Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
532 Millbrook Parkway Picayune, MS Beautifully Updated Home on the 14th Fairway in Millbrook EstatesYou don't want to miss th...	3 beds \| 2 baths \| 2,046 sq.ft.	$267,900	Airbnb cash on cash: 1.49% Traditional cash on cash: 4.77% Airbnb Rental Income: $1187 Traditional Rental Income: $1628 Airbnb ROI: 1.49% Traditional ROI: 4.77%
8 Jennie Lane Picayune, MS This charming brick home is almost 2800 square feet heated/cooled on over 2 acres. Feature...	4 beds \| 3 baths \| 2,757 sq.ft.	$459,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.24% Airbnb Rental Income: $null Traditional Rental Income: $2691 Airbnb ROI: N/A Traditional ROI: 4.24%
435 Millbrook Parkway Picayune, MS Well maintained home fronting GOLF COURSE! Large walk-in closets and kitchen pantry. Tota...	3 beds \| 2 baths \| 2,036 sq.ft.	$259,000	Airbnb cash on cash: 1.4% Traditional cash on cash: 7.13% Airbnb Rental Income: $1187 Traditional Rental Income: $2201 Airbnb ROI: 1.4% Traditional ROI: 7.13%
257 Rock Ranch Road Picayune, MS This private slice of country paradise is tucked away on a secluded 13.22 acre parcel, off...	3 beds \| 2 baths \| 1,250 sq.ft.	$189,000	Airbnb cash on cash: 2.31% Traditional cash on cash: 6.49% Airbnb Rental Income: $1187 Traditional Rental Income: $1551 Airbnb ROI: 2.31% Traditional ROI: 6.49%
11 Rosewood Dr. Picayune, MS Showcasing a remarkable four-bedroom, two-bathroom brick residence, encompassing 1800 squa...	4 beds \| 2 baths \| 1,804 sq.ft.	$279,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.17% Airbnb Rental Income: $null Traditional Rental Income: $2196 Airbnb ROI: N/A Traditional ROI: 6.17%
319 Dozier St Picayune, MS Roomy 3 bed/ 2 bath home originally built in 1945 that is perfect for a young family or a ...	3 beds \| 2 baths \| 1,485 sq.ft.	$179,843	Airbnb cash on cash: 2.33% Traditional cash on cash: 8.27% Airbnb Rental Income: $1187 Traditional Rental Income: $1816 Airbnb ROI: 2.33% Traditional ROI: 8.27%
820 Mitchell St. Picayune, MS If you are looking for a very well maintained 3 bedroom 2 bath home, this is the one! Very...	3 beds \| 2 baths \| N/A	$219,900	Airbnb cash on cash: 1.6% Traditional cash on cash: 6.7% Airbnb Rental Income: $1187 Traditional Rental Income: $1864 Airbnb ROI: 1.6% Traditional ROI: 6.7%
243 McSween Rd. Picayune, MS This 3 Bedroom 2 Bath open floor plan home is sitting on a little over 5 acres surrounded ...	3 beds \| 2 baths \| 1,720 sq.ft.	$289,900	Airbnb cash on cash: 0.78% Traditional cash on cash: 5.12% Airbnb Rental Income: $1187 Traditional Rental Income: $1983 Airbnb ROI: 0.78% Traditional ROI: 5.12%
516 Fifth Ave. Picayune, MS LOOK NO MORE! WELCOME HOME... Your white picket fence and Front Porch welcomes you into th...	2 beds \| 2 baths \| 1,101 sq.ft.	$179,000	Airbnb cash on cash: -0.16% Traditional cash on cash: 6.5% Airbnb Rental Income: $674 Traditional Rental Income: $1508 Airbnb ROI: -0.16% Traditional ROI: 6.5%
1404 Neal Rd Picayune, MS This spacious ranch style home features a huge family room with a woodburning fireplace; b...	3 beds \| 3 baths \| 3,047 sq.ft.	$415,000	Airbnb cash on cash: 0.01% Traditional cash on cash: 4.7% Airbnb Rental Income: $1187 Traditional Rental Income: $2621 Airbnb ROI: 0.01% Traditional ROI: 4.7%
52 FALCON DR Picayune, MS Motivated Seller! Show & bring Offers! If you need space, this is the place! This home ope...	3 beds \| 3 baths \| 2,536 sq.ft.	$398,900	Airbnb cash on cash: 0.59% Traditional cash on cash: 4.66% Airbnb Rental Income: $1187 Traditional Rental Income: $2323 Airbnb ROI: 0.59% Traditional ROI: 4.66%
206 Teddy Lane Picayune, MS House is in amazing condition. Comes with everything in it.	3 beds \| 2 baths \| 1,420 sq.ft.	$205,000	Airbnb cash on cash: 1.84% Traditional cash on cash: 6.58% Airbnb Rental Income: $1187 Traditional Rental Income: $1722 Airbnb ROI: 1.84% Traditional ROI: 6.58%
2107 Sheppard Blvd Picayune, MS MOVE IN READY!! This is a 3 bedroom 2 bathroom home with an extra room/office space, could...	3 beds \| 2 baths \| 1,895 sq.ft.	$245,000	Airbnb cash on cash: 1.25% Traditional cash on cash: 5.65% Airbnb Rental Income: $1187 Traditional Rental Income: $1817 Airbnb ROI: 1.25% Traditional ROI: 5.65%
921 Tung Tree Picayune, MS Gorgeous Home in the Heart of Picayune sits back on .623 if an acre in the beautiful estab...	3 beds \| 3 baths \| 2,984 sq.ft.	$409,000	Airbnb cash on cash: 0.21% Traditional cash on cash: 5.09% Airbnb Rental Income: $1187 Traditional Rental Income: $2669 Airbnb ROI: 0.21% Traditional ROI: 5.09%
25541 Broadridge Drive Picayune, MS WOW, what a unique find! This diamond in the rough is one of a kind and filled with charac...	4 beds \| 2 baths \| 2,339 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.95% Airbnb Rental Income: $null Traditional Rental Income: $2213 Airbnb ROI: N/A Traditional ROI: 6.95%
7711 Cuevas Town Road Picayune, MS Country Living at Its Finest! (Photos and virtual tour coming soon)This stunning 4-bedroom...	4 beds \| 5 baths \| 3,566 sq.ft.	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.41% Airbnb Rental Income: $null Traditional Rental Income: $3380 Airbnb ROI: N/A Traditional ROI: 4.41%
701 CARROLL ST Picayune, MS EXCELLENT RENTAL OPPORFTUNITY FOR INVESTOR-ALL UNITS ARE OCCUPIED-GREAT NEIGHBORHOOD-DOUBL...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
703 CARROLL ST Picayune, MS EXCELLENT RENTAL INVESTMENT - GREAT NEIGHBORHOOD - ELEMENTARY SCHOOL NEAR PROPERTY - PROPE...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
1551 N Beech St Picayune, MS This 3 bedroom 2 bath home sits just minutes from town! A great fenced in back yard! This ...	3 beds \| 2 baths \| 1,359 sq.ft.	$159,900	Airbnb cash on cash: 2.83% Traditional cash on cash: 8.88% Airbnb Rental Income: $1187 Traditional Rental Income: $1725 Airbnb ROI: 2.83% Traditional ROI: 8.88%
38 Wyatt Lane Picayune, MS Precious Acadian-style 3 bedroom, 2 bathroom home sitting on 2 beautiful acres in the coun...	3 beds \| 2 baths \| 1,572 sq.ft.	$249,900	Airbnb cash on cash: 1.13% Traditional cash on cash: 5.18% Airbnb Rental Income: $1187 Traditional Rental Income: $1755 Airbnb ROI: 1.13% Traditional ROI: 5.18%
31 Bear Path Picayune, MS Beautiful home in Hunters Trace, just hit the market. This lovely features a split floor p...	3 beds \| 2 baths \| 1,485 sq.ft.	$259,000	Airbnb cash on cash: 1.62% Traditional cash on cash: 5.75% Airbnb Rental Income: $1187 Traditional Rental Income: $1811 Airbnb ROI: 1.62% Traditional ROI: 5.75%
600 Third Ave. Picayune, MS Whether you have an extra large family in need of a mother-in-law suite OR are an investor...	5 beds \| 4 baths \| 3,880 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.82% Airbnb Rental Income: $null Traditional Rental Income: $3940 Airbnb ROI: N/A Traditional ROI: 11.82%
23355 Mitchell Road Picayune, MS Beautiful Custom Built Home with Acreage Listed Under Recent Appraised Value!! Come down t...	3 beds \| 2 baths \| 2,647 sq.ft.	$665,000	Airbnb cash on cash: -0.06% Traditional cash on cash: 2.14% Airbnb Rental Income: $1187 Traditional Rental Income: $2165 Airbnb ROI: -0.06% Traditional ROI: 2.14%
11362 OLD KILN RD Picayune, MS This meticulously crafted custom-built brick home on 5 acres is a must see! The home offer...	3 beds \| 2 baths \| 1,333 sq.ft.	$369,900	Airbnb cash on cash: 0.59% Traditional cash on cash: 3.02% Airbnb Rental Income: $1187 Traditional Rental Income: $1646 Airbnb ROI: 0.59% Traditional ROI: 3.02%
560 Fairway Dr Picayune, MS This CUSTOM built Modern New Orleans style shotgun home has 3 bed 2 bath home features so ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,500	Airbnb cash on cash: 0.53% Traditional cash on cash: 4.47% Airbnb Rental Income: $1187 Traditional Rental Income: $1997 Airbnb ROI: 0.53% Traditional ROI: 4.47%
3007 Fairway Drive Drive Picayune, MS Don't miss out on this fantastic opportunity in the heart of Picayune! This custom-built 3...	3 beds \| 2 baths \| 1,778 sq.ft.	$321,000	Airbnb cash on cash: 1.17% Traditional cash on cash: 5.24% Airbnb Rental Income: $1187 Traditional Rental Income: $2027 Airbnb ROI: 1.17% Traditional ROI: 5.24%
619 Deason Picayune, MS Our Audubon is under construction on an oversized wooded homesite in desirable Heritage Oa...	4 beds \| 3 baths \| 3,279 sq.ft.	$479,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.06% Airbnb Rental Income: $null Traditional Rental Income: $2725 Airbnb ROI: N/A Traditional ROI: 4.06%
706 North Buren Ave. Picayune, MS Looking for a move in ready 4 bedroom house that's affordable? Look no further! This cen...	4 beds \| 2 baths \| 1,239 sq.ft.	$136,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.32% Airbnb Rental Income: $null Traditional Rental Income: $1691 Airbnb ROI: N/A Traditional ROI: 10.32%
1210 Highland Dr. Picayune, MS Take a look at this beautiful Southern Charm Home! Separate Dining Rm, Kitchen, Office, Fa...	4 beds \| 3 baths \| 2,685 sq.ft.	$267,500	Airbnb cash on cash: N/A Traditional cash on cash: 8.99% Airbnb Rental Income: $null Traditional Rental Income: $2669 Airbnb ROI: N/A Traditional ROI: 8.99%
12525 Indian Springs Road Picayune, MS Check out this tucked away farmhouse on 2+/- acres. Featuring 4 beds/2 baths this home is ...	4 beds \| 2 baths \| 1,900 sq.ft.	$349,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.48% Airbnb Rental Income: $null Traditional Rental Income: $2123 Airbnb ROI: N/A Traditional ROI: 4.48%
11207 Chester Lee Rd. Picayune, MS Investor Special! Beautiful 3 bedroom, 2 bath home on 2.6 Acres. Home is located outside o...	3 beds \| 2 baths \| N/A	$210,000	Airbnb cash on cash: 1.75% Traditional cash on cash: 6.31% Airbnb Rental Income: $1187 Traditional Rental Income: $1708 Airbnb ROI: 1.75% Traditional ROI: 6.31%
601 Liberty Road Picayune, MS One of the most unique offerings in PRC in modern history. 2 Custom built homes on the ban...	5 beds \| 4 baths \| 2,465 sq.ft.	$825,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.7% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 1.7%
301 Williams Avenue Picayune, MS Zoned office professional, but may be used as a residential......... This property is cent...	2 beds \| 1 baths \| 1,488 sq.ft.	$115,000	Airbnb cash on cash: 0.71% Traditional cash on cash: 10.21% Airbnb Rental Income: $674 Traditional Rental Income: $1428 Airbnb ROI: 0.71% Traditional ROI: 10.21%
615 Carter Picayune, MS This beautifully remodeled three-bedroom, two-bathroom house is ready for you to move in. ...	3 beds \| 2 baths \| 1,304 sq.ft.	$175,900	Airbnb cash on cash: 2.71% Traditional cash on cash: 7.77% Airbnb Rental Income: $1187 Traditional Rental Income: $1648 Airbnb ROI: 2.71% Traditional ROI: 7.77%

Real Estate investment in Picayune, MS

There are 81 properties for sale in the city of Picayune . The median list price in Picayune is $240,000 and the average price per square foot is $118. In September 2025, the average monthly cash on cash return in Picayune is 7.00%. The average monthly rental income in Picayune is $2,096.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 81 investment properties available for sale in Picayune.

In 2025, the best neighborhood to buy investment property is Picayune.

The ROI for Long-Term is higher than the Short-Term in Picayune with average rental income of $2,096.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

532 Millbrook Parkway

Picayune, MS

3 beds | 2 baths | 2,046 sq.ft.

$267,900

Airbnb cash on cash: 1.49%

Traditional cash on cash: 4.77%

Airbnb Rental Income: $1187

Traditional Rental Income: $1628

Airbnb ROI: 1.49%

Traditional ROI: 4.77%

8 Jennie Lane

Picayune, MS

4 beds | 3 baths | 2,757 sq.ft.

$459,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.24%

Airbnb Rental Income: $null

Traditional Rental Income: $2691

Airbnb ROI: N/A

Traditional ROI: 4.24%

435 Millbrook Parkway

Picayune, MS

3 beds | 2 baths | 2,036 sq.ft.

$259,000

Airbnb cash on cash: 1.4%

Traditional cash on cash: 7.13%

Airbnb Rental Income: $1187

Traditional Rental Income: $2201

Airbnb ROI: 1.4%

Traditional ROI: 7.13%

257 Rock Ranch Road

Picayune, MS

3 beds | 2 baths | 1,250 sq.ft.

$189,000

Airbnb cash on cash: 2.31%

Traditional cash on cash: 6.49%

Airbnb Rental Income: $1187

Traditional Rental Income: $1551

Airbnb ROI: 2.31%

Traditional ROI: 6.49%

11 Rosewood Dr.

Picayune, MS

4 beds | 2 baths | 1,804 sq.ft.

$279,900

Airbnb cash on cash: N/A

Traditional cash on cash: 6.17%

Airbnb Rental Income: $null

Traditional Rental Income: $2196

Airbnb ROI: N/A

Traditional ROI: 6.17%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,485 sq.ft.

$179,843

Airbnb cash on cash: 2.33%

Traditional cash on cash: 8.27%

Airbnb Rental Income: $1187

Traditional Rental Income: $1816

Airbnb ROI: 2.33%

Traditional ROI: 8.27%

820 Mitchell St.

Picayune, MS

3 beds | 2 baths | N/A

$219,900

Airbnb cash on cash: 1.6%

Traditional cash on cash: 6.7%

Airbnb Rental Income: $1187

Traditional Rental Income: $1864

Airbnb ROI: 1.6%

Traditional ROI: 6.7%

243 McSween Rd.

Picayune, MS

3 beds | 2 baths | 1,720 sq.ft.

$289,900

Airbnb cash on cash: 0.78%

Traditional cash on cash: 5.12%

Airbnb Rental Income: $1187

Traditional Rental Income: $1983

Airbnb ROI: 0.78%