Real Estate Investment Properties for Sale in Saint James, MO

Looking for investment property in Saint James, MO with high ROI ?

Explore a variety of short-term homes & houses in Saint James, MO. Invest wisely with VRBO & Saint James, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Saint James, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
701 Orchard St SAINT JAMES, MO 701 Orchard St, SAINT JAMES, MO 65401 \| Other	2 beds \| 1 baths \| 1,527 sq.ft.	$44,900	Airbnb cash on cash: 8.63% Traditional cash on cash: 6.44% Airbnb Rental Income: $924 Traditional Rental Income: $480 Airbnb ROI: 8.63% Traditional ROI: 6.44%
532 E James Blvd SAINT JAMES, MO Lovely 3 Bedroom, 2 Bath Tri-Level home. Living Room, kitchen and dining room on main leve...	4 beds \| 2 baths \| 1,618 sq.ft.	$259,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.51% Airbnb Rental Income: $null Traditional Rental Income: $1323 Airbnb ROI: N/A Traditional ROI: 3.51%
20602 County Road 1000 SAINT JAMES, MO FIXER UPPER OPPORTUNITY - "Mom didn't like to live fancy". Big clean out, then tear out, ...	N/A beds \| N/A baths \| 1,259 sq.ft.	$134,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.29% Airbnb Rental Income: $null Traditional Rental Income: $771 Airbnb ROI: N/A Traditional ROI: 3.29%
419 E Hardy St SAINT JAMES, MO 419 E Hardy St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,752 sq.ft.	$289,000	Airbnb cash on cash: 0.54% Traditional cash on cash: 3.43% Airbnb Rental Income: $1155 Traditional Rental Income: $1561 Airbnb ROI: 0.54% Traditional ROI: 3.43%
12280 County Road 3450 SAINT JAMES, MO 12280 County Road 3450, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 3 baths \| 2,848 sq.ft.	$345,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.01% Airbnb Rental Income: $null Traditional Rental Income: $2351 Airbnb ROI: N/A Traditional ROI: 5.01%
603 W Springfield St SAINT JAMES, MO 603 W Springfield St, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 1 baths \| 840 sq.ft.	$64,900	Airbnb cash on cash: 5.6% Traditional cash on cash: 9.15% Airbnb Rental Income: $924 Traditional Rental Income: $811 Airbnb ROI: 5.6% Traditional ROI: 9.15%
13689 County Road 3590 SAINT JAMES, MO 13689 County Road 3590, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 2 baths \| 1,792 sq.ft.	$289,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.47% Airbnb Rental Income: $null Traditional Rental Income: $1845 Airbnb ROI: N/A Traditional ROI: 4.47%
200 Missouri Ave SAINT JAMES, MO 200 Missouri Ave, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 1 baths \| 806 sq.ft.	$164,900	Airbnb cash on cash: 1.15% Traditional cash on cash: 0.5% Airbnb Rental Income: $924 Traditional Rental Income: $480 Airbnb ROI: 1.15% Traditional ROI: 0.5%
121 Anna St SAINT JAMES, MO 121 Anna St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,443 sq.ft.	$159,900	Airbnb cash on cash: 2.5% Traditional cash on cash: 5.3% Airbnb Rental Income: $1155 Traditional Rental Income: $1201 Airbnb ROI: 2.5% Traditional ROI: 5.3%
34 Jana Ln SAINT JAMES, MO 34 Jana Ln, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,392 sq.ft.	$95,000	Airbnb cash on cash: 5.39% Traditional cash on cash: 11.1% Airbnb Rental Income: $1155 Traditional Rental Income: $1302 Airbnb ROI: 5.39% Traditional ROI: 11.1%
15227 County Road 1110 SAINT JAMES, MO 15227 County Road 1110, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,888 sq.ft.	$689,900	Airbnb cash on cash: -0.91% Traditional cash on cash: -0.08% Airbnb Rental Income: $1155 Traditional Rental Income: $1302 Airbnb ROI: -0.91% Traditional ROI: -0.08%
19353 County Road 1140 SAINT JAMES, MO 19353 County Road 1140, SAINT JAMES, MO 65559 \| Other	N/A beds \| N/A baths \| N/A	$300,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.61% Airbnb Rental Income: $null Traditional Rental Income: $820 Airbnb ROI: N/A Traditional ROI: 0.61%
1524 Lola Ln SAINT JAMES, MO 1524 Lola Ln, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 3 baths \| 2,365 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.63% Airbnb Rental Income: $null Traditional Rental Income: $2139 Airbnb ROI: N/A Traditional ROI: 4.63%
20262 Highway 8 SAINT JAMES, MO 20262 Highway 8, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,247 sq.ft.	$390,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 0.87% Airbnb Rental Income: $1155 Traditional Rental Income: $1128 Airbnb ROI: -0.1% Traditional ROI: 0.87%
348 Saint Francis Ave SAINT JAMES, MO 348 Saint Francis Ave, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,118 sq.ft.	$169,900	Airbnb cash on cash: 2.25% Traditional cash on cash: 4.47% Airbnb Rental Income: $1155 Traditional Rental Income: $1134 Airbnb ROI: 2.25% Traditional ROI: 4.47%
24701 County Road 434 SAINT JAMES, MO Discover the perfect blend of privacy, functionality, and rural charm with this unique 7.2...	3 beds \| 2 baths \| 2,784 sq.ft.	$449,500	Airbnb cash on cash: 0.18% Traditional cash on cash: 4.03% Airbnb Rental Income: $1155 Traditional Rental Income: $2394 Airbnb ROI: 0.18% Traditional ROI: 4.03%
14394 Dillon Outer Rd SAINT JAMES, MO	3 beds \| 2 baths \| 1,888 sq.ft.	$179,000	Airbnb cash on cash: 2.03% Traditional cash on cash: 5.14% Airbnb Rental Income: $1155 Traditional Rental Income: $1302 Airbnb ROI: 2.03% Traditional ROI: 5.14%
100 E Scioto St SAINT JAMES, MO 100 E Scioto St, SAINT JAMES, MO 65559 \| Single Family Residential	5 beds \| 2 baths \| 2,464 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.08% Airbnb Rental Income: $null Traditional Rental Income: $1990 Airbnb ROI: N/A Traditional ROI: 8.08%
433 E Scioto St SAINT JAMES, MO 433 E Scioto St, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 2 baths \| 1,560 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.81% Airbnb Rental Income: $null Traditional Rental Income: $1323 Airbnb ROI: N/A Traditional ROI: 3.81%
307 W Eldon St SAINT JAMES, MO 307 W Eldon St, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 1 baths \| 816 sq.ft.	$95,900	Airbnb cash on cash: 3.26% Traditional cash on cash: 2.18% Airbnb Rental Income: $924 Traditional Rental Income: $480 Airbnb ROI: 3.26% Traditional ROI: 2.18%
17015 County Road 1020 SAINT JAMES, MO 17015 County Road 1020, SAINT JAMES, MO 65559 \| Single Family Residential	5 beds \| 3 baths \| 4,742 sq.ft.	$649,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.77% Airbnb Rental Income: $null Traditional Rental Income: $2357 Airbnb ROI: N/A Traditional ROI: 1.77%
224 W Scioto St SAINT JAMES, MO 224 W Scioto St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,566 sq.ft.	$229,900	Airbnb cash on cash: 1.17% Traditional cash on cash: 3.17% Airbnb Rental Income: $1155 Traditional Rental Income: $1210 Airbnb ROI: 1.17% Traditional ROI: 3.17%
19982 State Highway 8 SAINT JAMES, MO 19982 State Highway 8, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,440 sq.ft.	$330,000	Airbnb cash on cash: 0.23% Traditional cash on cash: 2.28% Airbnb Rental Income: $1155 Traditional Rental Income: $1408 Airbnb ROI: 0.23% Traditional ROI: 2.28%
218 W Eldon St SAINT JAMES, MO 218 W Eldon St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,750 sq.ft.	$199,900	Airbnb cash on cash: 1.63% Traditional cash on cash: 4.41% Airbnb Rental Income: $1155 Traditional Rental Income: $1302 Airbnb ROI: 1.63% Traditional ROI: 4.41%
517 S Jefferson St SAINT JAMES, MO Historic German Victorian home currently operating as a successful Airbnb with proven shor...	2 beds \| 1 baths \| 1,669 sq.ft.	$275,000	Airbnb cash on cash: 0.49% Traditional cash on cash: 5.55% Airbnb Rental Income: $924 Traditional Rental Income: $1939 Airbnb ROI: 0.49% Traditional ROI: 5.55%
1001 Dunham Rd SAINT JAMES, MO 1001 Dunham Rd, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 2 baths \| 1,920 sq.ft.	$445,000	Airbnb cash on cash: -0.79% Traditional cash on cash: 2.64% Airbnb Rental Income: $924 Traditional Rental Income: $2010 Airbnb ROI: -0.79% Traditional ROI: 2.64%
1017 Amanda St SAINT JAMES, MO 1017 Amanda St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,624 sq.ft.	$245,000	Airbnb cash on cash: 0.98% Traditional cash on cash: 4.22% Airbnb Rental Income: $1155 Traditional Rental Income: $1523 Airbnb ROI: 0.98% Traditional ROI: 4.22%
8 Saint Ann Ave SAINT JAMES, MO 8 Saint Ann Ave, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,080 sq.ft.	$140,000	Airbnb cash on cash: 3.11% Traditional cash on cash: 5.45% Airbnb Rental Income: $1155 Traditional Rental Income: $1088 Airbnb ROI: 3.11% Traditional ROI: 5.45%
8 Saint Ann Ave SAINT JAMES, MO 8 Saint Ann Ave, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 1 baths \| 1,080 sq.ft.	$140,000	Airbnb cash on cash: 3.11% Traditional cash on cash: 5.34% Airbnb Rental Income: $1155 Traditional Rental Income: $1072 Airbnb ROI: 3.11% Traditional ROI: 5.34%
24265 Cr-434 SAINT JAMES, MO 24265 Cr-434, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 2,020 sq.ft.	$345,900	Airbnb cash on cash: 0.13% Traditional cash on cash: 1.76% Airbnb Rental Income: $1155 Traditional Rental Income: $1302 Airbnb ROI: 0.13% Traditional ROI: 1.76%
310 State Route DD SAINT JAMES, MO 310 State Route DD, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 1 baths \| 924 sq.ft.	$179,900	Airbnb cash on cash: 0.89% Traditional cash on cash: 0.3% Airbnb Rental Income: $924 Traditional Rental Income: $480 Airbnb ROI: 0.89% Traditional ROI: 0.3%
310 State Route DD SAINT JAMES, MO 310 State Route DD, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 1 baths \| 924 sq.ft.	$189,900	Airbnb cash on cash: 0.74% Traditional cash on cash: 2.25% Airbnb Rental Income: $924 Traditional Rental Income: $854 Airbnb ROI: 0.74% Traditional ROI: 2.25%
435 Forest Ln SAINT JAMES, MO 435 Forest Ln, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 1 baths \| 1,876 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.92% Airbnb Rental Income: $null Traditional Rental Income: $1200 Airbnb ROI: N/A Traditional ROI: 2.92%
528 Home Dr SAINT JAMES, MO 528 Home Dr, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 3 baths \| 2,750 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.34% Airbnb Rental Income: $null Traditional Rental Income: $2283 Airbnb ROI: N/A Traditional ROI: 5.34%
635 Saint David St SAINT JAMES, MO 635 Saint David St, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,434 sq.ft.	$269,900	Airbnb cash on cash: 0.71% Traditional cash on cash: 3.46% Airbnb Rental Income: $1155 Traditional Rental Income: $1472 Airbnb ROI: 0.71% Traditional ROI: 3.46%
14920 Dillon Outer Rd SAINT JAMES, MO 14920 Dillon Outer Rd, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 1,848 sq.ft.	$199,900	Airbnb cash on cash: 1.63% Traditional cash on cash: 6.04% Airbnb Rental Income: $1155 Traditional Rental Income: $1612 Airbnb ROI: 1.63% Traditional ROI: 6.04%
17545 State Route H SAINT JAMES, MO 17545 State Route H, SAINT JAMES, MO 65559 \| Single Family Residential	4 beds \| 2 baths \| 3,682 sq.ft.	$690,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.63% Airbnb Rental Income: $null Traditional Rental Income: $1763 Airbnb ROI: N/A Traditional ROI: 0.63%
107 E Springfield St SAINT JAMES, MO 107 E Springfield St, SAINT JAMES, MO 65559 \| Single Family Residential	2 beds \| 2 baths \| 3,136 sq.ft.	$159,000	Airbnb cash on cash: 0.97% Traditional cash on cash: 0.37% Airbnb Rental Income: $924 Traditional Rental Income: $480 Airbnb ROI: 0.97% Traditional ROI: 0.37%
21875 Vineyard Outer Rd SAINT JAMES, MO 21875 Vineyard Outer Rd, SAINT JAMES, MO 65559 \| Single Family Residential	3 beds \| 2 baths \| 2,100 sq.ft.	$489,000	Airbnb cash on cash: -0.5% Traditional cash on cash: 1.76% Airbnb Rental Income: $1155 Traditional Rental Income: $1830 Airbnb ROI: -0.5% Traditional ROI: 1.76%
19320 Highway 8 - Tract 3 SAINT JAMES, MO 19320 Highway 8 - Tract 3, SAINT JAMES, MO 65559 \| Other	N/A beds \| N/A baths \| N/A	$165,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.78% Airbnb Rental Income: $null Traditional Rental Income: $838 Airbnb ROI: N/A Traditional ROI: 2.78%

Real Estate investment in Saint-james, MO

There are 40 properties for sale in the city of Saint James . The median list price in Saint James is $254,450 and the average price per square foot is $148. In November 2026, the average monthly cash on cash return in Saint James is 4.00%. The average monthly rental income in Saint James is $1,302.

Saint-james, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 40 investment properties available for sale in Saint-james.

In 2026, the best neighborhood to buy investment property is SAINT JAMES.

The ROI for Long-Term is higher than the Short-Term in Saint-james with average rental income of $1,302.

Your search for investment property begins and ends here

Investment Property for Sale in Saint James, MO

701 Orchard St

SAINT JAMES, MO

2 beds | 1 baths | 1,527 sq.ft.

$44,900

Airbnb cash on cash: 8.63%

Traditional cash on cash: 6.44%

Airbnb Rental Income: $924

Traditional Rental Income: $480

Airbnb ROI: 8.63%

Traditional ROI: 6.44%

532 E James Blvd

SAINT JAMES, MO

4 beds | 2 baths | 1,618 sq.ft.

$259,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.51%

Airbnb Rental Income: $null

Traditional Rental Income: $1323

Airbnb ROI: N/A

Traditional ROI: 3.51%

20602 County Road 1000

SAINT JAMES, MO

N/A beds | N/A baths | 1,259 sq.ft.

$134,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.29%

Airbnb Rental Income: $null

Traditional Rental Income: $771

Airbnb ROI: N/A

Traditional ROI: 3.29%

419 E Hardy St

SAINT JAMES, MO

3 beds | 2 baths | 1,752 sq.ft.

$289,000

Airbnb cash on cash: 0.54%

Traditional cash on cash: 3.43%

Airbnb Rental Income: $1155

Traditional Rental Income: $1561

Airbnb ROI: 0.54%

Traditional ROI: 3.43%

12280 County Road 3450

SAINT JAMES, MO

4 beds | 3 baths | 2,848 sq.ft.

$345,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.01%

Airbnb Rental Income: $null

Traditional Rental Income: $2351

Airbnb ROI: N/A

Traditional ROI: 5.01%

603 W Springfield St

SAINT JAMES, MO

2 beds | 1 baths | 840 sq.ft.

$64,900

Airbnb cash on cash: 5.6%

Traditional cash on cash: 9.15%

Airbnb Rental Income: $924

Traditional Rental Income: $811

Airbnb ROI: 5.6%

Traditional ROI: 9.15%

13689 County Road 3590

SAINT JAMES, MO

4 beds | 2 baths | 1,792 sq.ft.

$289,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.47%

Airbnb Rental Income: $null

Traditional Rental Income: $1845

Airbnb ROI: N/A

Traditional ROI: 4.47%

200 Missouri Ave

SAINT JAMES, MO

2 beds | 1 baths | 806 sq.ft.

$164,900

Airbnb cash on cash: 1.15%

Traditional cash on cash: 0.5%

Airbnb Rental Income: $924

Traditional Rental Income: $480

Airbnb ROI: 1.15%