Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
68 Suwannee Avenue Panacea, FL Looking for a family vacation home or an investment property? This stunning 3-bedroom, 2-b...	3 beds \| 2 baths \| 1,020 sq.ft.	$269,000	Airbnb cash on cash: 1.08% Traditional cash on cash: 6.45% Airbnb Rental Income: $1150 Traditional Rental Income: $2131 Airbnb ROI: 1.08% Traditional ROI: 6.45%
201 Harbour Point Panacea, FL Waterfront Luxury in Shell Point - 4 Bed \| 3 Full & 2 Half Bath \| Private Dock & Boat Lift...	4 beds \| 5 baths \| 2,778 sq.ft.	$869,000	Airbnb cash on cash: 2.76% Traditional cash on cash: 5.15% Airbnb Rental Income: $4979 Traditional Rental Income: $5901 Airbnb ROI: 2.76% Traditional ROI: 5.15%
47 BLUE CRAB Lane Panacea, FL This 3-bedroom 2 bath is a Octagon home on .333 acres is built to withstand winds of 180 m...	3 beds \| 2 baths \| 1,280 sq.ft.	$995,000	Airbnb cash on cash: -1.15% Traditional cash on cash: 1.92% Airbnb Rental Income: $1150 Traditional Rental Income: $3619 Airbnb ROI: -1.15% Traditional ROI: 1.92%
92 Koch St Panacea, FL Bring the boat, pack a swimsuit and start enjoying the Forgotten Coast. Offered fully furn...	3 beds \| 2 baths \| 1,092 sq.ft.	$250,000	Airbnb cash on cash: 1.66% Traditional cash on cash: 5.37% Airbnb Rental Income: $1150 Traditional Rental Income: $1645 Airbnb ROI: 1.66% Traditional ROI: 5.37%
23 Monticello Avenue Panacea, FL Adorable, peaceful and quiet home located in the heart of Panacea on 17 platted lots total...	3 beds \| 2 baths \| 1,420 sq.ft.	$359,000	Airbnb cash on cash: 0.49% Traditional cash on cash: 5.61% Airbnb Rental Income: $1150 Traditional Rental Income: $2493 Airbnb ROI: 0.49% Traditional ROI: 5.61%
695 B6 Mashes Sands Road Panacea, FL Welcome Home to this 1656 sqft 2 bedroom 2.5 bath end unit townhouse in Marina Village. Fe...	2 beds \| 3 baths \| 1,656 sq.ft.	$425,000	Airbnb cash on cash: 3.67% Traditional cash on cash: 4.01% Airbnb Rental Income: $3180 Traditional Rental Income: $2597 Airbnb ROI: 3.67% Traditional ROI: 4.01%
2289 Surf Road #C3 Panacea, FL PRICED TO SELL!!! Escape to your own slice of paradise in this stunning 2-bedroom, 2.5-bat...	2 beds \| 3 baths \| 1,440 sq.ft.	$265,000	Airbnb cash on cash: 5.2% Traditional cash on cash: 3.81% Airbnb Rental Income: $3180 Traditional Rental Income: $2115 Airbnb ROI: 5.2% Traditional ROI: 3.81%
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$689,000	Airbnb cash on cash: -0.65% Traditional cash on cash: 2.5% Airbnb Rental Income: $1150 Traditional Rental Income: $2796 Airbnb ROI: -0.65% Traditional ROI: 2.5%
695 A4 Mashes Sands Road #A4 Panacea, FL Coastal Living with the Rare Convenience of a Private Elevator - Marina Village of Panacea...	2 beds \| 2 baths \| 1,332 sq.ft.	$425,000	Airbnb cash on cash: 3.93% Traditional cash on cash: 3.75% Airbnb Rental Income: $3180 Traditional Rental Income: $2390 Airbnb ROI: 3.93% Traditional ROI: 3.75%
103 Center Street Panacea, FL Spacious 3BR/2BA home in the heart of Panacea. Situated on two city lots. Offering approxi...	3 beds \| 2 baths \| 2,260 sq.ft.	$272,000	Airbnb cash on cash: 1.46% Traditional cash on cash: 8.9% Airbnb Rental Income: $1150 Traditional Rental Income: $2677 Airbnb ROI: 1.46% Traditional ROI: 8.9%
82 Coastal Highway Panacea, FL Investment Opportunity!!! Both residential and commercial opportunities with this property...	1 beds \| 1 baths \| 1,896 sq.ft.	$374,900	Airbnb cash on cash: -0.16% Traditional cash on cash: 1.94% Airbnb Rental Income: $883 Traditional Rental Income: $1285 Airbnb ROI: -0.16% Traditional ROI: 1.94%
43 Wood Stork Drive Panacea, FL Enjoy breathtaking views of Dickerson Bay overlooking the Gulf from this gorgeous 3 bedroo...	3 beds \| 2 baths \| 2,688 sq.ft.	$739,000	Airbnb cash on cash: -0.96% Traditional cash on cash: 1.98% Airbnb Rental Income: $1150 Traditional Rental Income: $2793 Airbnb ROI: -0.96% Traditional ROI: 1.98%
69 Suwanne Avenue Panacea, FL Welcome to your slice of Old Florida paradise! This fabulous 1940's Coastal bungalow sits ...	2 beds \| 2 baths \| 1,080 sq.ft.	$295,000	Airbnb cash on cash: 6.64% Traditional cash on cash: 5.38% Airbnb Rental Income: $3180 Traditional Rental Income: $2110 Airbnb ROI: 6.64% Traditional ROI: 5.38%
8 Stinson Taxiway Panacea, FL Welcome to the fly-in, gated community of Tarpine, located just minutes from the coast. Th...	3 beds \| 3 baths \| 2,505 sq.ft.	$526,000	Airbnb cash on cash: -0.27% Traditional cash on cash: 3.53% Airbnb Rental Income: $1150 Traditional Rental Income: $2640 Airbnb ROI: -0.27% Traditional ROI: 3.53%
19 Mashes Sands Road #F-12 Panacea, FL Experience care-free Coastal living. Bayfront condo located in the Heart of Panacea. Enjoy...	1 beds \| 1 baths \| 810 sq.ft.	$229,000	Airbnb cash on cash: -0.18% Traditional cash on cash: 4.71% Airbnb Rental Income: $883 Traditional Rental Income: $1607 Airbnb ROI: -0.18% Traditional ROI: 4.71%
695 MASHES SANDS Road Panacea, FL Marina Village is a unique fishing and sporting community located on the Ochlockonee Bay a...	3 beds \| 3 baths \| 1,656 sq.ft.	$405,000	Airbnb cash on cash: -0.17% Traditional cash on cash: 4.39% Airbnb Rental Income: $1150 Traditional Rental Income: $2499 Airbnb ROI: -0.17% Traditional ROI: 4.39%
27 CHICKASAW Street Panacea, FL Old Florida Charm Meets Coastal Living in the Heart of Panacea Just a few blocks from the ...	3 beds \| 2 baths \| 1,344 sq.ft.	$399,000	Airbnb cash on cash: 0.03% Traditional cash on cash: 3.31% Airbnb Rental Income: $1150 Traditional Rental Income: $1993 Airbnb ROI: 0.03% Traditional ROI: 3.31%
88 River Drive Panacea, FL Welcome to 88 River Drive in Panacea, Florida-a charming coastal property where relaxed li...	3 beds \| 2 baths \| 1,767 sq.ft.	$579,000	Airbnb cash on cash: -0.5% Traditional cash on cash: 2.71% Airbnb Rental Income: $1150 Traditional Rental Income: $2509 Airbnb ROI: -0.5% Traditional ROI: 2.71%
160 Mississippi Avenue Panacea, FL This home is a perfect mix of convenience and coastal charm. The marina is just two blocks...	3 beds \| 2 baths \| 1,210 sq.ft.	$289,000	Airbnb cash on cash: 0.95% Traditional cash on cash: 5.35% Airbnb Rental Income: $1150 Traditional Rental Income: $1967 Airbnb ROI: 0.95% Traditional ROI: 5.35%
25-A Mashes Sands Road Panacea, FL Wake up to breathtaking sunrises and panoramic views of Ochlockonee Bay as it opens into t...	4 beds \| 3 baths \| 1,736 sq.ft.	$499,000	Airbnb cash on cash: 6.48% Traditional cash on cash: 3.07% Airbnb Rental Income: $4979 Traditional Rental Income: $2368 Airbnb ROI: 6.48% Traditional ROI: 3.07%
11 -A6 Mashes Sands Road #A6 Panacea, FL Escape to this beauty of Florida's Forgotten Coast with this charming 2 bedroom, 1 bath co...	2 beds \| 1 baths \| 910 sq.ft.	$224,900	Airbnb cash on cash: 9.77% Traditional cash on cash: 6.19% Airbnb Rental Income: $3180 Traditional Rental Income: $1699 Airbnb ROI: 9.77% Traditional ROI: 6.19%
695 A6 Mashes Sands Road Panacea, FL Welcome to Marina Village! This beautifully updated 1,332 sq ft end unit townhouse offers ...	2 beds \| 2 baths \| 1,332 sq.ft.	$345,000	Airbnb cash on cash: 5.24% Traditional cash on cash: 5.44% Airbnb Rental Income: $3180 Traditional Rental Income: $2526 Airbnb ROI: 5.24% Traditional ROI: 5.44%
2301 Surf Road Panacea, FL Beautifully renovated bayfront home with direct Gulf access and stunning waterfront views!...	3 beds \| 2 baths \| 1,856 sq.ft.	$799,900	Airbnb cash on cash: -0.5% Traditional cash on cash: 2.04% Airbnb Rental Income: $1150 Traditional Rental Income: $2661 Airbnb ROI: -0.5% Traditional ROI: 2.04%
40 POMPANO Drive Panacea, FL Welcome to your slice of Old Florida paradise in the heart of Panacea! This charming canal...	3 beds \| 2 baths \| 1,560 sq.ft.	$430,000	Airbnb cash on cash: -0.39% Traditional cash on cash: 2.75% Airbnb Rental Income: $1150 Traditional Rental Income: $2033 Airbnb ROI: -0.39% Traditional ROI: 2.75%
151 Otter Lake Road Panacea, FL Fully renovated 3BR/2BA home with 1,196 sq ft in Panacea. New metal roof, new vinyl siding...	3 beds \| 2 baths \| 1,196 sq.ft.	$279,900	Airbnb cash on cash: 1.15% Traditional cash on cash: 5.22% Airbnb Rental Income: $1150 Traditional Rental Income: $1842 Airbnb ROI: 1.15% Traditional ROI: 5.22%
23 Pompano Drive Panacea, FL "Bring Offers!" Seller will pay up to $3,000 of Buyers closing cost. Hidden Gem - Bayfront...	2 beds \| 2 baths \| 1,940 sq.ft.	$640,000	Airbnb cash on cash: 2.32% Traditional cash on cash: 2.51% Airbnb Rental Income: $3180 Traditional Rental Income: $2573 Airbnb ROI: 2.32% Traditional ROI: 2.51%
40 Lakeview Dr Panacea, FL Charming beach cottage on Bald Point! FANTASTIC LOCATION adjacent to State Park property a...	2 beds \| 1 baths \| 1,059 sq.ft.	$389,000	Airbnb cash on cash: 5.3% Traditional cash on cash: 3.76% Airbnb Rental Income: $3180 Traditional Rental Income: $1899 Airbnb ROI: 5.3% Traditional ROI: 3.76%
50 Fiesta Dr Panacea, FL Come and relax at this adorable A-Frame house on the most popular Alligator Point. With a ...	2 beds \| 1 baths \| 874 sq.ft.	$399,900	Airbnb cash on cash: 8.43% Traditional cash on cash: 3.12% Airbnb Rental Income: $4979 Traditional Rental Income: $1970 Airbnb ROI: 8.43% Traditional ROI: 3.12%
1630 Alligator Dr Panacea, FL Priced to sale! Enjoy the best of both worlds with deeded Gulf beach access just across th...	2 beds \| 2 baths \| 1,093 sq.ft.	$425,000	Airbnb cash on cash: 7.12% Traditional cash on cash: 3.5% Airbnb Rental Income: $4979 Traditional Rental Income: $2400 Airbnb ROI: 7.12% Traditional ROI: 3.5%
1231 Alligator Dr Panacea, FL Welcome to AWESOME VIEW BEACH HOUSE-Your Coastal Escape! Experience the best of waterf...	3 beds \| 2 baths \| 1,380 sq.ft.	$1,200,000	Airbnb cash on cash: 1.73% Traditional cash on cash: 0.11% Airbnb Rental Income: $5175 Traditional Rental Income: $2315 Airbnb ROI: 1.73% Traditional ROI: 0.11%
1372 Alligator Dr Panacea, FL NEWER 2023 BUILT ALLIGATOR POINT GETAWAY! Paid off Solar Panel system for low to no cost u...	3 beds \| 2 baths \| 1,532 sq.ft.	$515,000	Airbnb cash on cash: 6.49% Traditional cash on cash: 2.87% Airbnb Rental Income: $5175 Traditional Rental Income: $2380 Airbnb ROI: 6.49% Traditional ROI: 2.87%
1505 Alligator Dr Panacea, FL Experience coastal living at its finest with this charming Gulf-front beach cottage locate...	2 beds \| 1 baths \| 900 sq.ft.	$725,000	Airbnb cash on cash: 4.22% Traditional cash on cash: 0.81% Airbnb Rental Income: $4979 Traditional Rental Income: $1656 Airbnb ROI: 4.22% Traditional ROI: 0.81%
214 Harbor Cir Panacea, FL Welcome to your perfect coastal escape at Alligator Point-where laid-back living meets bre...	3 beds \| 3 baths \| 1,388 sq.ft.	$545,000	Airbnb cash on cash: 6.28% Traditional cash on cash: 1.79% Airbnb Rental Income: $5175 Traditional Rental Income: $1836 Airbnb ROI: 6.28% Traditional ROI: 1.79%
7 Bass St Panacea, FL Welcome to 7 Bass St, a charming coastal retreat nestled in the serene community of Alliga...	4 beds \| 3 baths \| 1,800 sq.ft.	$574,900	Airbnb cash on cash: 5.61% Traditional cash on cash: 2.86% Airbnb Rental Income: $4979 Traditional Rental Income: $2421 Airbnb ROI: 5.61% Traditional ROI: 2.86%
1171 Alligator Dr Panacea, FL Breathtaking Gulf views and coastal charm await at this light-filled retreat along Florida...	3 beds \| 3 baths \| 1,376 sq.ft.	$799,900	Airbnb cash on cash: 3.71% Traditional cash on cash: 1.33% Airbnb Rental Income: $5175 Traditional Rental Income: $2352 Airbnb ROI: 3.71% Traditional ROI: 1.33%
1659 Alligator Dr Panacea, FL Welcome to one of the most desirable beachfront locations on Alligator Point. Nestled alon...	3 beds \| 2 baths \| 1,904 sq.ft.	$999,000	Airbnb cash on cash: 2.97% Traditional cash on cash: 1.85% Airbnb Rental Income: $5175 Traditional Rental Income: $3084 Airbnb ROI: 2.97% Traditional ROI: 1.85%
12 Marlin St Panacea, FL Gulf-Front Living on Florida's Forgotten Coast - Offered for the First Time Welcome to 12 ...	3 beds \| 2 baths \| 1,600 sq.ft.	$845,500	Airbnb cash on cash: 2.5% Traditional cash on cash: 1.75% Airbnb Rental Income: $3946 Traditional Rental Income: $2511 Airbnb ROI: 2.5% Traditional ROI: 1.75%
1446 Cypress St Panacea, FL Coastal-ready comfort with space to spread out - 1446 Cypress Street An updated home that'...	3 beds \| 2 baths \| 1,554 sq.ft.	$425,000	Airbnb cash on cash: 8.01% Traditional cash on cash: 3.35% Airbnb Rental Income: $5175 Traditional Rental Income: $2225 Airbnb ROI: 8.01% Traditional ROI: 3.35%
8 Bass St Panacea, FL Best Deal on the Beaches! Thoughtfully designed to include Storm shutters for protection, ...	3 beds \| 2 baths \| 1,352 sq.ft.	$599,000	Airbnb cash on cash: 5.75% Traditional cash on cash: 2.07% Airbnb Rental Income: $5175 Traditional Rental Income: $2065 Airbnb ROI: 5.75% Traditional ROI: 2.07%
1678 Alligator Dr Panacea, FL Enjoy breathtaking views of Alligator Bay and the tranquil lagoon from this stunning coast...	3 beds \| 2 baths \| 2,016 sq.ft.	$1,200,000	Airbnb cash on cash: 1.89% Traditional cash on cash: 1.23% Airbnb Rental Income: $5175 Traditional Rental Income: $3388 Airbnb ROI: 1.89% Traditional ROI: 1.23%

Real Estate investment in Panacea, FL

There are 54 properties for sale in the city of Panacea . The median list price in Panacea is $224,865 and the average price per square foot is $147. In September 2026, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,744.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 54 investment properties available for sale in Panacea.

In 2026, the best neighborhood to buy investment property is Panacea.

The ROI for Long-Term is higher than the Short-Term in Panacea with average rental income of $1,744.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

68 Suwannee Avenue

Panacea, FL

3 beds | 2 baths | 1,020 sq.ft.

$269,000

Airbnb cash on cash: 1.08%

Traditional cash on cash: 6.45%

Airbnb Rental Income: $1150

Traditional Rental Income: $2131

Airbnb ROI: 1.08%

Traditional ROI: 6.45%

201 Harbour Point

Panacea, FL

4 beds | 5 baths | 2,778 sq.ft.

$869,000

Airbnb cash on cash: 2.76%

Traditional cash on cash: 5.15%

Airbnb Rental Income: $4979

Traditional Rental Income: $5901

Airbnb ROI: 2.76%

Traditional ROI: 5.15%

47 BLUE CRAB Lane

Panacea, FL

3 beds | 2 baths | 1,280 sq.ft.

$995,000

Airbnb cash on cash: -1.15%

Traditional cash on cash: 1.92%

Airbnb Rental Income: $1150

Traditional Rental Income: $3619

Airbnb ROI: -1.15%

Traditional ROI: 1.92%

92 Koch St

Panacea, FL

3 beds | 2 baths | 1,092 sq.ft.

$250,000

Airbnb cash on cash: 1.66%

Traditional cash on cash: 5.37%

Airbnb Rental Income: $1150

Traditional Rental Income: $1645

Airbnb ROI: 1.66%

Traditional ROI: 5.37%

23 Monticello Avenue

Panacea, FL

3 beds | 2 baths | 1,420 sq.ft.

$359,000

Airbnb cash on cash: 0.49%

Traditional cash on cash: 5.61%

Airbnb Rental Income: $1150

Traditional Rental Income: $2493

Airbnb ROI: 0.49%

Traditional ROI: 5.61%

695 B6 Mashes Sands Road

Panacea, FL

2 beds | 3 baths | 1,656 sq.ft.

$425,000

Airbnb cash on cash: 3.67%

Traditional cash on cash: 4.01%

Airbnb Rental Income: $3180

Traditional Rental Income: $2597

Airbnb ROI: 3.67%

Traditional ROI: 4.01%

2289 Surf Road #C3

Panacea, FL

2 beds | 3 baths | 1,440 sq.ft.

$265,000

Airbnb cash on cash: 5.2%

Traditional cash on cash: 3.81%

Airbnb Rental Income: $3180

Traditional Rental Income: $2115

Airbnb ROI: 5.2%

Traditional ROI: 3.81%

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$689,000

Airbnb cash on cash: -0.65%

Traditional cash on cash: 2.5%

Airbnb Rental Income: $1150

Traditional Rental Income: $2796

Airbnb ROI: -0.65%