Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
532 Millbrook Parkway Picayune, MS Looking for a move-in ready home? Here it is! This spacious beauty has undergone impressiv...	3 beds \| 2 baths \| 2,046 sq.ft.	$276,500	Airbnb cash on cash: 2.47% Traditional cash on cash: 4.59% Airbnb Rental Income: $1518 Traditional Rental Income: $1628 Airbnb ROI: 2.47% Traditional ROI: 4.59%
8 Jennie Lane Picayune, MS This charming brick home is almost 2800 square feet heated/cooled on over 2 acres. Feature...	4 beds \| 3 baths \| 2,757 sq.ft.	$459,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.24% Airbnb Rental Income: $null Traditional Rental Income: $2691 Airbnb ROI: N/A Traditional ROI: 4.24%
435 Millbrook Parkway Picayune, MS Well maintained home fronting GOLF COURSE! Large walk-in closets and kitchen pantry. Tota...	3 beds \| 2 baths \| 2,036 sq.ft.	$254,000	Airbnb cash on cash: 2.59% Traditional cash on cash: 7.28% Airbnb Rental Income: $1518 Traditional Rental Income: $2201 Airbnb ROI: 2.59% Traditional ROI: 7.28%
11 Rosewood Dr. Picayune, MS Showcasing a remarkable four-bedroom, two-bathroom brick residence, encompassing 1800 squa...	4 beds \| 2 baths \| 1,804 sq.ft.	$279,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.17% Airbnb Rental Income: $null Traditional Rental Income: $2196 Airbnb ROI: N/A Traditional ROI: 6.17%
319 Dozier St Picayune, MS Roomy 3 bed/ 2 bath home originally built in 1945 that is perfect for a young family or a ...	3 beds \| 2 baths \| 1,485 sq.ft.	$175,000	Airbnb cash on cash: 4.1% Traditional cash on cash: 8.54% Airbnb Rental Income: $1518 Traditional Rental Income: $1816 Airbnb ROI: 4.1% Traditional ROI: 8.54%
820 Mitchell St. Picayune, MS If you are looking for a very well maintained 3 bedroom 2 bath home, this is the one! Very...	3 beds \| 2 baths \| N/A	$215,000	Airbnb cash on cash: 3.02% Traditional cash on cash: 6.89% Airbnb Rental Income: $1518 Traditional Rental Income: $1864 Airbnb ROI: 3.02% Traditional ROI: 6.89%
1404 Neal Rd Picayune, MS This spacious ranch style home features a huge family room with a woodburning fireplace; b...	3 beds \| 3 baths \| 3,047 sq.ft.	$393,000	Airbnb cash on cash: 0.86% Traditional cash on cash: 5.06% Airbnb Rental Income: $1518 Traditional Rental Income: $2621 Airbnb ROI: 0.86% Traditional ROI: 5.06%
54 Oak Point Rd Picayune, MS Escape to this picture-perfect 2-bedroom, 1-bathroom riverfront home, rebuilt from the sub...	2 beds \| 2 baths \| 1,010 sq.ft.	$149,500	Airbnb cash on cash: -1.61% Traditional cash on cash: 8.85% Airbnb Rental Income: $372 Traditional Rental Income: $1617 Airbnb ROI: -1.61% Traditional ROI: 8.85%
52 FALCON DR Picayune, MS Motivated Seller! Show & bring Offers! If you need space, this is the place! This home ope...	3 beds \| 3 baths \| 2,536 sq.ft.	$355,000	Airbnb cash on cash: 1.61% Traditional cash on cash: 5.35% Airbnb Rental Income: $1518 Traditional Rental Income: $2323 Airbnb ROI: 1.61% Traditional ROI: 5.35%
2107 Sheppard Blvd Picayune, MS MOVE IN READY!! This is a 3 bedroom 2 bathroom home with an extra room/office space, could...	3 beds \| 2 baths \| 1,895 sq.ft.	$245,000	Airbnb cash on cash: 2.44% Traditional cash on cash: 6.49% Airbnb Rental Income: $1518 Traditional Rental Income: $2013 Airbnb ROI: 2.44% Traditional ROI: 6.49%
902 Laird St. Picayune, MS Excellent starter home. Recently remodeled to include all new flooring, bathroom, and kitc...	3 beds \| 1 baths \| 1,221 sq.ft.	$175,000	Airbnb cash on cash: 4.1% Traditional cash on cash: 6.66% Airbnb Rental Income: $1518 Traditional Rental Income: $1504 Airbnb ROI: 4.1% Traditional ROI: 6.66%
25541 Broadridge Drive Picayune, MS WOW, what a unique find! This diamond in the rough is one of a kind and filled with charac...	4 beds \| 2 baths \| 2,339 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.95% Airbnb Rental Income: $null Traditional Rental Income: $2213 Airbnb ROI: N/A Traditional ROI: 6.95%
7711 Cuevas Town Road Picayune, MS Price Improvement Country Living at Its Finest!This stunning 4-bedroom, 5-bathroom tw...	4 beds \| 5 baths \| 3,566 sq.ft.	$579,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.59% Airbnb Rental Income: $null Traditional Rental Income: $3380 Airbnb ROI: N/A Traditional ROI: 4.59%
701 CARROLL ST Picayune, MS EXCELLENT RENTAL OPPORFTUNITY FOR INVESTOR-ALL UNITS ARE OCCUPIED-GREAT NEIGHBORHOOD-DOUBL...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
703 CARROLL ST Picayune, MS EXCELLENT RENTAL INVESTMENT - GREAT NEIGHBORHOOD - ELEMENTARY SCHOOL NEAR PROPERTY - PROPE...	5 beds \| 3 baths \| 2,288 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 6.84%
3010 WOODS Road Picayune, MS Opportunity Knocks! Here is a great opportunity to make this home your own. Brick home, 4 ...	4 beds \| 2 baths \| 2,032 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.62% Airbnb Rental Income: $null Traditional Rental Income: $1622 Airbnb ROI: N/A Traditional ROI: 4.62%
1551 N Beech St Picayune, MS This 3 bedroom 2 bath home sits just minutes from town! A great fenced in back yard! This ...	3 beds \| 2 baths \| 1,359 sq.ft.	$159,900	Airbnb cash on cash: 4.64% Traditional cash on cash: 8.88% Airbnb Rental Income: $1518 Traditional Rental Income: $1725 Airbnb ROI: 4.64% Traditional ROI: 8.88%
38 Wyatt Lane Picayune, MS Precious Acadian-style 3 bedroom, 2 bathroom home sitting on 2 beautiful acres in the coun...	3 beds \| 2 baths \| 1,572 sq.ft.	$248,800	Airbnb cash on cash: 2.31% Traditional cash on cash: 5.2% Airbnb Rental Income: $1518 Traditional Rental Income: $1755 Airbnb ROI: 2.31% Traditional ROI: 5.2%
3624 Highway 43 N Picayune, MS Cute country cottage set in the center of a large 2.5 acre lot with quick and easy access ...	3 beds \| 2 baths \| 1,167 sq.ft.	$230,000	Airbnb cash on cash: 2.72% Traditional cash on cash: 6.76% Airbnb Rental Income: $1518 Traditional Rental Income: $1957 Airbnb ROI: 2.72% Traditional ROI: 6.76%
560 Fairway Dr Picayune, MS This CUSTOM built Modern New Orleans style shotgun home has 3 bed 2 bath home features so ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,500	Airbnb cash on cash: 1.44% Traditional cash on cash: 4.47% Airbnb Rental Income: $1518 Traditional Rental Income: $1997 Airbnb ROI: 1.44% Traditional ROI: 4.47%
3007 Fairway Drive Drive Picayune, MS Don't miss out on this fantastic opportunity in the heart of Picayune! This custom-built 3...	3 beds \| 2 baths \| 1,778 sq.ft.	$321,000	Airbnb cash on cash: 2.09% Traditional cash on cash: 5.24% Airbnb Rental Income: $1518 Traditional Rental Income: $2027 Airbnb ROI: 2.09% Traditional ROI: 5.24%
619 Deason Picayune, MS Our Audubon is under construction on an oversized wooded homesite in desirable Heritage Oa...	4 beds \| 3 baths \| 3,279 sq.ft.	$449,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.44% Airbnb Rental Income: $null Traditional Rental Income: $2725 Airbnb ROI: N/A Traditional ROI: 4.44%
1210 Highland Dr. Picayune, MS Take a look at this beautiful Southern Charm Home! Separate Dining Rm, Kitchen, Office, Fa...	4 beds \| 3 baths \| 2,685 sq.ft.	$249,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.68% Airbnb Rental Income: $null Traditional Rental Income: $2669 Airbnb ROI: N/A Traditional ROI: 9.68%
11207 Chester Lee Rd. Picayune, MS Investor Special! Beautiful 3 bedroom, 2 bath home on 2.6 Acres. Home is located outside o...	3 beds \| 2 baths \| N/A	$210,000	Airbnb cash on cash: 3.13% Traditional cash on cash: 6.31% Airbnb Rental Income: $1518 Traditional Rental Income: $1708 Airbnb ROI: 3.13% Traditional ROI: 6.31%
601 Liberty Road Picayune, MS One of the most unique offerings in PRC in modern history. 2 Custom built homes on the ban...	5 beds \| 4 baths \| 2,465 sq.ft.	$750,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.05% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 2.05%
615 Carter Picayune, MS This beautifully remodeled three-bedroom, two-bathroom house is ready for you to move in. ...	3 beds \| 2 baths \| 1,304 sq.ft.	$169,999	Airbnb cash on cash: 4.54% Traditional cash on cash: 8.07% Airbnb Rental Income: $1518 Traditional Rental Income: $1648 Airbnb ROI: 4.54% Traditional ROI: 8.07%
1312 N Beech St Picayune, MS Well maintained older home 3 bedrooms 1 bath-large living room and dining room combined-ni...	3 beds \| 1 baths \| 1,246 sq.ft.	$165,000	Airbnb cash on cash: 4.78% Traditional cash on cash: 7.69% Airbnb Rental Income: $1518 Traditional Rental Income: $1534 Airbnb ROI: 4.78% Traditional ROI: 7.69%
1500 Goodyear Picayune, MS Beautifully restored 4-bedroom home in Historic Downtown Picayune. Step into nearly 2,000 ...	4 beds \| 3 baths \| 1,968 sq.ft.	$335,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.67% Airbnb Rental Income: $null Traditional Rental Income: $2340 Airbnb ROI: N/A Traditional ROI: 5.67%
256 Lake David Drive Picayune, MS Remodeled home with new roof, a/c and flooring. Fresh paint and appliances are just a few...	4 beds \| 2 baths \| 2,750 sq.ft.	$335,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.8% Airbnb Rental Income: $null Traditional Rental Income: $2320 Airbnb ROI: N/A Traditional ROI: 5.8%
501 Pemberton Place Picayune, MS Our brand new "Preston" is under construction with a late summer anticipated completion. O...	3 beds \| 2 baths \| 1,900 sq.ft.	$361,000	Airbnb cash on cash: 1.76% Traditional cash on cash: 5.03% Airbnb Rental Income: $1518 Traditional Rental Income: $2183 Airbnb ROI: 1.76% Traditional ROI: 5.03%
11192 Willie Lee Road Picayune, MS Charming 3 Bedroom home on 7.5 acres with heated pool & handicap accessible features.Welco...	3 beds \| 2 baths \| 2,000 sq.ft.	$370,000	Airbnb cash on cash: 1.47% Traditional cash on cash: 3.14% Airbnb Rental Income: $1518 Traditional Rental Income: $1658 Airbnb ROI: 1.47% Traditional ROI: 3.14%
202 N. Boley Dr. Picayune, MS Spacious home with a good sized fenced yard inside City Limits. This home offers a new roo...	4 beds \| 3 baths \| 2,787 sq.ft.	$305,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.49% Airbnb Rental Income: $null Traditional Rental Income: $2890 Airbnb ROI: N/A Traditional ROI: 8.49%

Real Estate investment in Picayune, MS

There are 79 properties for sale in the city of Picayune . The median list price in Picayune is $245,000 and the average price per square foot is $117. In October 2025, the average monthly cash on cash return in Picayune is 7.00%. The average monthly rental income in Picayune is $2,120.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 79 investment properties available for sale in Picayune.

In 2025, the best neighborhood to buy investment property is Picayune.

The ROI for Long-Term is higher than the Short-Term in Picayune with average rental income of $2,120.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

532 Millbrook Parkway

Picayune, MS

3 beds | 2 baths | 2,046 sq.ft.

$276,500

Airbnb cash on cash: 2.47%

Traditional cash on cash: 4.59%

Airbnb Rental Income: $1518

Traditional Rental Income: $1628

Airbnb ROI: 2.47%

Traditional ROI: 4.59%

8 Jennie Lane

Picayune, MS

4 beds | 3 baths | 2,757 sq.ft.

$459,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.24%

Airbnb Rental Income: $null

Traditional Rental Income: $2691

Airbnb ROI: N/A

Traditional ROI: 4.24%

435 Millbrook Parkway

Picayune, MS

3 beds | 2 baths | 2,036 sq.ft.

$254,000

Airbnb cash on cash: 2.59%

Traditional cash on cash: 7.28%

Airbnb Rental Income: $1518

Traditional Rental Income: $2201

Airbnb ROI: 2.59%

Traditional ROI: 7.28%

11 Rosewood Dr.

Picayune, MS

4 beds | 2 baths | 1,804 sq.ft.

$279,900

Airbnb cash on cash: N/A

Traditional cash on cash: 6.17%

Airbnb Rental Income: $null

Traditional Rental Income: $2196

Airbnb ROI: N/A

Traditional ROI: 6.17%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,485 sq.ft.

$175,000

Airbnb cash on cash: 4.1%

Traditional cash on cash: 8.54%

Airbnb Rental Income: $1518

Traditional Rental Income: $1816

Airbnb ROI: 4.1%

Traditional ROI: 8.54%

820 Mitchell St.

Picayune, MS

3 beds | 2 baths | N/A

$215,000

Airbnb cash on cash: 3.02%

Traditional cash on cash: 6.89%

Airbnb Rental Income: $1518

Traditional Rental Income: $1864

Airbnb ROI: 3.02%

Traditional ROI: 6.89%

1404 Neal Rd

Picayune, MS

3 beds | 3 baths | 3,047 sq.ft.

$393,000

Airbnb cash on cash: 0.86%

Traditional cash on cash: 5.06%

Airbnb Rental Income: $1518

Traditional Rental Income: $2621

Airbnb ROI: 0.86%

Traditional ROI: 5.06%

54 Oak Point Rd

Picayune, MS

2 beds | 2 baths | 1,010 sq.ft.

$149,500

Airbnb cash on cash: -1.61%

Traditional cash on cash: 8.85%

Airbnb Rental Income: $372

Traditional Rental Income: $1617

Airbnb ROI: -1.61%