Real Estate Investment Properties for Sale in Clarksdale, MS

Looking for investment property in Clarksdale, MS with high ROI ?

Explore a variety of short-term homes & houses in Clarksdale, MS. Invest wisely with VRBO & Clarksdale, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Clarksdale, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
249 Clark St Clarksdale, MS Welcome to the prettiest house in Clarksdale, MS.! Birthplace of The Blues! Located...	3 beds \| 2 baths \| 2,300 sq.ft.	$234,999	Airbnb cash on cash: 1.59% Traditional cash on cash: 9.52% Airbnb Rental Income: $1303 Traditional Rental Income: $2659 Airbnb ROI: 1.59% Traditional ROI: 9.52%
333 WESTOVER Clarksdale, MS A true modern architectural masterpiece. E. Fay Jonesâfamous for dramatic residential cr...	4 beds \| 8 baths \| N/A	$699,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.02% Airbnb Rental Income: $null Traditional Rental Income: $5972 Airbnb ROI: N/A Traditional ROI: 6.02%
340 Porter Dr Clarksdale, MS Welcome to your dream home at 340 Porter Drive in Clarksdale, Coahoma County! This impress...	3 beds \| 2 baths \| 3,300 sq.ft.	$350,000	Airbnb cash on cash: 0.51% Traditional cash on cash: 6.1% Airbnb Rental Income: $1303 Traditional Rental Income: $2732 Airbnb ROI: 0.51% Traditional ROI: 6.1%
111 Leflore Ave Clarksdale, MS 111 Leflore Ave, Clarksdale, MS 38614 \| Single Family Residential	8 beds \| 4 baths \| 4,562 sq.ft.	$410,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.49% Airbnb Rental Income: $null Traditional Rental Income: $4435 Airbnb ROI: N/A Traditional ROI: 9.49%
W Lee Drive Dr Clarksdale, MS W Lee Drive Dr, Clarksdale, MS 38614 \| Other	N/A beds \| N/A baths \| 1,528 sq.ft.	$610,000	Airbnb cash on cash: -1.59% Traditional cash on cash: 1.41% Airbnb Rental Income: $487 Traditional Rental Income: $1923 Airbnb ROI: -1.59% Traditional ROI: 1.41%
1000 S State St Clarksdale, MS 1000 S State St, Clarksdale, MS 38614 \| Other	N/A beds \| N/A baths \| N/A	$195,000	Airbnb cash on cash: -1.14% Traditional cash on cash: 2.04% Airbnb Rental Income: $487 Traditional Rental Income: $805 Airbnb ROI: -1.14% Traditional ROI: 2.04%
2190 Old Highway 49 Clarksdale, MS 2190 Old Highway 49, Clarksdale, MS 38614 \| Single Family Residential	6 beds \| 4 baths \| 7,000 sq.ft.	$615,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.99% Airbnb Rental Income: $null Traditional Rental Income: $3417 Airbnb ROI: N/A Traditional ROI: 3.99%
5 Cypress Ridge Dr Clarksdale, MS 5 Cypress Ridge Dr, Clarksdale, MS 38614 \| Other	N/A beds \| N/A baths \| N/A	$50,000	Airbnb cash on cash: -0.46% Traditional cash on cash: 11.08% Airbnb Rental Income: $487 Traditional Rental Income: $805 Airbnb ROI: -0.46% Traditional ROI: 11.08%
117 Mcguire Cv Clarksdale, MS 117 Mcguire Cv, Clarksdale, MS 38614 \| Single Family Residential	3 beds \| 2 baths \| 2,400 sq.ft.	$200,000	Airbnb cash on cash: 2.43% Traditional cash on cash: 9.19% Airbnb Rental Income: $1303 Traditional Rental Income: $2179 Airbnb ROI: 2.43% Traditional ROI: 9.19%
0 New Africa Rd Clarksdale, MS 0 New Africa Rd, Clarksdale, MS 38614 \| Other	N/A beds \| N/A baths \| N/A	$72,000	Airbnb cash on cash: -0.07% Traditional cash on cash: 8.64% Airbnb Rental Income: $487 Traditional Rental Income: $838 Airbnb ROI: -0.07% Traditional ROI: 8.64%
296 Crestline Ave Clarksdale, MS 296 Crestline Ave, Clarksdale, MS 38614 \| Single Family Residential	3 beds \| 2 baths \| 2,000 sq.ft.	$260,000	Airbnb cash on cash: 1.47% Traditional cash on cash: 6.53% Airbnb Rental Income: $1303 Traditional Rental Income: $2138 Airbnb ROI: 1.47% Traditional ROI: 6.53%
202 Gayle Dr Clarksdale, MS 202 Gayle Dr, Clarksdale, MS 38614 \| Single Family Residential	4 beds \| 3 baths \| 2,685 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.85% Airbnb Rental Income: $null Traditional Rental Income: $2757 Airbnb ROI: N/A Traditional ROI: 8.85%
228 Yazoo Ave #C Clarksdale, MS 228 Yazoo Ave #C, Clarksdale, MS 38614 \| Condo/Coop	1 beds \| 1 baths \| 704 sq.ft.	$149,500	Airbnb cash on cash: -2.57% Traditional cash on cash: 3.36% Airbnb Rental Income: $506 Traditional Rental Income: $1082 Airbnb ROI: -2.57% Traditional ROI: 3.36%
228 Yazoo Ave #D Clarksdale, MS 228 Yazoo Ave #D, Clarksdale, MS 38614 \| Condo/Coop	1 beds \| 1 baths \| 753 sq.ft.	$149,500	Airbnb cash on cash: -2.57% Traditional cash on cash: 3.45% Airbnb Rental Income: $506 Traditional Rental Income: $1094 Airbnb ROI: -2.57% Traditional ROI: 3.45%
228 Yazoo Ave #B Clarksdale, MS 228 Yazoo Ave #B, Clarksdale, MS 38614 \| Condo/Coop	1 beds \| 1 baths \| 704 sq.ft.	$149,500	Airbnb cash on cash: -2.57% Traditional cash on cash: 3.45% Airbnb Rental Income: $506 Traditional Rental Income: $1094 Airbnb ROI: -2.57% Traditional ROI: 3.45%
228 Yazoo Ave #A Clarksdale, MS 228 Yazoo Ave #A, Clarksdale, MS 38614 \| Condo/Coop	2 beds \| 2 baths \| 1,429 sq.ft.	$195,000	Airbnb cash on cash: -2.2% Traditional cash on cash: 5.6% Airbnb Rental Income: $584 Traditional Rental Income: $1742 Airbnb ROI: -2.2% Traditional ROI: 5.6%

Real Estate investment in Clarksdale, MS

There are 22 properties for sale in the city of Clarksdale . The median list price in Clarksdale is $148,750 and the average price per square foot is $66. In March 2026, the average monthly cash on cash return in Clarksdale is 15.00%. The average monthly rental income in Clarksdale is $2,094.

Clarksdale, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 22 investment properties available for sale in Clarksdale.

In 2026, the best neighborhood to buy investment property is Clarksdale.

The ROI for Short-Term is higher than the Long-Term in Clarksdale with average rental income of $584.

Your search for investment property begins and ends here

Investment Property for Sale in Clarksdale, MS

249 Clark St

Clarksdale, MS

3 beds | 2 baths | 2,300 sq.ft.

$234,999

Airbnb cash on cash: 1.59%

Traditional cash on cash: 9.52%

Airbnb Rental Income: $1303

Traditional Rental Income: $2659

Airbnb ROI: 1.59%

Traditional ROI: 9.52%

333 WESTOVER

Clarksdale, MS

4 beds | 8 baths | N/A

$699,900

Airbnb cash on cash: N/A

Traditional cash on cash: 6.02%

Airbnb Rental Income: $null

Traditional Rental Income: $5972

Airbnb ROI: N/A

Traditional ROI: 6.02%

340 Porter Dr

Clarksdale, MS

3 beds | 2 baths | 3,300 sq.ft.

$350,000

Airbnb cash on cash: 0.51%

Traditional cash on cash: 6.1%

Airbnb Rental Income: $1303

Traditional Rental Income: $2732

Airbnb ROI: 0.51%

Traditional ROI: 6.1%

111 Leflore Ave

Clarksdale, MS

8 beds | 4 baths | 4,562 sq.ft.

$410,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.49%

Airbnb Rental Income: $null

Traditional Rental Income: $4435

Airbnb ROI: N/A

Traditional ROI: 9.49%

W Lee Drive Dr

Clarksdale, MS

N/A beds | N/A baths | 1,528 sq.ft.

$610,000

Airbnb cash on cash: -1.59%

Traditional cash on cash: 1.41%

Airbnb Rental Income: $487

Traditional Rental Income: $1923

Airbnb ROI: -1.59%

Traditional ROI: 1.41%

1000 S State St

Clarksdale, MS

N/A beds | N/A baths | N/A

$195,000

Airbnb cash on cash: -1.14%

Traditional cash on cash: 2.04%

Airbnb Rental Income: $487

Traditional Rental Income: $805

Airbnb ROI: -1.14%

Traditional ROI: 2.04%

2190 Old Highway 49

Clarksdale, MS

6 beds | 4 baths | 7,000 sq.ft.

$615,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3.99%

Airbnb Rental Income: $null

Traditional Rental Income: $3417

Airbnb ROI: N/A

Traditional ROI: 3.99%

5 Cypress Ridge Dr

Clarksdale, MS

N/A beds | N/A baths | N/A

$50,000

Airbnb cash on cash: -0.46%

Traditional cash on cash: 11.08%

Airbnb Rental Income: $487

Traditional Rental Income: $805

Airbnb ROI: -0.46%