Real Estate Investment Properties for Sale in Defiance, MO

Looking for investment property in Defiance, MO with high ROI ?

Explore a variety of short-term homes & houses in Defiance, MO. Invest wisely with VRBO & Defiance, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Defiance, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
8 Whippoorwill Ct Defiance, MO This inviting log cabin nestled on 3 acres can be your own retreat! Gracious front walkway...	4 beds \| 3 baths \| 3,057 sq.ft.	$620,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.51% Airbnb Rental Income: $null Traditional Rental Income: $2468 Airbnb ROI: N/A Traditional ROI: 2.51%
800 Matson Hill Rd Defiance, MO Beautiful multilevel home on 8.25 wooded acres in the Wine Country of Defiance! Large entr...	4 beds \| 3 baths \| 2,479 sq.ft.	$649,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.44% Airbnb Rental Income: $null Traditional Rental Income: $2401 Airbnb ROI: N/A Traditional ROI: 2.44%
3901 Highway D Defiance, MO Full brick fixer upper to be sold "AS IS". Seller to make no repairs or warranty. Great in...	3 beds \| 1 baths \| 1,296 sq.ft.	$364,950	Airbnb cash on cash: 3.23% Traditional cash on cash: 1.13% Airbnb Rental Income: $2362 Traditional Rental Income: $1061 Airbnb ROI: 3.23% Traditional ROI: 1.13%
353 Callaway Ridge Drive Defiance, MO Experience the ultimate in privacy and natural beauty with this stunning custom waterfront...	3 beds \| 5 baths \| 4,037 sq.ft.	$2,750,000	Airbnb cash on cash: -0.67% Traditional cash on cash: 0.41% Airbnb Rental Income: $2362 Traditional Rental Income: $4526 Airbnb ROI: -0.67% Traditional ROI: 0.41%
2 Woodridge Dr Defiance, MO This handsome and spacious 4 bedroom 4 bath ranch home is beautifully situated on a 3 acre...	4 beds \| 3 baths \| 4,564 sq.ft.	$749,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.52% Airbnb Rental Income: $null Traditional Rental Income: $3849 Airbnb ROI: N/A Traditional ROI: 3.52%
110 Steeple Point Dr. Lot #14 Dr Defiance, MO 110 Steeple Point Dr. Lot #14 Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$238,900	Airbnb cash on cash: 0.84% Traditional cash on cash: 3.14% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 0.84% Traditional ROI: 3.14%
120 Steeple Point Dr. Lot #13 Dr Defiance, MO 120 Steeple Point Dr. Lot #13 Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$152,000	Airbnb cash on cash: 2.39% Traditional cash on cash: 5.97% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 2.39% Traditional ROI: 5.97%
180 Steeple Point Dr. Lot #7 Dr Defiance, MO 180 Steeple Point Dr. Lot #7 Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$151,000	Airbnb cash on cash: 2.42% Traditional cash on cash: 2.8% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: 2.42% Traditional ROI: 2.8%
130 Steeple Point Dr. Lot #12 Dr Defiance, MO 130 Steeple Point Dr. Lot #12 Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$151,000	Airbnb cash on cash: 2.42% Traditional cash on cash: 6.02% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 2.42% Traditional ROI: 6.02%
160 Steeple Point Dr. Lot #9 Dr Defiance, MO	N/A beds \| N/A baths \| N/A	$155,000	Airbnb cash on cash: 2.31% Traditional cash on cash: 2.68% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: 2.31% Traditional ROI: 2.68%
150 Steeple Point Dr. Lot #10 Dr Defiance, MO 150 Steeple Point Dr. Lot #10 Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$154,000	Airbnb cash on cash: 2.34% Traditional cash on cash: 5.87% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 2.34% Traditional ROI: 5.87%
161 Steeple Point Dr Defiance, MO 161 Steeple Point Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$165,000	Airbnb cash on cash: 2.06% Traditional cash on cash: 5.36% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 2.06% Traditional ROI: 5.36%
2461 Highway F Defiance, MO 2461 Highway F, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$449,900	Airbnb cash on cash: -0.35% Traditional cash on cash: 0.88% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: -0.35% Traditional ROI: 0.88%
449 Stones Throw Ct Defiance, MO 449 Stones Throw Ct, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$420,800	Airbnb cash on cash: -0.42% Traditional cash on cash: -0.28% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: -0.42% Traditional ROI: -0.28%
5011 Lily Rdg Defiance, MO 5011 Lily Rdg, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$279,900	Airbnb cash on cash: 0.44% Traditional cash on cash: 0.65% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: 0.44% Traditional ROI: 0.65%
5001 Lily Rdg Defiance, MO 5001 Lily Rdg, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$279,900	Airbnb cash on cash: 0.44% Traditional cash on cash: 2.41% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: 0.44% Traditional ROI: 2.41%
Lot 1 Boone Ridge Trl Defiance, MO Lot 1 Boone Ridge Trl, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$248,000	Airbnb cash on cash: 0.38% Traditional cash on cash: 0.62% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: 0.38% Traditional ROI: 0.62%
353 Callaway Ridge (25.5) Dr Defiance, MO Experience the ultimate in privacy and natural beauty with this stunning custom waterfront...	3 beds \| 4 baths \| 4,037 sq.ft.	$2,375,000	Airbnb cash on cash: -0.62% Traditional cash on cash: 0.66% Airbnb Rental Income: $2362 Traditional Rental Income: $4585 Airbnb ROI: -0.62% Traditional ROI: 0.66%
44 Wilderness Ln Defiance, MO 44 Wilderness Ln, Defiance, MO 63341 \| Single Family Residential	4 beds \| 2 baths \| 3,000 sq.ft.	$625,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.44% Airbnb Rental Income: $null Traditional Rental Income: $2108 Airbnb ROI: N/A Traditional ROI: 1.44%
3877 Highway D Defiance, MO 3877 Highway D, Defiance, MO 63341 \| Single Family Residential	3 beds \| 2 baths \| 1,600 sq.ft.	$520,000	Airbnb cash on cash: 1.51% Traditional cash on cash: 1.22% Airbnb Rental Income: $2362 Traditional Rental Income: $1641 Airbnb ROI: 1.51% Traditional ROI: 1.22%
1451 Highway F Defiance, MO 1451 Highway F, Defiance, MO 63341 \| Single Family Residential	3 beds \| 2 baths \| 1,944 sq.ft.	$679,900	Airbnb cash on cash: 0.7% Traditional cash on cash: 0.69% Airbnb Rental Income: $2362 Traditional Rental Income: $1778 Airbnb ROI: 0.7% Traditional ROI: 0.69%
4325 Hueffmeier Rd Defiance, MO 4325 Hueffmeier Rd, Defiance, MO 63341 \| Single Family Residential	4 beds \| 3 baths \| 5,609 sq.ft.	$1,690,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.58% Airbnb Rental Income: $null Traditional Rental Income: $2273 Airbnb ROI: N/A Traditional ROI: -0.58%
50 Sunfish Dr Defiance, MO 50 Sunfish Dr, Defiance, MO 63341 \| Single Family Residential	4 beds \| 4 baths \| 4,579 sq.ft.	$899,999	Airbnb cash on cash: N/A Traditional cash on cash: 1.3% Airbnb Rental Income: $null Traditional Rental Income: $2943 Airbnb ROI: N/A Traditional ROI: 1.3%
215 Rugged Acres Defiance, MO 215 Rugged Acres, Defiance, MO 63341 \| Single Family Residential	3 beds \| 2 baths \| 2,013 sq.ft.	$650,000	Airbnb cash on cash: 0.82% Traditional cash on cash: 1.84% Airbnb Rental Income: $2362 Traditional Rental Income: $2400 Airbnb ROI: 0.82% Traditional ROI: 1.84%
517 Callaway Estates Dr Defiance, MO 517 Callaway Estates Dr, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$350,000	Airbnb cash on cash: -0.11% Traditional cash on cash: 0.06% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: -0.11% Traditional ROI: 0.06%
214 Woodridge Ct Defiance, MO 214 Woodridge Ct, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$357,700	Airbnb cash on cash: -0.15% Traditional cash on cash: 1.4% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: -0.15% Traditional ROI: 1.4%
0 Defiance Rd Defiance, MO 0 Defiance Rd, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$425,000	Airbnb cash on cash: -0.26% Traditional cash on cash: -0.12% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: -0.26% Traditional ROI: -0.12%
4 Cooper's Ct Defiance, MO 4 Cooper's Ct, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$587,000	Airbnb cash on cash: -0.85% Traditional cash on cash: -0.75% Airbnb Rental Income: $1153 Traditional Rental Income: $827 Airbnb ROI: -0.85% Traditional ROI: -0.75%
12 Still Waters Ct Defiance, MO 12 Still Waters Ct, Defiance, MO 63341 \| Other	N/A beds \| N/A baths \| N/A	$350,000	Airbnb cash on cash: -0.11% Traditional cash on cash: 1.47% Airbnb Rental Income: $1153 Traditional Rental Income: $1292 Airbnb ROI: -0.11% Traditional ROI: 1.47%
60 Wilderness Lane Defiance, MO A rare opportunity tucked away on 3 beautiful acres. This 4 bd, 2.5 ba ranch offers the pe...	4 beds \| 3 baths \| 2,974 sq.ft.	$595,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.14% Airbnb Rental Income: $null Traditional Rental Income: $2871 Airbnb ROI: N/A Traditional ROI: 3.14%

Real Estate investment in Defiance, MO

There are 30 properties for sale in the city of Defiance . The median list price in Defiance is $374,776 and the average price per square foot is $260. In August 2026, the average monthly cash on cash return in Defiance is 1.00%. The average monthly rental income in Defiance is $1,292.

Defiance, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 30 investment properties available for sale in Defiance.

In 2026, the best neighborhood to buy investment property is Defiance.

The ROI for Short-Term is higher than the Long-Term in Defiance with average rental income of $1,153.

Your search for investment property begins and ends here

Investment Property for Sale in Defiance, MO

8 Whippoorwill Ct

Defiance, MO

4 beds | 3 baths | 3,057 sq.ft.

$620,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.51%

Airbnb Rental Income: $null

Traditional Rental Income: $2468

Airbnb ROI: N/A

Traditional ROI: 2.51%

800 Matson Hill Rd

Defiance, MO

4 beds | 3 baths | 2,479 sq.ft.

$649,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.44%

Airbnb Rental Income: $null

Traditional Rental Income: $2401

Airbnb ROI: N/A

Traditional ROI: 2.44%

3901 Highway D

Defiance, MO

3 beds | 1 baths | 1,296 sq.ft.

$364,950

Airbnb cash on cash: 3.23%

Traditional cash on cash: 1.13%

Airbnb Rental Income: $2362

Traditional Rental Income: $1061

Airbnb ROI: 3.23%

Traditional ROI: 1.13%

353 Callaway Ridge Drive

Defiance, MO

3 beds | 5 baths | 4,037 sq.ft.

$2,750,000

Airbnb cash on cash: -0.67%

Traditional cash on cash: 0.41%

Airbnb Rental Income: $2362

Traditional Rental Income: $4526

Airbnb ROI: -0.67%

Traditional ROI: 0.41%

2 Woodridge Dr

Defiance, MO

4 beds | 3 baths | 4,564 sq.ft.

$749,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.52%

Airbnb Rental Income: $null

Traditional Rental Income: $3849

Airbnb ROI: N/A

Traditional ROI: 3.52%

110 Steeple Point Dr. Lot #14 Dr

Defiance, MO

N/A beds | N/A baths | N/A

$238,900

Airbnb cash on cash: 0.84%

Traditional cash on cash: 3.14%

Airbnb Rental Income: $1153

Traditional Rental Income: $1292

Airbnb ROI: 0.84%

Traditional ROI: 3.14%

120 Steeple Point Dr. Lot #13 Dr

Defiance, MO

N/A beds | N/A baths | N/A

$152,000

Airbnb cash on cash: 2.39%

Traditional cash on cash: 5.97%

Airbnb Rental Income: $1153

Traditional Rental Income: $1292

Airbnb ROI: 2.39%

Traditional ROI: 5.97%

180 Steeple Point Dr. Lot #7 Dr

Defiance, MO

N/A beds | N/A baths | N/A

$151,000

Airbnb cash on cash: 2.42%

Traditional cash on cash: 2.8%

Airbnb Rental Income: $1153

Traditional Rental Income: $827

Airbnb ROI: 2.42%