Real Estate Investment Properties for Sale in De Soto, MO

Looking for investment property in De Soto, MO with high ROI ?

Explore a variety of short-term homes & houses in De Soto, MO. Invest wisely with VRBO & De Soto, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, MO

separator

PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2902 Clay Street De Soto, MO Caesar's Country Acres is an all-age community located in De Soto, Missouri, approximately...	N/A beds \| N/A baths \| N/A	$530,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.92% Airbnb Rental Income: $null Traditional Rental Income: $1430 Airbnb ROI: N/A Traditional ROI: 0.92%
3589 State Route 110 De Soto, MO Come and visit this rare opportunity just south of the Gateway City and on the doorstep of...	4 beds \| 4 baths \| 3,899 sq.ft.	$1,690,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.74% Airbnb Rental Income: $null Traditional Rental Income: $3360 Airbnb ROI: N/A Traditional ROI: 0.74%
615 Perry St De Soto, MO Welcome home to this cozy home right in the heart of De Soto. This two bed one bath home m...	2 beds \| 1 baths \| 775 sq.ft.	$165,000	Airbnb cash on cash: 2.82% Traditional cash on cash: 3.73% Airbnb Rental Income: $1158 Traditional Rental Income: $919 Airbnb ROI: 2.82% Traditional ROI: 3.73%
13723 Willow Wind Dr De Soto, MO OPEN SUNDAY MAY 3RD, 1-3PM.. Welcome Home!! You will fall in love with this newer 6 year...	4 beds \| 2 baths \| 1,597 sq.ft.	$469,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.23% Airbnb Rental Income: $null Traditional Rental Income: $1847 Airbnb ROI: N/A Traditional ROI: 2.23%
3772 GOLDENROD LN De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 768 sq.ft.	$130,000	Airbnb cash on cash: 3.8% Traditional cash on cash: 5.5% Airbnb Rental Income: $1158 Traditional Rental Income: $989 Airbnb ROI: 3.8% Traditional ROI: 5.5%
3401 FLUCOM RD De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 780 sq.ft.	$181,000	Airbnb cash on cash: 2.54% Traditional cash on cash: 4.66% Airbnb Rental Income: $1158 Traditional Rental Income: $1141 Airbnb ROI: 2.54% Traditional ROI: 4.66%
1592 Hickory Lndg De Soto, MO Priced to sell!! Seller has had a life change that is taking them out of the area and must...	2 beds \| 2 baths \| 2,657 sq.ft.	$274,999	Airbnb cash on cash: -0.06% Traditional cash on cash: 2.94% Airbnb Rental Income: $1158 Traditional Rental Income: $1552 Airbnb ROI: -0.06% Traditional ROI: 2.94%
700 Lovett St De Soto, MO Step inside! This Two-bedroom, one-bathroom home offers significant potential and was prev...	2 beds \| 1 baths \| 858 sq.ft.	$125,000	Airbnb cash on cash: 4.06% Traditional cash on cash: 6.53% Airbnb Rental Income: $1158 Traditional Rental Income: $1073 Airbnb ROI: 4.06% Traditional ROI: 6.53%
1539 Hickory Lndg De Soto, MO Welcome home to 1539 Hickory Landing, a beautiful ranch-style Villa built in 2024. This 3-...	3 beds \| 2 baths \| 1,604 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $1944 Airbnb ROI: N/A Traditional ROI: 4.45%
129 E Pratt St De Soto, MO This remodeled bungalow is move in ready and beaming with charm. A nice size level yard m...	1 beds \| 1 baths \| 616 sq.ft.	$89,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.57% Airbnb Rental Income: $null Traditional Rental Income: $709 Airbnb ROI: N/A Traditional ROI: 5.57%
706 Bogy St De Soto, MO Welcome to this beautifully updated split foyer home offering 4 bedrooms and 2 full bathro...	4 beds \| 2 baths \| 912 sq.ft.	$229,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.02% Airbnb Rental Income: $null Traditional Rental Income: $1464 Airbnb ROI: N/A Traditional ROI: 5.02%
123 E 2nd Street De Soto, MO Discover an Affordable 2 bedroom, 1 bath home in the heart of De Soto! this Charming Prope...	2 beds \| 1 baths \| 869 sq.ft.	$135,000	Airbnb cash on cash: 3.9% Traditional cash on cash: 7.21% Airbnb Rental Income: $1158 Traditional Rental Income: $1206 Airbnb ROI: 3.9% Traditional ROI: 7.21%
Lot 1B of Hawks Retreat De Soto, MO Lot 1B of Hawks Retreat, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.71% Airbnb Rental Income: $null Traditional Rental Income: $724 Airbnb ROI: N/A Traditional ROI: 0.71%
0 State Route 21 De Soto, MO 0 State Route 21, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$646,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.94% Airbnb Rental Income: $null Traditional Rental Income: $712 Airbnb ROI: N/A Traditional ROI: -0.94%
3933 Zell Cir De Soto, MO 3933 Zell Cir, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,344 sq.ft.	$167,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.75% Airbnb Rental Income: $null Traditional Rental Income: $1388 Airbnb ROI: N/A Traditional ROI: 5.75%
3700 State Road V De Soto, MO Approximately 34 acres with a 5-year-old custom home built for function, efficiency, and c...	4 beds \| 3 baths \| 2,698 sq.ft.	$850,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.67% Airbnb Rental Income: $null Traditional Rental Income: $2578 Airbnb ROI: N/A Traditional ROI: 1.67%
13670 Mammoth Rd De Soto, MO 13670 Mammoth Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,968 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.81% Airbnb Rental Income: $null Traditional Rental Income: $1853 Airbnb ROI: N/A Traditional ROI: 1.81%
1645 Brandywine Dr De Soto, MO STUNNING NEW BUILD located within Briarwood Estates lake & golf community, DeSoto address ...	3 beds \| 2 baths \| 1,600 sq.ft.	$349,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.86% Airbnb Rental Income: $null Traditional Rental Income: $1411 Airbnb ROI: N/A Traditional ROI: 2.86%
400 Hill Side Rd De Soto, MO 400 Hill Side Rd, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$55,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.47% Airbnb Rental Income: $null Traditional Rental Income: $857 Airbnb ROI: N/A Traditional ROI: 11.47%
14641 Engledow Springs Rd De Soto, MO 14641 Engledow Springs Rd, De Soto, MO 63020 \| Single Family Residential	N/A beds \| 1 baths \| 900 sq.ft.	$425,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.68% Airbnb Rental Income: $null Traditional Rental Income: $606 Airbnb ROI: N/A Traditional ROI: -0.68%
4305 Park Dr De Soto, MO Opportunity knocks at 4305 Park Dr in De Soto! Located in a desirable lake community, this...	2 beds \| 1 baths \| 1,050 sq.ft.	$99,900	Airbnb cash on cash: 4.19% Traditional cash on cash: 4.98% Airbnb Rental Income: $1158 Traditional Rental Income: $852 Airbnb ROI: 4.19% Traditional ROI: 4.98%
5270 US Highway 67 De Soto, MO 5270 US Highway 67, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$385,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.19% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: -0.19%
3948 Greenhouse Rd De Soto, MO 3948 Greenhouse Rd, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$105,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.33% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: 4.33%
605 E Stone St De Soto, MO	N/A beds \| N/A baths \| N/A	$64,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.16% Airbnb Rental Income: $null Traditional Rental Income: $747 Airbnb ROI: N/A Traditional ROI: 8.16%
1600 Hawkwood Trl De Soto, MO 1600 Hawkwood Trl, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$69,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.95% Airbnb Rental Income: $null Traditional Rental Income: $722 Airbnb ROI: N/A Traditional ROI: 6.95%
53 HIGHWAY E (vererans Dr) Dr De Soto, MO 53 HIGHWAY E (vererans Dr) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$50,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.63% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: 10.63%
4640 Dylan (lot 11) Dr De Soto, MO 4640 Dylan (lot 11) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$60,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.35% Airbnb Rental Income: $null Traditional Rental Income: $722 Airbnb ROI: N/A Traditional ROI: 8.35%
49 Monte Rosa Dr De Soto, MO 49 Monte Rosa Dr, De Soto, MO 63020 \| Single Family Residential	4 beds \| 3 baths \| 2,664 sq.ft.	$389,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.66% Airbnb Rental Income: $null Traditional Rental Income: $2224 Airbnb ROI: N/A Traditional ROI: 3.66%
2712 Creon De Soto, MO 2712 Creon, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,456 sq.ft.	$129,700	Airbnb cash on cash: N/A Traditional cash on cash: 7.98% Airbnb Rental Income: $null Traditional Rental Income: $1332 Airbnb ROI: N/A Traditional ROI: 7.98%
3548 State Road V De Soto, MO 3548 State Road V, De Soto, MO 63020 \| Single Family Residential	2 beds \| 1 baths \| 720 sq.ft.	$159,900	Airbnb cash on cash: 2.03% Traditional cash on cash: 1.67% Airbnb Rental Income: $1158 Traditional Rental Income: $721 Airbnb ROI: 2.03% Traditional ROI: 1.67%
308 N 7th St De Soto, MO 308 N 7th St, De Soto, MO 63020 \| Single Family Residential	2 beds \| 1 baths \| 832 sq.ft.	$125,000	Airbnb cash on cash: 3.72% Traditional cash on cash: 4.1% Airbnb Rental Income: $1158 Traditional Rental Income: $822 Airbnb ROI: 3.72% Traditional ROI: 4.1%
12928 Morgans Meadow Rd De Soto, MO 12928 Morgans Meadow Rd, De Soto, MO 63020 \| Single Family Residential	4 beds \| 3 baths \| 3,759 sq.ft.	$799,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.6% Airbnb Rental Income: $null Traditional Rental Income: $2039 Airbnb ROI: N/A Traditional ROI: 0.6%
1559 Berry Dairy Rd De Soto, MO 1559 Berry Dairy Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 3 baths \| 2,402 sq.ft.	$269,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.57% Airbnb Rental Income: $null Traditional Rental Income: $2002 Airbnb ROI: N/A Traditional ROI: 5.57%
4155 Highway 67 De Soto, MO 4155 Highway 67, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: -0.75% Airbnb Rental Income: $null Traditional Rental Income: $773 Airbnb ROI: N/A Traditional ROI: -0.75%
328 Sirius Rd De Soto, MO 328 Sirius Rd, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,792 sq.ft.	$155,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.92% Airbnb Rental Income: $null Traditional Rental Income: $1556 Airbnb ROI: N/A Traditional ROI: 7.92%
600 W Clement De Soto, MO Step inside this spacious and well-maintained 3 bed, 2 bath raised ranch offering comfort ...	3 beds \| 2 baths \| 1,196 sq.ft.	$234,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.09% Airbnb Rental Income: $null Traditional Rental Income: $1614 Airbnb ROI: N/A Traditional ROI: 5.09%
3980 Wilkinson Rd De Soto, MO 3980 Wilkinson Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,484 sq.ft.	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.69% Airbnb Rental Income: $null Traditional Rental Income: $1402 Airbnb ROI: N/A Traditional ROI: 2.69%
4267 Old Rd De Soto, MO Welcome to this vacant home set in a peaceful country setting surrounded by trees and fres...	2 beds \| 1 baths \| 848 sq.ft.	$145,000	Airbnb cash on cash: 3.15% Traditional cash on cash: 5.71% Airbnb Rental Income: $1158 Traditional Rental Income: $1132 Airbnb ROI: 3.15% Traditional ROI: 5.71%
217 Scenic Hills Dr De Soto, MO Walk-Out Ranch with Vaulted Ceilings, Divided Floor Plan, and 9' Basement Pour! This fresh...	3 beds \| 2 baths \| 1,628 sq.ft.	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.87% Airbnb Rental Income: $null Traditional Rental Income: $1797 Airbnb ROI: N/A Traditional ROI: 3.87%
1218 S 5th St De Soto, MO 1218 S 5th St, De Soto, MO 63020 \| Single Family Residential	2 beds \| 1 baths \| 996 sq.ft.	$79,900	Airbnb cash on cash: 6.73% Traditional cash on cash: 7.94% Airbnb Rental Income: $1158 Traditional Rental Income: $871 Airbnb ROI: 6.73% Traditional ROI: 7.94%

Real Estate investment in De-soto, MO

There are 70 properties for sale in the city of De Soto . The median list price in De Soto is $129,700 and the average price per square foot is $89. In May 2026, the average monthly cash on cash return in De Soto is 7.00%. The average monthly rental income in De Soto is $919.

De-soto, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 70 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Long-Term is higher than the Short-Term in De-soto with average rental income of $919.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, MO

2902 Clay Street

De Soto, MO

N/A beds | N/A baths | N/A

$530,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.92%

Airbnb Rental Income: $null

Traditional Rental Income: $1430

Airbnb ROI: N/A

Traditional ROI: 0.92%

3589 State Route 110

De Soto, MO

4 beds | 4 baths | 3,899 sq.ft.

$1,690,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.74%

Airbnb Rental Income: $null

Traditional Rental Income: $3360

Airbnb ROI: N/A

Traditional ROI: 0.74%

615 Perry St

De Soto, MO

2 beds | 1 baths | 775 sq.ft.

$165,000

Airbnb cash on cash: 2.82%

Traditional cash on cash: 3.73%

Airbnb Rental Income: $1158

Traditional Rental Income: $919

Airbnb ROI: 2.82%

Traditional ROI: 3.73%

13723 Willow Wind Dr

De Soto, MO

4 beds | 2 baths | 1,597 sq.ft.

$469,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.23%

Airbnb Rental Income: $null

Traditional Rental Income: $1847

Airbnb ROI: N/A

Traditional ROI: 2.23%

3772 GOLDENROD LN

De Soto, MO

2 beds | 1 baths | 768 sq.ft.

$130,000

Airbnb cash on cash: 3.8%

Traditional cash on cash: 5.5%

Airbnb Rental Income: $1158

Traditional Rental Income: $989

Airbnb ROI: 3.8%

Traditional ROI: 5.5%

3401 FLUCOM RD

De Soto, MO

2 beds | 1 baths | 780 sq.ft.

$181,000

Airbnb cash on cash: 2.54%

Traditional cash on cash: 4.66%

Airbnb Rental Income: $1158

Traditional Rental Income: $1141

Airbnb ROI: 2.54%

Traditional ROI: 4.66%

1592 Hickory Lndg

De Soto, MO

2 beds | 2 baths | 2,657 sq.ft.

$274,999

Airbnb cash on cash: -0.06%

Traditional cash on cash: 2.94%

Airbnb Rental Income: $1158

Traditional Rental Income: $1552

Airbnb ROI: -0.06%

Traditional ROI: 2.94%

700 Lovett St

De Soto, MO

2 beds | 1 baths | 858 sq.ft.

$125,000

Airbnb cash on cash: 4.06%

Traditional cash on cash: 6.53%

Airbnb Rental Income: $1158

Traditional Rental Income: $1073

Airbnb ROI: 4.06%