Real Estate Investment Properties for Sale in Seneca, MO

Looking for investment property in Seneca, MO with high ROI ?

Explore a variety of short-term homes & houses in Seneca, MO. Invest wisely with VRBO & Seneca, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
9698 Highway 43 Seneca, MO Not a cookie-cutter home! This spacious 3,187 sq ft property offers incredible flexibility...	3 beds \| 2 baths \| 3,187 sq.ft.	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.11% Airbnb Rental Income: $null Traditional Rental Income: $1610 Airbnb ROI: N/A Traditional ROI: 3.11%
7341 Bethel Road Seneca, MO Welcome to 7341 Bethel Rd-where modern luxury meets peaceful country living. Ideally posit...	5 beds \| 4 baths \| 4,138 sq.ft.	$650,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.5% Airbnb Rental Income: $null Traditional Rental Income: $2605 Airbnb ROI: N/A Traditional ROI: 2.5%
13453 Avalon Lane Seneca, MO Discover privacy, space, and charm with this traditional-style home nestled on 4.7 wooded ...	3 beds \| 2 baths \| 1,752 sq.ft.	$338,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $2371 Airbnb ROI: N/A Traditional ROI: 5.69%
12609 State Hwy 43 Seneca, MO Great investment property! Two mobile homes with storage that includes separate space for ...	3 beds \| 2 baths \| 1,216 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.59% Airbnb Rental Income: $null Traditional Rental Income: $1567 Airbnb ROI: N/A Traditional ROI: 5.59%
1020 Seneca Avenue Seneca, MO Cute little doll house! So many renovations have gone into this home. Central H/A, laminat...	2 beds \| 1 baths \| 1,000 sq.ft.	$119,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.6% Airbnb Rental Income: $null Traditional Rental Income: $1124 Airbnb ROI: N/A Traditional ROI: 7.6%
1418 Cherokee Avenue Seneca, MO Located right in front of the Seneca Fire Department. Conveniently located next restaurant...	4 beds \| 2 baths \| 1,737 sq.ft.	$169,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.35% Airbnb Rental Income: $null Traditional Rental Income: $1991 Airbnb ROI: N/A Traditional ROI: 10.35%
20540 HWY 43 Seneca, MO Welcome to your dream farmhouse retreat! This beautifully updated 3-bedroom, 2-bath home s...	3 beds \| 2 baths \| 1,504 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.99% Airbnb Rental Income: $null Traditional Rental Income: $1824 Airbnb ROI: N/A Traditional ROI: 5.99%
2004 Elm Street Seneca, MO Step inside and instantly feel at home in a cozy living room, where the fireplace creates ...	4 beds \| 3 baths \| 1,536 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.65% Airbnb Rental Income: $null Traditional Rental Income: $2061 Airbnb ROI: N/A Traditional ROI: 7.65%
431 Ottawa St Seneca, MO This adorable 3-bedroom, 1-bath home is full of updates and ready for new owners. Enjoy pe...	3 beds \| 1 baths \| 1,074 sq.ft.	$125,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.02% Airbnb Rental Income: $null Traditional Rental Income: $1327 Airbnb ROI: N/A Traditional ROI: 9.02%
608 Chippewa Street Seneca, MO Discover your perfect slice of small-town charm at 608 Chippewa St., Seneca, MO 64865! Nes...	2 beds \| 2 baths \| 1,085 sq.ft.	$174,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.52% Airbnb Rental Income: $null Traditional Rental Income: $1416 Airbnb ROI: N/A Traditional ROI: 6.52%
13860 Bethel Road Seneca, MO First time on the market! This one-owner Seneca home offers 3 beds, 2 baths, 2,128 sqft, a...	3 beds \| 2 baths \| 2,128 sq.ft.	$285,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.31% Airbnb Rental Income: $null Traditional Rental Income: $2151 Airbnb ROI: N/A Traditional ROI: 6.31%
6297 State Rte 43 Seneca, MO This property is a prime piece of real estate on Hwy 43. Surrounded by commercial property...	3 beds \| 1 baths \| 1,945 sq.ft.	$300,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.12% Airbnb Rental Income: $null Traditional Rental Income: $1616 Airbnb ROI: N/A Traditional ROI: 4.12%
606 Cemetery Road Seneca, MO Tucked inside Seneca city limits yet offering the peace and privacy of the countryside, th...	3 beds \| 2 baths \| 1,505 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.27% Airbnb Rental Income: $null Traditional Rental Income: $1845 Airbnb ROI: N/A Traditional ROI: 6.27%
1904 Cherry Street Seneca, MO Welcome home to this move-in ready 4-bedroom, 2.5-bath property perfectly situated on Cher...	4 beds \| 2 baths \| 2,773 sq.ft.	$305,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $2291 Airbnb ROI: N/A Traditional ROI: 5.69%
106 Greenfield Circle Seneca, MO Welcome to 106 Greenfield Circle in Seneca, a 3-bedroom, 1-bathroom home offering 1,258 sq...	3 beds \| 1 baths \| 1,258 sq.ft.	$125,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.03% Airbnb Rental Income: $null Traditional Rental Income: $1355 Airbnb ROI: N/A Traditional ROI: 9.03%
907 Warnall Circle Seneca, MO Welcome to 907 Warnall Circle, where the charm of small-town living meets stylish, modern ...	3 beds \| 2 baths \| 2,468 sq.ft.	$299,500	Airbnb cash on cash: N/A Traditional cash on cash: 5.82% Airbnb Rental Income: $null Traditional Rental Income: $2287 Airbnb ROI: N/A Traditional ROI: 5.82%
22 Oak Hill Drive Seneca, MO Welcome to this gorgeous home, where comfort meets convenience in the heart of Seneca. Thi...	3 beds \| 2 baths \| 1,400 sq.ft.	$224,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.36% Airbnb Rental Income: $null Traditional Rental Income: $1787 Airbnb ROI: N/A Traditional ROI: 6.36%
1816 Olive Street Seneca, MO Looking for a cozy home that doesn't break the bank? Look no further than 1816 Olive Stree...	3 beds \| 1 baths \| 1,292 sq.ft.	$129,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.94% Airbnb Rental Income: $null Traditional Rental Income: $1511 Airbnb ROI: N/A Traditional ROI: 9.94%
17981 Hottel Springs Rd Seneca, MO Tucked quietly along Hottel Springs Road on the outskirts of Seneca, this home rises from ...	5 beds \| 4 baths \| 5,557 sq.ft.	$574,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.52% Airbnb Rental Income: $null Traditional Rental Income: $3797 Airbnb ROI: N/A Traditional ROI: 5.52%
13591 Abilene Seneca, MO In a small town, tucked in the woods down a quiet dirt road, you'll find 13591 Abilene Lan...	2 beds \| 1 baths \| 784 sq.ft.	$102,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.34% Airbnb Rental Income: $null Traditional Rental Income: $1356 Airbnb ROI: N/A Traditional ROI: 11.34%
13595 Abilene Seneca, MO Tucked among mature trees on 5.26 peaceful acres, this inviting 4-bedroom, 2-bath home off...	4 beds \| 2 baths \| 1,863 sq.ft.	$201,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.09% Airbnb Rental Income: $null Traditional Rental Income: $2093 Airbnb ROI: N/A Traditional ROI: 9.09%
10626 W Highway 86 Seneca, MO Discover the perfect blend of comfort and countryside living in this impressive 2,613 squa...	3 beds \| 3 baths \| 2,613 sq.ft.	$320,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.83% Airbnb Rental Income: $null Traditional Rental Income: $2318 Airbnb ROI: N/A Traditional ROI: 5.83%

Real Estate investment in Seneca, MO

There are 22 properties for sale in the city of Seneca . The median list price in Seneca is $338,000 and the average price per square foot is $184. In February 2026, the average monthly cash on cash return in Seneca is 6.00%. The average monthly rental income in Seneca is $1,835.

Seneca, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 22 investment properties available for sale in Seneca.

The ROI for Short-Term is higher than the Long-Term in Seneca with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, MO

9698 Highway 43

Seneca, MO

3 beds | 2 baths | 3,187 sq.ft.

$360,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3.11%

Airbnb Rental Income: $null

Traditional Rental Income: $1610

Airbnb ROI: N/A

Traditional ROI: 3.11%

7341 Bethel Road

Seneca, MO

5 beds | 4 baths | 4,138 sq.ft.

$650,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.5%

Airbnb Rental Income: $null

Traditional Rental Income: $2605

Airbnb ROI: N/A

Traditional ROI: 2.5%

13453 Avalon Lane

Seneca, MO

3 beds | 2 baths | 1,752 sq.ft.

$338,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.69%

Airbnb Rental Income: $null

Traditional Rental Income: $2371

Airbnb ROI: N/A

Traditional ROI: 5.69%

12609 State Hwy 43

Seneca, MO

3 beds | 2 baths | 1,216 sq.ft.

$225,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.59%

Airbnb Rental Income: $null

Traditional Rental Income: $1567

Airbnb ROI: N/A

Traditional ROI: 5.59%

1020 Seneca Avenue

Seneca, MO

2 beds | 1 baths | 1,000 sq.ft.

$119,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.6%

Airbnb Rental Income: $null

Traditional Rental Income: $1124

Airbnb ROI: N/A

Traditional ROI: 7.6%

1418 Cherokee Avenue

Seneca, MO

4 beds | 2 baths | 1,737 sq.ft.

$169,900

Airbnb cash on cash: N/A

Traditional cash on cash: 10.35%

Airbnb Rental Income: $null

Traditional Rental Income: $1991

Airbnb ROI: N/A

Traditional ROI: 10.35%

20540 HWY 43

Seneca, MO

3 beds | 2 baths | 1,504 sq.ft.

$250,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.99%

Airbnb Rental Income: $null

Traditional Rental Income: $1824

Airbnb ROI: N/A

Traditional ROI: 5.99%

2004 Elm Street

Seneca, MO

4 beds | 3 baths | 1,536 sq.ft.

$229,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.65%

Airbnb Rental Income: $null

Traditional Rental Income: $2061

Airbnb ROI: N/A