Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

separator

PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
7 BASS Street Panacea, FL Welcome to 7 Bass St, a charming coastal retreat nestled in the serene community of Alliga...	4 beds \| 3 baths \| 1,800 sq.ft.	$574,900	Airbnb cash on cash: 6.68% Traditional cash on cash: 3.02% Airbnb Rental Income: $5487 Traditional Rental Income: $2421 Airbnb ROI: 6.68% Traditional ROI: 3.02%
47 BLUE CRAB Lane Panacea, FL Waterfront living awaits in Panacea Shores, where this three-bedroom, two-bath residence o...	3 beds \| 2 baths \| 1,280 sq.ft.	$1,050,000	Airbnb cash on cash: 0.23% Traditional cash on cash: 2.09% Airbnb Rental Income: $2381 Traditional Rental Income: $3619 Airbnb ROI: 0.23% Traditional ROI: 2.09%
695 B6 Mashes Sands Road Panacea, FL Welcome Home to this 1656 sqft 2 bedroom 2.5 bath end unit townhouse in Marina Village. Fe...	2 beds \| 3 baths \| 1,656 sq.ft.	$425,000	Airbnb cash on cash: 2.7% Traditional cash on cash: 4.01% Airbnb Rental Income: $2718 Traditional Rental Income: $2597 Airbnb ROI: 2.7% Traditional ROI: 4.01%
2289 Surf Road #C3 Panacea, FL Escape to your own slice of paradise in this stunning 2-bedroom, 2.5-bath condo at Bayside...	2 beds \| 3 baths \| 1,440 sq.ft.	$258,000	Airbnb cash on cash: 3.78% Traditional cash on cash: 3.94% Airbnb Rental Income: $2718 Traditional Rental Income: $2115 Airbnb ROI: 3.78% Traditional ROI: 3.94%
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$689,000	Airbnb cash on cash: 0.95% Traditional cash on cash: 2.5% Airbnb Rental Income: $2381 Traditional Rental Income: $2796 Airbnb ROI: 0.95% Traditional ROI: 2.5%
82 Coastal Highway Panacea, FL Investment Opportunity!!! Both residential and commercial opportunities with this property...	1 beds \| 1 baths \| 1,896 sq.ft.	$374,900	Airbnb cash on cash: 0.65% Traditional cash on cash: 1.94% Airbnb Rental Income: $1223 Traditional Rental Income: $1285 Airbnb ROI: 0.65% Traditional ROI: 1.94%
8 Stinson Taxiway Panacea, FL Welcome to the fly-in, gated community of Tarpine, located just minutes from the coast. Th...	3 beds \| 3 baths \| 2,505 sq.ft.	$495,000	Airbnb cash on cash: 1.99% Traditional cash on cash: 3.81% Airbnb Rental Income: $2381 Traditional Rental Income: $2640 Airbnb ROI: 1.99% Traditional ROI: 3.81%
88 River Drive Panacea, FL Welcome to 88 River Drive in Panacea, Florida-a charming coastal property where relaxed li...	3 beds \| 2 baths \| 1,767 sq.ft.	$569,000	Airbnb cash on cash: 1.44% Traditional cash on cash: 2.78% Airbnb Rental Income: $2381 Traditional Rental Income: $2509 Airbnb ROI: 1.44% Traditional ROI: 2.78%
160 Mississippi Avenue Panacea, FL This home is a perfect mix of convenience and coastal charm. The marina is just two blocks...	3 beds \| 2 baths \| 1,210 sq.ft.	$289,000	Airbnb cash on cash: 4.71% Traditional cash on cash: 5.35% Airbnb Rental Income: $2381 Traditional Rental Income: $1967 Airbnb ROI: 4.71% Traditional ROI: 5.35%
11 -A6 Mashes Sands Road #A6 Panacea, FL Escape to this beauty of Florida's Forgotten Coast with this charming 2 bedroom, 1 bath co...	2 beds \| 1 baths \| 910 sq.ft.	$221,000	Airbnb cash on cash: 8.12% Traditional cash on cash: 6.32% Airbnb Rental Income: $2718 Traditional Rental Income: $1699 Airbnb ROI: 8.12% Traditional ROI: 6.32%
2301 Surf Road Panacea, FL Beautifully renovated bayfront home with direct Gulf access and stunning waterfront views!...	3 beds \| 2 baths \| 1,856 sq.ft.	$749,900	Airbnb cash on cash: 1% Traditional cash on cash: 2.24% Airbnb Rental Income: $2381 Traditional Rental Income: $2661 Airbnb ROI: 1% Traditional ROI: 2.24%
151 Otter Lake Road Panacea, FL Fully renovated 3BR/2BA home with 1,196 sq ft in Panacea. New metal roof, new vinyl siding...	3 beds \| 2 baths \| 1,196 sq.ft.	$249,900	Airbnb cash on cash: 5.75% Traditional cash on cash: 5.95% Airbnb Rental Income: $2381 Traditional Rental Income: $1842 Airbnb ROI: 5.75% Traditional ROI: 5.95%
216 Levy Bay Road Panacea, FL REDUCED $50,000! Absolutely stunning Bayfront House in Panacea! This 5 bedroom, 3 full bat...	5 beds \| 3 baths \| 2,532 sq.ft.	$649,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.56% Airbnb Rental Income: $null Traditional Rental Income: $3814 Airbnb ROI: N/A Traditional ROI: 4.56%
40 Lakeview Drive Panacea, FL Charming beach cottage on Bald Point! FANTASTIC LOCATION adjacent to State Park property a...	2 beds \| 2 baths \| 1,059 sq.ft.	$389,000	Airbnb cash on cash: 4.25% Traditional cash on cash: 3.76% Airbnb Rental Income: $2718 Traditional Rental Income: $1899 Airbnb ROI: 4.25% Traditional ROI: 3.76%
11 Sunrise Lane Panacea, FL NEW: BUYER INCENTIVE!! $10,000 TOWARDS CLOSING COSTS AND REPAIRS! Perfect for full time li...	3 beds \| 2 baths \| 1,484 sq.ft.	$450,000	Airbnb cash on cash: 2.21% Traditional cash on cash: 3.42% Airbnb Rental Income: $2381 Traditional Rental Income: $2305 Airbnb ROI: 2.21% Traditional ROI: 3.42%
175 Tarpine Drive Panacea, FL Calling All Pilots! Here's your chance to live in a gated Fly-In Community! This three bed...	3 beds \| 2 baths \| 2,135 sq.ft.	$530,000	Airbnb cash on cash: 1.85% Traditional cash on cash: 2.84% Airbnb Rental Income: $2381 Traditional Rental Income: $2285 Airbnb ROI: 1.85% Traditional ROI: 2.84%
18 Suwannee Avenue Panacea, FL Welcome to this beautifully remodeled 2-bedroom, 2-bath cottage-style home in the heart of...	2 beds \| 2 baths \| 932 sq.ft.	$199,999	Airbnb cash on cash: 9.05% Traditional cash on cash: 7.39% Airbnb Rental Income: $2718 Traditional Rental Income: $1762 Airbnb ROI: 9.05% Traditional ROI: 7.39%
135 Dickson Bay Road Panacea, FL Escape to coastal paradise in the heart of Panacea. Discover this charming 3 BR, 2B home n...	3 beds \| 2 baths \| 1,392 sq.ft.	$294,900	Airbnb cash on cash: 4.83% Traditional cash on cash: 5.17% Airbnb Rental Income: $2381 Traditional Rental Income: $1889 Airbnb ROI: 4.83% Traditional ROI: 5.17%
43 Wood Stork Drive Panacea, FL Enjoy BREATHTAKING views of Dickerson Bay overlooking the Gulf from this gorgeous 3 bedroo...	3 beds \| 2 baths \| 2,688 sq.ft.	$699,000	Airbnb cash on cash: 0.62% Traditional cash on cash: 2.15% Airbnb Rental Income: $2381 Traditional Rental Income: $2793 Airbnb ROI: 0.62% Traditional ROI: 2.15%
23 Monticello Avenue Panacea, FL Adorable, peaceful and quiet home located in the heart of Panacea on 17 platted lots total...	3 beds \| 2 baths \| 1,420 sq.ft.	$359,000	Airbnb cash on cash: 3.54% Traditional cash on cash: 5.61% Airbnb Rental Income: $2381 Traditional Rental Income: $2493 Airbnb ROI: 3.54% Traditional ROI: 5.61%
2239 Surf Road Panacea, FL Enjoy the relaxed coastal lifestyle of Florida's Forgotten Coast! Located in the Ochlockon...	3 beds \| 3 baths \| 1,969 sq.ft.	$324,000	Airbnb cash on cash: 3.67% Traditional cash on cash: 5.1% Airbnb Rental Income: $2381 Traditional Rental Income: $2232 Airbnb ROI: 3.67% Traditional ROI: 5.1%
567 Mashes Sands Road Panacea, FL Vintage Coastal Charm with Endless Ochlockonee Bay Views! Step back in time while enjoying...	2 beds \| 2 baths \| 1,372 sq.ft.	$475,000	Airbnb cash on cash: 2.58% Traditional cash on cash: 3.32% Airbnb Rental Income: $2718 Traditional Rental Income: $2406 Airbnb ROI: 2.58% Traditional ROI: 3.32%
32 SUNRISE Lane Panacea, FL Welcome to 32 Sunrise Lane in beautiful Panacea, Florida, where waterfront living meets co...	2 beds \| 1 baths \| 1,180 sq.ft.	$439,000	Airbnb cash on cash: 2.88% Traditional cash on cash: 2.69% Airbnb Rental Income: $2718 Traditional Rental Income: $1999 Airbnb ROI: 2.88% Traditional ROI: 2.69%
330 Mashes Sands Road Panacea, FL Don't miss this beautiful, move-in-ready, 3 bedroom and 2 bath home on Mashes Sands Road! ...	3 beds \| 2 baths \| 1,560 sq.ft.	$360,000	Airbnb cash on cash: 3.15% Traditional cash on cash: 3.93% Airbnb Rental Income: $2381 Traditional Rental Income: $2057 Airbnb ROI: 3.15% Traditional ROI: 3.93%
19 Mashes Sands Road #F-12 Panacea, FL Gorgeous waterfront scenery! This attractive condo offers stunning bay front views includi...	1 beds \| 1 baths \| 810 sq.ft.	$225,000	Airbnb cash on cash: 1.16% Traditional cash on cash: 4.81% Airbnb Rental Income: $1223 Traditional Rental Income: $1607 Airbnb ROI: 1.16% Traditional ROI: 4.81%
10 Hidden Springs Drive Panacea, FL Coastal living with a peekaboo view of the bay! This fully updated 2BR/2.5BA home offers n...	2 beds \| 3 baths \| 1,536 sq.ft.	$314,900	Airbnb cash on cash: 4.51% Traditional cash on cash: 4.47% Airbnb Rental Income: $2718 Traditional Rental Income: $2062 Airbnb ROI: 4.51% Traditional ROI: 4.47%
12 Lake Essay Drive Panacea, FL This unique, hidden property is truly a sportsman's paradise! Lake Essay and a beautiful h...	2 beds \| 1 baths \| 864 sq.ft.	$209,000	Airbnb cash on cash: 8.46% Traditional cash on cash: 7.56% Airbnb Rental Income: $2718 Traditional Rental Income: $1898 Airbnb ROI: 8.46% Traditional ROI: 7.56%
92 KOCH Street Panacea, FL Bring the boat, pack a swimsuit, and start enjoying the Forgotten Coast! Offered fully fur...	3 beds \| 2 baths \| 1,092 sq.ft.	$199,000	Airbnb cash on cash: 7.7% Traditional cash on cash: 6.9% Airbnb Rental Income: $2381 Traditional Rental Income: $1645 Airbnb ROI: 7.7% Traditional ROI: 6.9%

Real Estate investment in Panacea, FL

There are 29 properties for sale in the city of Panacea . The median list price in Panacea is $134,536 and the average price per square foot is $89. In November 2026, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,767.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 29 investment properties available for sale in Panacea.

In 2026, the best neighborhood to buy investment property is Panacea.

The ROI for Short-Term is higher than the Long-Term in Panacea with average rental income of $2,381.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

7 BASS Street

Panacea, FL

4 beds | 3 baths | 1,800 sq.ft.

$574,900

Airbnb cash on cash: 6.68%

Traditional cash on cash: 3.02%

Airbnb Rental Income: $5487

Traditional Rental Income: $2421

Airbnb ROI: 6.68%

Traditional ROI: 3.02%

47 BLUE CRAB Lane

Panacea, FL

3 beds | 2 baths | 1,280 sq.ft.

$1,050,000

Airbnb cash on cash: 0.23%

Traditional cash on cash: 2.09%

Airbnb Rental Income: $2381

Traditional Rental Income: $3619

Airbnb ROI: 0.23%

Traditional ROI: 2.09%

695 B6 Mashes Sands Road

Panacea, FL

2 beds | 3 baths | 1,656 sq.ft.

$425,000

Airbnb cash on cash: 2.7%

Traditional cash on cash: 4.01%

Airbnb Rental Income: $2718

Traditional Rental Income: $2597

Airbnb ROI: 2.7%

Traditional ROI: 4.01%

2289 Surf Road #C3

Panacea, FL

2 beds | 3 baths | 1,440 sq.ft.

$258,000

Airbnb cash on cash: 3.78%

Traditional cash on cash: 3.94%

Airbnb Rental Income: $2718

Traditional Rental Income: $2115

Airbnb ROI: 3.78%

Traditional ROI: 3.94%

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$689,000

Airbnb cash on cash: 0.95%

Traditional cash on cash: 2.5%

Airbnb Rental Income: $2381

Traditional Rental Income: $2796

Airbnb ROI: 0.95%

Traditional ROI: 2.5%

82 Coastal Highway

Panacea, FL

1 beds | 1 baths | 1,896 sq.ft.

$374,900

Airbnb cash on cash: 0.65%

Traditional cash on cash: 1.94%

Airbnb Rental Income: $1223

Traditional Rental Income: $1285

Airbnb ROI: 0.65%

Traditional ROI: 1.94%

8 Stinson Taxiway

Panacea, FL

3 beds | 3 baths | 2,505 sq.ft.

$495,000

Airbnb cash on cash: 1.99%

Traditional cash on cash: 3.81%

Airbnb Rental Income: $2381

Traditional Rental Income: $2640

Airbnb ROI: 1.99%

Traditional ROI: 3.81%

88 River Drive

Panacea, FL

3 beds | 2 baths | 1,767 sq.ft.

$569,000

Airbnb cash on cash: 1.44%

Traditional cash on cash: 2.78%

Airbnb Rental Income: $2381

Traditional Rental Income: $2509

Airbnb ROI: 1.44%