Real Estate Investment Properties for Sale in De Soto, IA

Looking for investment property in De Soto, IA with high ROI ?

Explore a variety of short-term homes & houses in De Soto, IA. Invest wisely with VRBO & De Soto, IA Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, IA

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
I-80 & 169 Hwy De Soto, IA	N/A beds \| N/A baths \| N/A	$11,500,000	Airbnb cash on cash: N/A Traditional cash on cash: -2.48% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: -2.48%
820 Dallas St De Soto, IA Welcome home to this functional, well laid out home offering 4 bedrooms, 1 3/4 bathrooms, ...	4 beds \| 2 baths \| 1,086 sq.ft.	$254,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.18% Airbnb Rental Income: $null Traditional Rental Income: $1853 Airbnb ROI: N/A Traditional ROI: 5.18%
23935 360th Street De Soto, IA Brand new septic to be installed prior to closing!! Discover the perfect blend of comf...	2 beds \| 3 baths \| 2,255 sq.ft.	$595,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.9% Airbnb Rental Income: $null Traditional Rental Income: $2757 Airbnb ROI: N/A Traditional ROI: 2.9%
408 Maple Street De Soto, IA This spacious 3-bedroom walkout ranch is perfectly situated on a generous .65 acre lot. Em...	3 beds \| 3 baths \| 1,064 sq.ft.	$199,900	Airbnb cash on cash: 3.56% Traditional cash on cash: 6.97% Airbnb Rental Income: $1774 Traditional Rental Income: $1936 Airbnb ROI: 3.56% Traditional ROI: 6.97%
108 Maple Street De Soto, IA Welcome to this exceptional home that's the perfect blend of historic charm with modern up...	4 beds \| 3 baths \| 2,754 sq.ft.	$329,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.19% Airbnb Rental Income: $null Traditional Rental Income: $3407 Airbnb ROI: N/A Traditional ROI: 8.19%
340 Chestnut St De Soto, IA 340 Chestnut St, De Soto, IA 50069 \| Single Family Residential	4 beds \| 2 baths \| 2,432 sq.ft.	$698,450	Airbnb cash on cash: N/A Traditional cash on cash: 1.27% Airbnb Rental Income: $null Traditional Rental Income: $2615 Airbnb ROI: N/A Traditional ROI: 1.27%
35796 M Ave De Soto, IA 35796 M Ave, De Soto, IA 50069 \| Other	4 beds \| 3 baths \| 1,728 sq.ft.	$799,950	Airbnb cash on cash: N/A Traditional cash on cash: 0.41% Airbnb Rental Income: $null Traditional Rental Income: $2305 Airbnb ROI: N/A Traditional ROI: 0.41%
0 West Adjacent To 23152 347th St De Soto, IA 0 West Adjacent To 23152 347th St, De Soto, IA 50069 \| Other	N/A beds \| N/A baths \| N/A	$1,245,000	Airbnb cash on cash: N/A Traditional cash on cash: -1.75% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: -1.75%
0 Warren St De Soto, IA 0 Warren St, De Soto, IA 50069 \| Other	N/A beds \| N/A baths \| N/A	$150,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.05% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: 4.05%
1033 Linden Street De Soto, IA Keystone Equity Group presents the Zeta XL Plan, a thoughtfully designed ranch featuring 3...	3 beds \| 2 baths \| 1,353 sq.ft.	$304,900	Airbnb cash on cash: 1.62% Traditional cash on cash: 4.64% Airbnb Rental Income: $1774 Traditional Rental Income: $2158 Airbnb ROI: 1.62% Traditional ROI: 4.64%
1007 Polk Street De Soto, IA Keystone Equity Group presents the Zeta XL Plan featuring 3 bedrooms and 2 bathrooms. Qual...	3 beds \| 2 baths \| 1,353 sq.ft.	$329,900	Airbnb cash on cash: 1.3% Traditional cash on cash: 4.17% Airbnb Rental Income: $1774 Traditional Rental Income: $2178 Airbnb ROI: 1.3% Traditional ROI: 4.17%
1035 Linden Street De Soto, IA Keystone Equity Group presents the Alpha Plan featuring 4 bedrooms and 2.5 bathrooms. Qual...	4 beds \| 3 baths \| 1,646 sq.ft.	$311,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.03% Airbnb Rental Income: $null Traditional Rental Income: $2610 Airbnb ROI: N/A Traditional ROI: 6.03%
512 Maple Street De Soto, IA Welcome to this charming, 4BR, 2BA Ranch-style home, perfectly situated on 1/2 acre in the...	4 beds \| 2 baths \| 960 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.23% Airbnb Rental Income: $null Traditional Rental Income: $2000 Airbnb ROI: N/A Traditional ROI: 6.23%
605 Guthrie Avenue De Soto, IA Welcome to this beautifully refreshed home in Desoto, Iowa, offering stunning views of Iow...	2 beds \| 2 baths \| 1,238 sq.ft.	$255,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.81% Airbnb Rental Income: $null Traditional Rental Income: $1886 Airbnb ROI: N/A Traditional ROI: 4.81%

Real Estate investment in De-soto, IA

There are 14 properties for sale in the city of De Soto . The median list price in De Soto is $127,500 and the average price per square foot is $96. In January 2026, the average monthly cash on cash return in De Soto is 5.00%. The average monthly rental income in De Soto is $2,000.

De-soto, IA Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 14 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Long-Term is higher than the Short-Term in De-soto with average rental income of $2,000.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, IA

I-80 & 169 Hwy

De Soto, IA

N/A beds | N/A baths | N/A

$11,500,000

Airbnb cash on cash: N/A

Traditional cash on cash: -2.48%

Airbnb Rental Income: $null

Traditional Rental Income: $1038

Airbnb ROI: N/A

Traditional ROI: -2.48%

820 Dallas St

De Soto, IA

4 beds | 2 baths | 1,086 sq.ft.

$254,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.18%

Airbnb Rental Income: $null

Traditional Rental Income: $1853

Airbnb ROI: N/A

Traditional ROI: 5.18%

23935 360th Street

De Soto, IA

2 beds | 3 baths | 2,255 sq.ft.

$595,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.9%

Airbnb Rental Income: $null

Traditional Rental Income: $2757

Airbnb ROI: N/A

Traditional ROI: 2.9%

408 Maple Street

De Soto, IA

3 beds | 3 baths | 1,064 sq.ft.

$199,900

Airbnb cash on cash: 3.56%

Traditional cash on cash: 6.97%

Airbnb Rental Income: $1774

Traditional Rental Income: $1936

Airbnb ROI: 3.56%

Traditional ROI: 6.97%

108 Maple Street

De Soto, IA

4 beds | 3 baths | 2,754 sq.ft.

$329,900

Airbnb cash on cash: N/A

Traditional cash on cash: 8.19%

Airbnb Rental Income: $null

Traditional Rental Income: $3407

Airbnb ROI: N/A

Traditional ROI: 8.19%

340 Chestnut St

De Soto, IA

4 beds | 2 baths | 2,432 sq.ft.

$698,450

Airbnb cash on cash: N/A

Traditional cash on cash: 1.27%

Airbnb Rental Income: $null

Traditional Rental Income: $2615

Airbnb ROI: N/A

Traditional ROI: 1.27%

35796 M Ave

De Soto, IA

4 beds | 3 baths | 1,728 sq.ft.

$799,950

Airbnb cash on cash: N/A

Traditional cash on cash: 0.41%

Airbnb Rental Income: $null

Traditional Rental Income: $2305

Airbnb ROI: N/A

Traditional ROI: 0.41%

0 West Adjacent To 23152 347th St

De Soto, IA

N/A beds | N/A baths | N/A

$1,245,000

Airbnb cash on cash: N/A

Traditional cash on cash: -1.75%

Airbnb Rental Income: $null

Traditional Rental Income: $1038

Airbnb ROI: N/A