Real Estate Investment Properties for Sale in Picayune, MS

Looking for investment property in Picayune, MS with high ROI ?

Explore a variety of short-term homes & houses in Picayune, MS. Invest wisely with VRBO & Picayune, MS Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Picayune, MS

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
9003 Twin Oaks Ct. Picayune, MS Welcome to luxury waterfront living! Situated on a beautifully landscaped 1-acre lot, this...	5 beds \| N/A baths \| 3,882 sq.ft.	$550,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.2% Airbnb Rental Income: $null Traditional Rental Income: $2170 Airbnb ROI: N/A Traditional ROI: 2.2%
12 Seminole Drive Picayune, MS Back on the Market - No Fault of Seller! Experience the perfect balance of peace and conve...	3 beds \| 2 baths \| 1,714 sq.ft.	$289,900	Airbnb cash on cash: 0.91% Traditional cash on cash: 4.63% Airbnb Rental Income: $1176 Traditional Rental Income: $1808 Airbnb ROI: 0.91% Traditional ROI: 4.63%
8 Jennie Lane Picayune, MS This charming brick 2800 heating and cooled square foot residence, situated on over 2 acre...	4 beds \| N/A baths \| 2,757 sq.ft.	$415,000	Airbnb cash on cash: 0.49% Traditional cash on cash: 4.88% Airbnb Rental Income: $1407 Traditional Rental Income: $2691 Airbnb ROI: 0.49% Traditional ROI: 4.88%
118 TENNYSON Cove Picayune, MS Take a look at this beautifully renovated home, featuring brand-new appliances throughout....	3 beds \| 2 baths \| 1,514 sq.ft.	$185,000	Airbnb cash on cash: 2.26% Traditional cash on cash: 7.69% Airbnb Rental Income: $1176 Traditional Rental Income: $1747 Airbnb ROI: 2.26% Traditional ROI: 7.69%
8007 Fishhook Lane Picayune, MS This residence in The Woods subdivision showcases a new market listing, a three-bedroom, t...	3 beds \| 2 baths \| 1,900 sq.ft.	$329,999	Airbnb cash on cash: 0.45% Traditional cash on cash: 4.68% Airbnb Rental Income: $1176 Traditional Rental Income: $2104 Airbnb ROI: 0.45% Traditional ROI: 4.68%
319 Dozier St Picayune, MS Welcome to this beautifully renovated 3 BR /2 Bath residence situated on a spacious corner...	3 beds \| 2 baths \| 1,300 sq.ft.	$159,000	Airbnb cash on cash: 2.8% Traditional cash on cash: 9.55% Airbnb Rental Income: $1176 Traditional Rental Income: $1816 Airbnb ROI: 2.8% Traditional ROI: 9.55%
518 Fifth Ave Picayune, MS Welcome to the heart of Picayune! This charming 3-bedroom, 2-bath home is perfectly situat...	3 beds \| 2 baths \| 1,591 sq.ft.	$219,900	Airbnb cash on cash: 1.67% Traditional cash on cash: 6.39% Airbnb Rental Income: $1176 Traditional Rental Income: $1774 Airbnb ROI: 1.67% Traditional ROI: 6.39%
15 Meadow Path Circle Picayune, MS Welcome to this move-in ready all-brick home offering 4 bedrooms and 2 bathrooms. Step ins...	4 beds \| 2 baths \| 1,515 sq.ft.	$215,000	Airbnb cash on cash: 2.57% Traditional cash on cash: 7.01% Airbnb Rental Income: $1407 Traditional Rental Income: $1889 Airbnb ROI: 2.57% Traditional ROI: 7.01%
52 FALCON DR Picayune, MS Welcome home! This beautifully maintained property is move in ready and designed with both...	3 beds \| N/A baths \| 2,700 sq.ft.	$344,900	Airbnb cash on cash: 0.81% Traditional cash on cash: 5.54% Airbnb Rental Income: $1176 Traditional Rental Income: $2323 Airbnb ROI: 0.81% Traditional ROI: 5.54%
24327 Rester Rd Picayune, MS 3br, 2 bath home with an office on 4.8 acres with vaulted ceiling in family room, wood bur...	3 beds \| 2 baths \| 1,797 sq.ft.	$383,950	Airbnb cash on cash: 0.55% Traditional cash on cash: 3.97% Airbnb Rental Income: $1176 Traditional Rental Income: $2023 Airbnb ROI: 0.55% Traditional ROI: 3.97%
39 Leo Eaves Picayune, MS Check out this 3 bedroom/1.5 bathroom located right off of Caesar Road. This house sits on...	3 beds \| N/A baths \| 1,525 sq.ft.	$159,000	Airbnb cash on cash: 3.28% Traditional cash on cash: 8.25% Airbnb Rental Income: $1176 Traditional Rental Income: $1546 Airbnb ROI: 3.28% Traditional ROI: 8.25%
1003 Union School Road Picayune, MS Welcome to this beautifully maintained, updated home nestled in a quiet neighborhood just ...	3 beds \| 2 baths \| 2,472 sq.ft.	$234,900	Airbnb cash on cash: 1.34% Traditional cash on cash: 7.34% Airbnb Rental Income: $1176 Traditional Rental Income: $2124 Airbnb ROI: 1.34% Traditional ROI: 7.34%
124 Lake David Drive Picayune, MS This property has it all! Immaculate home with all updates including appliances. The kitch...	4 beds \| 2 baths \| 2,056 sq.ft.	$350,000	Airbnb cash on cash: 1.05% Traditional cash on cash: 5.36% Airbnb Rental Income: $1407 Traditional Rental Income: $2400 Airbnb ROI: 1.05% Traditional ROI: 5.36%
71 Timaquana Drive Picayune, MS Welcome to this beautiful 3-bedroom, 2-bath home! Situated on a spacious .86-acre lot with...	3 beds \| 2 baths \| 2,038 sq.ft.	$320,000	Airbnb cash on cash: 0.51% Traditional cash on cash: 4.67% Airbnb Rental Income: $1176 Traditional Rental Income: $2043 Airbnb ROI: 0.51% Traditional ROI: 4.67%
7711 Cuevas Town Rd Picayune, MS Now Priced to Sell - Private Cypress Home on 2.51 Acres! Now offered at a new, improved pr...	4 beds \| 5 baths \| 3,566 sq.ft.	$425,000	Airbnb cash on cash: 0.58% Traditional cash on cash: 6.6% Airbnb Rental Income: $1407 Traditional Rental Income: $3380 Airbnb ROI: 0.58% Traditional ROI: 6.6%
7021 Chinquapin Ct Picayune, MS Beautiful 3-bedroom, 2-bath home located in the desirable Woods Subdivision, just minutes ...	3 beds \| 2 baths \| 2,124 sq.ft.	$318,000	Airbnb cash on cash: 0.53% Traditional cash on cash: 3.69% Airbnb Rental Income: $1176 Traditional Rental Income: $1738 Airbnb ROI: 0.53% Traditional ROI: 3.69%
123 Tennyson Cove Picayune, MS Spacious 3-bedroom, 2-bath brick home nestled on a beautiful shaded lot with mature trees....	3 beds \| 2 baths \| 1,487 sq.ft.	$194,500	Airbnb cash on cash: 2.24% Traditional cash on cash: 6.49% Airbnb Rental Income: $1176 Traditional Rental Income: $1576 Airbnb ROI: 2.24% Traditional ROI: 6.49%
1551 N Beech Street Picayune, MS Charming 3 bed, 2 bath, with large fence in backyard with covered patio. Dining and Kitche...	3 beds \| 2 baths \| 1,415 sq.ft.	$135,000	Airbnb cash on cash: 3.38% Traditional cash on cash: 10.58% Airbnb Rental Income: $1176 Traditional Rental Income: $1725 Airbnb ROI: 3.38% Traditional ROI: 10.58%
3317 Jackson Landing Rd Picayune, MS Calling all investors...are you looking for a new project opportunity? This duplex is with...	4 beds \| N/A baths \| 1,328 sq.ft.	$100,000	Airbnb cash on cash: 7.35% Traditional cash on cash: 6.53% Airbnb Rental Income: $1407 Traditional Rental Income: $904 Airbnb ROI: 7.35% Traditional ROI: 6.53%
105 Jefferson Davis Picayune, MS The popular Frenchman design defines this beautiful residence, featuring four bedrooms, 2....	4 beds \| N/A baths \| 2,547 sq.ft.	$410,000	Airbnb cash on cash: 0.51% Traditional cash on cash: 4.6% Airbnb Rental Income: $1407 Traditional Rental Income: $2554 Airbnb ROI: 0.51% Traditional ROI: 4.6%
3624 Highway 43 N Picayune, MS Charming 3-bedroom, 1.5-bath home with a versatile sunroom, large fenced yard, and key sys...	3 beds \| N/A baths \| 1,167 sq.ft.	$215,000	Airbnb cash on cash: 1.62% Traditional cash on cash: 7.35% Airbnb Rental Income: $1176 Traditional Rental Income: $1957 Airbnb ROI: 1.62% Traditional ROI: 7.35%
25125 Road 394 Picayune, MS Private 8.21-acre retreat with multiple residences and exceptional amenities. This beautif...	4 beds \| N/A baths \| 2,500 sq.ft.	$450,000	Airbnb cash on cash: 0.31% Traditional cash on cash: 4.76% Airbnb Rental Income: $1407 Traditional Rental Income: $2859 Airbnb ROI: 0.31% Traditional ROI: 4.76%
27 Maroon Dr Picayune, MS Looking for subdivision life with lots of privacy? This recently renovated home is in like...	3 beds \| 2 baths \| 1,496 sq.ft.	$220,000	Airbnb cash on cash: 1.48% Traditional cash on cash: 6.12% Airbnb Rental Income: $1176 Traditional Rental Income: $1736 Airbnb ROI: 1.48% Traditional ROI: 6.12%
560 Fairway Dr Picayune, MS This CUSTOM built modern New Orleans style shotgun house has 3 bedrooms and 2 full baths. ...	3 beds \| 2 baths \| 1,838 sq.ft.	$322,000	Airbnb cash on cash: 0.5% Traditional cash on cash: 4.49% Airbnb Rental Income: $1176 Traditional Rental Income: $1997 Airbnb ROI: 0.5% Traditional ROI: 4.49%
818 Cedar Grove Ave Picayune, MS Check out this beautifully renovated home located in the heart of Picayune! This one has b...	4 beds \| 2 baths \| 1,850 sq.ft.	$214,700	Airbnb cash on cash: 2.52% Traditional cash on cash: 8.63% Airbnb Rental Income: $1407 Traditional Rental Income: $2225 Airbnb ROI: 2.52% Traditional ROI: 8.63%
1801 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.69% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.69%
1803 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.61% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.61%
1805 Read Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.61% Airbnb Rental Income: $null Traditional Rental Income: $2686 Airbnb ROI: N/A Traditional ROI: 9.61%
1922 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.68% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.68%
1924 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1926 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.73% Airbnb Rental Income: $null Traditional Rental Income: $2702 Airbnb ROI: N/A Traditional ROI: 9.73%
1928 Daniels Road Picayune, MS THIS PROPERTY IS BEING SOLD AS PART OF A PORTFOLIO OF MULTIFAMILY DUPLEXES (7 TOTAL) FRONT...	6 beds \| 2 baths \| 2,091 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.07% Airbnb Rental Income: $null Traditional Rental Income: $2776 Airbnb ROI: N/A Traditional ROI: 10.07%
711 Neal Road Picayune, MS Introducing this remarkable handicap accessible property, showcasing 1937 square feet of l...	3 beds \| 2 baths \| 1,937 sq.ft.	$239,000	Airbnb cash on cash: 1.77% Traditional cash on cash: 7.28% Airbnb Rental Income: $1176 Traditional Rental Income: $2036 Airbnb ROI: 1.77% Traditional ROI: 7.28%
501 Pemberton Place Picayune, MS Our brand new "Preston" is now complete in Heritage Oaks. Experience modern living in a co...	3 beds \| 2 baths \| 1,900 sq.ft.	$378,900	Airbnb cash on cash: 0.83% Traditional cash on cash: 4.75% Airbnb Rental Income: $1176 Traditional Rental Income: $2183 Airbnb ROI: 0.83% Traditional ROI: 4.75%
280 Bobby Lane Picayune, MS Introducing a newly listed three-bedroom, three-bath totally renovated in 2022, (plumbing,...	3 beds \| 3 baths \| 1,820 sq.ft.	$389,000	Airbnb cash on cash: 0.33% Traditional cash on cash: 3.9% Airbnb Rental Income: $1176 Traditional Rental Income: $2096 Airbnb ROI: 0.33% Traditional ROI: 3.9%
138 Essex Court Picayune, MS If you've been waiting for space, charm, and something that doesn't look like every other ...	4 beds \| 3 baths \| 2,008 sq.ft.	$235,000	Airbnb cash on cash: 2.6% Traditional cash on cash: 8.48% Airbnb Rental Income: $1407 Traditional Rental Income: $2291 Airbnb ROI: 2.6% Traditional ROI: 8.48%
11080 Road 231 Picayune, MS This stunning residence, situated on approximately 3.50 acres, has been newly listed. Prop...	3 beds \| 2 baths \| 2,402 sq.ft.	$499,000	Airbnb cash on cash: 0.31% Traditional cash on cash: 3.46% Airbnb Rental Income: $1176 Traditional Rental Income: $2262 Airbnb ROI: 0.31% Traditional ROI: 3.46%
852 Herrin Dr Picayune, MS Move-in ready and completely refreshed! This 3-bedroom, 1-bath home features fresh paint t...	3 beds \| 1 baths \| 1,247 sq.ft.	$159,000	Airbnb cash on cash: 3.09% Traditional cash on cash: 7.27% Airbnb Rental Income: $1176 Traditional Rental Income: $1426 Airbnb ROI: 3.09% Traditional ROI: 7.27%
131 Monk Mitchell Road Picayune, MS Very secluded and private! This home is hidden away from the main road and is accessible b...	3 beds \| N/A baths \| 2,558 sq.ft.	$336,000	Airbnb cash on cash: 0.51% Traditional cash on cash: 5.81% Airbnb Rental Income: $1176 Traditional Rental Income: $2464 Airbnb ROI: 0.51% Traditional ROI: 5.81%
522 E Canal Street Picayune, MS Step into a true piece of Picayune history filled with timeless Southern charm & character...	2 beds \| N/A baths \| 1,889 sq.ft.	$189,900	Airbnb cash on cash: -0.21% Traditional cash on cash: 9.57% Airbnb Rental Income: $602 Traditional Rental Income: $2078 Airbnb ROI: -0.21% Traditional ROI: 9.57%

Real Estate investment in Picayune, MS

There are 97 properties for sale in the city of Picayune . The median list price in Picayune is $204,877 and the average price per square foot is $107. In August 2026, the average monthly cash on cash return in Picayune is 6.00%. The average monthly rental income in Picayune is $2,023.

Picayune, MS Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 97 investment properties available for sale in Picayune.

In 2026, the best neighborhood to buy investment property is Picayune.

The ROI for Long-Term is higher than the Short-Term in Picayune with average rental income of $2,023.

Your search for investment property begins and ends here

Investment Property for Sale in Picayune, MS

9003 Twin Oaks Ct.

Picayune, MS

5 beds | N/A baths | 3,882 sq.ft.

$550,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.2%

Airbnb Rental Income: $null

Traditional Rental Income: $2170

Airbnb ROI: N/A

Traditional ROI: 2.2%

12 Seminole Drive

Picayune, MS

3 beds | 2 baths | 1,714 sq.ft.

$289,900

Airbnb cash on cash: 0.91%

Traditional cash on cash: 4.63%

Airbnb Rental Income: $1176

Traditional Rental Income: $1808

Airbnb ROI: 0.91%

Traditional ROI: 4.63%

8 Jennie Lane

Picayune, MS

4 beds | N/A baths | 2,757 sq.ft.

$415,000

Airbnb cash on cash: 0.49%

Traditional cash on cash: 4.88%

Airbnb Rental Income: $1407

Traditional Rental Income: $2691

Airbnb ROI: 0.49%

Traditional ROI: 4.88%

118 TENNYSON Cove

Picayune, MS

3 beds | 2 baths | 1,514 sq.ft.

$185,000

Airbnb cash on cash: 2.26%

Traditional cash on cash: 7.69%

Airbnb Rental Income: $1176

Traditional Rental Income: $1747

Airbnb ROI: 2.26%

Traditional ROI: 7.69%

8007 Fishhook Lane

Picayune, MS

3 beds | 2 baths | 1,900 sq.ft.

$329,999

Airbnb cash on cash: 0.45%

Traditional cash on cash: 4.68%

Airbnb Rental Income: $1176

Traditional Rental Income: $2104

Airbnb ROI: 0.45%

Traditional ROI: 4.68%

319 Dozier St

Picayune, MS

3 beds | 2 baths | 1,300 sq.ft.

$159,000

Airbnb cash on cash: 2.8%

Traditional cash on cash: 9.55%

Airbnb Rental Income: $1176

Traditional Rental Income: $1816

Airbnb ROI: 2.8%

Traditional ROI: 9.55%

518 Fifth Ave

Picayune, MS

3 beds | 2 baths | 1,591 sq.ft.

$219,900

Airbnb cash on cash: 1.67%

Traditional cash on cash: 6.39%

Airbnb Rental Income: $1176

Traditional Rental Income: $1774

Airbnb ROI: 1.67%

Traditional ROI: 6.39%

15 Meadow Path Circle

Picayune, MS

4 beds | 2 baths | 1,515 sq.ft.

$215,000

Airbnb cash on cash: 2.57%

Traditional cash on cash: 7.01%

Airbnb Rental Income: $1407

Traditional Rental Income: $1889

Airbnb ROI: 2.57%