Real Estate Investment Properties for Sale in Clayton, MO

Looking for investment property in Clayton, MO with high ROI ?

Explore a variety of short-term homes & houses in Clayton, MO. Invest wisely with VRBO & Clayton, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Clayton, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
907 S Hanley Road #5 Clayton, MO LOCATION, location, location! Interesting architectural building with easy access to all t...	1 beds \| 1 baths \| 837 sq.ft.	$155,000	Airbnb cash on cash: 2.41% Traditional cash on cash: 2.51% Airbnb Rental Income: $1583 Traditional Rental Income: $1146 Airbnb ROI: 2.41% Traditional ROI: 2.51%
8130 Roxburgh Drive Clayton, MO This beautiful 4 family apartment building is located in Clayshire Neighborhood just acros...	N/A beds \| N/A baths \| 4,480 sq.ft.	$850,000	Airbnb cash on cash: -1.42% Traditional cash on cash: -0.37% Airbnb Rental Income: $974 Traditional Rental Income: $1451 Airbnb ROI: -1.42% Traditional ROI: -0.37%
7720 Country Club Court Clayton, MO Brand new roof on this charming craftsman home that is located on a landmark street in Cla...	5 beds \| 2 baths \| 2,808 sq.ft.	$825,000	Airbnb cash on cash: 2.63% Traditional cash on cash: 1.53% Airbnb Rental Income: $4857 Traditional Rental Income: $3009 Airbnb ROI: 2.63% Traditional ROI: 1.53%
46 Broadview Drive Clayton, MO This elegant 2-story home exudes timeless majesty and refinement, offering an ideal backdr...	4 beds \| 3 baths \| 3,131 sq.ft.	$1,250,000	Airbnb cash on cash: -0.03% Traditional cash on cash: 0.6% Airbnb Rental Income: $3073 Traditional Rental Income: $3095 Airbnb ROI: -0.03% Traditional ROI: 0.6%
7788 Pershing Avenue Clayton, MO The Jewel behind the door. Old Town Clayton's BEST! 7788 Pershing Avenue draws its inspira...	3 beds \| 5 baths \| 4,284 sq.ft.	$1,750,000	Airbnb cash on cash: -0.92% Traditional cash on cash: 0.3% Airbnb Rental Income: $2447 Traditional Rental Income: $3830 Airbnb ROI: -0.92% Traditional ROI: 0.3%
710 S Hanley Road #10A Clayton, MO Ideally located in the well-managed Whitehall building, this elegant and spacious condo of...	3 beds \| 4 baths \| 2,766 sq.ft.	$442,000	Airbnb cash on cash: -4.24% Traditional cash on cash: -1.47% Airbnb Rental Income: $2447 Traditional Rental Income: $2996 Airbnb ROI: -4.24% Traditional ROI: -1.47%
150 Carondelet Plaza #702 Clayton, MO Stunning, sophisticated & sleek best describe this one-of-a-kind condominium in Claytonâ...	2 beds \| 3 baths \| 2,647 sq.ft.	$2,199,000	Airbnb cash on cash: -2.05% Traditional cash on cash: -1.35% Airbnb Rental Income: $1956 Traditional Rental Income: $2880 Airbnb ROI: -2.05% Traditional ROI: -1.35%
248 Gay Avenue Clayton, MO Exceptional Clayton estate is sophisticated elegance at its finest. This classy 4 bed, 6 b...	4 beds \| 6 baths \| 4,355 sq.ft.	$1,790,000	Airbnb cash on cash: -0.55% Traditional cash on cash: 1.81% Airbnb Rental Income: $3073 Traditional Rental Income: $6303 Airbnb ROI: -0.55% Traditional ROI: 1.81%
710 S South Hanley Road #17C Clayton, MO A very rare opportunity to purchase a nearly 4,000 sq. ft. penthouse in the sky on the 17t...	3 beds \| 3 baths \| 3,811 sq.ft.	$1,299,000	Airbnb cash on cash: -2.86% Traditional cash on cash: -2.16% Airbnb Rental Income: $2447 Traditional Rental Income: $2693 Airbnb ROI: -2.86% Traditional ROI: -2.16%
23 Topton Way #2B Clayton, MO Stylish Living in the Heart of Clayton! Welcome to this beautifully appointed 2bed/2.5 ba...	2 beds \| 3 baths \| 2,365 sq.ft.	$1,015,000	Airbnb cash on cash: -2.09% Traditional cash on cash: -0.87% Airbnb Rental Income: $1956 Traditional Rental Income: $2592 Airbnb ROI: -2.09% Traditional ROI: -0.87%
710 S Hanley Road #18B Clayton, MO The Whitehall at Its Finest â Spacious, Sophisticated, and Truly One of a Kind. Welcome ...	3 beds \| 4 baths \| 3,300 sq.ft.	$989,000	Airbnb cash on cash: -3.51% Traditional cash on cash: -2.2% Airbnb Rental Income: $2447 Traditional Rental Income: $3054 Airbnb ROI: -3.51% Traditional ROI: -2.2%
7539 Maryland Avenue Clayton, MO Built in 2022, this 4 bed/5 bath Clayton home has it ALL- elevator, pool, and a gate for d...	4 beds \| 5 baths \| 5,436 sq.ft.	$3,175,000	Airbnb cash on cash: -1.07% Traditional cash on cash: 0.44% Airbnb Rental Income: $3073 Traditional Rental Income: $6820 Airbnb ROI: -1.07% Traditional ROI: 0.44%
234 N Brentwood Boulevard Clayton, MO Rare opportunity to experience the pinnacle of refined living in this timeless and elegant...	5 beds \| 5 baths \| 5,006 sq.ft.	$3,100,000	Airbnb cash on cash: -0.37% Traditional cash on cash: -0.16% Airbnb Rental Income: $4857 Traditional Rental Income: $4453 Airbnb ROI: -0.37% Traditional ROI: -0.16%
122 N Bemiston Avenue Clayton, MO This thoughtfully designed home in old town Clayton is ready for its next owner! This sop...	3 beds \| 4 baths \| 3,112 sq.ft.	$1,665,000	Airbnb cash on cash: -0.81% Traditional cash on cash: 0.22% Airbnb Rental Income: $2447 Traditional Rental Income: $3449 Airbnb ROI: -0.81% Traditional ROI: 0.22%
8145 University Drive Clayton, MO Impeccably maintained and move-in ready, this Clayton Gardens home blends charm with thoug...	3 beds \| 3 baths \| 2,241 sq.ft.	$749,900	Airbnb cash on cash: 0.24% Traditional cash on cash: 1.57% Airbnb Rental Income: $2447 Traditional Rental Income: $2774 Airbnb ROI: 0.24% Traditional ROI: 1.57%
7428 Wellington Way Clayton, MO Stunning Mediterranean-style home in the heart of the Moorlands neighborhood in Clayton. T...	3 beds \| 3 baths \| 2,400 sq.ft.	$779,000	Airbnb cash on cash: 0.43% Traditional cash on cash: 2.19% Airbnb Rental Income: $2447 Traditional Rental Income: $3125 Airbnb ROI: 0.43% Traditional ROI: 2.19%
36 Aberdeen Place Clayton, MO Charming Hillcrest Home with Designer Touches and Prime Location Nestled in the highly so...	5 beds \| 4 baths \| 3,475 sq.ft.	$1,250,000	Airbnb cash on cash: 1.09% Traditional cash on cash: 1.16% Airbnb Rental Income: $4857 Traditional Rental Income: $3946 Airbnb ROI: 1.09% Traditional ROI: 1.16%

Real Estate investment in Clayton, MO

There are 19 properties for sale in the city of Clayton . The median list price in Clayton is $1,015,000 and the average price per square foot is $328. In July 2025, the average monthly cash on cash return in Clayton is N/A%. The average monthly rental income in Clayton is $3,009.

Clayton, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 19 investment properties available for sale in Clayton.

In 2025, the best neighborhood to buy investment property is Clayton.

The ROI for Long-Term is higher than the Short-Term in Clayton with average rental income of $3,009.

Your search for investment property begins and ends here

Investment Property for Sale in Clayton, MO

907 S Hanley Road #5

Clayton, MO

1 beds | 1 baths | 837 sq.ft.

$155,000

Airbnb cash on cash: 2.41%

Traditional cash on cash: 2.51%

Airbnb Rental Income: $1583

Traditional Rental Income: $1146

Airbnb ROI: 2.41%

Traditional ROI: 2.51%

8130 Roxburgh Drive

Clayton, MO

N/A beds | N/A baths | 4,480 sq.ft.

$850,000

Airbnb cash on cash: -1.42%

Traditional cash on cash: -0.37%

Airbnb Rental Income: $974

Traditional Rental Income: $1451

Airbnb ROI: -1.42%

Traditional ROI: -0.37%

7720 Country Club Court

Clayton, MO

5 beds | 2 baths | 2,808 sq.ft.

$825,000

Airbnb cash on cash: 2.63%

Traditional cash on cash: 1.53%

Airbnb Rental Income: $4857

Traditional Rental Income: $3009

Airbnb ROI: 2.63%

Traditional ROI: 1.53%

46 Broadview Drive

Clayton, MO

4 beds | 3 baths | 3,131 sq.ft.

$1,250,000

Airbnb cash on cash: -0.03%

Traditional cash on cash: 0.6%

Airbnb Rental Income: $3073

Traditional Rental Income: $3095

Airbnb ROI: -0.03%

Traditional ROI: 0.6%

7788 Pershing Avenue

Clayton, MO

3 beds | 5 baths | 4,284 sq.ft.

$1,750,000

Airbnb cash on cash: -0.92%

Traditional cash on cash: 0.3%

Airbnb Rental Income: $2447

Traditional Rental Income: $3830

Airbnb ROI: -0.92%

Traditional ROI: 0.3%

710 S Hanley Road #10A

Clayton, MO

3 beds | 4 baths | 2,766 sq.ft.

$442,000

Airbnb cash on cash: -4.24%

Traditional cash on cash: -1.47%

Airbnb Rental Income: $2447

Traditional Rental Income: $2996

Airbnb ROI: -4.24%

Traditional ROI: -1.47%

150 Carondelet Plaza #702

Clayton, MO

2 beds | 3 baths | 2,647 sq.ft.

$2,199,000

Airbnb cash on cash: -2.05%

Traditional cash on cash: -1.35%

Airbnb Rental Income: $1956

Traditional Rental Income: $2880

Airbnb ROI: -2.05%

Traditional ROI: -1.35%

248 Gay Avenue

Clayton, MO

4 beds | 6 baths | 4,355 sq.ft.

$1,790,000

Airbnb cash on cash: -0.55%

Traditional cash on cash: 1.81%

Airbnb Rental Income: $3073

Traditional Rental Income: $6303

Airbnb ROI: -0.55%