Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2212 E Canal Street Picayune, MS Maximize your ROI with this rare dual-income opportunity! This versatile property features...	4 beds \| 2 baths \| 2,068 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.18% Airbnb Rental Income: $null Traditional Rental Income: $2177 Airbnb ROI: N/A Traditional ROI: 9.18%
1005 Abbott Street Picayune, MS Solid brick home on slab with 3 bedrooms and 1 1/2 baths. Home features fenced back yard f...	3 beds \| 2 baths \| N/A	$164,999	Airbnb cash on cash: 0.74% Traditional cash on cash: 6.95% Airbnb Rental Income: $818 Traditional Rental Income: $1470 Airbnb ROI: 0.74% Traditional ROI: 6.95%
104 Oaks Court Picayune, MS Welcome to 104 Oaks Court, an outdoor enthusiast's dream. Located in Picayune city limits,...	4 beds \| 2 baths \| 1,546 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.44% Airbnb Rental Income: $null Traditional Rental Income: $1926 Airbnb ROI: N/A Traditional ROI: 6.44%
8 Jennie Lane Picayune, MS This charming brick home is almost 2800 square feet heated/cooled on over 2 acres. Feature...	4 beds \| 3 baths \| 2,757 sq.ft.	$429,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.66% Airbnb Rental Income: $null Traditional Rental Income: $2691 Airbnb ROI: N/A Traditional ROI: 4.66%
319 Dozier St Picayune, MS Roomy 3 bed/ 2 bath home originally built in 1945 that is perfect for a young family or a ...	3 beds \| 2 baths \| 1,485 sq.ft.	$175,000	Airbnb cash on cash: 0.6% Traditional cash on cash: 8.54% Airbnb Rental Income: $818 Traditional Rental Income: $1816 Airbnb ROI: 0.6% Traditional ROI: 8.54%
1404 Neal Road Picayune, MS Welcome home to modern luxury on over 2.5 acres in Picayune! This stunning, completely rem...	3 beds \| 3 baths \| 2,888 sq.ft.	$349,000	Airbnb cash on cash: -0.34% Traditional cash on cash: 6.15% Airbnb Rental Income: $818 Traditional Rental Income: $2621 Airbnb ROI: -0.34% Traditional ROI: 6.15%
24327 Rester Road Picayune, MS 3br, 2 bath home with an office on 4.8 acres with vaulted ceiling in family room, wood bur...	3 beds \| 2 baths \| 1,797 sq.ft.	$383,950	Airbnb cash on cash: -0.28% Traditional cash on cash: 3.97% Airbnb Rental Income: $818 Traditional Rental Income: $2023 Airbnb ROI: -0.28% Traditional ROI: 3.97%
2107 Sheppard Boulevard Picayune, MS Welcome to this beautifully updated 3-bedroom home with a versatile bonus room, offering o...	3 beds \| 2 baths \| 1,895 sq.ft.	$229,500	Airbnb cash on cash: -0.3% Traditional cash on cash: 6.7% Airbnb Rental Income: $818 Traditional Rental Income: $2013 Airbnb ROI: -0.3% Traditional ROI: 6.7%
205 South Monroe Ave. Picayune, MS This cozy little home is conveniently located and appears to have been renovated in the no...	3 beds \| 2 baths \| 1,022 sq.ft.	$134,900	Airbnb cash on cash: 1.28% Traditional cash on cash: 11.51% Airbnb Rental Income: $818 Traditional Rental Income: $1817 Airbnb ROI: 1.28% Traditional ROI: 11.51%
7711 Cuevas Town Road Picayune, MS Major Price Improvement - Act Fast! Now offered at a new, improved price--this is your opp...	4 beds \| 5 baths \| 3,566 sq.ft.	$549,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.89% Airbnb Rental Income: $null Traditional Rental Income: $3380 Airbnb ROI: N/A Traditional ROI: 4.89%
216 S GREEN AVE Picayune, MS Don't miss this recently updated 3-bedroom, 1.5-bath brick home located in town on a peace...	3 beds \| 2 baths \| 1,200 sq.ft.	$159,000	Airbnb cash on cash: 1.18% Traditional cash on cash: 8.99% Airbnb Rental Income: $818 Traditional Rental Income: $1680 Airbnb ROI: 1.18% Traditional ROI: 8.99%
7021 Chinquapin Ct Picayune, MS Beautiful 3-bedroom, 2-bath home located in the desirable Woods Subdivision, just minutes ...	3 beds \| 2 baths \| 2,124 sq.ft.	$330,000	Airbnb cash on cash: -0.52% Traditional cash on cash: 3.5% Airbnb Rental Income: $818 Traditional Rental Income: $1738 Airbnb ROI: -0.52% Traditional ROI: 3.5%
17 Pointer Trail Picayune, MS Neat 3 Bedroom 2 Bath split plan in Hunters Trace in Picayune. Most all of the homes in Hu...	3 beds \| 2 baths \| 1,328 sq.ft.	$150,000	Airbnb cash on cash: 0.3% Traditional cash on cash: 8.21% Airbnb Rental Income: $818 Traditional Rental Income: $1629 Airbnb ROI: 0.3% Traditional ROI: 8.21%
552 Fairway Dr Picayune, MS Gorgeous 4 bedroom 2 bath home Custom home with breathtaking views of the golf course! The...	4 beds \| 2 baths \| 1,962 sq.ft.	$332,500	Airbnb cash on cash: N/A Traditional cash on cash: 4.83% Airbnb Rental Income: $null Traditional Rental Income: $2167 Airbnb ROI: N/A Traditional ROI: 4.83%
105 Jefferson Davis Picayune, MS The popular Frenchman design defines this beautiful residence, featuring four bedrooms, 2....	4 beds \| 3 baths \| 2,547 sq.ft.	$420,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $2554 Airbnb ROI: N/A Traditional ROI: 4.45%
27 Maroon DR. Picayune, MS Looking for subdivision life with lots of privacy? This recently renovated home is in like...	3 beds \| 2 baths \| 1,496 sq.ft.	$220,000	Airbnb cash on cash: 0% Traditional cash on cash: 5.96% Airbnb Rental Income: $818 Traditional Rental Income: $1736 Airbnb ROI: 0% Traditional ROI: 5.96%
560 Fairway Dr Picayune, MS This CUSTOM built modern New Orleans style shotgun house has 3 bedrooms and 2 full baths. ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,000	Airbnb cash on cash: -0.48% Traditional cash on cash: 4.49% Airbnb Rental Income: $818 Traditional Rental Income: $1997 Airbnb ROI: -0.48% Traditional ROI: 4.49%
3007 Fairway Drive Picayune, MS Don't miss out on this fantastic opportunity in the heart of Picayune! This custom-built 3...	3 beds \| 2 baths \| 1,778 sq.ft.	$321,000	Airbnb cash on cash: 0.16% Traditional cash on cash: 5.24% Airbnb Rental Income: $818 Traditional Rental Income: $2027 Airbnb ROI: 0.16% Traditional ROI: 5.24%
818 Cedar Grove Ave Picayune, MS Check out this beautifully renovated home located in the heart of Picayune! This one has b...	4 beds \| 2 baths \| 1,850 sq.ft.	$242,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.55% Airbnb Rental Income: $null Traditional Rental Income: $2225 Airbnb ROI: N/A Traditional ROI: 7.55%
501 Pemberton Place Picayune, MS Our brand new "Preston" is now complete in Heritage Oaks. Experience modern living in a co...	3 beds \| 2 baths \| 1,900 sq.ft.	$378,900	Airbnb cash on cash: -0.01% Traditional cash on cash: 4.75% Airbnb Rental Income: $818 Traditional Rental Income: $2183 Airbnb ROI: -0.01% Traditional ROI: 4.75%
138 Essex Court Picayune, MS If you've been waiting for space, charm, and something that doesn't look like every other ...	4 beds \| 2 baths \| 2,008 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.1% Airbnb Rental Income: $null Traditional Rental Income: $2291 Airbnb ROI: N/A Traditional ROI: 8.1%
11080 Road 231 Picayune, MS This stunning residence, situated on approximately 3.50 acres, has been newly listed. Prop...	3 beds \| 2 baths \| 2,402 sq.ft.	$499,000	Airbnb cash on cash: -0.33% Traditional cash on cash: 3.46% Airbnb Rental Income: $818 Traditional Rental Income: $2262 Airbnb ROI: -0.33% Traditional ROI: 3.46%
307 S. STEELE AVE Picayune, MS Charming 4-Bedroom Home Close to Town! Welcome to this well-maintained 4-bedroom, 2-bath h...	4 beds \| 2 baths \| 1,518 sq.ft.	$174,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.33% Airbnb Rental Income: $null Traditional Rental Income: $1900 Airbnb ROI: N/A Traditional ROI: 9.33%
116 Monk Mitchell Road Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$498,000	Airbnb cash on cash: -0.7% Traditional cash on cash: 4.39% Airbnb Rental Income: $818 Traditional Rental Income: $2863 Airbnb ROI: -0.7% Traditional ROI: 4.39%
116 Monk Mitchell Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$498,000	Airbnb cash on cash: -0.7% Traditional cash on cash: 4.51% Airbnb Rental Income: $818 Traditional Rental Income: $2917 Airbnb ROI: -0.7% Traditional ROI: 4.51%
2302 Jackson Landing Rd. Picayune, MS Looking for a whole lot of space (inside and out)? Then look no further! This home is lo...	4 beds \| 2 baths \| 3,204 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.94% Airbnb Rental Income: $null Traditional Rental Income: $2028 Airbnb ROI: N/A Traditional ROI: 8.94%
605 Briarwood Picayune, MS LARGE home on the desirable west side of old Picayune!! Low traffic dead end street. Per...	4 beds \| 3 baths \| 2,932 sq.ft.	$287,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.52% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 7.52%
217 Pine Grove Rd Picayune, MS Don't miss out on your chance to enjoy country living at it's finest. Mature pines and ple...	3 beds \| 3 baths \| 3,066 sq.ft.	$497,000	Airbnb cash on cash: -0.5% Traditional cash on cash: 4.03% Airbnb Rental Income: $818 Traditional Rental Income: $2601 Airbnb ROI: -0.5% Traditional ROI: 4.03%
410 Grover Barrett Road Picayune, MS If you are looking for a property set up for entertaining and/or your own private hide-a-w...	1 beds \| 1 baths \| 406 sq.ft.	$185,000	Airbnb cash on cash: -1.56% Traditional cash on cash: 4.69% Airbnb Rental Income: $301 Traditional Rental Income: $1161 Airbnb ROI: -1.56% Traditional ROI: 4.69%
884 Herrin Drive Picayune, MS FULLY RENOVATED 3 bed 1 bath with BONUS ROOM. All new appliances and a modern day feel wi...	3 beds \| 1 baths \| 1,345 sq.ft.	$190,000	Airbnb cash on cash: 0.61% Traditional cash on cash: 6.11% Airbnb Rental Income: $818 Traditional Rental Income: $1486 Airbnb ROI: 0.61% Traditional ROI: 6.11%
12009 Circle G Ranch Road Picayune, MS Come Experience the perks of Country Living in this Updated 3 Bed/2 Bath home that is trul...	3 beds \| 2 baths \| 1,969 sq.ft.	$347,900	Airbnb cash on cash: -0.19% Traditional cash on cash: 4.76% Airbnb Rental Income: $818 Traditional Rental Income: $2112 Airbnb ROI: -0.19% Traditional ROI: 4.76%
446 Liberty Rd. Picayune, MS Discover the PERFECT blend of COMFORT and CONVENIENCE in this BEAUTIFUL 3 Bed/ 2.5 Bath ho...	3 beds \| 3 baths \| 2,363 sq.ft.	$339,000	Airbnb cash on cash: -0.34% Traditional cash on cash: 5.64% Airbnb Rental Income: $818 Traditional Rental Income: $2398 Airbnb ROI: -0.34% Traditional ROI: 5.64%
131 Monk Mitchell Road Picayune, MS Very secluded and private! This home is hidden away from the main road and is accessible b...	3 beds \| 3 baths \| 2,558 sq.ft.	$336,000	Airbnb cash on cash: -0.44% Traditional cash on cash: 5.81% Airbnb Rental Income: $818 Traditional Rental Income: $2464 Airbnb ROI: -0.44% Traditional ROI: 5.81%
146 Oak Point Rd Picayune, MS There is so much packed into this river camp. The home has 1 bed & 1.5 baths with the half...	1 beds \| 2 baths \| 1,040 sq.ft.	$119,500	Airbnb cash on cash: -2.08% Traditional cash on cash: 11.19% Airbnb Rental Income: $301 Traditional Rental Income: $1591 Airbnb ROI: -2.08% Traditional ROI: 11.19%
522 E Canal Street Picayune, MS This home is full of southern charm and character, a piece of Picayune History. This beau...	2 beds \| 2 baths \| 1,889 sq.ft.	$209,900	Airbnb cash on cash: -2.18% Traditional cash on cash: 8.59% Airbnb Rental Income: $147 Traditional Rental Income: $2078 Airbnb ROI: -2.18% Traditional ROI: 8.59%

Real Estate investment in Picayune, MS

There are 74 properties for sale in the city of Picayune . The median list price in Picayune is $230,000 and the average price per square foot is $102. In March 2026, the average monthly cash on cash return in Picayune is 6.00%. The average monthly rental income in Picayune is $1,997.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 74 investment properties available for sale in Picayune.

In 2026, the best neighborhood to buy investment property is Picayune.

The ROI for Short-Term is higher than the Long-Term in Picayune with average rental income of $818.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

2212 E Canal Street

Picayune, MS

4 beds | 2 baths | 2,068 sq.ft.

$199,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.18%

Airbnb Rental Income: $null

Traditional Rental Income: $2177

Airbnb ROI: N/A

Traditional ROI: 9.18%

1005 Abbott Street

Picayune, MS

3 beds | 2 baths | N/A

$164,999

Airbnb cash on cash: 0.74%

Traditional cash on cash: 6.95%

Airbnb Rental Income: $818

Traditional Rental Income: $1470

Airbnb ROI: 0.74%

Traditional ROI: 6.95%

104 Oaks Court

Picayune, MS

4 beds | 2 baths | 1,546 sq.ft.

$235,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.44%

Airbnb Rental Income: $null

Traditional Rental Income: $1926

Airbnb ROI: N/A

Traditional ROI: 6.44%

8 Jennie Lane

Picayune, MS

4 beds | 3 baths | 2,757 sq.ft.

$429,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.66%

Airbnb Rental Income: $null

Traditional Rental Income: $2691

Airbnb ROI: N/A

Traditional ROI: 4.66%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,485 sq.ft.

$175,000

Airbnb cash on cash: 0.6%

Traditional cash on cash: 8.54%

Airbnb Rental Income: $818

Traditional Rental Income: $1816

Airbnb ROI: 0.6%

Traditional ROI: 8.54%

1404 Neal Road

Picayune, MS

3 beds | 3 baths | 2,888 sq.ft.

$349,000

Airbnb cash on cash: -0.34%

Traditional cash on cash: 6.15%

Airbnb Rental Income: $818

Traditional Rental Income: $2621

Airbnb ROI: -0.34%

Traditional ROI: 6.15%

24327 Rester Road

Picayune, MS

3 beds | 2 baths | 1,797 sq.ft.

$383,950

Airbnb cash on cash: -0.28%

Traditional cash on cash: 3.97%

Airbnb Rental Income: $818

Traditional Rental Income: $2023

Airbnb ROI: -0.28%

Traditional ROI: 3.97%

2107 Sheppard Boulevard

Picayune, MS

3 beds | 2 baths | 1,895 sq.ft.

$229,500

Airbnb cash on cash: -0.3%

Traditional cash on cash: 6.7%

Airbnb Rental Income: $818

Traditional Rental Income: $2013

Airbnb ROI: -0.3%