \| 2,066 sq.ft.	$325,000	Airbnb cash on cash: 0.03% Traditional cash on cash: 5.86% Airbnb Rental Income: $813 Traditional Rental Income: $2271 Airbnb ROI: 0.03% Traditional ROI: 5.86%
804 E 7th St Tuscumbia, AL COMPLETELY RENOVATED from top to bottom, inside & out! Come see this charming 2 bedroom/1 ...	2 beds \| 1 baths \| 1,088 sq.ft.	$159,900	Airbnb cash on cash: 1.99% Traditional cash on cash: 6.86% Airbnb Rental Income: $942 Traditional Rental Income: $1339 Airbnb ROI: 1.99% Traditional ROI: 6.86%
1705 Keller Quarry Rd Tuscumbia, AL Charming 3 bedrooms, 2 bath home on 1 acre corner lot near Pickwick Lake. Freshly painted...	3 beds \| 2 baths \| 1,632 sq.ft.	$248,250	Airbnb cash on cash: 0.27% Traditional cash on cash: 6.65% Airbnb Rental Income: $813 Traditional Rental Income: $1984 Airbnb ROI: 0.27% Traditional ROI: 6.65%
120 River Dr Tuscumbia, AL NEW DRIVEWAY AND LANDSCAPING! NEW OUTSIDE PICS! Here is your opportunity to live in the ...	3 beds \| 2 baths \| 2,425 sq.ft.	$203,900	Airbnb cash on cash: 0.63% Traditional cash on cash: 10.25% Airbnb Rental Income: $813 Traditional Rental Income: $2349 Airbnb ROI: 0.63% Traditional ROI: 10.25%
1008 E 6th St Tuscumbia, AL Step into timeless charm at 1008 E 6th St in Historic Tuscumbia, AL! This classic two-stor...	3 beds \| 2 baths \| 2,277 sq.ft.	$209,900	Airbnb cash on cash: 0.57% Traditional cash on cash: 10.54% Airbnb Rental Income: $813 Traditional Rental Income: $2471 Airbnb ROI: 0.57% Traditional ROI: 10.54%
1001 N Cave St Tuscumbia, AL This charming 3 bedroom, 1 bath home is situated on a spacious corner lot and offers plent...	3 beds \| 1 baths \| 1,186 sq.ft.	$163,900	Airbnb cash on cash: 1.29% Traditional cash on cash: 8.56% Airbnb Rental Income: $813 Traditional Rental Income: $1627 Airbnb ROI: 1.29% Traditional ROI: 8.56%
304 5th St Tuscumbia, AL Now is your chance to own your first rental property or add a cash flowing duplex to your ...	N/A beds \| N/A baths \| N/A	$190,000	Airbnb cash on cash: 0.3% Traditional cash on cash: 4% Airbnb Rental Income: $813 Traditional Rental Income: $1157 Airbnb ROI: 0.3% Traditional ROI: 4%
406 N Commons St Tuscumbia, AL Located in a prime downtown Tuscumbia spot, this home sits on a corner lot with two parcel...	4 beds \| 3 baths \| 2,640 sq.ft.	$274,900	Airbnb cash on cash: 2.55% Traditional cash on cash: 11.09% Airbnb Rental Income: $1548 Traditional Rental Income: $3314 Airbnb ROI: 2.55% Traditional ROI: 11.09%
45 Sadie Lane Tuscumbia, AL Imagine owning this stunning move-in-ready home with up to $20,000 in free money to make i...	3 beds \| 2 baths \| 1,528 sq.ft.	$299,990	Airbnb cash on cash: -0.23% Traditional cash on cash: 5.54% Airbnb Rental Income: $813 Traditional Rental Income: $2117 Airbnb ROI: -0.23% Traditional ROI: 5.54%
85 Sadie Lane Tuscumbia, AL Up to $20,000 in Savings/free money, call for details.Priced at $272,990, this brand new c...	3 beds \| 2 baths \| 1,400 sq.ft.	$272,990	Airbnb cash on cash: -0.12% Traditional cash on cash: 5.78% Airbnb Rental Income: $813 Traditional Rental Income: $2006 Airbnb ROI: -0.12% Traditional ROI: 5.78%
125 Sadie Lane Tuscumbia, AL Up to 20K in savings/free money â call for details! Discover this just-built 1,554 sq ft...	3 beds \| 2 baths \| 1,554 sq.ft.	$299,990	Airbnb cash on cash: -0.23% Traditional cash on cash: 5.51% Airbnb Rental Income: $813 Traditional Rental Income: $2109 Airbnb ROI: -0.23% Traditional ROI: 5.51%
1211 Anna Dr Tuscumbia, AL Welcome to Southern Elegance! A home that transcends the ordinaryâan exquisite 5-bedroom...	5 beds \| 5 baths \| 3,484 sq.ft.	$989,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.86% Airbnb Rental Income: $null Traditional Rental Income: $4921 Airbnb ROI: N/A Traditional ROI: 3.86%
1306 Calhoun St Tuscumbia, AL You will love this home located in Tuscumbia with the school options of Deshler or Colbert...	3 beds \| 2 baths \| 1,589 sq.ft.	$220,000	Airbnb cash on cash: 0.6% Traditional cash on cash: 8.33% Airbnb Rental Income: $813 Traditional Rental Income: $2098 Airbnb ROI: 0.6% Traditional ROI: 8.33%
911 Madison St Tuscumbia, AL Charming 2-bedroom, 1-bath home in the heart of Tuscumbia, AL! This inviting residence fea...	2 beds \| 2 baths \| 1,632 sq.ft.	$149,900	Airbnb cash on cash: 2.05% Traditional cash on cash: 8.17% Airbnb Rental Income: $942 Traditional Rental Income: $1473 Airbnb ROI: 2.05% Traditional ROI: 8.17%
2675 E 6th St Tuscumbia, AL Renovated 3 bedroom, 2 bath painted brick home situated on a spacious 1-acre lot in Muscle...	3 beds \| 2 baths \| 1,439 sq.ft.	$230,900	Airbnb cash on cash: 0.65% Traditional cash on cash: 7.18% Airbnb Rental Income: $813 Traditional Rental Income: $1915 Airbnb ROI: 0.65% Traditional ROI: 7.18%
105 Studio Dr Tuscumbia, AL 105 Studio Dr, Tuscumbia, AL 35674 \| Other	N/A beds \| N/A baths \| N/A	$89,000	Airbnb cash on cash: -0.31% Traditional cash on cash: 5.16% Airbnb Rental Income: $482 Traditional Rental Income: $689 Airbnb ROI: -0.31% Traditional ROI: 5.16%
103 Studio Dr Tuscumbia, AL 103 Studio Dr, Tuscumbia, AL 35674 \| Other	N/A beds \| N/A baths \| N/A	$89,000	Airbnb cash on cash: -0.31% Traditional cash on cash: 6.26% Airbnb Rental Income: $482 Traditional Rental Income: $785 Airbnb ROI: -0.31% Traditional ROI: 6.26%
107 Studio Dr Tuscumbia, AL 107 Studio Dr, Tuscumbia, AL 35674 \| Other	N/A beds \| N/A baths \| N/A	$89,000	Airbnb cash on cash: -0.31% Traditional cash on cash: 5.14% Airbnb Rental Income: $482 Traditional Rental Income: $687 Airbnb ROI: -0.31% Traditional ROI: 5.14%
152 Harmony Dr Tuscumbia, AL Chic and move-in ready 4BR/2BA home, featuring an open-concept layout, tile floors through...	4 beds \| 2 baths \| 1,685 sq.ft.	$264,900	Airbnb cash on cash: 2.02% Traditional cash on cash: 6.16% Airbnb Rental Income: $1548 Traditional Rental Income: $2136 Airbnb ROI: 2.02% Traditional ROI: 6.16%
121 Walker Ave Tuscumbia, AL A touch of vintage with a modern vibe describes this beauty located in the quiet neighborh...	4 beds \| 2 baths \| 1,898 sq.ft.	$239,900	Airbnb cash on cash: 3.25% Traditional cash on cash: 9.33% Airbnb Rental Income: $1548 Traditional Rental Income: $2480 Airbnb ROI: 3.25% Traditional ROI: 9.33%
108 W Jackson St Tuscumbia, AL New roof coming soon !!!! Great Remodeled 3 bed 1 bath Cottage in the Heart of Tuscumbia ...	3 beds \| 1 baths \| 1,100 sq.ft.	$159,900	Airbnb cash on cash: 0.97% Traditional cash on cash: 6.03% Airbnb Rental Income: $813 Traditional Rental Income: $1262 Airbnb ROI: 0.97% Traditional ROI: 6.03%
435 Carter Dr Tuscumbia, AL Wake up to open views of the Tennessee River in a home where the water does most of the ta...	4 beds \| 3 baths \| 2,643 sq.ft.	$689,999	Airbnb cash on cash: 0.43% Traditional cash on cash: 2.87% Airbnb Rental Income: $1548 Traditional Rental Income: $2669 Airbnb ROI: 0.43% Traditional ROI: 2.87%
300 Fame Ave Tuscumbia, AL Muscle Shoals' newest planned community, Sound Crossing, has a home waiting for you and it...	3 beds \| 3 baths \| 2,976 sq.ft.	$525,500	Airbnb cash on cash: -0.6% Traditional cash on cash: 3.73% Airbnb Rental Income: $813 Traditional Rental Income: $2618 Airbnb ROI: -0.6% Traditional ROI: 3.73%
930 Twin Pines Cir Tuscumbia, AL Welcome to golf course living at its finest. This beautifully designed 4 bedroom, 2.5 bath...	4 beds \| 3 baths \| 2,800 sq.ft.	$379,900	Airbnb cash on cash: 1.45% Traditional cash on cash: 6.1% Airbnb Rental Income: $1548 Traditional Rental Income: $2759 Airbnb ROI: 1.45% Traditional ROI: 6.1%
1227 Twin Pines Cir Tuscumbia, AL Welcome home to this beautiful custom built brick estate constructed on a spacious half-ac...	4 beds \| 3 baths \| 2,438 sq.ft.	$465,000	Airbnb cash on cash: 0.94% Traditional cash on cash: 4.44% Airbnb Rental Income: $1548 Traditional Rental Income: $2624 Airbnb ROI: 0.94% Traditional ROI: 4.44%
1122 Paul E Johnson Dr Tuscumbia, AL Remodeled, move-in ready brick ranch in the heart of Tuscumbia! This 2 bed, 1 bath home fe...	2 beds \| 1 baths \| 864 sq.ft.	$119,900	Airbnb cash on cash: 2.8% Traditional cash on cash: 8.56% Airbnb Rental Income: $942 Traditional Rental Income: $1263 Airbnb ROI: 2.8% Traditional ROI: 8.56%
811 Rebel Dr Tuscumbia, AL Spacious 3 bedroom, 2 bath brick ranch offering approximately 1,800 sq ft of one-level liv...	3 beds \| 2 baths \| 1,800 sq.ft.	$204,900	Airbnb cash on cash: 0.62% Traditional cash on cash: 9.18% Airbnb Rental Income: $813 Traditional Rental Income: $2152 Airbnb ROI: 0.62% Traditional ROI: 9.18%
904 E 1st St Tuscumbia, AL Charming 2 bedroom, 1 bath cottage located in Tuscumbia! This cozy home features low-maint...	2 beds \| 1 baths \| 1,191 sq.ft.	$124,500	Airbnb cash on cash: 2.55% Traditional cash on cash: 11.92% Airbnb Rental Income: $942 Traditional Rental Income: $1719 Airbnb ROI: 2.55% Traditional ROI: 11.92%

Real Estate investment in Tuscumbia, AL

There are 69 properties for sale in the city of Tuscumbia . The median list price in Tuscumbia is $239,990 and the average price per square foot is $129. In May 2026, the average monthly cash on cash return in Tuscumbia is 6.00%. The average monthly rental income in Tuscumbia is $2,098.

Tuscumbia, AL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 69 investment properties available for sale in Tuscumbia.

In 2026, the best neighborhood to buy investment property is Tuscumbia.

The ROI for Long-Term is higher than the Short-Term in Tuscumbia with average rental income of $2,098.

Your search for investment property begins and ends here

Investment Property for Sale in Tuscumbia, AL

185 Valley Grove St

Tuscumbia, AL

3 beds | 3 baths | 1,825 sq.ft.

$445,000

Airbnb cash on cash: -0.28%

Traditional cash on cash: 4.12%

Airbnb Rental Income: $813

Traditional Rental Income: $2323

Airbnb ROI: -0.28%

Traditional ROI: 4.12%

909 Irene Ave

Tuscumbia, AL

3 beds | 1 baths | 1,392 sq.ft.

$189,500

Airbnb cash on cash: 0.87%

Traditional cash on cash: 7.37%

Airbnb Rental Income: $813

Traditional Rental Income: $1658

Airbnb ROI: 0.87%

Traditional ROI: 7.37%

1402 Meadow Dr

Tuscumbia, AL

4 beds | 3 baths | 2,556 sq.ft.

$369,900

Airbnb cash on cash: 1.48%

Traditional cash on cash: 5.95%

Airbnb Rental Income: $1548

Traditional Rental Income: $2655

Airbnb ROI: 1.48%

Traditional ROI: 5.95%

1009 Hemlock St

Tuscumbia, AL

4 beds | 3 baths | 2,003 sq.ft.

$249,900

Airbnb cash on cash: 2.77%

Traditional cash on cash: 6.55%

Airbnb Rental Income: $1548

Traditional Rental Income: $1994

Airbnb ROI: 2.77%

Traditional ROI: 6.55%

202 Fame Ave

Tuscumbia, AL

3 beds | 3 baths | 2,282 sq.ft.

$379,000

Airbnb cash on cash: -0.36%

Traditional cash on cash: 5.68%

Airbnb Rental Income: $813

Traditional Rental Income: $2638

Airbnb ROI: -0.36%

Traditional ROI: 5.68%

703 E 2nd St

Tuscumbia, AL

3 beds | 2 baths | 1,673 sq.ft.

$232,500

Airbnb cash on cash: 0.47%

Traditional cash on cash: 7.98%

Airbnb Rental Income: $813

Traditional Rental Income: $2138

Airbnb ROI: 0.47%

Traditional ROI: 7.98%

608 Eastman Ave

Tuscumbia, AL

3 beds | 3 baths | 2,300 sq.ft.

$329,900

Airbnb cash on cash: -0.04%

Traditional cash on cash: 6.99%

Airbnb Rental Income: $813

Traditional Rental Income: $2669

Airbnb ROI: -0.04%

Traditional ROI: 6.99%

304 Fame Ave

Tuscumbia, AL

3 beds | 3 baths | 2,282 sq.ft.

$387,000

Airbnb cash on cash: -0.38%

Traditional cash on cash: 5.56%

Airbnb Rental Income: $813

Traditional Rental Income: $2647

Airbnb ROI: -0.38%