Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
12 Seminole Drive Picayune, MS REDUCED and Seller is willing to assist with closing costs! Experience the perfect balance...	3 beds \| 2 baths \| 1,714 sq.ft.	$269,900	Airbnb cash on cash: 3.17% Traditional cash on cash: 5.04% Airbnb Rental Income: $1824 Traditional Rental Income: $1808 Airbnb ROI: 3.17% Traditional ROI: 5.04%
1006 Woods Road Picayune, MS Beautiful home located on the Main Lake! This home is situated on 2 ea. lots that have bee...	3 beds \| 2 baths \| 2,319 sq.ft.	$425,000	Airbnb cash on cash: 1.15% Traditional cash on cash: 2.37% Airbnb Rental Income: $1824 Traditional Rental Income: $1817 Airbnb ROI: 1.15% Traditional ROI: 2.37%
8 Jennie Lane Picayune, MS This charming brick 2800 heating and cooled square foot residence, situated on over 2 acre...	4 beds \| N/A baths \| 2,757 sq.ft.	$357,600	Airbnb cash on cash: 0.8% Traditional cash on cash: 5.94% Airbnb Rental Income: $1386 Traditional Rental Income: $2691 Airbnb ROI: 0.8% Traditional ROI: 5.94%
3 Elk Ct Picayune, MS This home is as cute as can be & exceptionally well maintained! Situated on over an acre o...	3 beds \| 2 baths \| 1,600 sq.ft.	$267,900	Airbnb cash on cash: 3.1% Traditional cash on cash: 5.02% Airbnb Rental Income: $1824 Traditional Rental Income: $1817 Airbnb ROI: 3.1% Traditional ROI: 5.02%
518 Fifth Ave Picayune, MS Welcome to the heart of Picayune! This charming 3-bedroom, 2-bath home is perfectly situat...	3 beds \| 2 baths \| 1,591 sq.ft.	$204,500	Airbnb cash on cash: 4.65% Traditional cash on cash: 6.93% Airbnb Rental Income: $1824 Traditional Rental Income: $1774 Airbnb ROI: 4.65% Traditional ROI: 6.93%
25 Sam Powell Rd. Picayune, MS Welcome to 25 Sam Powell Rd where you will find a 3 bedroom 2 bath brick home. This home h...	3 beds \| 2 baths \| 1,356 sq.ft.	$160,000	Airbnb cash on cash: 6.3% Traditional cash on cash: 8.11% Airbnb Rental Income: $1824 Traditional Rental Income: $1608 Airbnb ROI: 6.3% Traditional ROI: 8.11%
23415 Indian Ridge Rd Picayune, MS Charming 3-bedroom, 2-bath cottage-style home with an easy, open layout. Renovated in 2021...	3 beds \| 2 baths \| 1,868 sq.ft.	$224,900	Airbnb cash on cash: 4.01% Traditional cash on cash: 7.01% Airbnb Rental Income: $1824 Traditional Rental Income: $1970 Airbnb ROI: 4.01% Traditional ROI: 7.01%
611 Charlotte Dr Picayune, MS Welcome to this spacious 5 bedroom, 2 bath home offering approximately 2,443 sq. ft. of li...	5 beds \| 2 baths \| 2,443 sq.ft.	$280,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.71% Airbnb Rental Income: $null Traditional Rental Income: $2340 Airbnb ROI: N/A Traditional ROI: 6.71%
512 Pemberton Place Picayune, MS This beautiful 3 bed 2bath home with an extra room with built in bunks offers the perfect ...	3 beds \| N/A baths \| 2,434 sq.ft.	$419,000	Airbnb cash on cash: 1.51% Traditional cash on cash: 2.8% Airbnb Rental Income: $1824 Traditional Rental Income: $1837 Airbnb ROI: 1.51% Traditional ROI: 2.8%
7711 Cuevas Town Road Picayune, MS *BACK ON THE MARKET- BELOW APPRAISED VALUE* Private Cypress Home on 2.51 Acres! Now of...	4 beds \| 5 baths \| 3,566 sq.ft.	$425,000	Airbnb cash on cash: 0.54% Traditional cash on cash: 6.6% Airbnb Rental Income: $1386 Traditional Rental Income: $3380 Airbnb ROI: 0.54% Traditional ROI: 6.6%
721 Bouie Rd. Picayune, MS Beautifully situated on approximately 1 acre, this charming 3-bedroom, 2-bath home offers ...	3 beds \| 2 baths \| 2,313 sq.ft.	$185,000	Airbnb cash on cash: 5.23% Traditional cash on cash: 6.94% Airbnb Rental Income: $1824 Traditional Rental Income: $1631 Airbnb ROI: 5.23% Traditional ROI: 6.94%
123 Tennyson Cove Picayune, MS Spacious 3-bedroom, 2-bath brick home nestled on a beautiful shaded lot with mature trees....	3 beds \| 2 baths \| 1,487 sq.ft.	$184,500	Airbnb cash on cash: 5.49% Traditional cash on cash: 6.89% Airbnb Rental Income: $1824 Traditional Rental Income: $1576 Airbnb ROI: 5.49% Traditional ROI: 6.89%
68 Oak Point Road Picayune, MS Fronting on the Pearl River! Well maintained home just minutes outside of Picayune city li...	3 beds \| 1 baths \| 1,024 sq.ft.	$149,000	Airbnb cash on cash: 7.44% Traditional cash on cash: 4.31% Airbnb Rental Income: $1824 Traditional Rental Income: $885 Airbnb ROI: 7.44% Traditional ROI: 4.31%
38 Wyatt Lane Picayune, MS This exquisite Acadian style home spans 1572 square feet, featuring 3 bedrooms and 2 bathr...	3 beds \| 2 baths \| 1,572 sq.ft.	$259,900	Airbnb cash on cash: 3.21% Traditional cash on cash: 4.94% Airbnb Rental Income: $1824 Traditional Rental Income: $1755 Airbnb ROI: 3.21% Traditional ROI: 4.94%
105 Jefferson Davis Picayune, MS The popular Frenchman design defines this beautiful residence, featuring four bedrooms, 2....	4 beds \| N/A baths \| 2,547 sq.ft.	$396,000	Airbnb cash on cash: 0.55% Traditional cash on cash: 4.82% Airbnb Rental Income: $1386 Traditional Rental Income: $2554 Airbnb ROI: 0.55% Traditional ROI: 4.82%
3624 Highway 43 N Picayune, MS Charming 3-bedroom, 1.5-bath home with a versatile sunroom, large fenced yard, and key sys...	3 beds \| N/A baths \| 1,167 sq.ft.	$215,000	Airbnb cash on cash: 4.27% Traditional cash on cash: 7.35% Airbnb Rental Income: $1824 Traditional Rental Income: $1957 Airbnb ROI: 4.27% Traditional ROI: 7.35%
10201 Possum Fork Road Picayune, MS Discover the potential for your next chapter with this beautiful 3bdr/2bath brick home in ...	3 beds \| 2 baths \| N/A	$279,000	Airbnb cash on cash: 2.91% Traditional cash on cash: 5.15% Airbnb Rental Income: $1824 Traditional Rental Income: $1921 Airbnb ROI: 2.91% Traditional ROI: 5.15%
27 Maroon DR. Picayune, MS Looking for subdivision life with lots of privacy? This recently renovated home is in like...	3 beds \| N/A baths \| 1,496 sq.ft.	$218,000	Airbnb cash on cash: 4.06% Traditional cash on cash: 6.03% Airbnb Rental Income: $1824 Traditional Rental Income: $1736 Airbnb ROI: 4.06% Traditional ROI: 6.03%
560 Fairway Dr Picayune, MS This CUSTOM built modern New Orleans style shotgun house has 3 bedrooms and 2 full baths. ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,000	Airbnb cash on cash: 2.29% Traditional cash on cash: 4.49% Airbnb Rental Income: $1824 Traditional Rental Income: $1997 Airbnb ROI: 2.29% Traditional ROI: 4.49%
1801 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.69% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.69%
1803 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.61% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.61%
1805 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.61% Airbnb Rental Income: $null Traditional Rental Income: $2686 Airbnb ROI: N/A Traditional ROI: 9.61%
1922 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.68% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.68%
1924 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1926 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1928 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.07% Airbnb Rental Income: $null Traditional Rental Income: $2776 Airbnb ROI: N/A Traditional ROI: 10.07%
711 Neal Rd Picayune, MS 711 Neal Rd in Picayune, MS, presents a refined residential opportunity designed for comfo...	3 beds \| 2 baths \| 1,937 sq.ft.	$219,900	Airbnb cash on cash: 4.6% Traditional cash on cash: 7.99% Airbnb Rental Income: $1824 Traditional Rental Income: $2036 Airbnb ROI: 4.6% Traditional ROI: 7.99%
280 Bobby Lane Picayune, MS Introducing a newly listed three-bedroom, three-bath residence showcasing 1820 square feet...	3 beds \| 3 baths \| 1,820 sq.ft.	$379,900	Airbnb cash on cash: 1.87% Traditional cash on cash: 4.02% Airbnb Rental Income: $1824 Traditional Rental Income: $2096 Airbnb ROI: 1.87% Traditional ROI: 4.02%
11080 Road 231 Picayune, MS This stunning residence, situated on approximately 3.50 acres, has been newly listed. Prop...	3 beds \| 2 baths \| 2,402 sq.ft.	$499,000	Airbnb cash on cash: 1.46% Traditional cash on cash: 3.46% Airbnb Rental Income: $1824 Traditional Rental Income: $2262 Airbnb ROI: 1.46% Traditional ROI: 3.46%
961 Ceasar Road Picayune, MS Located just outside of city limits. This home has been completely updated and is turnkey ...	3 beds \| N/A baths \| 1,240 sq.ft.	$240,000	Airbnb cash on cash: 4.36% Traditional cash on cash: 4.36% Airbnb Rental Income: $1824 Traditional Rental Income: $1331 Airbnb ROI: 4.36% Traditional ROI: 4.36%
15 Legacy Drive Picayune, MS Luxury waterfront living meets exceptional craftsmanship in this one-of-a-kind custom esta...	4 beds \| 4 baths \| 2,869 sq.ft.	$998,900	Airbnb cash on cash: -0.4% Traditional cash on cash: 2.96% Airbnb Rental Income: $1386 Traditional Rental Income: $4091 Airbnb ROI: -0.4% Traditional ROI: 2.96%
12009 Circle G Ranch Road Picayune, MS Come enjoy the Perks of Country Living with the calmness and Peacefulness of Mother Nature...	3 beds \| 2 baths \| 1,969 sq.ft.	$347,000	Airbnb cash on cash: 2.38% Traditional cash on cash: 4.77% Airbnb Rental Income: $1824 Traditional Rental Income: $2112 Airbnb ROI: 2.38% Traditional ROI: 4.77%
131 Monk Mitchell Road Picayune, MS Very secluded and private! This home is hidden away from the main road and is accessible b...	4 beds \| N/A baths \| 2,558 sq.ft.	$336,000	Airbnb cash on cash: 1.06% Traditional cash on cash: 5.81% Airbnb Rental Income: $1386 Traditional Rental Income: $2464 Airbnb ROI: 1.06% Traditional ROI: 5.81%
1102 Jackson Landing Road Picayune, MS Beautifully Updated 3-Bedroom Home in Picayune Welcome to 1102 Jackson Landing Road in Pic...	3 beds \| 2 baths \| 1,357 sq.ft.	$149,900	Airbnb cash on cash: 6.72% Traditional cash on cash: 9.73% Airbnb Rental Income: $1824 Traditional Rental Income: $1762 Airbnb ROI: 6.72% Traditional ROI: 9.73%
2498 Hwy. 43 S Picayune, MS Located just outside the city limits, this home has had many updates and getting ready for...	3 beds \| 2 baths \| 1,851 sq.ft.	$300,000	Airbnb cash on cash: 2.83% Traditional cash on cash: 5.83% Airbnb Rental Income: $1824 Traditional Rental Income: $2178 Airbnb ROI: 2.83% Traditional ROI: 5.83%
52 Oliver Davis Rd Picayune, MS Excellent starter home on the south side of Picayune. This home features a brick exterior,...	3 beds \| 2 baths \| 1,426 sq.ft.	$215,000	Airbnb cash on cash: 4.27% Traditional cash on cash: 6.05% Airbnb Rental Income: $1824 Traditional Rental Income: $1692 Airbnb ROI: 4.27% Traditional ROI: 6.05%
27 Spice St Picayune, MS USDA RD ELIGIBLE address with 100% financing available! Enjoy THANKSGIVING & FOOTBALL with...	2 beds \| N/A baths \| 1,100 sq.ft.	$158,390	Airbnb cash on cash: 0.78% Traditional cash on cash: 6.04% Airbnb Rental Income: $807 Traditional Rental Income: $1279 Airbnb ROI: 0.78% Traditional ROI: 6.04%
1500 Goodyear Blvd. Picayune, MS This beautiful brick home with high-end finishes has 4 bedrooms 3 Full baths located in a ...	4 beds \| N/A baths \| 1,968 sq.ft.	$329,500	Airbnb cash on cash: 1.02% Traditional cash on cash: 5.39% Airbnb Rental Income: $1386 Traditional Rental Income: $2322 Airbnb ROI: 1.02% Traditional ROI: 5.39%
3926 Hwy 43 N Picayune, MS 4 BR/3ba home on 10 Acres. Eat in kitchen, living room, den (converted garage), laundry ro...	4 beds \| 3 baths \| 2,379 sq.ft.	$729,000	Airbnb cash on cash: -0.52% Traditional cash on cash: 1.74% Airbnb Rental Income: $1386 Traditional Rental Income: $2505 Airbnb ROI: -0.52% Traditional ROI: 1.74%
149 Grover Barrett Road Picayune, MS This home has had many updates within the last year. Many include new kitchen counter tops...	2 beds \| 1 baths \| 908 sq.ft.	$179,000	Airbnb cash on cash: 0.85% Traditional cash on cash: 4.08% Airbnb Rental Income: $807 Traditional Rental Income: $1034 Airbnb ROI: 0.85% Traditional ROI: 4.08%

Real Estate investment in Picayune, MS

There are 105 properties for sale in the city of Picayune . The median list price in Picayune is $237,387 and the average price per square foot is $114. In November 2026, the average monthly cash on cash return in Picayune is 6.00%. The average monthly rental income in Picayune is $1,872.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 105 investment properties available for sale in Picayune.

In 2026, the best neighborhood to buy investment property is Picayune.

The ROI for Long-Term is higher than the Short-Term in Picayune with average rental income of $1,872.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

12 Seminole Drive

Picayune, MS

3 beds | 2 baths | 1,714 sq.ft.

$269,900

Airbnb cash on cash: 3.17%

Traditional cash on cash: 5.04%

Airbnb Rental Income: $1824

Traditional Rental Income: $1808

Airbnb ROI: 3.17%

Traditional ROI: 5.04%

1006 Woods Road

Picayune, MS

3 beds | 2 baths | 2,319 sq.ft.

$425,000

Airbnb cash on cash: 1.15%

Traditional cash on cash: 2.37%

Airbnb Rental Income: $1824

Traditional Rental Income: $1817

Airbnb ROI: 1.15%

Traditional ROI: 2.37%

8 Jennie Lane

Picayune, MS

4 beds | N/A baths | 2,757 sq.ft.

$357,600

Airbnb cash on cash: 0.8%

Traditional cash on cash: 5.94%

Airbnb Rental Income: $1386

Traditional Rental Income: $2691

Airbnb ROI: 0.8%

Traditional ROI: 5.94%

3 Elk Ct

Picayune, MS

3 beds | 2 baths | 1,600 sq.ft.

$267,900

Airbnb cash on cash: 3.1%

Traditional cash on cash: 5.02%

Airbnb Rental Income: $1824

Traditional Rental Income: $1817

Airbnb ROI: 3.1%

Traditional ROI: 5.02%

518 Fifth Ave

Picayune, MS

3 beds | 2 baths | 1,591 sq.ft.

$204,500

Airbnb cash on cash: 4.65%

Traditional cash on cash: 6.93%

Airbnb Rental Income: $1824

Traditional Rental Income: $1774

Airbnb ROI: 4.65%

Traditional ROI: 6.93%

25 Sam Powell Rd.

Picayune, MS

3 beds | 2 baths | 1,356 sq.ft.

$160,000

Airbnb cash on cash: 6.3%

Traditional cash on cash: 8.11%

Airbnb Rental Income: $1824

Traditional Rental Income: $1608

Airbnb ROI: 6.3%

Traditional ROI: 8.11%

23415 Indian Ridge Rd

Picayune, MS

3 beds | 2 baths | 1,868 sq.ft.

$224,900

Airbnb cash on cash: 4.01%

Traditional cash on cash: 7.01%

Airbnb Rental Income: $1824

Traditional Rental Income: $1970

Airbnb ROI: 4.01%

Traditional ROI: 7.01%

611 Charlotte Dr

Picayune, MS

5 beds | 2 baths | 2,443 sq.ft.

$280,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.71%

Airbnb Rental Income: $null

Traditional Rental Income: $2340

Airbnb ROI: N/A