Real Estate Investment Properties for Sale in Defiance, OH

Looking for investment property in Defiance, OH with high ROI ?

Explore a variety of short-term homes & houses in Defiance, OH. Invest wisely with VRBO & Defiance, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Defiance, OH

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
333 East St Defiance, OH Investor and homebuyer opportunity! This property was recently foreclosed upon and is now ...	4 beds \| 2 baths \| 1,408 sq.ft.	$175,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.34% Airbnb Rental Income: $null Traditional Rental Income: $2072 Airbnb ROI: N/A Traditional ROI: 9.34%
2851 N State Route 66 Defiance, OH Buy through Auction.com. This property is being offered for sale exclusively on Auction.co...	3 beds \| 2 baths \| 2,226 sq.ft.	$319,000	Airbnb cash on cash: 3.87% Traditional cash on cash: 5.66% Airbnb Rental Income: $2245 Traditional Rental Income: $2219 Airbnb ROI: 3.87% Traditional ROI: 5.66%
15172 Dohoney Rd Defiance, OH 15172 Dohoney Rd, Defiance, OH 43512 \| Single Family Residential	3 beds \| 2 baths \| 1,718 sq.ft.	$235,000	Airbnb cash on cash: 4.61% Traditional cash on cash: 6.65% Airbnb Rental Income: $2245 Traditional Rental Income: $2136 Airbnb ROI: 4.61% Traditional ROI: 6.65%
1461 Lee Ann Ave Defiance, OH 1461 Lee Ann Ave, Defiance, OH 43512 \| Single Family Residential	4 beds \| 2 baths \| 2,276 sq.ft.	$339,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.71% Airbnb Rental Income: $null Traditional Rental Income: $2762 Airbnb ROI: N/A Traditional ROI: 5.71%
20975 Buckskin Rd Defiance, OH 20975 Buckskin Rd, Defiance, OH 43512 \| Single Family Residential	3 beds \| 2 baths \| 1,293 sq.ft.	$268,900	Airbnb cash on cash: 3.72% Traditional cash on cash: 4.02% Airbnb Rental Income: $2245 Traditional Rental Income: $1758 Airbnb ROI: 3.72% Traditional ROI: 4.02%
Baltimore St Defiance, OH Baltimore St, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$149,900	Airbnb cash on cash: 3.62% Traditional cash on cash: 3.01% Airbnb Rental Income: $1396 Traditional Rental Income: $888 Airbnb ROI: 3.62% Traditional ROI: 3.01%
575 Cleveland Ave Defiance, OH	N/A beds \| N/A baths \| 0 sq.ft.	$250,000	Airbnb cash on cash: 1.19% Traditional cash on cash: 0.92% Airbnb Rental Income: $1396 Traditional Rental Income: $910 Airbnb ROI: 1.19% Traditional ROI: 0.92%
8627 N State Route 66 Defiance, OH 8627 N State Route 66, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$295,000	Airbnb cash on cash: 0.63% Traditional cash on cash: 0.39% Airbnb Rental Income: $1396 Traditional Rental Income: $909 Airbnb ROI: 0.63% Traditional ROI: 0.39%
1459 Deerwood Dr Defiance, OH	N/A beds \| N/A baths \| 0 sq.ft.	$72,900	Airbnb cash on cash: 9.71% Traditional cash on cash: 10.83% Airbnb Rental Income: $1396 Traditional Rental Income: $1055 Airbnb ROI: 9.71% Traditional ROI: 10.83%
0 Agnes St Defiance, OH 0 Agnes St, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$350,000	Airbnb cash on cash: 0.14% Traditional cash on cash: 0.7% Airbnb Rental Income: $1396 Traditional Rental Income: $1159 Airbnb ROI: 0.14% Traditional ROI: 0.7%
0 Domersville Rd Defiance, OH 0 Domersville Rd, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$4,740,000	Airbnb cash on cash: -2.35% Traditional cash on cash: -2.37% Airbnb Rental Income: $1396 Traditional Rental Income: $887 Airbnb ROI: -2.35% Traditional ROI: -2.37%
0 Carpenter Rd Defiance, OH 0 Carpenter Rd, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$612,856	Airbnb cash on cash: -1.01% Traditional cash on cash: -1.12% Airbnb Rental Income: $1396 Traditional Rental Income: $909 Airbnb ROI: -1.01% Traditional ROI: -1.12%
605 Riverside Ave Defiance, OH 605 Riverside Ave, Defiance, OH 43512 \| Single Family Residential	2 beds \| 1 baths \| 1,050 sq.ft.	$99,900	Airbnb cash on cash: 3.71% Traditional cash on cash: 11.17% Airbnb Rental Income: $1064 Traditional Rental Income: $1423 Airbnb ROI: 3.71% Traditional ROI: 11.17%
726 Indian Bridge Ln Defiance, OH 726 Indian Bridge Ln, Defiance, OH 43512 \| Single Family Residential	2 beds \| 1 baths \| 1,418 sq.ft.	$99,000	Airbnb cash on cash: 3.76% Traditional cash on cash: 10.23% Airbnb Rental Income: $1064 Traditional Rental Income: $1321 Airbnb ROI: 3.76% Traditional ROI: 10.23%
305 W 1st St Defiance, OH 305 W 1st St, Defiance, OH 43512 \| Single Family Residential	4 beds \| 2 baths \| 2,497 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.39% Airbnb Rental Income: $null Traditional Rental Income: $2437 Airbnb ROI: N/A Traditional ROI: 7.39%
336 Holgate Ave Defiance, OH 336 Holgate Ave, Defiance, OH 43512 \| Single Family Residential	4 beds \| 3 baths \| 2,566 sq.ft.	$279,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.19% Airbnb Rental Income: $null Traditional Rental Income: $2914 Airbnb ROI: N/A Traditional ROI: 8.19%
823 Nicholas St Defiance, OH 823 Nicholas St, Defiance, OH 43512 \| Single Family Residential	2 beds \| 1 baths \| 912 sq.ft.	$115,000	Airbnb cash on cash: 2.92% Traditional cash on cash: 7.42% Airbnb Rental Income: $1064 Traditional Rental Income: $1198 Airbnb ROI: 2.92% Traditional ROI: 7.42%
214 Union St Defiance, OH 214 Union St, Defiance, OH 43512 \| Single Family Residential	2 beds \| 1 baths \| 1,100 sq.ft.	$164,900	Airbnb cash on cash: 1.32% Traditional cash on cash: 6.4% Airbnb Rental Income: $1064 Traditional Rental Income: $1497 Airbnb ROI: 1.32% Traditional ROI: 6.4%
218 Union St Defiance, OH 218 Union St, Defiance, OH 43512 \| Single Family Residential	2 beds \| 1 baths \| 1,100 sq.ft.	$164,900	Airbnb cash on cash: 1.32% Traditional cash on cash: 6.67% Airbnb Rental Income: $1064 Traditional Rental Income: $1540 Airbnb ROI: 1.32% Traditional ROI: 6.67%
16407 St Rt 15 Defiance, OH 16407 St Rt 15, Defiance, OH 43512 \| Single Family Residential	4 beds \| 2 baths \| 2,125 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.5% Airbnb Rental Income: $null Traditional Rental Income: $2363 Airbnb ROI: N/A Traditional ROI: 5.5%
13332 St Rt 15 Defiance, OH 13332 St Rt 15, Defiance, OH 43512 \| Single Family Residential	3 beds \| 2 baths \| 1,741 sq.ft.	$359,000	Airbnb cash on cash: 2.17% Traditional cash on cash: 3.45% Airbnb Rental Income: $2245 Traditional Rental Income: $2113 Airbnb ROI: 2.17% Traditional ROI: 3.45%
00 Carpenter Rd Defiance, OH 00 Carpenter Rd, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| N/A	$1,999,200	Airbnb cash on cash: -2.08% Traditional cash on cash: -2.11% Airbnb Rental Income: $1396 Traditional Rental Income: $909 Airbnb ROI: -2.08% Traditional ROI: -2.11%
0 N St Rt 66 State Hwy Defiance, OH 0 N St Rt 66 State Highway, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| N/A	$199,000	Airbnb cash on cash: 2.13% Traditional cash on cash: 1.67% Airbnb Rental Income: $1396 Traditional Rental Income: $887 Airbnb ROI: 2.13% Traditional ROI: 1.67%
1481 Lee Ann Ave Defiance, OH 1481 Lee Ann Ave, Defiance, OH 43512 \| Single Family Residential	4 beds \| 2 baths \| 2,072 sq.ft.	$289,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.84% Airbnb Rental Income: $null Traditional Rental Income: $2688 Airbnb ROI: N/A Traditional ROI: 6.84%
85 Cypress Hill Dr Defiance, OH 85 Cypress Hill Dr, Defiance, OH 43512 \| Townhouse	3 beds \| 2 baths \| 1,433 sq.ft.	$219,900	Airbnb cash on cash: 4.56% Traditional cash on cash: 7.45% Airbnb Rental Income: $2245 Traditional Rental Income: $2283 Airbnb ROI: 4.56% Traditional ROI: 7.45%
22585 Defiance-paulding County Line Rd Defiance, OH 22585 Defiance-paulding County Line Rd, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| N/A	$185,000	Airbnb cash on cash: 2.47% Traditional cash on cash: 1.98% Airbnb Rental Income: $1396 Traditional Rental Income: $888 Airbnb ROI: 2.47% Traditional ROI: 1.98%
1506 Bristow Ct Defiance, OH 1506 Bristow Ct, Defiance, OH 43512 \| Condo/Coop	2 beds \| 2 baths \| 1,674 sq.ft.	$310,000	Airbnb cash on cash: -1.27% Traditional cash on cash: 4.72% Airbnb Rental Income: $1064 Traditional Rental Income: $2445 Airbnb ROI: -1.27% Traditional ROI: 4.72%
905 Corwin St Defiance, OH 905 Corwin St, Defiance, OH 43512 \| Single Family Residential	4 beds \| 3 baths \| 2,720 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.44% Airbnb Rental Income: $null Traditional Rental Income: $3194 Airbnb ROI: N/A Traditional ROI: 8.44%
1017 Wayne Ave Defiance, OH 1017 Wayne Ave, Defiance, OH 43512 \| Single Family Residential	3 beds \| 2 baths \| 1,248 sq.ft.	$160,000	Airbnb cash on cash: 7.87% Traditional cash on cash: 8.23% Airbnb Rental Income: $2245 Traditional Rental Income: $1737 Airbnb ROI: 7.87% Traditional ROI: 8.23%
91 Cypress Hill Dr Defiance, OH 91 Cypress Hill Dr, Defiance, OH 43512 \| Townhouse	4 beds \| 2 baths \| 1,811 sq.ft.	$253,305	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $2680 Airbnb ROI: N/A Traditional ROI: 7.81%
1398 Milwaukee Ave Defiance, OH	1 beds \| 1 baths \| 520 sq.ft.	$53,000	Airbnb cash on cash: -0.2% Traditional cash on cash: 11.16% Airbnb Rental Income: $486 Traditional Rental Income: $826 Airbnb ROI: -0.2% Traditional ROI: 11.16%
93 Cypress Hill Dr Defiance, OH 93 Cypress Hill Dr, Defiance, OH 43512 \| Townhouse	3 beds \| 2 baths \| 1,433 sq.ft.	$219,900	Airbnb cash on cash: 4.56% Traditional cash on cash: 7.45% Airbnb Rental Income: $2245 Traditional Rental Income: $2283 Airbnb ROI: 4.56% Traditional ROI: 7.45%
1765 S Jefferson Ave Defiance, OH 1765 S Jefferson Ave, Defiance, OH 43512 \| Other	N/A beds \| N/A baths \| N/A	$95,000	Airbnb cash on cash: 7% Traditional cash on cash: 6.06% Airbnb Rental Income: $1396 Traditional Rental Income: $888 Airbnb ROI: 7% Traditional ROI: 6.06%
207 Jefferson Ave Defiance, OH 207 Jefferson Ave, Defiance, OH 43512 \| Single Family Residential	4 beds \| 2 baths \| 2,294 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.2% Airbnb Rental Income: $null Traditional Rental Income: $2381 Airbnb ROI: N/A Traditional ROI: 8.2%
3541 Adams Ridge Rd Defiance, OH 3541 Adams Ridge Rd, Defiance, OH 43512 \| Single Family Residential	3 beds \| 2 baths \| 1,824 sq.ft.	$274,900	Airbnb cash on cash: 3.59% Traditional cash on cash: 5.69% Airbnb Rental Income: $2245 Traditional Rental Income: $2225 Airbnb ROI: 3.59% Traditional ROI: 5.69%
8820 Ohio 15 Defiance, OH 8820 Ohio 15, Defiance, OH 43512 \| Single Family Residential	3 beds \| 1 baths \| 1,568 sq.ft.	$195,000	Airbnb cash on cash: 6.04% Traditional cash on cash: 5.96% Airbnb Rental Income: $2245 Traditional Rental Income: $1667 Airbnb ROI: 6.04% Traditional ROI: 5.96%

Real Estate investment in Defiance, OH

There are 176 properties for sale in the city of Defiance . The median list price in Defiance is $184,112 and the average price per square foot is $120. In November 2026, the average monthly cash on cash return in Defiance is 7.00%. The average monthly rental income in Defiance is $1,815.

Defiance, OH Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 176 investment properties available for sale in Defiance.

In 2026, the best neighborhood to buy investment property is Defiance.

The ROI for Long-Term is higher than the Short-Term in Defiance with average rental income of $1,815.

Your search for investment property begins and ends here

Investment Property for Sale in Defiance, OH

333 East St

Defiance, OH

4 beds | 2 baths | 1,408 sq.ft.

$175,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.34%

Airbnb Rental Income: $null

Traditional Rental Income: $2072

Airbnb ROI: N/A

Traditional ROI: 9.34%

2851 N State Route 66

Defiance, OH

3 beds | 2 baths | 2,226 sq.ft.

$319,000

Airbnb cash on cash: 3.87%

Traditional cash on cash: 5.66%

Airbnb Rental Income: $2245

Traditional Rental Income: $2219

Airbnb ROI: 3.87%

Traditional ROI: 5.66%

15172 Dohoney Rd

Defiance, OH

3 beds | 2 baths | 1,718 sq.ft.

$235,000

Airbnb cash on cash: 4.61%

Traditional cash on cash: 6.65%

Airbnb Rental Income: $2245

Traditional Rental Income: $2136

Airbnb ROI: 4.61%

Traditional ROI: 6.65%

1461 Lee Ann Ave

Defiance, OH

4 beds | 2 baths | 2,276 sq.ft.

$339,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.71%

Airbnb Rental Income: $null

Traditional Rental Income: $2762

Airbnb ROI: N/A

Traditional ROI: 5.71%

20975 Buckskin Rd

Defiance, OH

3 beds | 2 baths | 1,293 sq.ft.

$268,900

Airbnb cash on cash: 3.72%

Traditional cash on cash: 4.02%

Airbnb Rental Income: $2245

Traditional Rental Income: $1758

Airbnb ROI: 3.72%

Traditional ROI: 4.02%

Baltimore St

Defiance, OH

N/A beds | N/A baths | 0 sq.ft.

$149,900

Airbnb cash on cash: 3.62%

Traditional cash on cash: 3.01%

Airbnb Rental Income: $1396

Traditional Rental Income: $888

Airbnb ROI: 3.62%

Traditional ROI: 3.01%

575 Cleveland Ave

Defiance, OH

N/A beds | N/A baths | 0 sq.ft.

$250,000

Airbnb cash on cash: 1.19%

Traditional cash on cash: 0.92%

Airbnb Rental Income: $1396

Traditional Rental Income: $910

Airbnb ROI: 1.19%

Traditional ROI: 0.92%

8627 N State Route 66

Defiance, OH

N/A beds | N/A baths | 0 sq.ft.

$295,000

Airbnb cash on cash: 0.63%

Traditional cash on cash: 0.39%

Airbnb Rental Income: $1396

Traditional Rental Income: $909

Airbnb ROI: 0.63%