Real Estate Investment Properties for Sale in Murphysboro, IL

Looking for investment property in Murphysboro, IL with high ROI ?

Explore a variety of short-term homes & houses in Murphysboro, IL. Invest wisely with VRBO & Murphysboro, IL Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Murphysboro, IL

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
8 Buena Vista Dr Murphysboro, IL 3 bed 2 bath home located in the outskirts of town in Westwood Hills, this home features n...	3 beds \| 2 baths \| 1,667 sq.ft.	$180,000	Airbnb cash on cash: 2.82% Traditional cash on cash: 7.79% Airbnb Rental Income: $1451 Traditional Rental Income: $1871 Airbnb ROI: 2.82% Traditional ROI: 7.79%
37 Westwood Ln Murphysboro, IL This very nice, well built Colonial style home has 4 bedroom, 3 bath. Many updates includ...	4 beds \| 3 baths \| 2,652 sq.ft.	$289,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.99% Airbnb Rental Income: $null Traditional Rental Income: $2889 Airbnb ROI: N/A Traditional ROI: 7.99%
2202 Illinois Ave #3 & 4 Murphysboro, IL Fantastic investment opportunity! This property features two units, each with 2 bedrooms, ...	4 beds \| 2 baths \| 2,016 sq.ft.	$109,000	Airbnb cash on cash: 3.04% Traditional cash on cash: 11.79% Airbnb Rental Income: $1298 Traditional Rental Income: $1816 Airbnb ROI: 3.04% Traditional ROI: 11.79%
5559 Country Club Rd Murphysboro, IL Investors, take note! Whether you're looking to generate extra income or just getting star...	4 beds \| 2 baths \| N/A	$199,000	Airbnb cash on cash: 2.08% Traditional cash on cash: 7.23% Airbnb Rental Income: $1451 Traditional Rental Income: $1993 Airbnb ROI: 2.08% Traditional ROI: 7.23%
8994 Old Highway 13 Hwy Murphysboro, IL Nestled in a country setting overlooking field and trees, this brick/vinyl ranch offers so...	4 beds \| 2 baths \| 2,109 sq.ft.	$249,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.6% Airbnb Rental Income: $null Traditional Rental Income: $2559 Airbnb ROI: N/A Traditional ROI: 7.6%
2101 Walnut St Murphysboro, IL Welcome to 2101 Walnut Street, a beautifully maintained two-story home full of character a...	3 beds \| 2 baths \| 3,574 sq.ft.	$219,000	Airbnb cash on cash: 0.46% Traditional cash on cash: 9.75% Airbnb Rental Income: $1451 Traditional Rental Income: $2947 Airbnb ROI: 0.46% Traditional ROI: 9.75%
8384 HICKORY RIDGE Road Murphysboro, IL Welcome to 8384 Hickory Ridge Road - your peaceful countryside retreat in Murphysboro! Thi...	4 beds \| 2 baths \| 2,400 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.79% Airbnb Rental Income: $null Traditional Rental Income: $1814 Airbnb ROI: N/A Traditional ROI: 5.79%
170 Melody Ln Murphysboro, IL Tucked away on a quiet dead-end road, 170 Melody Lane in Murphysboro offers peaceful livin...	3 beds \| 2 baths \| 1,689 sq.ft.	$189,000	Airbnb cash on cash: 2.4% Traditional cash on cash: 9.53% Airbnb Rental Income: $1451 Traditional Rental Income: $2301 Airbnb ROI: 2.4% Traditional ROI: 9.53%

Real Estate investment in Murphysboro, IL

There are 47 properties for sale in the city of Murphysboro . The median list price in Murphysboro is $113,700 and the average price per square foot is $68. In March 2026, the average monthly cash on cash return in Murphysboro is 12.00%. The average monthly rental income in Murphysboro is $1,744.

Murphysboro, IL Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 47 investment properties available for sale in Murphysboro.

In 2026, the best neighborhood to buy investment property is Murphysboro.

The ROI for Short-Term is higher than the Long-Term in Murphysboro with average rental income of $1,451.

Your search for investment property begins and ends here

Investment Property for Sale in Murphysboro, IL

8 Buena Vista Dr

Murphysboro, IL

3 beds | 2 baths | 1,667 sq.ft.

$180,000

Airbnb cash on cash: 2.82%

Traditional cash on cash: 7.79%

Airbnb Rental Income: $1451

Traditional Rental Income: $1871

Airbnb ROI: 2.82%

Traditional ROI: 7.79%

37 Westwood Ln

Murphysboro, IL

4 beds | 3 baths | 2,652 sq.ft.

$289,500

Airbnb cash on cash: N/A

Traditional cash on cash: 7.99%

Airbnb Rental Income: $null

Traditional Rental Income: $2889

Airbnb ROI: N/A

Traditional ROI: 7.99%

2202 Illinois Ave #3 & 4

Murphysboro, IL

4 beds | 2 baths | 2,016 sq.ft.

$109,000

Airbnb cash on cash: 3.04%

Traditional cash on cash: 11.79%

Airbnb Rental Income: $1298

Traditional Rental Income: $1816

Airbnb ROI: 3.04%

Traditional ROI: 11.79%

5559 Country Club Rd

Murphysboro, IL

4 beds | 2 baths | N/A

$199,000

Airbnb cash on cash: 2.08%

Traditional cash on cash: 7.23%

Airbnb Rental Income: $1451

Traditional Rental Income: $1993

Airbnb ROI: 2.08%

Traditional ROI: 7.23%

8994 Old Highway 13 Hwy

Murphysboro, IL

4 beds | 2 baths | 2,109 sq.ft.

$249,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.6%

Airbnb Rental Income: $null

Traditional Rental Income: $2559

Airbnb ROI: N/A

Traditional ROI: 7.6%

2101 Walnut St

Murphysboro, IL

3 beds | 2 baths | 3,574 sq.ft.

$219,000

Airbnb cash on cash: 0.46%

Traditional cash on cash: 9.75%

Airbnb Rental Income: $1451

Traditional Rental Income: $2947

Airbnb ROI: 0.46%

Traditional ROI: 9.75%

8384 HICKORY RIDGE Road

Murphysboro, IL

4 beds | 2 baths | 2,400 sq.ft.

$220,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.79%

Airbnb Rental Income: $null

Traditional Rental Income: $1814

Airbnb ROI: N/A

Traditional ROI: 5.79%

170 Melody Ln

Murphysboro, IL

3 beds | 2 baths | 1,689 sq.ft.

$189,000

Airbnb cash on cash: 2.4%

Traditional cash on cash: 9.53%

Airbnb Rental Income: $1451

Traditional Rental Income: $2301

Airbnb ROI: 2.4%