Real Estate Investment Properties for Sale in De Soto, MO

Looking for investment property in De Soto, MO with high ROI ?

Explore a variety of short-term homes & houses in De Soto, MO. Invest wisely with VRBO & De Soto, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2902 Clay Street De Soto, MO Caesar's Country Acres is an all-age community located in De Soto, Missouri, approximately...	N/A beds \| N/A baths \| N/A	$530,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.92% Airbnb Rental Income: $null Traditional Rental Income: $1430 Airbnb ROI: N/A Traditional ROI: 0.92%
3589 State Route 110 De Soto, MO Come and visit this rare opportunity just south of the Gateway City and on the doorstep of...	4 beds \| 4 baths \| 3,899 sq.ft.	$1,599,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.84% Airbnb Rental Income: $null Traditional Rental Income: $3360 Airbnb ROI: N/A Traditional ROI: 0.84%
615 Perry St De Soto, MO Welcome home to this cozy home right in the heart of De Soto. This two bed one bath home m...	2 beds \| 1 baths \| 775 sq.ft.	$159,900	Airbnb cash on cash: 0.21% Traditional cash on cash: 3.88% Airbnb Rental Income: $657 Traditional Rental Income: $919 Airbnb ROI: 0.21% Traditional ROI: 3.88%
514 S 2nd St De Soto, MO Solid bungalow in the heart of town. The yard is fully fenced and has a few shade trees in...	2 beds \| 1 baths \| 910 sq.ft.	$130,000	Airbnb cash on cash: 0.61% Traditional cash on cash: 5.12% Airbnb Rental Income: $657 Traditional Rental Income: $922 Airbnb ROI: 0.61% Traditional ROI: 5.12%
2151 Lake Park Trl De Soto, MO Beautiful acreage with a lake. Totaling 24.85 acres of seclusion. Looking for someone with...	N/A beds \| N/A baths \| N/A	$234,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.51% Airbnb Rental Income: $null Traditional Rental Income: $1742 Airbnb ROI: N/A Traditional ROI: 5.51%
12272 Hyfield Rd De Soto, MO Hurry this gorgeous and private 8.3 (+/-) acres in Hillsboro School district will not last...	3 beds \| 2 baths \| 1,728 sq.ft.	$389,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.75% Airbnb Rental Income: $null Traditional Rental Income: $1642 Airbnb ROI: N/A Traditional ROI: 2.75%
14280 W Sunrise Lake Dr De Soto, MO Welcome home to 14280 West Sunrise Lake Drive! This charming 2 bedroom, 1 bathroom waterfr...	2 beds \| 1 baths \| 1,152 sq.ft.	$185,000	Airbnb cash on cash: -0.38% Traditional cash on cash: 3.47% Airbnb Rental Income: $657 Traditional Rental Income: $1036 Airbnb ROI: -0.38% Traditional ROI: 3.47%
700 Lovett St De Soto, MO Step inside! This Two-bedroom, one-bathroom home offers significant potential and was prev...	2 beds \| 1 baths \| 858 sq.ft.	$112,500	Airbnb cash on cash: 0.76% Traditional cash on cash: 7.33% Airbnb Rental Income: $657 Traditional Rental Income: $1073 Airbnb ROI: 0.76% Traditional ROI: 7.33%
2518 Meredith Dr De Soto, MO Beautiful log cabin situated on over 5 acre wooded lot. Magnificent great room with floor...	3 beds \| 2 baths \| 2,596 sq.ft.	$465,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.95% Airbnb Rental Income: $null Traditional Rental Income: $2110 Airbnb ROI: N/A Traditional ROI: 2.95%
1539 Hickory Lndg De Soto, MO Welcome home to 1539 Hickory Landing, a beautiful ranch-style Villa built in 2024. This 3-...	3 beds \| 2 baths \| 1,604 sq.ft.	$290,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.54% Airbnb Rental Income: $null Traditional Rental Income: $1944 Airbnb ROI: N/A Traditional ROI: 4.54%
1553 Hickory Lndg De Soto, MO 2 Bedroom and 2 full Bathrooms, Welcome to the Villas at West Ridge. What a great opportu...	2 beds \| 2 baths \| 1,460 sq.ft.	$284,000	Airbnb cash on cash: -1.72% Traditional cash on cash: 3.29% Airbnb Rental Income: $657 Traditional Rental Income: $1698 Airbnb ROI: -1.72% Traditional ROI: 3.29%
618 Woods End Trl De Soto, MO Calling all investors. Lots of potential in this lake front property on over 3 acres. 3 Be...	2 beds \| 1 baths \| 2,052 sq.ft.	$339,000	Airbnb cash on cash: -0.65% Traditional cash on cash: 2.91% Airbnb Rental Income: $657 Traditional Rental Income: $1495 Airbnb ROI: -0.65% Traditional ROI: 2.91%
129 E Pratt St De Soto, MO This remodeled bungalow is move in ready and beaming with charm. A nice size level yard m...	1 beds \| 1 baths \| 616 sq.ft.	$84,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.94% Airbnb Rental Income: $null Traditional Rental Income: $709 Airbnb ROI: N/A Traditional ROI: 5.94%
5336 Morse Ave De Soto, MO Enter this beautifully updated 3-bedroom, 1-bath home featuring stylish new flooring and f...	3 beds \| 1 baths \| 392 sq.ft.	$184,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.91% Airbnb Rental Income: $null Traditional Rental Income: $1371 Airbnb ROI: N/A Traditional ROI: 5.91%
Lot 1B of Hawks Retreat De Soto, MO Lot 1B of Hawks Retreat, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.71% Airbnb Rental Income: $null Traditional Rental Income: $724 Airbnb ROI: N/A Traditional ROI: 0.71%
0 State Route 21 De Soto, MO 0 State Route 21, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.57% Airbnb Rental Income: $null Traditional Rental Income: $712 Airbnb ROI: N/A Traditional ROI: -0.57%
13670 Mammoth Rd De Soto, MO 13670 Mammoth Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,968 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.81% Airbnb Rental Income: $null Traditional Rental Income: $1853 Airbnb ROI: N/A Traditional ROI: 1.81%
400 Hill Side Rd De Soto, MO 400 Hill Side Rd, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$55,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.47% Airbnb Rental Income: $null Traditional Rental Income: $857 Airbnb ROI: N/A Traditional ROI: 11.47%
14641 Engledow Springs Rd De Soto, MO 14641 Engledow Springs Rd, De Soto, MO 63020 \| Single Family Residential	N/A beds \| 1 baths \| 900 sq.ft.	$399,900	Airbnb cash on cash: N/A Traditional cash on cash: -0.59% Airbnb Rental Income: $null Traditional Rental Income: $606 Airbnb ROI: N/A Traditional ROI: -0.59%
4305 Park Dr De Soto, MO Opportunity knocks at 4305 Park Dr in De Soto! Located in a desirable lake community, this...	2 beds \| 1 baths \| 1,050 sq.ft.	$94,500	Airbnb cash on cash: -0.06% Traditional cash on cash: 5.3% Airbnb Rental Income: $657 Traditional Rental Income: $852 Airbnb ROI: -0.06% Traditional ROI: 5.3%
53 HIGHWAY E (vererans Dr) Dr De Soto, MO 53 HIGHWAY E (vererans Dr) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$50,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.63% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: 10.63%
4640 Dylan (lot 11) Dr De Soto, MO 4640 Dylan (lot 11) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$60,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.35% Airbnb Rental Income: $null Traditional Rental Income: $722 Airbnb ROI: N/A Traditional ROI: 8.35%
49 Monte Rosa Dr De Soto, MO 49 Monte Rosa Dr, De Soto, MO 63020 \| Single Family Residential	4 beds \| 3 baths \| 2,664 sq.ft.	$369,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.96% Airbnb Rental Income: $null Traditional Rental Income: $2224 Airbnb ROI: N/A Traditional ROI: 3.96%
2712 Creon De Soto, MO 2712 Creon, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,456 sq.ft.	$129,700	Airbnb cash on cash: N/A Traditional cash on cash: 7.98% Airbnb Rental Income: $null Traditional Rental Income: $1332 Airbnb ROI: N/A Traditional ROI: 7.98%
1510 Villa Dr De Soto, MO 1510 Villa Dr, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,512 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.75% Airbnb Rental Income: $null Traditional Rental Income: $1442 Airbnb ROI: N/A Traditional ROI: 3.75%
1559 Berry Dairy Rd De Soto, MO 1559 Berry Dairy Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 3 baths \| 2,402 sq.ft.	$329,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.21% Airbnb Rental Income: $null Traditional Rental Income: $2002 Airbnb ROI: N/A Traditional ROI: 4.21%
4155 Highway 67 De Soto, MO 4155 Highway 67, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: -0.75% Airbnb Rental Income: $null Traditional Rental Income: $773 Airbnb ROI: N/A Traditional ROI: -0.75%
217 Donnelly St De Soto, MO It's back and better than before! If you looked before, please look again! This home is pe...	2 beds \| 1 baths \| 900 sq.ft.	$149,500	Airbnb cash on cash: 0.25% Traditional cash on cash: 6.36% Airbnb Rental Income: $657 Traditional Rental Income: $1233 Airbnb ROI: 0.25% Traditional ROI: 6.36%
1218 S 5th St De Soto, MO 1218 S 5th St, De Soto, MO 63020 \| Single Family Residential	2 beds \| 1 baths \| 996 sq.ft.	$74,900	Airbnb cash on cash: 1.63% Traditional cash on cash: 8.56% Airbnb Rental Income: $657 Traditional Rental Income: $871 Airbnb ROI: 1.63% Traditional ROI: 8.56%
605 Stone St De Soto, MO Home can not be shown. DO NOT disturb occupants	3 beds \| 2 baths \| 1,884 sq.ft.	$210,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.36% Airbnb Rental Income: $null Traditional Rental Income: $1643 Airbnb ROI: N/A Traditional ROI: 6.36%
Lot #2 Clarke St De Soto, MO Lot #2 Clarke St, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$65,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $792 Airbnb ROI: N/A Traditional ROI: 8.83%
Lot #1 Clarke St De Soto, MO Lot #1 Clarke St, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$65,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $792 Airbnb ROI: N/A Traditional ROI: 8.83%
Lot #3 Clarke St De Soto, MO Lot #3 Clarke St, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$65,000	Airbnb cash on cash: N/A Traditional cash on cash: 9% Airbnb Rental Income: $null Traditional Rental Income: $803 Airbnb ROI: N/A Traditional ROI: 9%
16 Monte Rosa Dr De Soto, MO LAKEVIEW!! OPEN HOUSE SATURDAY and SUNDAY!! May 23 and 24th from 1-3!! Stop by for a qu...	5 beds \| 2 baths \| 1,800 sq.ft.	$339,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.13% Airbnb Rental Income: $null Traditional Rental Income: $2527 Airbnb ROI: N/A Traditional ROI: 6.13%
101 W Lakeview Dr De Soto, MO 101 W Lakeview Dr, De Soto, MO 63020 \| Single Family Residential	4 beds \| 4 baths \| 4,262 sq.ft.	$699,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.08% Airbnb Rental Income: $null Traditional Rental Income: $2795 Airbnb ROI: N/A Traditional ROI: 2.08%
00 Autumn Wood Rd De Soto, MO 00 Autumn Wood Rd, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$58,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.52% Airbnb Rental Income: $null Traditional Rental Income: $832 Airbnb ROI: N/A Traditional ROI: 9.52%
3220 Baisch Dr De Soto, MO 3220 Baisch Dr, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,871 sq.ft.	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.22% Airbnb Rental Income: $null Traditional Rental Income: $1628 Airbnb ROI: N/A Traditional ROI: 3.22%
601 Boyne St De Soto, MO 601 Boyne St, De Soto, MO 63020 \| Single Family Residential	4 beds \| 3 baths \| 1,968 sq.ft.	$309,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.11% Airbnb Rental Income: $null Traditional Rental Income: $1865 Airbnb ROI: N/A Traditional ROI: 4.11%
4109 Black Berry Mnr De Soto, MO 4109 Black Berry Mnr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$64,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.48% Airbnb Rental Income: $null Traditional Rental Income: $832 Airbnb ROI: N/A Traditional ROI: 9.48%
1516 N Main St De Soto, MO 1516 N Main St, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$100,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.64% Airbnb Rental Income: $null Traditional Rental Income: $832 Airbnb ROI: N/A Traditional ROI: 5.64%

Real Estate investment in De-soto, MO

There are 78 properties for sale in the city of De Soto . The median list price in De Soto is $199,880 and the average price per square foot is $128. In August 2026, the average monthly cash on cash return in De Soto is 5.00%. The average monthly rental income in De Soto is $922.

De-soto, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 78 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Short-Term is higher than the Long-Term in De-soto with average rental income of $657.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, MO

2902 Clay Street

De Soto, MO

N/A beds | N/A baths | N/A

$530,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.92%

Airbnb Rental Income: $null

Traditional Rental Income: $1430

Airbnb ROI: N/A

Traditional ROI: 0.92%

3589 State Route 110

De Soto, MO

4 beds | 4 baths | 3,899 sq.ft.

$1,599,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.84%

Airbnb Rental Income: $null

Traditional Rental Income: $3360

Airbnb ROI: N/A

Traditional ROI: 0.84%

615 Perry St

De Soto, MO

2 beds | 1 baths | 775 sq.ft.

$159,900

Airbnb cash on cash: 0.21%

Traditional cash on cash: 3.88%

Airbnb Rental Income: $657

Traditional Rental Income: $919

Airbnb ROI: 0.21%

Traditional ROI: 3.88%

514 S 2nd St

De Soto, MO

2 beds | 1 baths | 910 sq.ft.

$130,000

Airbnb cash on cash: 0.61%

Traditional cash on cash: 5.12%

Airbnb Rental Income: $657

Traditional Rental Income: $922

Airbnb ROI: 0.61%

Traditional ROI: 5.12%

2151 Lake Park Trl

De Soto, MO

N/A beds | N/A baths | N/A

$234,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.51%

Airbnb Rental Income: $null

Traditional Rental Income: $1742

Airbnb ROI: N/A

Traditional ROI: 5.51%

12272 Hyfield Rd

De Soto, MO

3 beds | 2 baths | 1,728 sq.ft.

$389,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.75%

Airbnb Rental Income: $null

Traditional Rental Income: $1642

Airbnb ROI: N/A

Traditional ROI: 2.75%

14280 W Sunrise Lake Dr

De Soto, MO

2 beds | 1 baths | 1,152 sq.ft.

$185,000

Airbnb cash on cash: -0.38%

Traditional cash on cash: 3.47%

Airbnb Rental Income: $657

Traditional Rental Income: $1036

Airbnb ROI: -0.38%

Traditional ROI: 3.47%

700 Lovett St

De Soto, MO

2 beds | 1 baths | 858 sq.ft.

$112,500

Airbnb cash on cash: 0.76%

Traditional cash on cash: 7.33%

Airbnb Rental Income: $657

Traditional Rental Income: $1073

Airbnb ROI: 0.76%