Real Estate Investment Properties for Sale in Panacea, FL

Looking for investment property in Panacea, FL with high ROI ?

Explore a variety of short-term homes & houses in Panacea, FL. Invest wisely with VRBO & Panacea, FL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Panacea, FL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
47 BLUE CRAB Lane Panacea, FL This 3-bedroom 2 bath is a Octagon home on .333 acres is built to withstand winds of 180 m...	3 beds \| 2 baths \| 1,280 sq.ft.	$1,150,000	Airbnb cash on cash: -0.46% Traditional cash on cash: 0.19% Airbnb Rental Income: $2171 Traditional Rental Income: $2308 Airbnb ROI: -0.46% Traditional ROI: 0.19%
38 Sunrise Lane Panacea, FL This beautiful beach house is being sold furnished, ready for you to bring your suitcases ...	3 beds \| 3 baths \| 1,508 sq.ft.	$699,900	Airbnb cash on cash: 0.65% Traditional cash on cash: 1.87% Airbnb Rental Income: $2171 Traditional Rental Income: $2419 Airbnb ROI: 0.65% Traditional ROI: 1.87%
79 Ida Street Panacea, FL Lots of upgrades to include new flooring, paint, windows, kitchen upgrade with new counter...	3 beds \| 2 baths \| 1,008 sq.ft.	$155,000	Airbnb cash on cash: 8.52% Traditional cash on cash: 8.31% Airbnb Rental Income: $2171 Traditional Rental Income: $1590 Airbnb ROI: 8.52% Traditional ROI: 8.31%
25 Mashes Sands Road unit: I #I Panacea, FL Welcome to your dream waterfront home! Nestled at Georges Lighthouse, this exquisite townh...	3 beds \| 3 baths \| 1,481 sq.ft.	$425,000	Airbnb cash on cash: 1.33% Traditional cash on cash: 2.69% Airbnb Rental Income: $2171 Traditional Rental Income: $2163 Airbnb ROI: 1.33% Traditional ROI: 2.69%
12 Lake Essay Drive Panacea, FL Escape to Wild Azalea Cottage on Lake Essay-a serene lakefront retreat where you can relax...	2 beds \| 1 baths \| 1,148 sq.ft.	$239,900	Airbnb cash on cash: 3.32% Traditional cash on cash: 6.86% Airbnb Rental Income: $1645 Traditional Rental Income: $1985 Airbnb ROI: 3.32% Traditional ROI: 6.86%
2289 Surf Road unit: A7 #A7 Panacea, FL Imagine waking up to uninterrupted bay views from every floor while sipping your morning c...	2 beds \| 3 baths \| 1,440 sq.ft.	$369,000	Airbnb cash on cash: 2.13% Traditional cash on cash: 5.93% Airbnb Rental Income: $1645 Traditional Rental Income: $2497 Airbnb ROI: 2.13% Traditional ROI: 5.93%
39 Aucilla Street Panacea, FL A MUST SEE home with acreage! Beautifully maintained three-bedroom, two-bath home on 2.88 ...	3 beds \| 2 baths \| 2,093 sq.ft.	$549,000	Airbnb cash on cash: 1.41% Traditional cash on cash: 2.85% Airbnb Rental Income: $2171 Traditional Rental Income: $2356 Airbnb ROI: 1.41% Traditional ROI: 2.85%
11 A3 Mashes Sands Road unit: A #A Panacea, FL Beautifully Remodeled 2BR/1BA Condo in a gated Waterfront Community! Enjoy resort-style li...	2 beds \| 1 baths \| 910 sq.ft.	$239,900	Airbnb cash on cash: 2.85% Traditional cash on cash: 5.05% Airbnb Rental Income: $1645 Traditional Rental Income: $1680 Airbnb ROI: 2.85% Traditional ROI: 5.05%
562 Mashes Sands Road Panacea, FL This classic 2 bedroom, 1.5 bath A-frame home offers the ideal blend of comfort, simplicit...	2 beds \| 2 baths \| 1,080 sq.ft.	$299,900	Airbnb cash on cash: 2.1% Traditional cash on cash: 4.31% Airbnb Rental Income: $1645 Traditional Rental Income: $1806 Airbnb ROI: 2.1% Traditional ROI: 4.31%
84 Chattahoochee Street Panacea, FL Discover the potential in this 3-bedroom, 2-bath home nestled on a spacious 1-acre lot in ...	3 beds \| 2 baths \| 1,813 sq.ft.	$229,900	Airbnb cash on cash: 5.37% Traditional cash on cash: 7.93% Airbnb Rental Income: $2171 Traditional Rental Income: $2177 Airbnb ROI: 5.37% Traditional ROI: 7.93%
5 Alapaha Avenue Panacea, FL Welcome to your coastal retreat in the heart of Panacea! This charming 3-bedroom, 2-bath s...	3 beds \| 2 baths \| 1,104 sq.ft.	$209,000	Airbnb cash on cash: 5.67% Traditional cash on cash: 6.31% Airbnb Rental Income: $2171 Traditional Rental Income: $1747 Airbnb ROI: 5.67% Traditional ROI: 6.31%
11 SANDPIPER Drive Panacea, FL This recently remodeled home offers a water view in a gated community with easy access to ...	2 beds \| 2 baths \| 1,400 sq.ft.	$362,500	Airbnb cash on cash: 1.18% Traditional cash on cash: 3.31% Airbnb Rental Income: $1645 Traditional Rental Income: $1907 Airbnb ROI: 1.18% Traditional ROI: 3.31%
23 Monticello Avenue Panacea, FL Adorable, peaceful and quiet home located in the heart of Panacea on 17 platted lots total...	3 beds \| 2 baths \| 1,420 sq.ft.	$359,000	Airbnb cash on cash: 3.02% Traditional cash on cash: 4.21% Airbnb Rental Income: $2171 Traditional Rental Income: $2021 Airbnb ROI: 3.02% Traditional ROI: 4.21%
100 River Drive Panacea, FL This true Old Florida style cottage on Ochlockonee Bay-where two rivers meet the Gulf-is n...	2 beds \| 2 baths \| 1,230 sq.ft.	$585,000	Airbnb cash on cash: 0.16% Traditional cash on cash: 2.12% Airbnb Rental Income: $1645 Traditional Rental Income: $2253 Airbnb ROI: 0.16% Traditional ROI: 2.12%
88 Warbird Circle Panacea, FL New construction in gated Tarpine community that includes access to airport and community ...	3 beds \| 2 baths \| 1,527 sq.ft.	$445,000	Airbnb cash on cash: 2.57% Traditional cash on cash: 3.54% Airbnb Rental Income: $2171 Traditional Rental Income: $2021 Airbnb ROI: 2.57% Traditional ROI: 3.54%
47 Aucilla Street Panacea, FL Discover the perfect blend of privacy, functionality, and coastal living with this excepti...	3 beds \| 2 baths \| 2,093 sq.ft.	$695,000	Airbnb cash on cash: 0.47% Traditional cash on cash: 1.63% Airbnb Rental Income: $2171 Traditional Rental Income: $2368 Airbnb ROI: 0.47% Traditional ROI: 1.63%
2413 Surf Road Panacea, FL Welcome home to this bayfront property, situated on over a half acre lot, with 90 feet of ...	2 beds \| 2 baths \| 1,600 sq.ft.	$529,900	Airbnb cash on cash: 0.52% Traditional cash on cash: 2.68% Airbnb Rental Income: $1645 Traditional Rental Income: $2249 Airbnb ROI: 0.52% Traditional ROI: 2.68%
22 Otter Lake Road Panacea, FL Welcome to 22 Otter Lake Rd! This 3 Bedroom 2 Bath home offers peaceful living in a quiet ...	3 beds \| 2 baths \| 2,172 sq.ft.	$325,000	Airbnb cash on cash: 3.3% Traditional cash on cash: 5.75% Airbnb Rental Income: $2171 Traditional Rental Income: $2369 Airbnb ROI: 3.3% Traditional ROI: 5.75%
695 Mashes Sands Road unit: A5 #A5 Panacea, FL A beautifully maintained 2BR / 2.5BA townhouse + loft offering spectacular views of Ochloc...	2 beds \| 3 baths \| 1,332 sq.ft.	$415,000	Airbnb cash on cash: 0.99% Traditional cash on cash: 3.22% Airbnb Rental Income: $1645 Traditional Rental Income: $2048 Airbnb ROI: 0.99% Traditional ROI: 3.22%
695 B6 Mashes Sands Road Panacea, FL Welcome Home to this 1656 sqft 2 bedroom 2.5 bath end unit townhouse in Marina Village. Fe...	2 beds \| 3 baths \| 1,656 sq.ft.	$425,000	Airbnb cash on cash: 0.46% Traditional cash on cash: 3.21% Airbnb Rental Income: $1645 Traditional Rental Income: $2279 Airbnb ROI: 0.46% Traditional ROI: 3.21%
572 Mashes Sands Road Panacea, FL Experience the charm of coastal living less than a mile from the public boat dock, Mashes ...	3 beds \| 2 baths \| 1,694 sq.ft.	$440,000	Airbnb cash on cash: 2.06% Traditional cash on cash: 3.07% Airbnb Rental Income: $2171 Traditional Rental Income: $2035 Airbnb ROI: 2.06% Traditional ROI: 3.07%
201 Harbour Point Panacea, FL Waterfront Luxury in Shell Point - 4 Bed \| 3 Full & 2 Half Bath \| Private Dock & Boat Lift...	4 beds \| 5 baths \| 2,778 sq.ft.	$925,000	Airbnb cash on cash: -1.14% Traditional cash on cash: 3.98% Airbnb Rental Income: $1244 Traditional Rental Income: $5255 Airbnb ROI: -1.14% Traditional ROI: 3.98%
35 Harbour Point Drive Panacea, FL This spacious townhouse encompasses two and a half stories, delivering both comfort and st...	2 beds \| 3 baths \| 1,495 sq.ft.	$380,000	Airbnb cash on cash: 1.17% Traditional cash on cash: 4.86% Airbnb Rental Income: $1645 Traditional Rental Income: $2496 Airbnb ROI: 1.17% Traditional ROI: 4.86%
8 Bass St Panacea, FL Best Deal on the Beaches! Thoughtfully designed to include Storm shutters for protection, ...	3 beds \| 2 baths \| 1,352 sq.ft.	$599,000	Airbnb cash on cash: 1.29% Traditional cash on cash: 1.67% Airbnb Rental Income: $2181 Traditional Rental Income: $1840 Airbnb ROI: 1.29% Traditional ROI: 1.67%
203 Harbor Cir Panacea, FL Enjoy spectacular Bayfront sunrises from this beautifully designed 3-bedroom, 2.5-bath hom...	3 beds \| 2 baths \| 1,200 sq.ft.	$799,000	Airbnb cash on cash: 1.06% Traditional cash on cash: 1.59% Airbnb Rental Income: $2181 Traditional Rental Income: $2025 Airbnb ROI: 1.06% Traditional ROI: 1.59%
1630 Alligator Dr Panacea, FL Enjoy the best of both worlds with deeded Gulf beach access just across the street with a ...	2 beds \| 2 baths \| 1,093 sq.ft.	$499,900	Airbnb cash on cash: 0.19% Traditional cash on cash: 2.32% Airbnb Rental Income: $1453 Traditional Rental Income: $2017 Airbnb ROI: 0.19% Traditional ROI: 2.32%
1372 Chip Morrison Dr Panacea, FL One or more photos have been virtually staged. Luxury Coastal Retreat with Stunning Gulf V...	4 beds \| 3 baths \| 2,100 sq.ft.	$1,329,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 1.52% Airbnb Rental Income: $1756 Traditional Rental Income: $3277 Airbnb ROI: -0.1% Traditional ROI: 1.52%
7 Bass St Panacea, FL Move-in ready 4BR/3BA home on Alligator Point with amazing beach views and direct Beach ac...	4 beds \| 3 baths \| 1,800 sq.ft.	$675,000	Airbnb cash on cash: 0.56% Traditional cash on cash: 2.45% Airbnb Rental Income: $1756 Traditional Rental Income: $2466 Airbnb ROI: 0.56% Traditional ROI: 2.45%
1678 Alligator Dr Panacea, FL Enjoy breathtaking views of Alligator Bay and the tranquil lagoon from this stunning coast...	3 beds \| 2 baths \| 2,016 sq.ft.	$1,200,000	Airbnb cash on cash: -0.35% Traditional cash on cash: 0.64% Airbnb Rental Income: $2181 Traditional Rental Income: $2739 Airbnb ROI: -0.35% Traditional ROI: 0.64%
1463 Cypress St Panacea, FL Enjoy Gulf Coast living at its finest in this elevated 2-bedroom, 1 full-bath and 2 half b...	2 beds \| 1 baths \| 1,620 sq.ft.	$499,000	Airbnb cash on cash: 0.11% Traditional cash on cash: 2.49% Airbnb Rental Income: $1453 Traditional Rental Income: $2134 Airbnb ROI: 0.11% Traditional ROI: 2.49%
1372 Alligator Dr Panacea, FL NEWER 2023 BUILT ALLIGATOR POINT GETAWAY! Paid off Solar Panel system for low to no cost u...	3 beds \| 2 baths \| 1,532 sq.ft.	$549,000	Airbnb cash on cash: 1.11% Traditional cash on cash: 2.34% Airbnb Rental Income: $2181 Traditional Rental Income: $2261 Airbnb ROI: 1.11% Traditional ROI: 2.34%
1125 Alligator Dr Panacea, FL The "Quirky Crab" on Alligator Point is everything you are looking for in a coastal beach ...	3 beds \| 2 baths \| 1,376 sq.ft.	$995,000	Airbnb cash on cash: 0.12% Traditional cash on cash: 0.87% Airbnb Rental Income: $2181 Traditional Rental Income: $2318 Airbnb ROI: 0.12% Traditional ROI: 0.87%
637 Mariner Cir Panacea, FL Discover the timeless charm of this classic 1960's beach house, nestled along Florida's Fo...	2 beds \| 2 baths \| 1,080 sq.ft.	$420,000	Airbnb cash on cash: 0.6% Traditional cash on cash: 2.94% Airbnb Rental Income: $1453 Traditional Rental Income: $1944 Airbnb ROI: 0.6% Traditional ROI: 2.94%
6 Kingfish St Panacea, FL Bald Point Beach Estate aptly named "Heavenly Sunrise" offers a rare opportunity to own an...	4 beds \| 3 baths \| 1,952 sq.ft.	$1,100,000	Airbnb cash on cash: -0.09% Traditional cash on cash: 1.25% Airbnb Rental Income: $1756 Traditional Rental Income: $2651 Airbnb ROI: -0.09% Traditional ROI: 1.25%
50 Fiesta Dr Panacea, FL Come and relax at this adorable A-Frame house on the most popular Alligator Point. With a ...	1 beds \| 1 baths \| 874 sq.ft.	$415,000	Airbnb cash on cash: 2.23% Traditional cash on cash: 1.81% Airbnb Rental Income: $2260 Traditional Rental Income: $1531 Airbnb ROI: 2.23% Traditional ROI: 1.81%
582 Bald Point Rd Panacea, FL Beautiful custom-built beach builder-owned and built home directly on the Gulf at Bald Poi...	4 beds \| 2 baths \| 2,888 sq.ft.	$1,395,000	Airbnb cash on cash: -0.32% Traditional cash on cash: 1.25% Airbnb Rental Income: $1737 Traditional Rental Income: $3303 Airbnb ROI: -0.32% Traditional ROI: 1.25%
1219 Alligator Dr Panacea, FL Stunning home on the beach on Alligator Point. A must see. This home is very unique with a...	4 beds \| 2 baths \| 1,632 sq.ft.	$799,000	Airbnb cash on cash: 0.08% Traditional cash on cash: 1.32% Airbnb Rental Income: $1756 Traditional Rental Income: $2198 Airbnb ROI: 0.08% Traditional ROI: 1.32%
1464 Alligator Dr Panacea, FL Nestled beneath the pines, the beautifully updated 1942 cottage blends vintage charm with ...	3 beds \| 2 baths \| 2,159 sq.ft.	$890,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 2.47% Airbnb Rental Income: $2181 Traditional Rental Income: $2980 Airbnb ROI: 0.84% Traditional ROI: 2.47%
1651 Alligator Dr Panacea, FL Costal Cottage Retreat on Alligator Point - Steps from the Marina Discover the charm of co...	2 beds \| 2 baths \| 1,200 sq.ft.	$840,000	Airbnb cash on cash: -0.5% Traditional cash on cash: 0.81% Airbnb Rental Income: $1453 Traditional Rental Income: $2048 Airbnb ROI: -0.5% Traditional ROI: 0.81%
42 Fiesta Dr Panacea, FL Classic Florida Beach House with views of Alligator Bay and Canal Frontage with Dock! This...	3 beds \| 2 baths \| 1,178 sq.ft.	$599,000	Airbnb cash on cash: 1.29% Traditional cash on cash: 1.89% Airbnb Rental Income: $2181 Traditional Rental Income: $1964 Airbnb ROI: 1.29% Traditional ROI: 1.89%

Real Estate investment in Panacea, FL

There are 54 properties for sale in the city of Panacea . The median list price in Panacea is $369,000 and the average price per square foot is $243. In February 2026, the average monthly cash on cash return in Panacea is 2.00%. The average monthly rental income in Panacea is $1,740.

Panacea, FL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 54 investment properties available for sale in Panacea.

In 2026, the best neighborhood to buy investment property is Panacea.

The ROI for Long-Term is higher than the Short-Term in Panacea with average rental income of $1,740.

Your search for investment property begins and ends here

Investment Property for Sale in Panacea, FL

47 BLUE CRAB Lane

Panacea, FL

3 beds | 2 baths | 1,280 sq.ft.

$1,150,000

Airbnb cash on cash: -0.46%

Traditional cash on cash: 0.19%

Airbnb Rental Income: $2171

Traditional Rental Income: $2308

Airbnb ROI: -0.46%

Traditional ROI: 0.19%

38 Sunrise Lane

Panacea, FL

3 beds | 3 baths | 1,508 sq.ft.

$699,900

Airbnb cash on cash: 0.65%

Traditional cash on cash: 1.87%

Airbnb Rental Income: $2171

Traditional Rental Income: $2419

Airbnb ROI: 0.65%

Traditional ROI: 1.87%

79 Ida Street

Panacea, FL

3 beds | 2 baths | 1,008 sq.ft.

$155,000

Airbnb cash on cash: 8.52%

Traditional cash on cash: 8.31%

Airbnb Rental Income: $2171

Traditional Rental Income: $1590

Airbnb ROI: 8.52%

Traditional ROI: 8.31%

25 Mashes Sands Road unit: I #I

Panacea, FL

3 beds | 3 baths | 1,481 sq.ft.

$425,000

Airbnb cash on cash: 1.33%

Traditional cash on cash: 2.69%

Airbnb Rental Income: $2171

Traditional Rental Income: $2163

Airbnb ROI: 1.33%

Traditional ROI: 2.69%

12 Lake Essay Drive

Panacea, FL

2 beds | 1 baths | 1,148 sq.ft.

$239,900

Airbnb cash on cash: 3.32%

Traditional cash on cash: 6.86%

Airbnb Rental Income: $1645

Traditional Rental Income: $1985

Airbnb ROI: 3.32%

Traditional ROI: 6.86%

2289 Surf Road unit: A7 #A7

Panacea, FL

2 beds | 3 baths | 1,440 sq.ft.

$369,000

Airbnb cash on cash: 2.13%

Traditional cash on cash: 5.93%

Airbnb Rental Income: $1645

Traditional Rental Income: $2497

Airbnb ROI: 2.13%

Traditional ROI: 5.93%

39 Aucilla Street

Panacea, FL

3 beds | 2 baths | 2,093 sq.ft.

$549,000

Airbnb cash on cash: 1.41%

Traditional cash on cash: 2.85%

Airbnb Rental Income: $2171

Traditional Rental Income: $2356

Airbnb ROI: 1.41%

Traditional ROI: 2.85%

11 A3 Mashes Sands Road unit: A #A

Panacea, FL

2 beds | 1 baths | 910 sq.ft.

$239,900

Airbnb cash on cash: 2.85%

Traditional cash on cash: 5.05%

Airbnb Rental Income: $1645

Traditional Rental Income: $1680

Airbnb ROI: 2.85%