Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2212 E Canal Street Picayune, MS Maximize your ROI with this rare dual-income opportunity! This versatile property features...	4 beds \| 2 baths \| 2,068 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.18% Airbnb Rental Income: $null Traditional Rental Income: $2177 Airbnb ROI: N/A Traditional ROI: 9.18%
1005 Abbott Street Picayune, MS Solid brick home on slab with 3 bedrooms and 1 1/2 baths. Home features fenced back yard f...	3 beds \| 2 baths \| N/A	$174,900	Airbnb cash on cash: 0.94% Traditional cash on cash: 6.46% Airbnb Rental Income: $887 Traditional Rental Income: $1470 Airbnb ROI: 0.94% Traditional ROI: 6.46%
104 Oaks Court Picayune, MS Welcome to 104 Oaks Court, an outdoor enthusiast's dream. Located in Picayune city limits,...	4 beds \| 2 baths \| 1,546 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.12% Airbnb Rental Income: $null Traditional Rental Income: $1926 Airbnb ROI: N/A Traditional ROI: 6.12%
8 Jennie Lane Picayune, MS This charming brick home is almost 2800 square feet heated/cooled on over 2 acres. Feature...	4 beds \| 3 baths \| 2,757 sq.ft.	$429,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.66% Airbnb Rental Income: $null Traditional Rental Income: $2691 Airbnb ROI: N/A Traditional ROI: 4.66%
319 Dozier St Picayune, MS Roomy 3 bed/ 2 bath home originally built in 1945 that is perfect for a young family or a ...	3 beds \| 2 baths \| 1,485 sq.ft.	$175,000	Airbnb cash on cash: 0.94% Traditional cash on cash: 8.54% Airbnb Rental Income: $887 Traditional Rental Income: $1816 Airbnb ROI: 0.94% Traditional ROI: 8.54%
9 Timaquana Dr. Picayune, MS Very efficient 3 bedroom brick home. Round Rock developmemnt. Utility room is large enough...	3 beds \| 2 baths \| 1,736 sq.ft.	$275,000	Airbnb cash on cash: -0.04% Traditional cash on cash: 5.59% Airbnb Rental Income: $887 Traditional Rental Income: $2010 Airbnb ROI: -0.04% Traditional ROI: 5.59%
820 Mitchell St. Picayune, MS If you are looking for a very well maintained 3 bedroom 2 bath home, this is the one! Very...	3 beds \| 2 baths \| N/A	$208,900	Airbnb cash on cash: 0.51% Traditional cash on cash: 7.14% Airbnb Rental Income: $887 Traditional Rental Income: $1864 Airbnb ROI: 0.51% Traditional ROI: 7.14%
415 Fifth Ave Picayune, MS Located on a corner lot along 5th Ave in Picayune. This historic 2 story home is rich w/ c...	3 beds \| 3 baths \| 2,410 sq.ft.	$299,900	Airbnb cash on cash: -0.18% Traditional cash on cash: 7.27% Airbnb Rental Income: $887 Traditional Rental Income: $2653 Airbnb ROI: -0.18% Traditional ROI: 7.27%
1404 NEAL RD Picayune, MS This stunning, remodeled 3-BR/2.5-BA home on over 2.5 acres in Picayune is packed w/high-e...	3 beds \| 3 baths \| 2,888 sq.ft.	$349,000	Airbnb cash on cash: -0.14% Traditional cash on cash: 6.17% Airbnb Rental Income: $887 Traditional Rental Income: $2621 Airbnb ROI: -0.14% Traditional ROI: 6.17%
628 Telly Rd Picayune, MS Beautiful remodeled 3 bed 2 bath sitting on .77 acres in the city limits of Picayune. Welc...	3 beds \| 2 baths \| 1,600 sq.ft.	$234,900	Airbnb cash on cash: 0.25% Traditional cash on cash: 6.38% Airbnb Rental Income: $887 Traditional Rental Income: $1911 Airbnb ROI: 0.25% Traditional ROI: 6.38%
24327 Rester Road Picayune, MS 3br, 2 bath home with an office on 4.8 acres with vaulted ceiling in family room, wood bur...	3 beds \| 2 baths \| 1,797 sq.ft.	$383,950	Airbnb cash on cash: -0.12% Traditional cash on cash: 3.97% Airbnb Rental Income: $887 Traditional Rental Income: $2023 Airbnb ROI: -0.12% Traditional ROI: 3.97%
2107 Sheppard Blvd Picayune, MS MOVE IN READY!! This is a 3 bedroom 2 bathroom home with an extra room/office space, could...	3 beds \| 2 baths \| 1,895 sq.ft.	$238,000	Airbnb cash on cash: 0.23% Traditional cash on cash: 6.73% Airbnb Rental Income: $887 Traditional Rental Income: $2013 Airbnb ROI: 0.23% Traditional ROI: 6.73%
7711 Cuevas Town Road Picayune, MS **PRICE IMPROVEMENT** Versatile Country Estate with Workshop & No Restrictions Discove...	4 beds \| 5 baths \| 3,566 sq.ft.	$559,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.79% Airbnb Rental Income: $null Traditional Rental Income: $3380 Airbnb ROI: N/A Traditional ROI: 4.79%
701 CARROLL ST Picayune, MS EXCELLENT RENTAL OPPORFTUNITY FOR INVESTOR-ALL UNITS ARE OCCUPIED-GREAT NEIGHBORHOOD-DOUBL...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
703 CARROLL ST Picayune, MS EXCELLENT RENTAL INVESTMENT - GREAT NEIGHBORHOOD - ELEMENTARY SCHOOL NEAR PROPERTY - PROPE...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
38 Wyatt Lane Picayune, MS Precious Acadian-style 3 bedroom, 2 bathroom home sitting on 2 beautiful acres in the coun...	3 beds \| 2 baths \| 1,572 sq.ft.	$247,900	Airbnb cash on cash: 0.08% Traditional cash on cash: 5.22% Airbnb Rental Income: $887 Traditional Rental Income: $1755 Airbnb ROI: 0.08% Traditional ROI: 5.22%
552 Fairway Dr Picayune, MS Gorgeous 4 bedroom 2 bath home Custom home with breathtaking views of the golf course! The...	4 beds \| 2 baths \| 1,962 sq.ft.	$332,500	Airbnb cash on cash: N/A Traditional cash on cash: 4.83% Airbnb Rental Income: $null Traditional Rental Income: $2167 Airbnb ROI: N/A Traditional ROI: 4.83%
105 Jefferson Davis Picayune, MS The popular Frenchman design defines this beautiful residence, featuring four bedrooms, 2....	4 beds \| 3 baths \| 2,547 sq.ft.	$420,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $2554 Airbnb ROI: N/A Traditional ROI: 4.45%
3624 Highway 43 N Picayune, MS Cute country cottage set in the center of a large 2.5 acre lot with quick and easy access ...	3 beds \| 2 baths \| 1,167 sq.ft.	$230,000	Airbnb cash on cash: 0.3% Traditional cash on cash: 6.76% Airbnb Rental Income: $887 Traditional Rental Income: $1957 Airbnb ROI: 0.3% Traditional ROI: 6.76%
25125 Road 394 Picayune, MS Private 8.21-acre retreat with multiple residences and exceptional amenities. This beautif...	4 beds \| 4 baths \| 2,500 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.76% Airbnb Rental Income: $null Traditional Rental Income: $2859 Airbnb ROI: N/A Traditional ROI: 4.76%
76 Otis Stewart Rd Picayune, MS NEW YEAR, NEW HOME! Welcome to the property you've been searching for. This beautifully up...	4 beds \| 3 baths \| 3,060 sq.ft.	$459,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.08% Airbnb Rental Income: $null Traditional Rental Income: $2445 Airbnb ROI: N/A Traditional ROI: 4.08%
560 Fairway Dr Picayune, MS This CUSTOM built modern New Orleans style shotgun house has 3 bedrooms and 2 full baths. ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,000	Airbnb cash on cash: -0.29% Traditional cash on cash: 4.49% Airbnb Rental Income: $887 Traditional Rental Income: $1997 Airbnb ROI: -0.29% Traditional ROI: 4.49%
3007 Fairway Drive Picayune, MS Don't miss out on this fantastic opportunity in the heart of Picayune! This custom-built 3...	3 beds \| 2 baths \| 1,778 sq.ft.	$321,000	Airbnb cash on cash: 0.35% Traditional cash on cash: 5.24% Airbnb Rental Income: $887 Traditional Rental Income: $2027 Airbnb ROI: 0.35% Traditional ROI: 5.24%
818 Cedar Grove Ave Picayune, MS Check out this beautifully renovated home located in the heart of Picayune! This one has b...	4 beds \| 2 baths \| 1,850 sq.ft.	$249,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.3% Airbnb Rental Income: $null Traditional Rental Income: $2225 Airbnb ROI: N/A Traditional ROI: 7.3%
619 Deason Drive Picayune, MS Our Audubon is recently upgraded on an oversized wooded homesite in desirable Heritage Oak...	4 beds \| 3 baths \| 3,279 sq.ft.	$469,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.18% Airbnb Rental Income: $null Traditional Rental Income: $2725 Airbnb ROI: N/A Traditional ROI: 4.18%
221 S Curran Avenue Picayune, MS Recently Renovated to bring up to current features including adding a primary bedroom and ...	3 beds \| 2 baths \| 1,554 sq.ft.	$199,000	Airbnb cash on cash: 0.77% Traditional cash on cash: 8.1% Airbnb Rental Income: $887 Traditional Rental Income: $1936 Airbnb ROI: 0.77% Traditional ROI: 8.1%
1312 N Beech St Picayune, MS Well maintained older home 3 bedrooms 1 bath-large living room and dining room combined-ni...	3 beds \| 1 baths \| 1,246 sq.ft.	$165,000	Airbnb cash on cash: 1.44% Traditional cash on cash: 7.69% Airbnb Rental Income: $887 Traditional Rental Income: $1534 Airbnb ROI: 1.44% Traditional ROI: 7.69%
1705 Audubon Drive Picayune, MS BACK ON THE MARKET AT NO FAULT OF THE SELLERS! PRICE REDUCED BELOW APPRAISAL! NEW UPDATES ...	3 beds \| 2 baths \| 1,210 sq.ft.	$179,900	Airbnb cash on cash: 1.34% Traditional cash on cash: 6.94% Airbnb Rental Income: $887 Traditional Rental Income: $1508 Airbnb ROI: 1.34% Traditional ROI: 6.94%
501 Pemberton Place Picayune, MS Our brand new "Preston" is now complete in Heritage Oaks. Experience modern living in a co...	3 beds \| 2 baths \| 1,900 sq.ft.	$372,900	Airbnb cash on cash: 0.17% Traditional cash on cash: 4.84% Airbnb Rental Income: $887 Traditional Rental Income: $2183 Airbnb ROI: 0.17% Traditional ROI: 4.84%
11192 Willie Lee Road Picayune, MS Charming 3 Bedroom home on 7.5 acres with heated pool & handicap accessible features.Welco...	3 beds \| 2 baths \| 2,000 sq.ft.	$370,000	Airbnb cash on cash: -0.05% Traditional cash on cash: 3.14% Airbnb Rental Income: $887 Traditional Rental Income: $1658 Airbnb ROI: -0.05% Traditional ROI: 3.14%
202 N. Boley Dr. Picayune, MS Spacious home with a good sized fenced yard inside City Limits. This home offers a BRAND N...	4 beds \| 3 baths \| 2,787 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.65% Airbnb Rental Income: $null Traditional Rental Income: $2890 Airbnb ROI: N/A Traditional ROI: 8.65%
138 Essex Court Picayune, MS If you've been waiting for space, charm, and something that doesn't look like every other ...	4 beds \| 2 baths \| 2,008 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.1% Airbnb Rental Income: $null Traditional Rental Income: $2291 Airbnb ROI: N/A Traditional ROI: 8.1%
11080 Road 231 Picayune, MS This stunning residence, situated on 3 APPX acres, has been newly listed. Property boasts ...	3 beds \| 2 baths \| 2,402 sq.ft.	$499,000	Airbnb cash on cash: -0.21% Traditional cash on cash: 3.46% Airbnb Rental Income: $887 Traditional Rental Income: $2262 Airbnb ROI: -0.21% Traditional ROI: 3.46%
307 S. STEELE AVE Picayune, MS Charming 4-Bedroom Home Close to Town! Welcome to this well-maintained 4-bedroom, 2-bath h...	4 beds \| 2 baths \| 1,518 sq.ft.	$174,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.33% Airbnb Rental Income: $null Traditional Rental Income: $1900 Airbnb ROI: N/A Traditional ROI: 9.33%
116 Monk Mitchell Road Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$500,000	Airbnb cash on cash: -0.58% Traditional cash on cash: 4.37% Airbnb Rental Income: $887 Traditional Rental Income: $2863 Airbnb ROI: -0.58% Traditional ROI: 4.37%
116 Monk Mitchell Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$500,000	Airbnb cash on cash: -0.58% Traditional cash on cash: 4.48% Airbnb Rental Income: $887 Traditional Rental Income: $2917 Airbnb ROI: -0.58% Traditional ROI: 4.48%
2302 Jackson Landing Rd. Picayune, MS Looking for a whole lot of space (inside and out)? Then look no further! This home is lo...	4 beds \| 2 baths \| 3,204 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.94% Airbnb Rental Income: $null Traditional Rental Income: $2028 Airbnb ROI: N/A Traditional ROI: 8.94%
605 Briarwood Picayune, MS LARGE home on the desirable west side of old Picayune!! Low traffic dead end street. Per...	4 beds \| 3 baths \| 2,932 sq.ft.	$287,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.52% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 7.52%

Real Estate investment in Picayune, MS

There are 69 properties for sale in the city of Picayune . The median list price in Picayune is $248,900 and the average price per square foot is $117. In February 2026, the average monthly cash on cash return in Picayune is 7.00%. The average monthly rental income in Picayune is $2,119.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 69 investment properties available for sale in Picayune.

In 2026, the best neighborhood to buy investment property is Picayune.

The ROI for Short-Term is higher than the Long-Term in Picayune with average rental income of $887.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

2212 E Canal Street

Picayune, MS

4 beds | 2 baths | 2,068 sq.ft.

$199,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.18%

Airbnb Rental Income: $null

Traditional Rental Income: $2177

Airbnb ROI: N/A

Traditional ROI: 9.18%

1005 Abbott Street

Picayune, MS

3 beds | 2 baths | N/A

$174,900

Airbnb cash on cash: 0.94%

Traditional cash on cash: 6.46%

Airbnb Rental Income: $887

Traditional Rental Income: $1470

Airbnb ROI: 0.94%

Traditional ROI: 6.46%

104 Oaks Court

Picayune, MS

4 beds | 2 baths | 1,546 sq.ft.

$245,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.12%

Airbnb Rental Income: $null

Traditional Rental Income: $1926

Airbnb ROI: N/A

Traditional ROI: 6.12%

8 Jennie Lane

Picayune, MS

4 beds | 3 baths | 2,757 sq.ft.

$429,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.66%

Airbnb Rental Income: $null

Traditional Rental Income: $2691

Airbnb ROI: N/A

Traditional ROI: 4.66%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,485 sq.ft.

$175,000

Airbnb cash on cash: 0.94%

Traditional cash on cash: 8.54%

Airbnb Rental Income: $887

Traditional Rental Income: $1816

Airbnb ROI: 0.94%

Traditional ROI: 8.54%

9 Timaquana Dr.

Picayune, MS

3 beds | 2 baths | 1,736 sq.ft.

$275,000

Airbnb cash on cash: -0.04%

Traditional cash on cash: 5.59%

Airbnb Rental Income: $887

Traditional Rental Income: $2010

Airbnb ROI: -0.04%

Traditional ROI: 5.59%

820 Mitchell St.

Picayune, MS

3 beds | 2 baths | N/A

$208,900

Airbnb cash on cash: 0.51%

Traditional cash on cash: 7.14%

Airbnb Rental Income: $887

Traditional Rental Income: $1864

Airbnb ROI: 0.51%

Traditional ROI: 7.14%

415 Fifth Ave

Picayune, MS

3 beds | 3 baths | 2,410 sq.ft.

$299,900

Airbnb cash on cash: -0.18%

Traditional cash on cash: 7.27%

Airbnb Rental Income: $887

Traditional Rental Income: $2653

Airbnb ROI: -0.18%