Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$699,900	Airbnb cash on cash: 5.53% Traditional cash on cash: 1.87% Airbnb Rental Income: $5991 Traditional Rental Income: $2419 Airbnb ROI: 5.53% Traditional ROI: 1.87%
31 Sunrise Lane Panacea, FL GULL COTTAGE! This 1958 canal front cottage has been well maintained, upgraded, updated, r...	2 beds \| 3 baths \| 1,521 sq.ft.	$399,000	Airbnb cash on cash: 2.73% Traditional cash on cash: 3.68% Airbnb Rental Income: $2270 Traditional Rental Income: $2061 Airbnb ROI: 2.73% Traditional ROI: 3.68%
25 Mashes Sands Road unit: I #I Panacea, FL Welcome to your dream waterfront home! Nestled at Georges Lighthouse, this exquisite townh...	3 beds \| 3 baths \| 1,481 sq.ft.	$425,000	Airbnb cash on cash: 9.32% Traditional cash on cash: 2.69% Airbnb Rental Income: $5991 Traditional Rental Income: $2163 Airbnb ROI: 9.32% Traditional ROI: 2.69%
12 Lake Essay Drive Panacea, FL Escape to Wild Azalea Cottage on Lake Essay. Relax and unwind; enjoy soothing birdsong and...	2 beds \| 1 baths \| 1,148 sq.ft.	$249,900	Airbnb cash on cash: 5.36% Traditional cash on cash: 6.55% Airbnb Rental Income: $2270 Traditional Rental Income: $1985 Airbnb ROI: 5.36% Traditional ROI: 6.55%
2489 Surf Road Panacea, FL "High Point" is aptly named as this magnificent home sits atop a lot and a half overlookin...	4 beds \| 4 baths \| 3,228 sq.ft.	$819,900	Airbnb cash on cash: 1.24% Traditional cash on cash: 5.32% Airbnb Rental Income: $2969 Traditional Rental Income: $5404 Airbnb ROI: 1.24% Traditional ROI: 5.32%
69 Suwanne Avenue Panacea, FL Charming 1940's Bungalow in the Heart of Panacea Welcome to your slice of Old Florida para...	2 beds \| 2 baths \| 1,080 sq.ft.	$295,000	Airbnb cash on cash: 3.91% Traditional cash on cash: 4.64% Airbnb Rental Income: $2270 Traditional Rental Income: $1904 Airbnb ROI: 3.91% Traditional ROI: 4.64%
2289 Surf Road unit: A7 #A7 Panacea, FL Imagine waking up to uninterrupted bay views from every floor while sipping your morning c...	2 beds \| 3 baths \| 1,440 sq.ft.	$369,000	Airbnb cash on cash: 3.63% Traditional cash on cash: 6.77% Airbnb Rental Income: $2270 Traditional Rental Income: $2790 Airbnb ROI: 3.63% Traditional ROI: 6.77%
18 Suwannee Avenue Panacea, FL Welcome to this beautifully remodeled 2-bedroom, 2-bath cottage-style home in the heart of...	2 beds \| 2 baths \| 932 sq.ft.	$214,999	Airbnb cash on cash: 6.53% Traditional cash on cash: 6.82% Airbnb Rental Income: $2270 Traditional Rental Income: $1762 Airbnb ROI: 6.53% Traditional ROI: 6.82%
39 Aucilla Street Panacea, FL A MUST SEE property! Beautifully maintained three-bedroom, two-bath home on 2.88 acres fea...	3 beds \| 2 baths \| 2,093 sq.ft.	$549,000	Airbnb cash on cash: 7.62% Traditional cash on cash: 2.85% Airbnb Rental Income: $5991 Traditional Rental Income: $2356 Airbnb ROI: 7.62% Traditional ROI: 2.85%
11 Blue Heron Way Panacea, FL Welcome home to the simple charm this 3 bedroom 2 bath canal front getaway offers. A perfe...	3 beds \| 2 baths \| 1,093 sq.ft.	$429,000	Airbnb cash on cash: 9.79% Traditional cash on cash: 2.59% Airbnb Rental Income: $5991 Traditional Rental Income: $1911 Airbnb ROI: 9.79% Traditional ROI: 2.59%
11 A3 Mashes Sands Road unit: A #A Panacea, FL Beautifully Remodeled 2BR/1BA Condo in a gated Waterfront Community! Enjoy resort-style li...	2 beds \| 1 baths \| 910 sq.ft.	$239,900	Airbnb cash on cash: 5.15% Traditional cash on cash: 5.05% Airbnb Rental Income: $2270 Traditional Rental Income: $1680 Airbnb ROI: 5.15% Traditional ROI: 5.05%
562 Mashes Sands Road Panacea, FL This classic 2 bedroom, 1.5 bath A-frame home offers the ideal blend of comfort, simplicit...	2 beds \| 2 baths \| 1,080 sq.ft.	$299,900	Airbnb cash on cash: 3.94% Traditional cash on cash: 4.31% Airbnb Rental Income: $2270 Traditional Rental Income: $1806 Airbnb ROI: 3.94% Traditional ROI: 4.31%
100 River Drive Panacea, FL This true Old Florida style cottage on Ochlockonee Bay-where two rivers meet the Gulf-is n...	2 beds \| 2 baths \| 1,230 sq.ft.	$585,000	Airbnb cash on cash: 1.12% Traditional cash on cash: 2.12% Airbnb Rental Income: $2270 Traditional Rental Income: $2253 Airbnb ROI: 1.12% Traditional ROI: 2.12%
203 & 201 Harbor Circle Panacea, FL Enjoy spectacular bayfront sunrises from this beautifully designed 3-bedroom, 2.5-bath hom...	3 beds \| 2 baths \| 1,200 sq.ft.	$975,000	Airbnb cash on cash: 4.19% Traditional cash on cash: 3.04% Airbnb Rental Income: $5991 Traditional Rental Income: $3763 Airbnb ROI: 4.19% Traditional ROI: 3.04%
201 Harbour Point Panacea, FL Waterfront Luxury in Shell Point - 4 Bed \| 3 Full & 2 Half Bath \| Private Dock & Boat Lift...	4 beds \| 5 baths \| 2,778 sq.ft.	$949,000	Airbnb cash on cash: 0.47% Traditional cash on cash: 3.83% Airbnb Rental Income: $2969 Traditional Rental Income: $5255 Airbnb ROI: 0.47% Traditional ROI: 3.83%
35 Harbour Point Drive Panacea, FL This spacious townhouse encompasses two and a half stories, delivering both comfort and st...	2 beds \| 3 baths \| 1,495 sq.ft.	$380,000	Airbnb cash on cash: 2.63% Traditional cash on cash: 4.86% Airbnb Rental Income: $2270 Traditional Rental Income: $2496 Airbnb ROI: 2.63% Traditional ROI: 4.86%
1448 CYPRESS STREET Panacea, FL 1448 Cypress Street, Alligator Point, FL 32346 Offered at $625,000 3 Bedrooms \| 3 Bathro...	3 beds \| 4 baths \| 1,412 sq.ft.	$625,000	Airbnb cash on cash: 6.46% Traditional cash on cash: 2.51% Airbnb Rental Income: $5991 Traditional Rental Income: $2505 Airbnb ROI: 6.46% Traditional ROI: 2.51%
1667 Alligator Drive Panacea, FL Blending modern updates with timeless coastal charm, this home is truly move-in ready. A r...	3 beds \| 4 baths \| 3,146 sq.ft.	$1,945,000	Airbnb cash on cash: 1.19% Traditional cash on cash: 1.16% Airbnb Rental Income: $5991 Traditional Rental Income: $4740 Airbnb ROI: 1.19% Traditional ROI: 1.16%

Real Estate investment in Panacea, FL

There are 18 properties for sale in the city of Panacea . The median list price in Panacea is $399,500 and the average price per square foot is $250. In October 2025, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,765.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 18 investment properties available for sale in Panacea.

In 2025, the best neighborhood to buy investment property is Panacea.

The ROI for Short-Term is higher than the Long-Term in Panacea with average rental income of $2,270.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$699,900

Airbnb cash on cash: 5.53%

Traditional cash on cash: 1.87%

Airbnb Rental Income: $5991

Traditional Rental Income: $2419

Airbnb ROI: 5.53%

Traditional ROI: 1.87%

31 Sunrise Lane

Panacea, FL

2 beds | 3 baths | 1,521 sq.ft.

$399,000

Airbnb cash on cash: 2.73%

Traditional cash on cash: 3.68%

Airbnb Rental Income: $2270

Traditional Rental Income: $2061

Airbnb ROI: 2.73%

Traditional ROI: 3.68%

25 Mashes Sands Road unit: I #I

Panacea, FL

3 beds | 3 baths | 1,481 sq.ft.

$425,000

Airbnb cash on cash: 9.32%

Traditional cash on cash: 2.69%

Airbnb Rental Income: $5991

Traditional Rental Income: $2163

Airbnb ROI: 9.32%

Traditional ROI: 2.69%

12 Lake Essay Drive

Panacea, FL

2 beds | 1 baths | 1,148 sq.ft.

$249,900

Airbnb cash on cash: 5.36%

Traditional cash on cash: 6.55%

Airbnb Rental Income: $2270

Traditional Rental Income: $1985

Airbnb ROI: 5.36%

Traditional ROI: 6.55%

2489 Surf Road

Panacea, FL

4 beds | 4 baths | 3,228 sq.ft.

$819,900

Airbnb cash on cash: 1.24%

Traditional cash on cash: 5.32%

Airbnb Rental Income: $2969

Traditional Rental Income: $5404

Airbnb ROI: 1.24%

Traditional ROI: 5.32%

69 Suwanne Avenue

Panacea, FL

2 beds | 2 baths | 1,080 sq.ft.

$295,000

Airbnb cash on cash: 3.91%

Traditional cash on cash: 4.64%

Airbnb Rental Income: $2270

Traditional Rental Income: $1904

Airbnb ROI: 3.91%

Traditional ROI: 4.64%

2289 Surf Road unit: A7 #A7

Panacea, FL

2 beds | 3 baths | 1,440 sq.ft.

$369,000

Airbnb cash on cash: 3.63%

Traditional cash on cash: 6.77%

Airbnb Rental Income: $2270

Traditional Rental Income: $2790

Airbnb ROI: 3.63%

Traditional ROI: 6.77%

18 Suwannee Avenue

Panacea, FL

2 beds | 2 baths | 932 sq.ft.

$214,999

Airbnb cash on cash: 6.53%

Traditional cash on cash: 6.82%

Airbnb Rental Income: $2270

Traditional Rental Income: $1762

Airbnb ROI: 6.53%