Real Estate Investment Properties for Sale in Mayo, FL

Looking for investment property in Mayo, FL with high ROI ?

Explore a variety of short-term homes & houses in Mayo, FL. Invest wisely with VRBO & Mayo, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Mayo, FL

separator

PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
365 NW COUNTY ROAD 292 Mayo, FL Seller is offering a $25,000.00 credit to Buyer on this sustainable homestead situated on ...	5 beds \| 2 baths \| 2,400 sq.ft.	$795,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.76% Airbnb Rental Income: $null Traditional Rental Income: $2795 Airbnb ROI: N/A Traditional ROI: 1.76%
243 NE WESLEY STREET Mayo, FL Updated 2/2 mobile home with added Privacy just a short distance to the Suwannee River. Ne...	2 beds \| 2 baths \| 924 sq.ft.	$138,000	Airbnb cash on cash: 5.56% Traditional cash on cash: 10.46% Airbnb Rental Income: $1442 Traditional Rental Income: $1661 Airbnb ROI: 5.56% Traditional ROI: 10.46%
1015 NE NORTHWOOD DRIVE Mayo, FL Under contract-accepting backup offers. Spacious 5-Bedroom Retreat with Pool, Privacy & Mo...	5 beds \| 4 baths \| 3,210 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.16% Airbnb Rental Income: $null Traditional Rental Income: $4468 Airbnb ROI: N/A Traditional ROI: 8.16%
113 SE Parker Rd Mayo, FL Welcome to a unique opportunity in the heart of North Florida! Nestled among majestic live...	4 beds \| 2 baths \| 2,052 sq.ft.	$350,000	Airbnb cash on cash: 2.29% Traditional cash on cash: 5.6% Airbnb Rental Income: $1644 Traditional Rental Income: $2267 Airbnb ROI: 2.29% Traditional ROI: 5.6%
314 SW Wildwood Drive Mayo, FL Tucked away down a quiet dirt road, this 3BR/3BA brick home sits on 5.73 peaceful acres ju...	3 beds \| 3 baths \| 2,368 sq.ft.	$299,000	Airbnb cash on cash: 4.1% Traditional cash on cash: 7.82% Airbnb Rental Income: $2298 Traditional Rental Income: $2773 Airbnb ROI: 4.1% Traditional ROI: 7.82%
565 NE MARION ROAD Mayo, FL Escape to your own private oasis on the beautiful Suwannee River! This one-of-a-kind cedar...	2 beds \| 2 baths \| 1,200 sq.ft.	$435,000	Airbnb cash on cash: 0.83% Traditional cash on cash: 4.23% Airbnb Rental Income: $1442 Traditional Rental Income: $2397 Airbnb ROI: 0.83% Traditional ROI: 4.23%
720 SW County Road 300 Mayo, FL *Wonderfuly Private 10+ (Farm Friendly) Acres to enjoy the morning Sunrise and the evening...	4 beds \| 3 baths \| 2,498 sq.ft.	$550,000	Airbnb cash on cash: 0.96% Traditional cash on cash: 4.2% Airbnb Rental Income: $1644 Traditional Rental Income: $2842 Airbnb ROI: 0.96% Traditional ROI: 4.2%

Real Estate investment in Mayo, FL

There are 7 properties for sale in the city of Mayo . The median list price in Mayo is $392,500 and the average price per square foot is $174. In November 2025, the average monthly cash on cash return in Mayo is 7.00%. The average monthly rental income in Mayo is $2,784.

Mayo, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 7 investment properties available for sale in Mayo.

In 2025, the best neighborhood to buy investment property is Mayo.

The ROI for Long-Term is higher than the Short-Term in Mayo with average rental income of $2,784.

Your search for investment property begins and ends here

Investment Property for Sale in Mayo, FL

365 NW COUNTY ROAD 292

Mayo, FL

5 beds | 2 baths | 2,400 sq.ft.

$795,000

Airbnb cash on cash: N/A

Traditional cash on cash: 1.76%

Airbnb Rental Income: $null

Traditional Rental Income: $2795

Airbnb ROI: N/A

Traditional ROI: 1.76%

243 NE WESLEY STREET

Mayo, FL

2 beds | 2 baths | 924 sq.ft.

$138,000

Airbnb cash on cash: 5.56%

Traditional cash on cash: 10.46%

Airbnb Rental Income: $1442

Traditional Rental Income: $1661

Airbnb ROI: 5.56%

Traditional ROI: 10.46%

1015 NE NORTHWOOD DRIVE

Mayo, FL

5 beds | 4 baths | 3,210 sq.ft.

$475,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.16%

Airbnb Rental Income: $null

Traditional Rental Income: $4468

Airbnb ROI: N/A

Traditional ROI: 8.16%

113 SE Parker Rd

Mayo, FL

4 beds | 2 baths | 2,052 sq.ft.

$350,000

Airbnb cash on cash: 2.29%

Traditional cash on cash: 5.6%

Airbnb Rental Income: $1644

Traditional Rental Income: $2267

Airbnb ROI: 2.29%

Traditional ROI: 5.6%

314 SW Wildwood Drive

Mayo, FL

3 beds | 3 baths | 2,368 sq.ft.

$299,000

Airbnb cash on cash: 4.1%

Traditional cash on cash: 7.82%

Airbnb Rental Income: $2298

Traditional Rental Income: $2773

Airbnb ROI: 4.1%

Traditional ROI: 7.82%

565 NE MARION ROAD

Mayo, FL

2 beds | 2 baths | 1,200 sq.ft.

$435,000

Airbnb cash on cash: 0.83%

Traditional cash on cash: 4.23%

Airbnb Rental Income: $1442

Traditional Rental Income: $2397

Airbnb ROI: 0.83%

Traditional ROI: 4.23%

720 SW County Road 300

Mayo, FL

4 beds | 3 baths | 2,498 sq.ft.

$550,000

Airbnb cash on cash: 0.96%

Traditional cash on cash: 4.2%

Airbnb Rental Income: $1644

Traditional Rental Income: $2842

Airbnb ROI: 0.96%

Traditional ROI: 4.2%

Real Estate investment in Mayo, FL

Mayo, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

How many investment properties are available for sale in Mayo?

Which neighborhoods in Mayo to invest in 2025?

Long-Term vs. Short-Term Rentals in Mayo, Florida: Which will earn the best returns?

Use analytics to find lucrative traditional or Airbnb properties in a matter of minutes.

No more spreadsheets, no more searching.