Real Estate Investment Properties for Sale in Seneca, MO

Looking for investment property in Seneca, MO with high ROI ?

Explore a variety of short-term homes & houses in Seneca, MO. Invest wisely with VRBO & Seneca, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
436 Oneida Street Seneca, MO Welcome to timeless charm reimagined at 436 Oneida Street in Seneca, Missouri--a beautiful...	3 beds \| 3 baths \| 2,190 sq.ft.	$324,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.92% Airbnb Rental Income: $null Traditional Rental Income: $2619 Airbnb ROI: N/A Traditional ROI: 6.92%
1014 Cherokee Avenue Seneca, MO Experience refined elegance in this stunningly restored historic home, where timeless arch...	4 beds \| 3 baths \| 2,396 sq.ft.	$285,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.89% Airbnb Rental Income: $null Traditional Rental Income: $2573 Airbnb ROI: N/A Traditional ROI: 7.89%
1903 Cherry Street Seneca, MO 2 Bedroom, 1 Bathroom, Raised Ranch Style Home sitting on a Drive Under Garage and Unfinis...	2 beds \| 1 baths \| 912 sq.ft.	$169,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.86% Airbnb Rental Income: $null Traditional Rental Income: $1288 Airbnb ROI: N/A Traditional ROI: 5.86%
12609 State Hwy 43 Seneca, MO Great investment property! Two mobile homes with storage that includes separate space for ...	3 beds \| 2 baths \| 1,216 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.59% Airbnb Rental Income: $null Traditional Rental Income: $1567 Airbnb ROI: N/A Traditional ROI: 5.59%
1020 Seneca Avenue Seneca, MO Charming 2-bedroom, 1-bath home in Seneca featuring thoughtful updates! This well-maintain...	2 beds \| 1 baths \| 1,000 sq.ft.	$119,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.6% Airbnb Rental Income: $null Traditional Rental Income: $1124 Airbnb ROI: N/A Traditional ROI: 7.6%
1418 Cherokee Avenue Seneca, MO Located right in front of the Seneca Fire Department. Conveniently located next restaurant...	4 beds \| 2 baths \| 1,737 sq.ft.	$169,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.35% Airbnb Rental Income: $null Traditional Rental Income: $1991 Airbnb ROI: N/A Traditional ROI: 10.35%
5111 State Highway BB Seneca, MO This gated estate sits on 18+ Acres with a 2500+ square foot home, walk in pool and a 60x6...	5 beds \| 4 baths \| 2,562 sq.ft.	$724,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.57% Airbnb Rental Income: $null Traditional Rental Income: $2033 Airbnb ROI: N/A Traditional ROI: 1.57%
13860 Bethel Road Seneca, MO Peaceful country living with space, views, and room to enjoy! This well-maintained 3-bedro...	3 beds \| 2 baths \| 2,156 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.89% Airbnb Rental Income: $null Traditional Rental Income: $2151 Airbnb ROI: N/A Traditional ROI: 6.89%
606 Cemetery Road Seneca, MO Tucked inside Seneca city limits yet offering the peace and privacy of the countryside, th...	3 beds \| 2 baths \| 1,505 sq.ft.	$199,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.69% Airbnb Rental Income: $null Traditional Rental Income: $1845 Airbnb ROI: N/A Traditional ROI: 7.69%
1904 Cherry Street Seneca, MO Welcome home to this move-in ready 4-bedroom, 2.5-bath property perfectly situated on Cher...	4 beds \| 3 baths \| 2,773 sq.ft.	$259,900	Airbnb cash on cash: N/A Traditional cash on cash: 7% Airbnb Rental Income: $null Traditional Rental Income: $2291 Airbnb ROI: N/A Traditional ROI: 7%
1306 Curtin Avenue Seneca, MO Charming home on a corner lot in Seneca School District. It has been remodeled with beauti...	2 beds \| 1 baths \| 1,204 sq.ft.	$175,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $1242 Airbnb ROI: N/A Traditional ROI: 5.69%
514 Ottawa Street Seneca, MO Move in ready home in the heart of Seneca. Freshly remodeled with new flooring and paint, ...	2 beds \| 1 baths \| 1,053 sq.ft.	$89,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.75% Airbnb Rental Income: $null Traditional Rental Income: $1236 Airbnb ROI: N/A Traditional ROI: 11.75%
5053 State Route 43 Seneca, MO Escape to the peace and privacy of country living with this versatile 5-bedroom, 3-bath pr...	5 beds \| 3 baths \| 2,800 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.28% Airbnb Rental Income: $null Traditional Rental Income: $2667 Airbnb ROI: N/A Traditional ROI: 4.28%
336 Wills Lane Seneca, MO Peace in the Valley! This is the place you end up with after 35 years of work grooming and...	3 beds \| 2 baths \| 1,526 sq.ft.	$829,900	Airbnb cash on cash: N/A Traditional cash on cash: 0.98% Airbnb Rental Income: $null Traditional Rental Income: $1720 Airbnb ROI: N/A Traditional ROI: 0.98%
1429 Saint Anne Street Seneca, MO Enjoy the best of both worlds with this charming 3-bedroom, 1-bath home offering a peacefu...	3 beds \| 1 baths \| 953 sq.ft.	$169,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.99% Airbnb Rental Income: $null Traditional Rental Income: $1133 Airbnb ROI: N/A Traditional ROI: 4.99%
2394 Holly Road Seneca, MO Welcome to Holly Rd, where peaceful country living meets everyday comfort. Situated on 5.2...	3 beds \| 2 baths \| 2,200 sq.ft.	$219,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.01% Airbnb Rental Income: $null Traditional Rental Income: $1674 Airbnb ROI: N/A Traditional ROI: 6.01%
608 Chippewa Street Seneca, MO Discover your perfect slice of small-town charm at 608 Chippewa St., Seneca, MO 64865! Nes...	2 beds \| 2 baths \| 1,085 sq.ft.	$174,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.52% Airbnb Rental Income: $null Traditional Rental Income: $1416 Airbnb ROI: N/A Traditional ROI: 6.52%
907 Liberty Drive Seneca, MO Perched up on the hillside of Hillcrest Estates, you will find this excellent ranch style ...	3 beds \| 2 baths \| 1,705 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.95% Airbnb Rental Income: $null Traditional Rental Income: $1891 Airbnb ROI: N/A Traditional ROI: 6.95%
9664 Bethel Road Seneca, MO Newly remodeled. Split bedroom plan. A spacious covered, screened in front porch is perfec...	4 beds \| 2 baths \| 2,200 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.84% Airbnb Rental Income: $null Traditional Rental Income: $2147 Airbnb ROI: N/A Traditional ROI: 7.84%
608 Osage Street Seneca, MO Move-in ready 3 bed, 1 bath home on a large lot! Features an open kitchen and living room ...	3 beds \| 1 baths \| 1,300 sq.ft.	$149,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.36% Airbnb Rental Income: $null Traditional Rental Income: $1345 Airbnb ROI: N/A Traditional ROI: 7.36%

Real Estate investment in Seneca, MO

There are 21 properties for sale in the city of Seneca . The median list price in Seneca is $349,900 and the average price per square foot is $190. In May 2026, the average monthly cash on cash return in Seneca is 7.00%. The average monthly rental income in Seneca is $1,783.

Seneca, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 21 investment properties available for sale in Seneca.

The ROI for Short-Term is higher than the Long-Term in Seneca with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, MO

436 Oneida Street

Seneca, MO

3 beds | 3 baths | 2,190 sq.ft.

$324,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.92%

Airbnb Rental Income: $null

Traditional Rental Income: $2619

Airbnb ROI: N/A

Traditional ROI: 6.92%

1014 Cherokee Avenue

Seneca, MO

4 beds | 3 baths | 2,396 sq.ft.

$285,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.89%

Airbnb Rental Income: $null

Traditional Rental Income: $2573

Airbnb ROI: N/A

Traditional ROI: 7.89%

1903 Cherry Street

Seneca, MO

2 beds | 1 baths | 912 sq.ft.

$169,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.86%

Airbnb Rental Income: $null

Traditional Rental Income: $1288

Airbnb ROI: N/A

Traditional ROI: 5.86%

12609 State Hwy 43

Seneca, MO

3 beds | 2 baths | 1,216 sq.ft.

$225,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.59%

Airbnb Rental Income: $null

Traditional Rental Income: $1567

Airbnb ROI: N/A

Traditional ROI: 5.59%

1020 Seneca Avenue

Seneca, MO

2 beds | 1 baths | 1,000 sq.ft.

$119,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.6%

Airbnb Rental Income: $null

Traditional Rental Income: $1124

Airbnb ROI: N/A

Traditional ROI: 7.6%

1418 Cherokee Avenue

Seneca, MO

4 beds | 2 baths | 1,737 sq.ft.

$169,900

Airbnb cash on cash: N/A

Traditional cash on cash: 10.35%

Airbnb Rental Income: $null

Traditional Rental Income: $1991

Airbnb ROI: N/A

Traditional ROI: 10.35%

5111 State Highway BB

Seneca, MO

5 beds | 4 baths | 2,562 sq.ft.

$724,900

Airbnb cash on cash: N/A

Traditional cash on cash: 1.57%

Airbnb Rental Income: $null

Traditional Rental Income: $2033

Airbnb ROI: N/A

Traditional ROI: 1.57%

13860 Bethel Road

Seneca, MO

3 beds | 2 baths | 2,156 sq.ft.

$265,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.89%

Airbnb Rental Income: $null

Traditional Rental Income: $2151

Airbnb ROI: N/A