Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
40 Lakeview Drive Panacea, FL Charming beach cottage on Bald Point! FANTASTIC LOCATION adjacent to State Park property a...	2 beds \| 2 baths \| 1,059 sq.ft.	$389,000	Airbnb cash on cash: 1.8% Traditional cash on cash: 3.76% Airbnb Rental Income: $1645 Traditional Rental Income: $1899 Airbnb ROI: 1.8% Traditional ROI: 3.76%
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$689,000	Airbnb cash on cash: 0.67% Traditional cash on cash: 2.5% Airbnb Rental Income: $2171 Traditional Rental Income: $2796 Airbnb ROI: 0.67% Traditional ROI: 2.5%
40 POMPANO Drive Panacea, FL Welcome to your slice of Old Florida paradise in the heart of Panacea! This charming canal...	3 beds \| 2 baths \| 1,560 sq.ft.	$475,000	Airbnb cash on cash: 1.47% Traditional cash on cash: 2.4% Airbnb Rental Income: $2171 Traditional Rental Income: $2033 Airbnb ROI: 1.47% Traditional ROI: 2.4%
39 Aucilla Street Panacea, FL Furniture is Virtually staged. A MUST SEE home with acreage! Beautifully maintained three-...	3 beds \| 2 baths \| 2,093 sq.ft.	$549,000	Airbnb cash on cash: 1.41% Traditional cash on cash: 3.72% Airbnb Rental Income: $2171 Traditional Rental Income: $2801 Airbnb ROI: 1.41% Traditional ROI: 3.72%
12 Lake Essay Drive Panacea, FL Bring your boats and don't miss the chance to own this delightful 2-bedroom, 1-bath cottag...	2 beds \| 1 baths \| 1,148 sq.ft.	$229,900	Airbnb cash on cash: 3.51% Traditional cash on cash: 6.8% Airbnb Rental Income: $1645 Traditional Rental Income: $1898 Airbnb ROI: 3.51% Traditional ROI: 6.8%
2289 Surf Road #C3 Panacea, FL Escape to your own slice of paradise in this stunning 2-bedroom, 2.5-bath condo at Bayside...	2 beds \| 3 baths \| 1,440 sq.ft.	$275,000	Airbnb cash on cash: 0.04% Traditional cash on cash: 3.64% Airbnb Rental Income: $1645 Traditional Rental Income: $2115 Airbnb ROI: 0.04% Traditional ROI: 3.64%
23 Monticello Avenue Panacea, FL Adorable, peaceful and quiet home located in the heart of Panacea on 17 platted lots total...	3 beds \| 2 baths \| 1,420 sq.ft.	$359,000	Airbnb cash on cash: 3.02% Traditional cash on cash: 5.61% Airbnb Rental Income: $2171 Traditional Rental Income: $2493 Airbnb ROI: 3.02% Traditional ROI: 5.61%
88 Warbird Circle Panacea, FL New construction in gated Tarpine community that includes access to airport and community ...	3 beds \| 2 baths \| 1,527 sq.ft.	$445,000	Airbnb cash on cash: 2.57% Traditional cash on cash: 4.5% Airbnb Rental Income: $2171 Traditional Rental Income: $2421 Airbnb ROI: 2.57% Traditional ROI: 4.5%
7 BASS STREET Panacea, FL Welcome to 7 Bass St, a charming coastal retreat nestled in the serene community of Alliga...	4 beds \| 3 baths \| 1,800 sq.ft.	$669,987	Airbnb cash on cash: -0.06% Traditional cash on cash: 2.46% Airbnb Rental Income: $1244 Traditional Rental Income: $2421 Airbnb ROI: -0.06% Traditional ROI: 2.46%
47 BLUE CRAB Lane Panacea, FL This 3-bedroom 2 bath is a Octagon home on .333 acres is built to withstand winds of 180 m...	3 beds \| 2 baths \| 1,280 sq.ft.	$995,000	Airbnb cash on cash: -0.23% Traditional cash on cash: 1.92% Airbnb Rental Income: $2171 Traditional Rental Income: $3619 Airbnb ROI: -0.23% Traditional ROI: 1.92%
367 Mashes Sands Road Panacea, FL Welcome to 367 Mashes Sands Road, a rare waterfront retreat on beautiful Ochlockonee Bay o...	3 beds \| 3 baths \| 2,028 sq.ft.	$499,900	Airbnb cash on cash: 1.78% Traditional cash on cash: 5.89% Airbnb Rental Income: $2171 Traditional Rental Income: $3543 Airbnb ROI: 1.78% Traditional ROI: 5.89%
201 Harbour Point Panacea, FL Waterfront Luxury in Shell Point - 4 Bed \| 3 Full & 2 Half Bath \| Private Dock & Boat Lift...	4 beds \| 5 baths \| 2,778 sq.ft.	$869,000	Airbnb cash on cash: -1.09% Traditional cash on cash: 5.15% Airbnb Rental Income: $1244 Traditional Rental Income: $5901 Airbnb ROI: -1.09% Traditional ROI: 5.15%
2489 Surf Road Panacea, FL "High Point" is aptly named as this magnificent home sits atop a lot and a half overlookin...	4 beds \| 4 baths \| 3,228 sq.ft.	$759,900	Airbnb cash on cash: -0.62% Traditional cash on cash: 10.22% Airbnb Rental Income: $1244 Traditional Rental Income: $8521 Airbnb ROI: -0.62% Traditional ROI: 10.22%
69 Suwanne Avenue Panacea, FL Welcome to your slice of Old Florida paradise! This fabulous 1940's Coastal bungalow sits ...	2 beds \| 2 baths \| 1,080 sq.ft.	$295,000	Airbnb cash on cash: 2.04% Traditional cash on cash: 5.38% Airbnb Rental Income: $1645 Traditional Rental Income: $2110 Airbnb ROI: 2.04% Traditional ROI: 5.38%
18 Suwannee Avenue Panacea, FL Welcome to this beautifully remodeled 2-bedroom, 2-bath cottage-style home in the heart of...	2 beds \| 2 baths \| 932 sq.ft.	$220,000	Airbnb cash on cash: 3.86% Traditional cash on cash: 6.65% Airbnb Rental Income: $1645 Traditional Rental Income: $1762 Airbnb ROI: 3.86% Traditional ROI: 6.65%
11 A3 Mashes Sands Road #A Panacea, FL Beautifully Remodeled 2BR/1BA Condo in a gated Waterfront Community! Enjoy resort-style li...	2 beds \| 1 baths \| 910 sq.ft.	$219,900	Airbnb cash on cash: 3.19% Traditional cash on cash: 6.47% Airbnb Rental Income: $1645 Traditional Rental Income: $1864 Airbnb ROI: 3.19% Traditional ROI: 6.47%
84 Chattahoochee Street Panacea, FL Discover the potential in this 3-bedroom, 2-bath home nestled on a spacious 1-acre lot in ...	3 beds \| 2 baths \| 1,813 sq.ft.	$199,900	Airbnb cash on cash: 6.3% Traditional cash on cash: 11.6% Airbnb Rental Income: $2171 Traditional Rental Income: $2625 Airbnb ROI: 6.3% Traditional ROI: 11.6%
103 Center Street Panacea, FL Spacious 3BR/2BA home in the heart of Crawfordville situated on two city lots. Offering ap...	3 beds \| 2 baths \| 2,260 sq.ft.	$295,000	Airbnb cash on cash: 4.34% Traditional cash on cash: 8.14% Airbnb Rental Income: $2171 Traditional Rental Income: $2677 Airbnb ROI: 4.34% Traditional ROI: 8.14%
2289 Surf Road #A7 Panacea, FL Imagine waking up to uninterrupted bay views from every floor while sipping your morning c...	2 beds \| 3 baths \| 1,440 sq.ft.	$325,000	Airbnb cash on cash: 2.55% Traditional cash on cash: 8.29% Airbnb Rental Income: $1645 Traditional Rental Income: $2936 Airbnb ROI: 2.55% Traditional ROI: 8.29%
47 Aucilla Street Panacea, FL Set in a peaceful and friendly coastal environment, this well-maintained homestead offers ...	3 beds \| 2 baths \| 2,093 sq.ft.	$695,000	Airbnb cash on cash: 0.47% Traditional cash on cash: 1.63% Airbnb Rental Income: $2171 Traditional Rental Income: $2368 Airbnb ROI: 0.47% Traditional ROI: 1.63%
22 Otter Lake Road Panacea, FL Welcome to 22 Otter Lake Rd! This 3 Bedroom 2 Bath home offers peaceful living in a quiet ...	3 beds \| 2 baths \| 2,172 sq.ft.	$315,000	Airbnb cash on cash: 3.44% Traditional cash on cash: 7.1% Airbnb Rental Income: $2171 Traditional Rental Income: $2706 Airbnb ROI: 3.44% Traditional ROI: 7.1%
695 B6 Mashes Sands Road Panacea, FL Welcome Home to this 1656 sqft 2 bedroom 2.5 bath end unit townhouse in Marina Village. Fe...	2 beds \| 3 baths \| 1,656 sq.ft.	$425,000	Airbnb cash on cash: 0.46% Traditional cash on cash: 4.01% Airbnb Rental Income: $1645 Traditional Rental Income: $2597 Airbnb ROI: 0.46% Traditional ROI: 4.01%
572 Mashes Sands Road Panacea, FL Be near the water with no HOA dues and experience the charm of coastal living less than a ...	3 beds \| 2 baths \| 1,694 sq.ft.	$399,000	Airbnb cash on cash: 2.37% Traditional cash on cash: 4.41% Airbnb Rental Income: $2171 Traditional Rental Income: $2383 Airbnb ROI: 2.37% Traditional ROI: 4.41%
1629 Coastal Hwy Panacea, FL THE PERFECT BUSINESS OPPORTUNITY WITH A BAY VIEW!!! This incredible commercial property of...	N/A beds \| N/A baths \| 1,788 sq.ft.	$284,900	Airbnb cash on cash: 4% Traditional cash on cash: 7.04% Airbnb Rental Income: $2213 Traditional Rental Income: $2470 Airbnb ROI: 4% Traditional ROI: 7.04%
695 A6 Mashes Sands Road Panacea, FL Welcome to Marina Village! This beautifully updated 1,332 sq ft end unit townhouse offers ...	3 beds \| 3 baths \| 1,332 sq.ft.	$384,900	Airbnb cash on cash: 2.27% Traditional cash on cash: 4.78% Airbnb Rental Income: $2171 Traditional Rental Income: $2526 Airbnb ROI: 2.27% Traditional ROI: 4.78%
68 Suwannee Avenue Panacea, FL Looking for a family vacation home or an investment property? This stunning 3-bedroom, 2-b...	3 beds \| 2 baths \| 1,020 sq.ft.	$269,000	Airbnb cash on cash: 4.44% Traditional cash on cash: 6.45% Airbnb Rental Income: $2171 Traditional Rental Income: $2131 Airbnb ROI: 4.44% Traditional ROI: 6.45%
7 Cutty Sark Court Panacea, FL Experience refined coastal living in this exceptional bayfront retreat designed for both l...	3 beds \| 3 baths \| 2,327 sq.ft.	$1,150,000	Airbnb cash on cash: -0.43% Traditional cash on cash: 1.63% Airbnb Rental Income: $2171 Traditional Rental Income: $3822 Airbnb ROI: -0.43% Traditional ROI: 1.63%
695 A4 Mashes Sands Road #A4 Panacea, FL Coastal Living with the Rare Convenience of a Private Elevator - Marina Village of Panacea...	2 beds \| 2 baths \| 1,332 sq.ft.	$425,000	Airbnb cash on cash: 0.72% Traditional cash on cash: 3.75% Airbnb Rental Income: $1645 Traditional Rental Income: $2390 Airbnb ROI: 0.72% Traditional ROI: 3.75%
82 Coastal Highway Panacea, FL Investment Opportunity!!! Both residential and commercial opportunities with this property...	1 beds \| 1 baths \| 1,896 sq.ft.	$375,000	Airbnb cash on cash: 0.68% Traditional cash on cash: 1.94% Airbnb Rental Income: $1235 Traditional Rental Income: $1285 Airbnb ROI: 0.68% Traditional ROI: 1.94%
88 Driftwood Drive Panacea, FL Wake up to breathtaking water views and end the day with stunning sunsets right from your ...	3 beds \| 2 baths \| 1,854 sq.ft.	$825,000	Airbnb cash on cash: 0.28% Traditional cash on cash: 1.55% Airbnb Rental Income: $2171 Traditional Rental Income: $2594 Airbnb ROI: 0.28% Traditional ROI: 1.55%
43 Wood Stork Drive Panacea, FL Enjoy breathtaking views of Dickerson Bay overlooking the Gulf from this gorgeous 3 bedroo...	3 beds \| 2 baths \| 2,688 sq.ft.	$799,900	Airbnb cash on cash: 0.18% Traditional cash on cash: 1.75% Airbnb Rental Income: $2171 Traditional Rental Income: $2793 Airbnb ROI: 0.18% Traditional ROI: 1.75%
19 Mashes Sands Road #F-12 Panacea, FL Experience care-free Coastal living. Bayfront condo located in the Heart of Panacea. Enjoy...	1 beds \| 1 baths \| 810 sq.ft.	$229,000	Airbnb cash on cash: 1.17% Traditional cash on cash: 4.71% Airbnb Rental Income: $1235 Traditional Rental Income: $1607 Airbnb ROI: 1.17% Traditional ROI: 4.71%
11 A9 Mashes Sands Road #A-9 Panacea, FL End Unit in Georges Lighthouse, a waterfront resort community. Waterside end unit, with wr...	1 beds \| 2 baths \| 945 sq.ft.	$234,900	Airbnb cash on cash: 1.51% Traditional cash on cash: 5.6% Airbnb Rental Income: $1235 Traditional Rental Income: $1749 Airbnb ROI: 1.51% Traditional ROI: 5.6%

Real Estate investment in Panacea, FL

There are 37 properties for sale in the city of Panacea . The median list price in Panacea is $367,000 and the average price per square foot is $225. In May 2026, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,967.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 37 investment properties available for sale in Panacea.

In 2026, the best neighborhood to buy investment property is Panacea.

The ROI for Long-Term is higher than the Short-Term in Panacea with average rental income of $1,967.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

40 Lakeview Drive

Panacea, FL

2 beds | 2 baths | 1,059 sq.ft.

$389,000

Airbnb cash on cash: 1.8%

Traditional cash on cash: 3.76%

Airbnb Rental Income: $1645

Traditional Rental Income: $1899

Airbnb ROI: 1.8%

Traditional ROI: 3.76%

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$689,000

Airbnb cash on cash: 0.67%

Traditional cash on cash: 2.5%

Airbnb Rental Income: $2171

Traditional Rental Income: $2796

Airbnb ROI: 0.67%

Traditional ROI: 2.5%

40 POMPANO Drive

Panacea, FL

3 beds | 2 baths | 1,560 sq.ft.

$475,000

Airbnb cash on cash: 1.47%

Traditional cash on cash: 2.4%

Airbnb Rental Income: $2171

Traditional Rental Income: $2033

Airbnb ROI: 1.47%

Traditional ROI: 2.4%

39 Aucilla Street

Panacea, FL

3 beds | 2 baths | 2,093 sq.ft.

$549,000

Airbnb cash on cash: 1.41%

Traditional cash on cash: 3.72%

Airbnb Rental Income: $2171

Traditional Rental Income: $2801

Airbnb ROI: 1.41%

Traditional ROI: 3.72%

12 Lake Essay Drive

Panacea, FL

2 beds | 1 baths | 1,148 sq.ft.

$229,900

Airbnb cash on cash: 3.51%

Traditional cash on cash: 6.8%

Airbnb Rental Income: $1645

Traditional Rental Income: $1898

Airbnb ROI: 3.51%

Traditional ROI: 6.8%

2289 Surf Road #C3

Panacea, FL

2 beds | 3 baths | 1,440 sq.ft.

$275,000

Airbnb cash on cash: 0.04%

Traditional cash on cash: 3.64%

Airbnb Rental Income: $1645

Traditional Rental Income: $2115

Airbnb ROI: 0.04%

Traditional ROI: 3.64%

23 Monticello Avenue

Panacea, FL

3 beds | 2 baths | 1,420 sq.ft.

$359,000

Airbnb cash on cash: 3.02%

Traditional cash on cash: 5.61%

Airbnb Rental Income: $2171

Traditional Rental Income: $2493

Airbnb ROI: 3.02%

Traditional ROI: 5.61%

88 Warbird Circle

Panacea, FL

3 beds | 2 baths | 1,527 sq.ft.

$445,000

Airbnb cash on cash: 2.57%

Traditional cash on cash: 4.5%

Airbnb Rental Income: $2171

Traditional Rental Income: $2421

Airbnb ROI: 2.57%