Real Estate Investment Properties for Sale in Florence, SC

Looking for investment property in Florence, SC with high ROI ?

Explore a variety of short-term homes & houses in Florence, SC. Invest wisely with VRBO & Florence, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Florence, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2317 Lampley Way Florence, SC Welcome to this beautifully maintained 4-bedroom, 2.5-bath home located in the sought-afte...	4 beds \| 3 baths \| 1,967 sq.ft.	$299,900	Airbnb cash on cash: 3.01% Traditional cash on cash: 6.83% Airbnb Rental Income: $1889 Traditional Rental Income: $2463 Airbnb ROI: 3.01% Traditional ROI: 6.83%
3313 Trenton Street Florence, SC Welcome to this classic two-story brick home, perfectly positioned on a spacious .53-acre ...	4 beds \| 3 baths \| 2,670 sq.ft.	$379,000	Airbnb cash on cash: 2.07% Traditional cash on cash: 5.97% Airbnb Rental Income: $1889 Traditional Rental Income: $2773 Airbnb ROI: 2.07% Traditional ROI: 5.97%
1914 Deerwood Place Florence, SC Welcome to 1914 Deerwood Place, a beautifully updated home tucked away on a quiet cul-de-s...	4 beds \| 3 baths \| 2,696 sq.ft.	$439,900	Airbnb cash on cash: 2.01% Traditional cash on cash: 5.49% Airbnb Rental Income: $1889 Traditional Rental Income: $2819 Airbnb ROI: 2.01% Traditional ROI: 5.49%
3109 Duchess Ln. Florence, SC Welcome to the desirable Kingsgate neighborhood! This 4-bedroom home (plus a large bonus r...	4 beds \| 4 baths \| 2,856 sq.ft.	$525,000	Airbnb cash on cash: 1.59% Traditional cash on cash: 4.82% Airbnb Rental Income: $1889 Traditional Rental Income: $2969 Airbnb ROI: 1.59% Traditional ROI: 4.82%
1465 Gardener Rd. Florence, SC Welcome to 1465 Gardener Road, a beautifully maintained single-story home located in the d...	3 beds \| 2 baths \| 1,514 sq.ft.	$259,900	Airbnb cash on cash: 1.08% Traditional cash on cash: 6.13% Airbnb Rental Income: $1116 Traditional Rental Income: $1981 Airbnb ROI: 1.08% Traditional ROI: 6.13%
3107 Duchess Lane Florence, SC Discover Your Dream Home in Florence's Premier Neighborhood Welcome to a stunning four-be...	4 beds \| 4 baths \| 3,705 sq.ft.	$739,900	Airbnb cash on cash: 0.85% Traditional cash on cash: 3.65% Airbnb Rental Income: $1889 Traditional Rental Income: $3320 Airbnb ROI: 0.85% Traditional ROI: 3.65%
906/908 Sherwood Drive Florence, SC Brick duplex. Each side has 2 bedrooms and 1 bathroom. Large great room. Outside storage ...	N/A beds \| N/A baths \| N/A	$207,000	Airbnb cash on cash: 4.93% Traditional cash on cash: 4.63% Airbnb Rental Income: $1889 Traditional Rental Income: $1327 Airbnb ROI: 4.93% Traditional ROI: 4.63%
1915 Damon Drive Florence, SC Well maintained home situated on corner lot in established neighborhood. Spacious step d...	3 beds \| 3 baths \| 1,900 sq.ft.	$259,900	Airbnb cash on cash: 1.41% Traditional cash on cash: 7.07% Airbnb Rental Income: $1116 Traditional Rental Income: $2129 Airbnb ROI: 1.41% Traditional ROI: 7.07%
418 Chippenham Lane Florence, SC Updated 3 bedrooms 2 bath house in West Florence neighborhood, Foxcroft. Conveniently loc...	3 beds \| 2 baths \| 1,710 sq.ft.	$244,900	Airbnb cash on cash: 1.23% Traditional cash on cash: 6.45% Airbnb Rental Income: $1116 Traditional Rental Income: $1948 Airbnb ROI: 1.23% Traditional ROI: 6.45%
808 Cloisters Drive Florence, SC Beautifully Maintained Home located in the Cloisters Subdivision in Florence SC. Large Liv...	3 beds \| 3 baths \| 2,340 sq.ft.	$329,900	Airbnb cash on cash: 0.52% Traditional cash on cash: 6.15% Airbnb Rental Income: $1116 Traditional Rental Income: $2485 Airbnb ROI: 0.52% Traditional ROI: 6.15%
3241 Lakeshore Drive Florence, SC Discover your perfect 4000 sq-ft, lakefront sanctuary in this stunning four-bedroom, four-...	4 beds \| 5 baths \| 4,000 sq.ft.	$849,900	Airbnb cash on cash: 0.07% Traditional cash on cash: 5.01% Airbnb Rental Income: $1889 Traditional Rental Income: $5299 Airbnb ROI: 0.07% Traditional ROI: 5.01%
2614 Kingston Dr Florence, SC This home has so much to offer. Featuring 3 bedrooms, 2 bathrooms, large lot, attached car...	3 beds \| 2 baths \| 1,871 sq.ft.	$163,000	Airbnb cash on cash: 2.6% Traditional cash on cash: 11.28% Airbnb Rental Income: $1116 Traditional Rental Income: $2092 Airbnb ROI: 2.6% Traditional ROI: 11.28%
1305 Virginia Acres Florence, SC A must see well maintained brick home with 3 bedrooms and 2 baths all on a 1/2 acre lot lo...	3 beds \| 2 baths \| 1,646 sq.ft.	$214,000	Airbnb cash on cash: 1.63% Traditional cash on cash: 7.59% Airbnb Rental Income: $1116 Traditional Rental Income: $1950 Airbnb ROI: 1.63% Traditional ROI: 7.59%
3406 Sussex Court Florence, SC Welcome to this fabulous home and what it offers. Beautiful traditional floor plan with l...	4 beds \| 4 baths \| 3,477 sq.ft.	$439,500	Airbnb cash on cash: 1.57% Traditional cash on cash: 6.4% Airbnb Rental Income: $1889 Traditional Rental Income: $3374 Airbnb ROI: 1.57% Traditional ROI: 6.4%
844 Ventura Court Florence, SC New Construction by Golden Construction. Conveniently located in Clark Place subdivision. ...	3 beds \| N/A baths \| 1,367 sq.ft.	$195,000	Airbnb cash on cash: 1.93% Traditional cash on cash: 8.11% Airbnb Rental Income: $1116 Traditional Rental Income: $1886 Airbnb ROI: 1.93% Traditional ROI: 8.11%
1007 W. Palmetto St Florence, SC This charming 1933 property offers flexibility for a single-family home or an income-produ...	4 beds \| 4 baths \| 4,236 sq.ft.	$350,000	Airbnb cash on cash: 2.36% Traditional cash on cash: 9.73% Airbnb Rental Income: $1889 Traditional Rental Income: $3806 Airbnb ROI: 2.36% Traditional ROI: 9.73%
1868 Houndsfield Drive Florence, SC Experience refined country living in Houndsfield Estates, just minutes from downtown Flore...	4 beds \| 5 baths \| 4,750 sq.ft.	$850,000	Airbnb cash on cash: 0.07% Traditional cash on cash: 4.13% Airbnb Rental Income: $1889 Traditional Rental Income: $4599 Airbnb ROI: 0.07% Traditional ROI: 4.13%
1066 Via Salvatore Florence, SC Welcome to 1066 Via Salvatore, where modern elegance meets everyday comfort in the sought-...	4 beds \| N/A baths \| 2,238 sq.ft.	$355,000	Airbnb cash on cash: 2.31% Traditional cash on cash: 6.03% Airbnb Rental Income: $1889 Traditional Rental Income: $2625 Airbnb ROI: 2.31% Traditional ROI: 6.03%
1460 Chandler Circle Florence, SC	3 beds \| 3 baths \| 1,904 sq.ft.	$299,000	Airbnb cash on cash: 0.27% Traditional cash on cash: 5.5% Airbnb Rental Income: $1116 Traditional Rental Income: $2213 Airbnb ROI: 0.27% Traditional ROI: 5.5%
2910 Redwood Dr Florence, SC This 4-bedroom, 2.5-bathroom home offers an incredible opportunity to make it your own. Ne...	4 beds \| 3 baths \| 2,027 sq.ft.	$179,900	Airbnb cash on cash: 5.65% Traditional cash on cash: 9.42% Airbnb Rental Income: $1889 Traditional Rental Income: $2030 Airbnb ROI: 5.65% Traditional ROI: 9.42%
904 Beverly Drive Florence, SC	3 beds \| 2 baths \| 2,268 sq.ft.	$305,000	Airbnb cash on cash: 0.97% Traditional cash on cash: 4.75% Airbnb Rental Income: $1116 Traditional Rental Income: $1826 Airbnb ROI: 0.97% Traditional ROI: 4.75%
708 Muirfield Place Florence, SC Welcome to 708 Muirfield Place, a stunning all-brick home nestled on the water in prestigi...	4 beds \| 4 baths \| 3,809 sq.ft.	$579,500	Airbnb cash on cash: -0.17% Traditional cash on cash: 2.54% Airbnb Rental Income: $1889 Traditional Rental Income: $2852 Airbnb ROI: -0.17% Traditional ROI: 2.54%
3000 Willett Ct. Florence, SC Looking for space, style, and a great location? This 4-bedroom, 2.5-bath corner lot home h...	4 beds \| 3 baths \| 2,312 sq.ft.	$435,000	Airbnb cash on cash: 1.6% Traditional cash on cash: 3.66% Airbnb Rental Income: $1889 Traditional Rental Income: $2222 Airbnb ROI: 1.6% Traditional ROI: 3.66%
1801 Woods Drive Florence, SC Charming 3 Bedroom, 2 Bath Home â Move-In Ready! Welcome to this beautiful and well-main...	3 beds \| 2 baths \| 1,564 sq.ft.	$235,000	Airbnb cash on cash: 1.35% Traditional cash on cash: 6.8% Airbnb Rental Income: $1116 Traditional Rental Income: $1954 Airbnb ROI: 1.35% Traditional ROI: 6.8%
1244 Strada Amore #3 Florence, SC Welcome to 1244 Strada Amore! This well maintained 2-bedroom, 2-bathroom second floor cond...	2 beds \| 2 baths \| 1,475 sq.ft.	$160,000	Airbnb cash on cash: 0.65% Traditional cash on cash: 5.57% Airbnb Rental Income: $1052 Traditional Rental Income: $1439 Airbnb ROI: 0.65% Traditional ROI: 5.57%
213 Creek Drive Florence, SC Well maintained home located in established neighborhood. This charming 2 bedroom, 1 bath ...	2 beds \| 1 baths \| 1,389 sq.ft.	$170,000	Airbnb cash on cash: 2.1% Traditional cash on cash: 5.75% Airbnb Rental Income: $1052 Traditional Rental Income: $1279 Airbnb ROI: 2.1% Traditional ROI: 5.75%
130 Mustang Rd Florence, SC 2 Brick Ranch Homes---1) Home 3/1 Super Nice inside & 1 - Brick Ranch Home 3/...	3 beds \| 1 baths \| 1,316 sq.ft.	$449,900	Airbnb cash on cash: 0.17% Traditional cash on cash: 1.63% Airbnb Rental Income: $1116 Traditional Rental Income: $1356 Airbnb ROI: 0.17% Traditional ROI: 1.63%
494 Gloria Ct Florence, SC Welcome to 494 Gloria Court â a newer home full of charm and comfort, located just steps...	3 beds \| 3 baths \| 1,887 sq.ft.	$314,000	Airbnb cash on cash: 0.63% Traditional cash on cash: 4.4% Airbnb Rental Income: $1116 Traditional Rental Income: $1856 Airbnb ROI: 0.63% Traditional ROI: 4.4%
1013 Summer Duck Loop Florence, SC First Floor Main bedroom and Fully Fenced In Yard!!!! This beautiful home, built in 2023...	4 beds \| 3 baths \| 2,145 sq.ft.	$339,900	Airbnb cash on cash: 2.48% Traditional cash on cash: 5.47% Airbnb Rental Income: $1889 Traditional Rental Income: $2340 Airbnb ROI: 2.48% Traditional ROI: 5.47%
2600 Kingston Dr. Florence, SC Welcome to 2600 Kingston Drive in the Parkwood neighborhood!?This charming single-story ho...	3 beds \| 2 baths \| 1,428 sq.ft.	$229,900	Airbnb cash on cash: 1.91% Traditional cash on cash: 5.22% Airbnb Rental Income: $1116 Traditional Rental Income: $1461 Airbnb ROI: 1.91% Traditional ROI: 5.22%
4169 Rodanthe Cir. Florence, SC Welcome home to this stunning 4-bedroom, 3.5-bathroom home nestled in the desirable West F...	4 beds \| 4 baths \| 2,573 sq.ft.	$449,900	Airbnb cash on cash: 1.76% Traditional cash on cash: 4.56% Airbnb Rental Income: $1889 Traditional Rental Income: $2567 Airbnb ROI: 1.76% Traditional ROI: 4.56%
3155 S Cashua Drive, #11 Florence, SC WELCOME HOME to this cozy and beautiful two bedroom, two bath condo in Pine Lakes Subdivis...	2 beds \| 2 baths \| 1,200 sq.ft.	$133,900	Airbnb cash on cash: 2.2% Traditional cash on cash: 6.25% Airbnb Rental Income: $1052 Traditional Rental Income: $1208 Airbnb ROI: 2.2% Traditional ROI: 6.25%
226 S Wallace Road Florence, SC What a fantastic property with tons of updatesâand boy, does it look good! This 3-bedroo...	3 beds \| 2 baths \| 1,650 sq.ft.	$245,000	Airbnb cash on cash: 1.23% Traditional cash on cash: 5.3% Airbnb Rental Income: $1116 Traditional Rental Income: $1683 Airbnb ROI: 1.23% Traditional ROI: 5.3%
313 S Gaillard St Florence, SC Three bedroom oand one bathroom home in Florence, SC is seconds from McLeod Hospital. With...	3 beds \| 1 baths \| 1,074 sq.ft.	$165,000	Airbnb cash on cash: 2.82% Traditional cash on cash: 6.99% Airbnb Rental Income: $1116 Traditional Rental Income: $1396 Airbnb ROI: 2.82% Traditional ROI: 6.99%
1110-G Third Loop Road Florence, SC Location, location, location, located off 3rd Loop near center of town/Desirable Brick Bon...	3 beds \| 2 baths \| 1,300 sq.ft.	$132,000	Airbnb cash on cash: 3.81% Traditional cash on cash: 11.78% Airbnb Rental Income: $1116 Traditional Rental Income: $1752 Airbnb ROI: 3.81% Traditional ROI: 11.78%
2220 Oakwood Lane APT A8 Florence, SC Welcome to your new home. Nestled within the quiet Foxboro Subdivision this beautiful 2 be...	2 beds \| 2 baths \| 1,088 sq.ft.	$127,900	Airbnb cash on cash: 3.26% Traditional cash on cash: 9.66% Airbnb Rental Income: $1052 Traditional Rental Income: $1475 Airbnb ROI: 3.26% Traditional ROI: 9.66%
1002 Romsey Place Florence, SC What a fantastic property overlooking Lake Oakdaleâpacked with updates and ready to impr...	3 beds \| 3 baths \| 2,385 sq.ft.	$365,000	Airbnb cash on cash: 0.58% Traditional cash on cash: 5.09% Airbnb Rental Income: $1116 Traditional Rental Income: $2285 Airbnb ROI: 0.58% Traditional ROI: 5.09%
1451 Gregg Ave. Florence, SC A lovely little bungalow on a large corner lot in W Florence with lots of quaint charm. Co...	3 beds \| 1 baths \| 990 sq.ft.	$155,850	Airbnb cash on cash: 2.63% Traditional cash on cash: 8.34% Airbnb Rental Income: $1116 Traditional Rental Income: $1591 Airbnb ROI: 2.63% Traditional ROI: 8.34%
2797 Leola Hill Drive Florence, SC Nestled on the outskirts of Florence, SC, this beautifully updated 3-bedroom, 2-full bathr...	3 beds \| 2 baths \| 1,680 sq.ft.	$189,000	Airbnb cash on cash: 2.4% Traditional cash on cash: 8.01% Airbnb Rental Income: $1116 Traditional Rental Income: $1750 Airbnb ROI: 2.4% Traditional ROI: 8.01%
2207 S Vance Drive Florence, SC Welcome to this inviting 3-bedroom, 2-bathroom home situated in the heart of Florence, SC....	3 beds \| 2 baths \| 1,620 sq.ft.	$249,000	Airbnb cash on cash: 1.5% Traditional cash on cash: 6.43% Airbnb Rental Income: $1116 Traditional Rental Income: $1901 Airbnb ROI: 1.5% Traditional ROI: 6.43%

Real Estate investment in Florence, SC

There are 244 properties for sale in the city of Florence . The median list price in Florence is $299,900 and the average price per square foot is $135. In November 2025, the average monthly cash on cash return in Florence is 6.00%. The average monthly rental income in Florence is $2,143.

Florence, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 244 investment properties available for sale in Florence.

In 2025, the best neighborhood to buy investment property is Florence.

The ROI for Long-Term is higher than the Short-Term in Florence with average rental income of $2,143.

Your search for investment property begins and ends here

Investment Property for Sale in Florence, SC

2317 Lampley Way

Florence, SC

4 beds | 3 baths | 1,967 sq.ft.

$299,900

Airbnb cash on cash: 3.01%

Traditional cash on cash: 6.83%

Airbnb Rental Income: $1889

Traditional Rental Income: $2463

Airbnb ROI: 3.01%

Traditional ROI: 6.83%

3313 Trenton Street

Florence, SC

4 beds | 3 baths | 2,670 sq.ft.

$379,000

Airbnb cash on cash: 2.07%

Traditional cash on cash: 5.97%

Airbnb Rental Income: $1889

Traditional Rental Income: $2773

Airbnb ROI: 2.07%

Traditional ROI: 5.97%

1914 Deerwood Place

Florence, SC

4 beds | 3 baths | 2,696 sq.ft.

$439,900

Airbnb cash on cash: 2.01%

Traditional cash on cash: 5.49%

Airbnb Rental Income: $1889

Traditional Rental Income: $2819

Airbnb ROI: 2.01%

Traditional ROI: 5.49%

3109 Duchess Ln.

Florence, SC

4 beds | 4 baths | 2,856 sq.ft.

$525,000

Airbnb cash on cash: 1.59%

Traditional cash on cash: 4.82%

Airbnb Rental Income: $1889

Traditional Rental Income: $2969

Airbnb ROI: 1.59%

Traditional ROI: 4.82%

1465 Gardener Rd.

Florence, SC

3 beds | 2 baths | 1,514 sq.ft.

$259,900

Airbnb cash on cash: 1.08%

Traditional cash on cash: 6.13%

Airbnb Rental Income: $1116

Traditional Rental Income: $1981

Airbnb ROI: 1.08%

Traditional ROI: 6.13%

3107 Duchess Lane

Florence, SC

4 beds | 4 baths | 3,705 sq.ft.

$739,900

Airbnb cash on cash: 0.85%

Traditional cash on cash: 3.65%

Airbnb Rental Income: $1889

Traditional Rental Income: $3320

Airbnb ROI: 0.85%

Traditional ROI: 3.65%

906/908 Sherwood Drive

Florence, SC

N/A beds | N/A baths | N/A

$207,000

Airbnb cash on cash: 4.93%

Traditional cash on cash: 4.63%

Airbnb Rental Income: $1889

Traditional Rental Income: $1327

Airbnb ROI: 4.93%

Traditional ROI: 4.63%

1915 Damon Drive

Florence, SC

3 beds | 3 baths | 1,900 sq.ft.

$259,900

Airbnb cash on cash: 1.41%

Traditional cash on cash: 7.07%

Airbnb Rental Income: $1116

Traditional Rental Income: $2129

Airbnb ROI: 1.41%