Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$699,900	Airbnb cash on cash: 0.65% Traditional cash on cash: 1.87% Airbnb Rental Income: $2171 Traditional Rental Income: $2419 Airbnb ROI: 0.65% Traditional ROI: 1.87%
39 Aucilla Street Panacea, FL A MUST SEE property! Beautifully maintained three-bedroom, two-bath home on 2.88 acres fea...	3 beds \| 2 baths \| 2,093 sq.ft.	$549,000	Airbnb cash on cash: 1.41% Traditional cash on cash: 2.85% Airbnb Rental Income: $2171 Traditional Rental Income: $2356 Airbnb ROI: 1.41% Traditional ROI: 2.85%
13 Aucilla Street Panacea, FL 2019 custom-built house with over 2,100 sq. ft. of conditioned space. House sits upon 1 se...	2 beds \| 3 baths \| 2,171 sq.ft.	$400,000	Airbnb cash on cash: 0.9% Traditional cash on cash: 4.75% Airbnb Rental Income: $1645 Traditional Rental Income: $2625 Airbnb ROI: 0.9% Traditional ROI: 4.75%
88 Warbird Circle Panacea, FL New construction in gated Tarpine community that includes access to airport and community ...	3 beds \| 2 baths \| 1,527 sq.ft.	$445,000	Airbnb cash on cash: 2.57% Traditional cash on cash: 3.54% Airbnb Rental Income: $2171 Traditional Rental Income: $2021 Airbnb ROI: 2.57% Traditional ROI: 3.54%
47 BLUE CRAB Lane Panacea, FL This 3-bedroom 2 bath is a Octagon home on .333 acres is built to withstand winds of 180 m...	3 beds \| 2 baths \| 1,280 sq.ft.	$1,150,000	Airbnb cash on cash: -0.46% Traditional cash on cash: 0.19% Airbnb Rental Income: $2171 Traditional Rental Income: $2308 Airbnb ROI: -0.46% Traditional ROI: 0.19%
201 Harbour Point Panacea, FL Waterfront Luxury in Shell Point - 4 Bed \| 3 Full & 2 Half Bath \| Private Dock & Boat Lift...	4 beds \| 5 baths \| 2,778 sq.ft.	$949,000	Airbnb cash on cash: -1.16% Traditional cash on cash: 3.83% Airbnb Rental Income: $1244 Traditional Rental Income: $5255 Airbnb ROI: -1.16% Traditional ROI: 3.83%
2489 Surf Road Panacea, FL "High Point" is aptly named as this magnificent home sits atop a lot and a half overlookin...	4 beds \| 4 baths \| 3,228 sq.ft.	$819,900	Airbnb cash on cash: -0.64% Traditional cash on cash: 5.32% Airbnb Rental Income: $1244 Traditional Rental Income: $5404 Airbnb ROI: -0.64% Traditional ROI: 5.32%
79 Ida Street Panacea, FL Lots of upgrades to include new flooring, paint, windows, kitchen upgrade with new counter...	3 beds \| 2 baths \| 1,008 sq.ft.	$155,000	Airbnb cash on cash: 8.52% Traditional cash on cash: 8.31% Airbnb Rental Income: $2171 Traditional Rental Income: $1590 Airbnb ROI: 8.52% Traditional ROI: 8.31%
25 Mashes Sands Road unit: I #I Panacea, FL Welcome to your dream waterfront home! Nestled at Georges Lighthouse, this exquisite townh...	3 beds \| 3 baths \| 1,481 sq.ft.	$425,000	Airbnb cash on cash: 1.33% Traditional cash on cash: 2.69% Airbnb Rental Income: $2171 Traditional Rental Income: $2163 Airbnb ROI: 1.33% Traditional ROI: 2.69%
35 Sunrise Lane Panacea, FL Live the southern sportsman's lifestyle in this coastal home nestled right in the middle o...	2 beds \| 2 baths \| 1,642 sq.ft.	$459,000	Airbnb cash on cash: 0.4% Traditional cash on cash: 3.21% Airbnb Rental Income: $1645 Traditional Rental Income: $2391 Airbnb ROI: 0.4% Traditional ROI: 3.21%
70 Harrison Street Panacea, FL Completely Renovated Gem on One Acre in Panacea, FL! Welcome to 70 Harrison Street - a bea...	3 beds \| 2 baths \| 1,768 sq.ft.	$329,000	Airbnb cash on cash: 3.51% Traditional cash on cash: 4.9% Airbnb Rental Income: $2171 Traditional Rental Income: $2051 Airbnb ROI: 3.51% Traditional ROI: 4.9%
21 Saint James Street Panacea, FL Absolutely Gorgeous! Simply the cutest, artsy cottage for sale in Panacea! Adorable 3 Bedr...	3 beds \| 1 baths \| 1,334 sq.ft.	$325,000	Airbnb cash on cash: 3.37% Traditional cash on cash: 4.23% Airbnb Rental Income: $2171 Traditional Rental Income: $1883 Airbnb ROI: 3.37% Traditional ROI: 4.23%
2289 Surf Road unit: A7 #A7 Panacea, FL Imagine waking up to uninterrupted bay views from every floor while sipping your morning c...	2 beds \| 3 baths \| 1,440 sq.ft.	$369,000	Airbnb cash on cash: 2.13% Traditional cash on cash: 6.77% Airbnb Rental Income: $1645 Traditional Rental Income: $2790 Airbnb ROI: 2.13% Traditional ROI: 6.77%
203 & 201 Harbor Circle Panacea, FL Enjoy spectacular bayfront sunrises from this beautifully designed 3-bedroom, 2.5-bath hom...	3 beds \| 2 baths \| 1,200 sq.ft.	$975,000	Airbnb cash on cash: 0.68% Traditional cash on cash: 3.04% Airbnb Rental Income: $2171 Traditional Rental Income: $3763 Airbnb ROI: 0.68% Traditional ROI: 3.04%
35 Harbour Point Drive Panacea, FL This spacious townhouse encompasses two and a half stories, delivering both comfort and st...	2 beds \| 3 baths \| 1,495 sq.ft.	$380,000	Airbnb cash on cash: 1.17% Traditional cash on cash: 4.86% Airbnb Rental Income: $1645 Traditional Rental Income: $2496 Airbnb ROI: 1.17% Traditional ROI: 4.86%
5 Alapaha Avenue Panacea, FL Welcome to your coastal retreat in the heart of Panacea! This charming 3-bedroom, 2-bath s...	3 beds \| 2 baths \| 1,104 sq.ft.	$209,000	Airbnb cash on cash: 5.67% Traditional cash on cash: 6.31% Airbnb Rental Income: $2171 Traditional Rental Income: $1747 Airbnb ROI: 5.67% Traditional ROI: 6.31%
11 A3 Mashes Sands Road unit: A #A Panacea, FL Beautifully Remodeled 2BR/1BA Condo in a gated Waterfront Community! Enjoy resort-style li...	2 beds \| 1 baths \| 910 sq.ft.	$239,900	Airbnb cash on cash: 2.85% Traditional cash on cash: 5.05% Airbnb Rental Income: $1645 Traditional Rental Income: $1680 Airbnb ROI: 2.85% Traditional ROI: 5.05%
562 Mashes Sands Road Panacea, FL This classic 2 bedroom, 1.5 bath A-frame home offers the ideal blend of comfort, simplicit...	2 beds \| 2 baths \| 1,080 sq.ft.	$299,900	Airbnb cash on cash: 2.1% Traditional cash on cash: 4.31% Airbnb Rental Income: $1645 Traditional Rental Income: $1806 Airbnb ROI: 2.1% Traditional ROI: 4.31%
84 Chattahoochee Street Panacea, FL Discover the potential in this 3-bedroom, 2-bath home nestled on a spacious 1-acre lot in ...	3 beds \| 2 baths \| 1,813 sq.ft.	$249,900	Airbnb cash on cash: 4.87% Traditional cash on cash: 7.23% Airbnb Rental Income: $2171 Traditional Rental Income: $2177 Airbnb ROI: 4.87% Traditional ROI: 7.23%
100 River Drive Panacea, FL This true Old Florida style cottage on Ochlockonee Bay-where two rivers meet the Gulf-is n...	2 beds \| 2 baths \| 1,230 sq.ft.	$585,000	Airbnb cash on cash: 0.16% Traditional cash on cash: 2.12% Airbnb Rental Income: $1645 Traditional Rental Income: $2253 Airbnb ROI: 0.16% Traditional ROI: 2.12%
28 Piney Street Panacea, FL Welcome to your coastal retreat! Nestled in the heart of Panacea, this delightful 3-bedroo...	3 beds \| 2 baths \| 1,116 sq.ft.	$274,900	Airbnb cash on cash: 4.28% Traditional cash on cash: 6.19% Airbnb Rental Income: $2171 Traditional Rental Income: $2113 Airbnb ROI: 4.28% Traditional ROI: 6.19%
206 Clark Drive Panacea, FL Welcome to your coastal retreat! Nestled in the serene setting of Panacea, Florida, this c...	2 beds \| 1 baths \| 888 sq.ft.	$300,000	Airbnb cash on cash: 2.47% Traditional cash on cash: 3.41% Airbnb Rental Income: $1645 Traditional Rental Income: $1447 Airbnb ROI: 2.47% Traditional ROI: 3.41%
605 Alligator Drive Panacea, FL Discover a rare opportunity on Florida's Forgotten Coast! This well-kept 3-bedroom, 2-bath...	3 beds \| 2 baths \| 984 sq.ft.	$285,000	Airbnb cash on cash: 3.81% Traditional cash on cash: 3.61% Airbnb Rental Income: $2171 Traditional Rental Income: $1567 Airbnb ROI: 3.81% Traditional ROI: 3.61%
2501 Surf Road Panacea, FL Live at the Coast and enjoy those gorgeous sunrises and sunsets! Cute home on Ochlockonee ...	3 beds \| 2 baths \| 1,408 sq.ft.	$524,000	Airbnb cash on cash: 1.42% Traditional cash on cash: 2.75% Airbnb Rental Income: $2171 Traditional Rental Income: $2275 Airbnb ROI: 1.42% Traditional ROI: 2.75%

Real Estate investment in Panacea, FL

There are 24 properties for sale in the city of Panacea . The median list price in Panacea is $390,000 and the average price per square foot is $257. In December 2025, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,746.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 24 investment properties available for sale in Panacea.

In 2025, the best neighborhood to buy investment property is Panacea.

The ROI for Long-Term is higher than the Short-Term in Panacea with average rental income of $1,746.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$699,900

Airbnb cash on cash: 0.65%

Traditional cash on cash: 1.87%

Airbnb Rental Income: $2171

Traditional Rental Income: $2419

Airbnb ROI: 0.65%

Traditional ROI: 1.87%

39 Aucilla Street

Panacea, FL

3 beds | 2 baths | 2,093 sq.ft.

$549,000

Airbnb cash on cash: 1.41%

Traditional cash on cash: 2.85%

Airbnb Rental Income: $2171

Traditional Rental Income: $2356

Airbnb ROI: 1.41%

Traditional ROI: 2.85%

13 Aucilla Street

Panacea, FL

2 beds | 3 baths | 2,171 sq.ft.

$400,000

Airbnb cash on cash: 0.9%

Traditional cash on cash: 4.75%

Airbnb Rental Income: $1645

Traditional Rental Income: $2625

Airbnb ROI: 0.9%

Traditional ROI: 4.75%

88 Warbird Circle

Panacea, FL

3 beds | 2 baths | 1,527 sq.ft.

$445,000

Airbnb cash on cash: 2.57%

Traditional cash on cash: 3.54%

Airbnb Rental Income: $2171

Traditional Rental Income: $2021

Airbnb ROI: 2.57%

Traditional ROI: 3.54%

47 BLUE CRAB Lane

Panacea, FL

3 beds | 2 baths | 1,280 sq.ft.

$1,150,000

Airbnb cash on cash: -0.46%

Traditional cash on cash: 0.19%

Airbnb Rental Income: $2171

Traditional Rental Income: $2308

Airbnb ROI: -0.46%

Traditional ROI: 0.19%

201 Harbour Point

Panacea, FL

4 beds | 5 baths | 2,778 sq.ft.

$949,000

Airbnb cash on cash: -1.16%

Traditional cash on cash: 3.83%

Airbnb Rental Income: $1244

Traditional Rental Income: $5255

Airbnb ROI: -1.16%

Traditional ROI: 3.83%

2489 Surf Road

Panacea, FL

4 beds | 4 baths | 3,228 sq.ft.

$819,900

Airbnb cash on cash: -0.64%

Traditional cash on cash: 5.32%

Airbnb Rental Income: $1244

Traditional Rental Income: $5404

Airbnb ROI: -0.64%

Traditional ROI: 5.32%

79 Ida Street

Panacea, FL

3 beds | 2 baths | 1,008 sq.ft.

$155,000

Airbnb cash on cash: 8.52%

Traditional cash on cash: 8.31%

Airbnb Rental Income: $2171

Traditional Rental Income: $1590

Airbnb ROI: 8.52%