Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
12 Seminole Drive Picayune, MS Experience the perfect balance of peace and convenience in this meticulously maintained ho...	3 beds \| 2 baths \| 1,714 sq.ft.	$299,900	Airbnb cash on cash: -0.83% Traditional cash on cash: 4.45% Airbnb Rental Income: $606 Traditional Rental Income: $1808 Airbnb ROI: -0.83% Traditional ROI: 4.45%
2212 E Canal Street Picayune, MS Maximize your ROI with this rare dual-income opportunity! This versatile property features...	4 beds \| 2 baths \| 2,068 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.38% Airbnb Rental Income: $null Traditional Rental Income: $2177 Airbnb ROI: N/A Traditional ROI: 9.38%
8 Jennie Lane Picayune, MS This charming brick home is almost 2800 square feet heated/cooled on over 2 acres. Feature...	4 beds \| 3 baths \| 2,757 sq.ft.	$429,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.66% Airbnb Rental Income: $null Traditional Rental Income: $2691 Airbnb ROI: N/A Traditional ROI: 4.66%
8007 Fishhook Lane Picayune, MS This residence in The Woods subdivision showcases a new market listing, a three-bedroom, t...	3 beds \| 2 baths \| 1,900 sq.ft.	$345,000	Airbnb cash on cash: -1.12% Traditional cash on cash: 4.4% Airbnb Rental Income: $606 Traditional Rental Income: $2104 Airbnb ROI: -1.12% Traditional ROI: 4.4%
319 Dozier St Picayune, MS Roomy 3 bed/ 2 bath home originally built in 1945 that is perfect for a young family or a ...	3 beds \| 2 baths \| 1,485 sq.ft.	$175,000	Airbnb cash on cash: -0.46% Traditional cash on cash: 8.54% Airbnb Rental Income: $606 Traditional Rental Income: $1816 Airbnb ROI: -0.46% Traditional ROI: 8.54%
413 S Haugh Avenue Picayune, MS Welcome to your new home! This adorable single-family residence features 3 bedrooms and 2 ...	3 beds \| 2 baths \| 1,069 sq.ft.	$159,999	Airbnb cash on cash: -0.34% Traditional cash on cash: 6.82% Airbnb Rental Income: $606 Traditional Rental Income: $1411 Airbnb ROI: -0.34% Traditional ROI: 6.82%
59 Hunters Trace Picayune, MS Welcome home to this beautifully maintained 3 bedroom, 2 bathroom home built in 2021 and n...	3 beds \| 2 baths \| 1,484 sq.ft.	$249,900	Airbnb cash on cash: -0.64% Traditional cash on cash: 5.95% Airbnb Rental Income: $606 Traditional Rental Income: $1872 Airbnb ROI: -0.64% Traditional ROI: 5.95%
124 Lake David Drive Picayune, MS This property has it all! Immaculate home with all updates including appliances. The kitc...	4 beds \| 2 baths \| 2,056 sq.ft.	$350,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.36% Airbnb Rental Income: $null Traditional Rental Income: $2400 Airbnb ROI: N/A Traditional ROI: 5.36%
205 South Monroe Ave. Picayune, MS This cozy little home is conveniently located and appears to have been renovated in the no...	3 beds \| 2 baths \| 1,022 sq.ft.	$134,900	Airbnb cash on cash: -0.08% Traditional cash on cash: 8.6% Airbnb Rental Income: $606 Traditional Rental Income: $1440 Airbnb ROI: -0.08% Traditional ROI: 8.6%
7711 Cuevas Town Road Picayune, MS Major Price Improvement - Act Fast! Now offered at a new, improved price--this is your opp...	4 beds \| 5 baths \| 3,566 sq.ft.	$549,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.89% Airbnb Rental Income: $null Traditional Rental Income: $3380 Airbnb ROI: N/A Traditional ROI: 4.89%
216 S GREEN AVE Picayune, MS Don't miss this recently updated 3-bedroom, 1.5-bath brick home located in town on a peace...	3 beds \| 2 baths \| 1,200 sq.ft.	$159,000	Airbnb cash on cash: 0.01% Traditional cash on cash: 8.99% Airbnb Rental Income: $606 Traditional Rental Income: $1680 Airbnb ROI: 0.01% Traditional ROI: 8.99%
7021 Chinquapin Ct Picayune, MS Beautiful 3-bedroom, 2-bath home located in the desirable Woods Subdivision, just minutes ...	3 beds \| 2 baths \| 2,124 sq.ft.	$330,000	Airbnb cash on cash: -1.09% Traditional cash on cash: 3.5% Airbnb Rental Income: $606 Traditional Rental Income: $1738 Airbnb ROI: -1.09% Traditional ROI: 3.5%
105 Jefferson Davis Picayune, MS The popular Frenchman design defines this beautiful residence, featuring four bedrooms, 2....	4 beds \| 3 baths \| 2,547 sq.ft.	$420,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $2554 Airbnb ROI: N/A Traditional ROI: 4.45%
25125 Road 394 Picayune, MS Private 8.21-acre retreat with multiple residences and exceptional amenities. This beautif...	4 beds \| 4 baths \| 2,500 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.76% Airbnb Rental Income: $null Traditional Rental Income: $2859 Airbnb ROI: N/A Traditional ROI: 4.76%
27 Maroon DR. Picayune, MS Looking for subdivision life with lots of privacy? This recently renovated home is in like...	3 beds \| 2 baths \| 1,496 sq.ft.	$220,000	Airbnb cash on cash: -0.85% Traditional cash on cash: 5.96% Airbnb Rental Income: $606 Traditional Rental Income: $1736 Airbnb ROI: -0.85% Traditional ROI: 5.96%
560 Fairway Dr Picayune, MS This CUSTOM built modern New Orleans style shotgun house has 3 bedrooms and 2 full baths. ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,000	Airbnb cash on cash: -1.07% Traditional cash on cash: 4.49% Airbnb Rental Income: $606 Traditional Rental Income: $1997 Airbnb ROI: -1.07% Traditional ROI: 4.49%
818 Cedar Grove Ave Picayune, MS Check out this beautifully renovated home located in the heart of Picayune! This one has b...	4 beds \| 2 baths \| 1,850 sq.ft.	$229,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.04% Airbnb Rental Income: $null Traditional Rental Income: $2225 Airbnb ROI: N/A Traditional ROI: 8.04%
1801 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.7% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.7%
1803 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.61% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.61%
1805 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.62% Airbnb Rental Income: $null Traditional Rental Income: $2686 Airbnb ROI: N/A Traditional ROI: 9.62%
1922 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.68% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.68%
1924 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1926 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1928 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 4 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.07% Airbnb Rental Income: $null Traditional Rental Income: $2776 Airbnb ROI: N/A Traditional ROI: 10.07%
711 Neal Road Picayune, MS Introducing this remarkable handicap accessible property, showcasing 1937 square feet of l...	3 beds \| 2 baths \| 1,937 sq.ft.	$239,000	Airbnb cash on cash: -0.33% Traditional cash on cash: 7.28% Airbnb Rental Income: $606 Traditional Rental Income: $2036 Airbnb ROI: -0.33% Traditional ROI: 7.28%
501 Pemberton Place Picayune, MS Our brand new "Preston" is now complete in Heritage Oaks. Experience modern living in a co...	3 beds \| 2 baths \| 1,900 sq.ft.	$378,900	Airbnb cash on cash: -0.5% Traditional cash on cash: 4.75% Airbnb Rental Income: $606 Traditional Rental Income: $2183 Airbnb ROI: -0.5% Traditional ROI: 4.75%
138 Essex Court Picayune, MS If you've been waiting for space, charm, and something that doesn't look like every other ...	4 beds \| 3 baths \| 2,008 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.48% Airbnb Rental Income: $null Traditional Rental Income: $2291 Airbnb ROI: N/A Traditional ROI: 8.48%
11080 Road 231 Picayune, MS This stunning residence, situated on approximately 3.50 acres, has been newly listed. Prop...	3 beds \| 2 baths \| 2,402 sq.ft.	$499,000	Airbnb cash on cash: -0.71% Traditional cash on cash: 3.46% Airbnb Rental Income: $606 Traditional Rental Income: $2262 Airbnb ROI: -0.71% Traditional ROI: 3.46%
307 S. STEELE AVE Picayune, MS Charming 4-Bedroom Home Close to Town! Welcome to this well-maintained 4-bedroom, 2-bath h...	4 beds \| 2 baths \| 1,518 sq.ft.	$174,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.33% Airbnb Rental Income: $null Traditional Rental Income: $1900 Airbnb ROI: N/A Traditional ROI: 9.33%
116 Monk Mitchell Road Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$487,000	Airbnb cash on cash: -1.08% Traditional cash on cash: 4.51% Airbnb Rental Income: $606 Traditional Rental Income: $2863 Airbnb ROI: -1.08% Traditional ROI: 4.51%
116 Monk Mitchell Picayune, MS Spacious 3-bedroom, 3-bath home nestled on 21.75 beautiful acres featuring a mix of mature...	3 beds \| 4 baths \| 3,681 sq.ft.	$487,000	Airbnb cash on cash: -1.08% Traditional cash on cash: 4.63% Airbnb Rental Income: $606 Traditional Rental Income: $2917 Airbnb ROI: -1.08% Traditional ROI: 4.63%
2302 Jackson Landing Rd. Picayune, MS Looking for a whole lot of space (inside and out)? Then look no further! This home is lo...	4 beds \| 2 baths \| 3,204 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.94% Airbnb Rental Income: $null Traditional Rental Income: $2028 Airbnb ROI: N/A Traditional ROI: 8.94%
605 Briarwood Picayune, MS LARGE home on the desirable west side of old Picayune!! Low traffic dead end street. Per...	4 beds \| 3 baths \| 2,932 sq.ft.	$285,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.59% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 7.59%
446 Liberty Rd. Picayune, MS Discover the PERFECT blend of COMFORT and CONVENIENCE in this BEAUTIFUL 3 Bed/ 2.5 Bath ho...	3 beds \| 3 baths \| 2,363 sq.ft.	$339,000	Airbnb cash on cash: -0.9% Traditional cash on cash: 5.64% Airbnb Rental Income: $606 Traditional Rental Income: $2398 Airbnb ROI: -0.9% Traditional ROI: 5.64%
131 Monk Mitchell Road Picayune, MS Very secluded and private! This home is hidden away from the main road and is accessible b...	3 beds \| 3 baths \| 2,558 sq.ft.	$336,000	Airbnb cash on cash: -1% Traditional cash on cash: 5.81% Airbnb Rental Income: $606 Traditional Rental Income: $2464 Airbnb ROI: -1% Traditional ROI: 5.81%
522 E Canal Street Picayune, MS Step into a true piece of Picayune history filled with timeless Southern charm & character...	2 beds \| 2 baths \| 1,889 sq.ft.	$189,900	Airbnb cash on cash: -1.88% Traditional cash on cash: 9.58% Airbnb Rental Income: $239 Traditional Rental Income: $2078 Airbnb ROI: -1.88% Traditional ROI: 9.58%
115 Oak Allee Drive Picayune, MS Stunning 4-Bedroom Home with Pool on 1.76 Acres in Salem Oaks - Optional Additional Acreag...	4 beds \| 3 baths \| 2,942 sq.ft.	$595,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.65% Airbnb Rental Income: $null Traditional Rental Income: $2984 Airbnb ROI: N/A Traditional ROI: 3.65%
26340 Strickland Rd. Picayune, MS Cute and affordable home in the country on a quiet acre! Large living area, 2 bedrooms, ca...	2 beds \| 1 baths \| 1,006 sq.ft.	$99,000	Airbnb cash on cash: -2.97% Traditional cash on cash: 10.07% Airbnb Rental Income: $239 Traditional Rental Income: $1266 Airbnb ROI: -2.97% Traditional ROI: 10.07%

Real Estate investment in Picayune, MS

There are 77 properties for sale in the city of Picayune . The median list price in Picayune is $242,250 and the average price per square foot is $115. In May 2026, the average monthly cash on cash return in Picayune is 6.00%. The average monthly rental income in Picayune is $2,140.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 77 investment properties available for sale in Picayune.

In 2026, the best neighborhood to buy investment property is Picayune.

The ROI for Long-Term is higher than the Short-Term in Picayune with average rental income of $2,140.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

12 Seminole Drive

Picayune, MS

3 beds | 2 baths | 1,714 sq.ft.

$299,900

Airbnb cash on cash: -0.83%

Traditional cash on cash: 4.45%

Airbnb Rental Income: $606

Traditional Rental Income: $1808

Airbnb ROI: -0.83%

Traditional ROI: 4.45%

2212 E Canal Street

Picayune, MS

4 beds | 2 baths | 2,068 sq.ft.

$195,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.38%

Airbnb Rental Income: $null

Traditional Rental Income: $2177

Airbnb ROI: N/A

Traditional ROI: 9.38%

8 Jennie Lane

Picayune, MS

4 beds | 3 baths | 2,757 sq.ft.

$429,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.66%

Airbnb Rental Income: $null

Traditional Rental Income: $2691

Airbnb ROI: N/A

Traditional ROI: 4.66%

8007 Fishhook Lane

Picayune, MS

3 beds | 2 baths | 1,900 sq.ft.

$345,000

Airbnb cash on cash: -1.12%

Traditional cash on cash: 4.4%

Airbnb Rental Income: $606

Traditional Rental Income: $2104

Airbnb ROI: -1.12%

Traditional ROI: 4.4%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,485 sq.ft.

$175,000

Airbnb cash on cash: -0.46%

Traditional cash on cash: 8.54%

Airbnb Rental Income: $606

Traditional Rental Income: $1816

Airbnb ROI: -0.46%

Traditional ROI: 8.54%

413 S Haugh Avenue

Picayune, MS

3 beds | 2 baths | 1,069 sq.ft.

$159,999

Airbnb cash on cash: -0.34%

Traditional cash on cash: 6.82%

Airbnb Rental Income: $606

Traditional Rental Income: $1411

Airbnb ROI: -0.34%

Traditional ROI: 6.82%

59 Hunters Trace

Picayune, MS

3 beds | 2 baths | 1,484 sq.ft.

$249,900

Airbnb cash on cash: -0.64%

Traditional cash on cash: 5.95%

Airbnb Rental Income: $606

Traditional Rental Income: $1872

Airbnb ROI: -0.64%

Traditional ROI: 5.95%

124 Lake David Drive

Picayune, MS

4 beds | 2 baths | 2,056 sq.ft.

$350,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.36%

Airbnb Rental Income: $null

Traditional Rental Income: $2400

Airbnb ROI: N/A