Real Estate Investment Properties for Sale in Seneca, SC

Looking for investment property in Seneca, SC with high ROI ?

Explore a variety of short-term homes & houses in Seneca, SC. Invest wisely with VRBO & Seneca, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
104 Knollwood Drive Seneca, SC Discover unparalleled comfort and expansive living in this remarkable residence, perfectly...	5 beds \| 4 baths \| 6,000 sq.ft.	$639,900	Airbnb cash on cash: 0.86% Traditional cash on cash: 4.79% Airbnb Rental Income: $2074 Traditional Rental Income: $3887 Airbnb ROI: 0.86% Traditional ROI: 4.79%
623 W Springwood Drive Seneca, SC Charming, move-in-ready brick home on a fully fenced 0.47 of an acre lot bordering protect...	3 beds \| 2 baths \| N/A	$267,500	Airbnb cash on cash: 3.35% Traditional cash on cash: 5.28% Airbnb Rental Income: $1827 Traditional Rental Income: $1820 Airbnb ROI: 3.35% Traditional ROI: 5.28%
520 Serria Way Seneca, SC 520 Serria Way is the home you have been waiting on placed on .58 +/- acres with a fenced ...	3 beds \| 2 baths \| N/A	$385,000	Airbnb cash on cash: 1.87% Traditional cash on cash: 3.49% Airbnb Rental Income: $1827 Traditional Rental Income: $1921 Airbnb ROI: 1.87% Traditional ROI: 3.49%
113 Cane Creek Harbor Road Seneca, SC Lake Keowee Waterfront at an irreplaceable price- Low maintenance living within merely min...	3 beds \| 3 baths \| 2,535 sq.ft.	$625,000	Airbnb cash on cash: 0.88% Traditional cash on cash: 3.13% Airbnb Rental Income: $1827 Traditional Rental Income: $2650 Airbnb ROI: 0.88% Traditional ROI: 3.13%
111 N Grant Road Seneca, SC Home and 12 acres in a highly desired location just minutes from the new Target shopping c...	4 beds \| 5 baths \| 3,390 sq.ft.	$899,900	Airbnb cash on cash: 0.95% Traditional cash on cash: 3.97% Airbnb Rental Income: $2373 Traditional Rental Income: $4319 Airbnb ROI: 0.95% Traditional ROI: 3.97%
136 Loran Pointe Circle Seneca, SC Welcome to 136 Loran Pointe Circle, a remarkable Seneca property that truly redefines vers...	4 beds \| 3 baths \| N/A	$615,000	Airbnb cash on cash: 1.74% Traditional cash on cash: 3.1% Airbnb Rental Income: $2373 Traditional Rental Income: $2573 Airbnb ROI: 1.74% Traditional ROI: 3.1%
609 Providence Point Drive Seneca, SC Welcome home to this spacious 4-bedroom, 2.5 bath residence situated on a desirable corner...	4 beds \| 3 baths \| 2,500 sq.ft.	$479,000	Airbnb cash on cash: 2.17% Traditional cash on cash: 3.52% Airbnb Rental Income: $2373 Traditional Rental Income: $2395 Airbnb ROI: 2.17% Traditional ROI: 3.52%
11048 Ferncliff Drive Seneca, SC Tucked away in an established subdivision just minutes from Clemson and Seneca, this move-...	3 beds \| 2 baths \| 1,508 sq.ft.	$264,500	Airbnb cash on cash: 3.26% Traditional cash on cash: 5.32% Airbnb Rental Income: $1827 Traditional Rental Income: $1849 Airbnb ROI: 3.26% Traditional ROI: 5.32%
216 Riverbank Court Seneca, SC Through no fault of seller this super opportunity is back on the market. This beautifully ...	3 beds \| 3 baths \| 3,300 sq.ft.	$389,900	Airbnb cash on cash: 1.81% Traditional cash on cash: 4% Airbnb Rental Income: $1827 Traditional Rental Income: $2136 Airbnb ROI: 1.81% Traditional ROI: 4%
109 Oak Crest Circle Seneca, SC Beautiful Home in prestige's subdivision of Stillwater, 5 minutes from Clemson University....	3 beds \| 2 baths \| 1,943 sq.ft.	$480,000	Airbnb cash on cash: 1.47% Traditional cash on cash: 3.14% Airbnb Rental Income: $1827 Traditional Rental Income: $2087 Airbnb ROI: 1.47% Traditional ROI: 3.14%
905 N Crestview Drive Seneca, SC This beautiful four-bedroom three bath home in Woodland Acres welcomes you with a spacious...	4 beds \| 3 baths \| 2,200 sq.ft.	$289,900	Airbnb cash on cash: 4.64% Traditional cash on cash: 7.29% Airbnb Rental Income: $2373 Traditional Rental Income: $2512 Airbnb ROI: 4.64% Traditional ROI: 7.29%
1298 Carradine Road Seneca, SC A RARE opportunity - A peaceful retreat just 9 min to Clemson (avoiding Tiger Blvd), with ...	3 beds \| 3 baths \| N/A	$369,000	Airbnb cash on cash: 2.13% Traditional cash on cash: 4.39% Airbnb Rental Income: $1827 Traditional Rental Income: $2118 Airbnb ROI: 2.13% Traditional ROI: 4.39%
851 Louie Lane Seneca, SC Newer roof, windows, and appliances! Welcome to this charming, single-level residence in t...	4 beds \| 2 baths \| 1,335 sq.ft.	$235,000	Airbnb cash on cash: 6.06% Traditional cash on cash: 5.42% Airbnb Rental Income: $2373 Traditional Rental Income: $1646 Airbnb ROI: 6.06% Traditional ROI: 5.42%
510 Return Church Road Seneca, SC Newly renovated three bedroom three bath home on 2 acres! Open floor plan with vaulted cei...	3 beds \| 3 baths \| N/A	$379,900	Airbnb cash on cash: 2.35% Traditional cash on cash: 4.8% Airbnb Rental Income: $1827 Traditional Rental Income: $2209 Airbnb ROI: 2.35% Traditional ROI: 4.8%
1279 Coneross Point Drive Seneca, SC Are you seeking a move in ready 3 bedroom home tucked away in quiet seclusion with privacy...	3 beds \| 2 baths \| 1,417 sq.ft.	$459,000	Airbnb cash on cash: 1.68% Traditional cash on cash: 3.28% Airbnb Rental Income: $1827 Traditional Rental Income: $2024 Airbnb ROI: 1.68% Traditional ROI: 3.28%
209 Amethyst Way Seneca, SC Lake days come easy here, with a private covered dock, a rare shoreline entertaining deck,...	5 beds \| 4 baths \| N/A	$2,195,000	Airbnb cash on cash: -0.91% Traditional cash on cash: 0.03% Airbnb Rental Income: $2074 Traditional Rental Income: $3445 Airbnb ROI: -0.91% Traditional ROI: 0.03%
109 Lanford Drive Seneca, SC Fully renovated & move-in ready, this spacious 4-bedroom, 3-bath brick ranch offers approx...	4 beds \| 3 baths \| 2,300 sq.ft.	$400,000	Airbnb cash on cash: 2.92% Traditional cash on cash: 4.25% Airbnb Rental Income: $2373 Traditional Rental Income: $2288 Airbnb ROI: 2.92% Traditional ROI: 4.25%
227 Serenity Bay Drive Seneca, SC Welcome to your laid-back lake escape at 227 Serenity Bay on Lake Keowee -a warm, inviting...	4 beds \| 4 baths \| 2,755 sq.ft.	$865,000	Airbnb cash on cash: -0.04% Traditional cash on cash: 1.83% Airbnb Rental Income: $2373 Traditional Rental Income: $3293 Airbnb ROI: -0.04% Traditional ROI: 1.83%
731 Harts Cove Way Seneca, SC Welcome to 731 Harts Cove Way, this is a well maintained and thoughtfully cared for 3 bed,...	3 beds \| 3 baths \| N/A	$265,000	Airbnb cash on cash: 2.14% Traditional cash on cash: 4.75% Airbnb Rental Income: $1827 Traditional Rental Income: $1986 Airbnb ROI: 2.14% Traditional ROI: 4.75%
2011 Ridgeview Lane Seneca, SC Tucked away in a peaceful wooded setting, this inviting 4-bedroom, 2-bath home blends priv...	4 beds \| 2 baths \| 1,568 sq.ft.	$294,900	Airbnb cash on cash: 4.83% Traditional cash on cash: 5.23% Airbnb Rental Income: $2373 Traditional Rental Income: $1900 Airbnb ROI: 4.83% Traditional ROI: 5.23%
212 Winding Lane Seneca, SC Welcome home! This 3 bedroom, 3.5 bath home sits on 2.3 fully fenced acres just minutes fr...	3 beds \| 4 baths \| N/A	$588,000	Airbnb cash on cash: 1.07% Traditional cash on cash: 3.47% Airbnb Rental Income: $1827 Traditional Rental Income: $2654 Airbnb ROI: 1.07% Traditional ROI: 3.47%
3607 Rocky Creek Drive Seneca, SC Welcome to this spacious and beautifully maintained one-level home, perfectly suited for t...	3 beds \| 2 baths \| 2,200 sq.ft.	$399,900	Airbnb cash on cash: 2.02% Traditional cash on cash: 4.02% Airbnb Rental Income: $1827 Traditional Rental Income: $2085 Airbnb ROI: 2.02% Traditional ROI: 4.02%
805 Goddard Avenue Seneca, SC If you've been looking for a solid, completely updated home that is easy to take care of, ...	3 beds \| 2 baths \| 1,232 sq.ft.	$179,000	Airbnb cash on cash: 6% Traditional cash on cash: 8.57% Airbnb Rental Income: $1827 Traditional Rental Income: $1772 Airbnb ROI: 6% Traditional ROI: 8.57%
1200 Loran Pointe Circle Seneca, SC This stunning three-bedroom, two-and-a-half-bath home on Lake Keowee offers a rare opportu...	3 beds \| 4 baths \| N/A	$899,000	Airbnb cash on cash: -0.63% Traditional cash on cash: 1.57% Airbnb Rental Income: $1827 Traditional Rental Income: $3172 Airbnb ROI: -0.63% Traditional ROI: 1.57%
304 Shrine Club Road Seneca, SC Sweetly renovated 4 bed, 2 bath home on almost an acre in Seneca! Located in the Bountylan...	4 beds \| 2 baths \| 1,551 sq.ft.	$298,000	Airbnb cash on cash: 4.47% Traditional cash on cash: 4.81% Airbnb Rental Income: $2373 Traditional Rental Income: $1884 Airbnb ROI: 4.47% Traditional ROI: 4.81%
323 Meldau Road Seneca, SC Lakefront on a quite cove on Hartwell with a dock in place, and only minutes from Clemson ...	4 beds \| 3 baths \| N/A	$699,000	Airbnb cash on cash: 1.03% Traditional cash on cash: 1.54% Airbnb Rental Income: $2373 Traditional Rental Income: $2120 Airbnb ROI: 1.03% Traditional ROI: 1.54%
110 S Fairplay Street Seneca, SC Come experience the charm of this historical home located in the heart of downtown Seneca....	4 beds \| 4 baths \| N/A	$524,900	Airbnb cash on cash: 2.33% Traditional cash on cash: 5.06% Airbnb Rental Income: $2373 Traditional Rental Income: $3128 Airbnb ROI: 2.33% Traditional ROI: 5.06%
401 S Cherry Street Seneca, SC Modern Quadplex in Prime Location! Excellent opportunity with this newly renovated quadple...	N/A beds \| N/A baths \| 3,740 sq.ft.	$749,000	Airbnb cash on cash: -1.43% Traditional cash on cash: 0.3% Airbnb Rental Income: $451 Traditional Rental Income: $1397 Airbnb ROI: -1.43% Traditional ROI: 0.3%
1133 Harts Ridge Drive Seneca, SC Calling All Investors, Clemson University Students, Parents & Fans! Don't miss this opport...	3 beds \| 3 baths \| N/A	$259,000	Airbnb cash on cash: 2.49% Traditional cash on cash: 5.44% Airbnb Rental Income: $1827 Traditional Rental Income: $2054 Airbnb ROI: 2.49% Traditional ROI: 5.44%

Real Estate investment in Seneca, SC

There are 178 properties for sale in the city of Seneca . The median list price in Seneca is $269,111 and the average price per square foot is $105. In June 2026, the average monthly cash on cash return in Seneca is 3.00%. The average monthly rental income in Seneca is $2,041.

Seneca, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 178 investment properties available for sale in Seneca.

In 2026, the best neighborhood to buy investment property is Seneca.

The ROI for Long-Term is higher than the Short-Term in Seneca with average rental income of $2,041.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, SC

104 Knollwood Drive

Seneca, SC

5 beds | 4 baths | 6,000 sq.ft.

$639,900

Airbnb cash on cash: 0.86%

Traditional cash on cash: 4.79%

Airbnb Rental Income: $2074

Traditional Rental Income: $3887

Airbnb ROI: 0.86%

Traditional ROI: 4.79%

623 W Springwood Drive

Seneca, SC

3 beds | 2 baths | N/A

$267,500

Airbnb cash on cash: 3.35%

Traditional cash on cash: 5.28%

Airbnb Rental Income: $1827

Traditional Rental Income: $1820

Airbnb ROI: 3.35%

Traditional ROI: 5.28%

520 Serria Way

Seneca, SC

3 beds | 2 baths | N/A

$385,000

Airbnb cash on cash: 1.87%

Traditional cash on cash: 3.49%

Airbnb Rental Income: $1827

Traditional Rental Income: $1921

Airbnb ROI: 1.87%

Traditional ROI: 3.49%

113 Cane Creek Harbor Road

Seneca, SC

3 beds | 3 baths | 2,535 sq.ft.

$625,000

Airbnb cash on cash: 0.88%

Traditional cash on cash: 3.13%

Airbnb Rental Income: $1827

Traditional Rental Income: $2650

Airbnb ROI: 0.88%

Traditional ROI: 3.13%

111 N Grant Road

Seneca, SC

4 beds | 5 baths | 3,390 sq.ft.

$899,900

Airbnb cash on cash: 0.95%

Traditional cash on cash: 3.97%

Airbnb Rental Income: $2373

Traditional Rental Income: $4319

Airbnb ROI: 0.95%

Traditional ROI: 3.97%

136 Loran Pointe Circle

Seneca, SC

4 beds | 3 baths | N/A

$615,000

Airbnb cash on cash: 1.74%

Traditional cash on cash: 3.1%

Airbnb Rental Income: $2373

Traditional Rental Income: $2573

Airbnb ROI: 1.74%

Traditional ROI: 3.1%

609 Providence Point Drive

Seneca, SC

4 beds | 3 baths | 2,500 sq.ft.

$479,000

Airbnb cash on cash: 2.17%

Traditional cash on cash: 3.52%

Airbnb Rental Income: $2373

Traditional Rental Income: $2395

Airbnb ROI: 2.17%

Traditional ROI: 3.52%

11048 Ferncliff Drive

Seneca, SC

3 beds | 2 baths | 1,508 sq.ft.

$264,500

Airbnb cash on cash: 3.26%

Traditional cash on cash: 5.32%

Airbnb Rental Income: $1827

Traditional Rental Income: $1849

Airbnb ROI: 3.26%