Real Estate Investment Properties for Sale in Lake City, SC

Looking for investment property in Lake City, SC with high ROI ?

Explore a variety of short-term homes & houses in Lake City, SC. Invest wisely with VRBO & Lake City, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Lake City, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
605 E Main St LAKE CITY, SC Own this a beautiful home in downtown Lake City, S.C. Established in 1936, the character o...	3 beds \| 2 baths \| 2,923 sq.ft.	$244,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.37% Airbnb Rental Income: $null Traditional Rental Income: $2385 Airbnb ROI: N/A Traditional ROI: 8.37%
520 E Main Street LAKE CITY, SC Welcome to peaceful living and stylish functionality! This 3 bedroom, 2 bath home is brimm...	3 beds \| 2 baths \| 2,620 sq.ft.	$322,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.4% Airbnb Rental Income: $null Traditional Rental Income: $2662 Airbnb ROI: N/A Traditional ROI: 6.4%
1484 Fitch Rd LAKE CITY, SC Luxurious 3-Bedroom Retreat on 3 Lush Acres â Your Private Oasis Awaits! Escape to elega...	3 beds \| 2 baths \| 4,089 sq.ft.	$574,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.7% Airbnb Rental Income: $null Traditional Rental Income: $2207 Airbnb ROI: N/A Traditional ROI: 2.7%
3017 Barrineau Rd LAKE CITY, SC Rare find in the heart of Barrineau! Charming 3 bed, 2 bath home in a quaint small town! T...	3 beds \| 2 baths \| 1,344 sq.ft.	$229,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.74% Airbnb Rental Income: $null Traditional Rental Income: $1778 Airbnb ROI: N/A Traditional ROI: 6.74%
1309 N Matthews Road LAKE CITY, SC SOLD "AS IS". This beautiful property has 4.29 acres. The downstairs is heated and coole...	2 beds \| 3 baths \| 1,659 sq.ft.	$207,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.96% Airbnb Rental Income: $null Traditional Rental Income: $2159 Airbnb ROI: N/A Traditional ROI: 8.96%
319 Floyd Ave LAKE CITY, SC Welcome to your new home in the heart of Lake City, SC! This charming 3-bedroom, 1.5-bathr...	4 beds \| 2 baths \| 1,300 sq.ft.	$194,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.32% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 11.32%
722 Twin Oaks Circle LAKE CITY, SC NEW LISTING ALERT! 722 Twin Oaks Circle Lake City, SC $225,000\| 3 Bedrooms \| 2 1/2 Bat...	3 beds \| 3 baths \| 1,603 sq.ft.	$224,500	Airbnb cash on cash: N/A Traditional cash on cash: 8.97% Airbnb Rental Income: $null Traditional Rental Income: $2535 Airbnb ROI: N/A Traditional ROI: 8.97%
52 Acres-TBD Vox Hwy LAKE CITY, SC 52 Acres-TBD Vox Hwy, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$221,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.01% Airbnb Rental Income: $null Traditional Rental Income: $843 Airbnb ROI: N/A Traditional ROI: 2.01%
217 Smith St LAKE CITY, SC 217 Smith St, LAKE CITY, SC 29560 \| Single Family Residential	4 beds \| 2 baths \| 2,216 sq.ft.	$229,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $2346 Airbnb ROI: N/A Traditional ROI: 8.83%
116 S Second Ave LAKE CITY, SC 116 S Second Ave, LAKE CITY, SC 29560 \| Single Family Residential	4 beds \| 2 baths \| 3,510 sq.ft.	$279,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.72% Airbnb Rental Income: $null Traditional Rental Income: $2272 Airbnb ROI: N/A Traditional ROI: 6.72%
3728 W Turbeville Hwy LAKE CITY, SC 3728 W Turbeville Hwy, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,100 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.22% Airbnb Rental Income: $null Traditional Rental Income: $2111 Airbnb ROI: N/A Traditional ROI: 3.22%
220 Brantley St LAKE CITY, SC 220 Brantley St, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,578 sq.ft.	$323,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.44% Airbnb Rental Income: $null Traditional Rental Income: $2221 Airbnb ROI: N/A Traditional ROI: 5.44%
739 & 741 Jones Rd LAKE CITY, SC 739 & 741 Jones Rd, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,500 sq.ft.	$3,500,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.93% Airbnb Rental Income: $null Traditional Rental Income: $2157 Airbnb ROI: N/A Traditional ROI: -0.93%
5.9AC W Main St LAKE CITY, SC 5.9AC W Main St, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$109,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.53% Airbnb Rental Income: $null Traditional Rental Income: $843 Airbnb ROI: N/A Traditional ROI: 5.53%
213 Creek Dr LAKE CITY, SC 213 Creek Dr, LAKE CITY, SC 29560 \| Single Family Residential	2 beds \| 1 baths \| 1,389 sq.ft.	$170,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.06% Airbnb Rental Income: $null Traditional Rental Income: $1492 Airbnb ROI: N/A Traditional ROI: 7.06%
528 Azalea Dr LAKE CITY, SC 528 Azalea Dr, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 1,472 sq.ft.	$215,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.32% Airbnb Rental Income: $null Traditional Rental Income: $2108 Airbnb ROI: N/A Traditional ROI: 8.32%
1302 Bragdon Rd LAKE CITY, SC 1302 Bragdon Rd, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$80,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.58% Airbnb Rental Income: $null Traditional Rental Income: $971 Airbnb ROI: N/A Traditional ROI: 9.58%
13.32 Ac - 1014 W Highway 378 Byp LAKE CITY, SC 13.32 Ac - 1014 W Highway 378 Byp, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$135,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.2% Airbnb Rental Income: $null Traditional Rental Income: $971 Airbnb ROI: N/A Traditional ROI: 5.2%
711 Cade Rd LAKE CITY, SC 711 Cade Rd, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$515,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.26% Airbnb Rental Income: $null Traditional Rental Income: $975 Airbnb ROI: N/A Traditional ROI: 0.26%
269 State Road S-21-85 LAKE CITY, SC Quite location in the country just outside of town. This home offers 3 bedrooms 2 baths, g...	3 beds \| 2 baths \| 1,708 sq.ft.	$181,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.42% Airbnb Rental Income: $null Traditional Rental Income: $2480 Airbnb ROI: N/A Traditional ROI: 11.42%

Real Estate investment in Lake-city, SC

There are 20 properties for sale in the city of Lake City . The median list price in Lake City is $249,450 and the average price per square foot is $133. In May 2026, the average monthly cash on cash return in Lake City is 15.00%. The average monthly rental income in Lake City is $1,100.

Lake-city, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 20 investment properties available for sale in Lake-city.

The ROI for Short-Term is higher than the Long-Term in Lake-city with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Lake City, SC

605 E Main St

LAKE CITY, SC

3 beds | 2 baths | 2,923 sq.ft.

$244,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.37%

Airbnb Rental Income: $null

Traditional Rental Income: $2385

Airbnb ROI: N/A

Traditional ROI: 8.37%

520 E Main Street

LAKE CITY, SC

3 beds | 2 baths | 2,620 sq.ft.

$322,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.4%

Airbnb Rental Income: $null

Traditional Rental Income: $2662

Airbnb ROI: N/A

Traditional ROI: 6.4%

1484 Fitch Rd

LAKE CITY, SC

3 beds | 2 baths | 4,089 sq.ft.

$574,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.7%

Airbnb Rental Income: $null

Traditional Rental Income: $2207

Airbnb ROI: N/A

Traditional ROI: 2.7%

3017 Barrineau Rd

LAKE CITY, SC

3 beds | 2 baths | 1,344 sq.ft.

$229,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.74%

Airbnb Rental Income: $null

Traditional Rental Income: $1778

Airbnb ROI: N/A

Traditional ROI: 6.74%

1309 N Matthews Road

LAKE CITY, SC

2 beds | 3 baths | 1,659 sq.ft.

$207,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.96%

Airbnb Rental Income: $null

Traditional Rental Income: $2159

Airbnb ROI: N/A

Traditional ROI: 8.96%

319 Floyd Ave

LAKE CITY, SC

4 beds | 2 baths | 1,300 sq.ft.

$194,000

Airbnb cash on cash: N/A

Traditional cash on cash: 11.32%

Airbnb Rental Income: $null

Traditional Rental Income: $2387

Airbnb ROI: N/A

Traditional ROI: 11.32%

722 Twin Oaks Circle

LAKE CITY, SC

3 beds | 3 baths | 1,603 sq.ft.

$224,500

Airbnb cash on cash: N/A

Traditional cash on cash: 8.97%

Airbnb Rental Income: $null

Traditional Rental Income: $2535

Airbnb ROI: N/A

Traditional ROI: 8.97%

52 Acres-TBD Vox Hwy

LAKE CITY, SC

N/A beds | N/A baths | N/A

$221,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.01%

Airbnb Rental Income: $null

Traditional Rental Income: $843

Airbnb ROI: N/A