Real Estate Investment Properties for Sale in De Soto, IA

Looking for investment property in De Soto, IA with high ROI ?

Explore a variety of short-term homes & houses in De Soto, IA. Invest wisely with VRBO & De Soto, IA Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, IA

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
I-80 & 169 Hwy De Soto, IA	N/A beds \| N/A baths \| N/A	$11,500,000	Airbnb cash on cash: N/A Traditional cash on cash: -2.48% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: -2.48%
1011 Polk St De Soto, IA Nearly new and move-in ready, this beautiful home offers the perfect blend of small-town c...	5 beds \| 3 baths \| 1,268 sq.ft.	$335,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.59% Airbnb Rental Income: $null Traditional Rental Income: $1711 Airbnb ROI: N/A Traditional ROI: 2.59%
316 Oak St De Soto, IA Enjoy the best of both worlds with peaceful small-town living and convenient access to the...	3 beds \| 2 baths \| 1,254 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.96% Airbnb Rental Income: $null Traditional Rental Income: $2129 Airbnb ROI: N/A Traditional ROI: 4.96%
340 Chestnut St De Soto, IA 340 Chestnut St, De Soto, IA 50069 \| Single Family Residential	4 beds \| 2 baths \| 2,432 sq.ft.	$625,000	Airbnb cash on cash: -2.04% Traditional cash on cash: 1.72% Airbnb Rental Income: $734 Traditional Rental Income: $2615 Airbnb ROI: -2.04% Traditional ROI: 1.72%
0 West Adjacent To 23152 347th St De Soto, IA 0 West Adjacent To 23152 347th St, De Soto, IA 50069 \| Other	N/A beds \| N/A baths \| N/A	$1,160,000	Airbnb cash on cash: N/A Traditional cash on cash: -1.69% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: -1.69%
0 Warren St De Soto, IA 0 Warren St, De Soto, IA 50069 \| Other	N/A beds \| N/A baths \| N/A	$125,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.31% Airbnb Rental Income: $null Traditional Rental Income: $1038 Airbnb ROI: N/A Traditional ROI: 5.31%
1033 Linden St De Soto, IA Keystone Equity Group presents the Zeta XL Plan, a thoughtfully designed ranch featuring 3...	3 beds \| 2 baths \| 1,353 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.76% Airbnb Rental Income: $null Traditional Rental Income: $2158 Airbnb ROI: N/A Traditional ROI: 4.76%
1007 Polk St De Soto, IA Keystone Equity Group presents the Zeta XL Plan featuring 3 bedrooms and 2 bathrooms. Qual...	3 beds \| 2 baths \| 1,353 sq.ft.	$319,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.4% Airbnb Rental Income: $null Traditional Rental Income: $2178 Airbnb ROI: N/A Traditional ROI: 4.4%
335 Chestnut St De Soto, IA 335 Chestnut St, De Soto, IA 50069 \| Single Family Residential	4 beds \| 3 baths \| 1,900 sq.ft.	$825,000	Airbnb cash on cash: -2.18% Traditional cash on cash: 1.01% Airbnb Rental Income: $734 Traditional Rental Income: $2870 Airbnb ROI: -2.18% Traditional ROI: 1.01%
204 Maple St De Soto, IA Charming 1.5-story farmhouse-style home in the small town of De Soto! This 3-bedroom, 1-ba...	3 beds \| 1 baths \| 1,327 sq.ft.	$195,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.22% Airbnb Rental Income: $null Traditional Rental Income: $1827 Airbnb ROI: N/A Traditional ROI: 7.22%
805 Warren St De Soto, IA Welcome to this split-level home offering 4 bedrooms, 2 bathrooms. The functional layout f...	4 beds \| 2 baths \| 1,188 sq.ft.	$229,900	Airbnb cash on cash: -1.09% Traditional cash on cash: 6.57% Airbnb Rental Income: $734 Traditional Rental Income: $2090 Airbnb ROI: -1.09% Traditional ROI: 6.57%
23716 360th St De Soto, IA 23716 360th St, De Soto, IA 50069 \| Other	N/A beds \| N/A baths \| N/A	$7,561,350	Airbnb cash on cash: N/A Traditional cash on cash: -2.41% Airbnb Rental Income: $null Traditional Rental Income: $1178 Airbnb ROI: N/A Traditional ROI: -2.41%
612 Dallas St De Soto, IA 612 Dallas St, De Soto, IA 50069 \| Single Family Residential	3 beds \| 2 baths \| 912 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.84% Airbnb Rental Income: $null Traditional Rental Income: $1700 Airbnb ROI: N/A Traditional ROI: 4.84%
208 Willow Street De Soto, IA Welcome home to your own private oasis in the heart of De Soto! This charming ranch sits o...	3 beds \| 2 baths \| 1,144 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.95% Airbnb Rental Income: $null Traditional Rental Income: $1857 Airbnb ROI: N/A Traditional ROI: 3.95%
23152 347th Street De Soto, IA Ranch (with loft) 5644SF finished, walkout basement, large kitchen, large eating area, lar...	5 beds \| 4 baths \| 3,364 sq.ft.	$820,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.32% Airbnb Rental Income: $null Traditional Rental Income: $3691 Airbnb ROI: N/A Traditional ROI: 2.32%
111 Elm St De Soto, IA Ranch home built in 2026, with 1,142 SF, 2 BR, 2 bath, with 2 car attached garage plus roo...	2 beds \| 2 baths \| 1,142 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.31% Airbnb Rental Income: $null Traditional Rental Income: $1999 Airbnb ROI: N/A Traditional ROI: 4.31%

Real Estate investment in De-soto, IA

There are 16 properties for sale in the city of De Soto . The median list price in De Soto is $237,358 and the average price per square foot is $162. In October 2026, the average monthly cash on cash return in De Soto is 4.00%. The average monthly rental income in De Soto is $1,900.

De-soto, IA Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 16 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Long-Term is higher than the Short-Term in De-soto with average rental income of $1,900.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, IA

I-80 & 169 Hwy

De Soto, IA

N/A beds | N/A baths | N/A

$11,500,000

Airbnb cash on cash: N/A

Traditional cash on cash: -2.48%

Airbnb Rental Income: $null

Traditional Rental Income: $1038

Airbnb ROI: N/A

Traditional ROI: -2.48%

1011 Polk St

De Soto, IA

5 beds | 3 baths | 1,268 sq.ft.

$335,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.59%

Airbnb Rental Income: $null

Traditional Rental Income: $1711

Airbnb ROI: N/A

Traditional ROI: 2.59%

316 Oak St

De Soto, IA

3 beds | 2 baths | 1,254 sq.ft.

$295,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.96%

Airbnb Rental Income: $null

Traditional Rental Income: $2129

Airbnb ROI: N/A

Traditional ROI: 4.96%

340 Chestnut St

De Soto, IA

4 beds | 2 baths | 2,432 sq.ft.

$625,000

Airbnb cash on cash: -2.04%

Traditional cash on cash: 1.72%

Airbnb Rental Income: $734

Traditional Rental Income: $2615

Airbnb ROI: -2.04%

Traditional ROI: 1.72%

0 West Adjacent To 23152 347th St

De Soto, IA

N/A beds | N/A baths | N/A

$1,160,000

Airbnb cash on cash: N/A

Traditional cash on cash: -1.69%

Airbnb Rental Income: $null

Traditional Rental Income: $1038

Airbnb ROI: N/A

Traditional ROI: -1.69%

0 Warren St

De Soto, IA

N/A beds | N/A baths | N/A

$125,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.31%

Airbnb Rental Income: $null

Traditional Rental Income: $1038

Airbnb ROI: N/A

Traditional ROI: 5.31%

1033 Linden St

De Soto, IA

3 beds | 2 baths | 1,353 sq.ft.

$299,900

Airbnb cash on cash: N/A

Traditional cash on cash: 4.76%

Airbnb Rental Income: $null

Traditional Rental Income: $2158

Airbnb ROI: N/A

Traditional ROI: 4.76%

1007 Polk St

De Soto, IA

3 beds | 2 baths | 1,353 sq.ft.

$319,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.4%

Airbnb Rental Income: $null

Traditional Rental Income: $2178

Airbnb ROI: N/A