Real Estate Investment Properties for Sale in Chamberlain, SD

Looking for investment property in Chamberlain, SD with high ROI ?

Explore a variety of short-term homes & houses in Chamberlain, SD. Invest wisely with VRBO & Chamberlain, SD Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chamberlain, SD

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1020 Lloyd Lane Chamberlain, SD Fabulous floor plan with large island and walk through pantry. Two necessary amenities th...	3 beds \| 2 baths \| 1,680 sq.ft.	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.88% Airbnb Rental Income: $null Traditional Rental Income: $2519 Airbnb ROI: N/A Traditional ROI: 6.88%
301 S Main Street Chamberlain, SD Beautifully kept and with each room, the 1900's period brings back yesteryear. Solid inte...	3 beds \| N/A baths \| 1,804 sq.ft.	$224,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.62% Airbnb Rental Income: $null Traditional Rental Income: $2122 Airbnb ROI: N/A Traditional ROI: 7.62%
24269 State 50 Hwy Hwy Chamberlain, SD Nestled just outside of Chamberlain, this rustic log cabin offers the perfect blend of pea...	3 beds \| 2 baths \| 2,015 sq.ft.	$590,000	Airbnb cash on cash: N/A Traditional cash on cash: 3% Airbnb Rental Income: $null Traditional Rental Income: $2557 Airbnb ROI: N/A Traditional ROI: 3%
300 E Stearns Ave Ave Chamberlain, SD This stunning Tudor-style home stands out with its steep rooflines, brick-and-stucco exter...	3 beds \| 1 baths \| 2,135 sq.ft.	$279,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.51% Airbnb Rental Income: $null Traditional Rental Income: $2570 Airbnb ROI: N/A Traditional ROI: 7.51%
208 Lakeview Ave Chamberlain, SD This home offers a very homey feeling with an easy traffic flow from room to room. Three ...	5 beds \| 2 baths \| 2,106 sq.ft.	$369,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.5% Airbnb Rental Income: $null Traditional Rental Income: $2734 Airbnb ROI: N/A Traditional ROI: 5.5%
207 Cherry Ln Chamberlain, SD	3 beds \| 2 baths \| 2,700 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.23% Airbnb Rental Income: $null Traditional Rental Income: $2264 Airbnb ROI: N/A Traditional ROI: 6.23%
24889 343rd Ave Chamberlain, SD Ultimate retreat within minutes of Chamberlain and the Missouri River! This charming ranch...	3 beds \| 2 baths \| 1,568 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.9% Airbnb Rental Income: $null Traditional Rental Income: $2035 Airbnb ROI: N/A Traditional ROI: 5.9%
610 S Byron Blvd Chamberlain, SD	3 beds \| 2 baths \| 1,852 sq.ft.	$614,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.79% Airbnb Rental Income: $null Traditional Rental Income: $2440 Airbnb ROI: N/A Traditional ROI: 1.79%
304 E Beebe Ave Chamberlain, SD Charming home with wonderful space and many bedrooms. Main floor has a great flow to and f...	5 beds \| 3 baths \| 1,816 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.92% Airbnb Rental Income: $null Traditional Rental Income: $2532 Airbnb ROI: N/A Traditional ROI: 6.92%
24565 345th Ave Ave Chamberlain, SD	3 beds \| 2 baths \| 1,664 sq.ft.	$425,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.7% Airbnb Rental Income: $null Traditional Rental Income: $2084 Airbnb ROI: N/A Traditional ROI: 2.7%
120 Wilderness Cove Dr Chamberlain, SD	N/A beds \| N/A baths \| N/A	$170,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.05% Airbnb Rental Income: $null Traditional Rental Income: $796 Airbnb ROI: N/A Traditional ROI: 2.05%
300 E Stearns Ave Chamberlain, SD This stunning Tudor-style home stands out with its steep rooflines, brick-and-stucco exter...	3 beds \| 2 baths \| 2,135 sq.ft.	$279,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.24% Airbnb Rental Income: $null Traditional Rental Income: $2500 Airbnb ROI: N/A Traditional ROI: 7.24%
301 S Courtland St Chamberlain, SD Charming and full of personality, this 3-bedroom, 2-bath home in Chamberlain offers space,...	3 beds \| 3 baths \| 2,440 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.64% Airbnb Rental Income: $null Traditional Rental Income: $3105 Airbnb ROI: N/A Traditional ROI: 7.64%
24889 343rd Ave Ave Chamberlain, SD	3 beds \| 2 baths \| 1,568 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $2061 Airbnb ROI: N/A Traditional ROI: 5.43%
1209 S Main St Chamberlain, SD	4 beds \| 2 baths \| 2,322 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.55% Airbnb Rental Income: $null Traditional Rental Income: $2304 Airbnb ROI: N/A Traditional ROI: 6.55%
417 N Sanborn St St Chamberlain, SD Spacious and well-appointed 5-bedroom, 5-bathroom home designed for comfort, entertaining,...	5 beds \| 4 baths \| 3,410 sq.ft.	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.91% Airbnb Rental Income: $null Traditional Rental Income: $5133 Airbnb ROI: N/A Traditional ROI: 6.91%
407 S River St St Chamberlain, SD	N/A beds \| N/A baths \| N/A	$160,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.73% Airbnb Rental Income: $null Traditional Rental Income: $860 Airbnb ROI: N/A Traditional ROI: 2.73%
205 Terrace Road Chamberlain, SD This home a lot to offer. Entry foyer with ceramic tile and large coat/umbrella closet. ...	4 beds \| 3 baths \| 2,190 sq.ft.	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.93% Airbnb Rental Income: $null Traditional Rental Income: $2854 Airbnb ROI: N/A Traditional ROI: 5.93%
203 E Lawler Ave Chamberlain, SD	4 beds \| 3 baths \| 3,400 sq.ft.	$340,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.14% Airbnb Rental Income: $null Traditional Rental Income: $3108 Airbnb ROI: N/A Traditional ROI: 7.14%
815 N Martin Chamberlain, SD This home offers a combination of affordability, practicality, and future potential that i...	2 beds \| 1 baths \| 864 sq.ft.	$173,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.11% Airbnb Rental Income: $null Traditional Rental Income: $1450 Airbnb ROI: N/A Traditional ROI: 6.11%
722 S Courtland Chamberlain, SD Owners have remodeled and built custom homes for years and it is exciting to see their tal...	4 beds \| 3 baths \| 1,463 sq.ft.	$309,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.49% Airbnb Rental Income: $null Traditional Rental Income: $2488 Airbnb ROI: N/A Traditional ROI: 6.49%
110 S River St Chamberlain, SD Opportunities to purchase a home on Chamberlain's highly sought-after River Street are few...	4 beds \| 2 baths \| 1,144 sq.ft.	$310,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.4% Airbnb Rental Income: $null Traditional Rental Income: $2117 Airbnb ROI: N/A Traditional ROI: 5.4%
508 Stockwell Chamberlain, SD This home, built in 1908 has seen numerous updates throughout it's years. The improvement...	3 beds \| 2 baths \| 1,557 sq.ft.	$125,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.38% Airbnb Rental Income: $null Traditional Rental Income: $1358 Airbnb ROI: N/A Traditional ROI: 8.38%

Real Estate investment in Chamberlain, SD

There are 23 properties for sale in the city of Chamberlain . The median list price in Chamberlain is $323,500 and the average price per square foot is $162. In June 2026, the average monthly cash on cash return in Chamberlain is 6.00%. The average monthly rental income in Chamberlain is $2,304.

Chamberlain, SD Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 23 investment properties available for sale in Chamberlain.

The ROI for Short-Term is higher than the Long-Term in Chamberlain with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Chamberlain, SD

1020 Lloyd Lane

Chamberlain, SD

3 beds | 2 baths | 1,680 sq.ft.

$299,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.88%

Airbnb Rental Income: $null

Traditional Rental Income: $2519

Airbnb ROI: N/A

Traditional ROI: 6.88%

301 S Main Street

Chamberlain, SD

3 beds | N/A baths | 1,804 sq.ft.

$224,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.62%

Airbnb Rental Income: $null

Traditional Rental Income: $2122

Airbnb ROI: N/A

Traditional ROI: 7.62%

24269 State 50 Hwy Hwy

Chamberlain, SD

3 beds | 2 baths | 2,015 sq.ft.

$590,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3%

Airbnb Rental Income: $null

Traditional Rental Income: $2557

Airbnb ROI: N/A

Traditional ROI: 3%

300 E Stearns Ave Ave

Chamberlain, SD

3 beds | 1 baths | 2,135 sq.ft.

$279,500

Airbnb cash on cash: N/A

Traditional cash on cash: 7.51%

Airbnb Rental Income: $null

Traditional Rental Income: $2570

Airbnb ROI: N/A

Traditional ROI: 7.51%

208 Lakeview Ave

Chamberlain, SD

5 beds | 2 baths | 2,106 sq.ft.

$369,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.5%

Airbnb Rental Income: $null

Traditional Rental Income: $2734

Airbnb ROI: N/A

Traditional ROI: 5.5%

207 Cherry Ln

Chamberlain, SD

3 beds | 2 baths | 2,700 sq.ft.

$270,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.23%

Airbnb Rental Income: $null

Traditional Rental Income: $2264

Airbnb ROI: N/A

Traditional ROI: 6.23%

24889 343rd Ave

Chamberlain, SD

3 beds | 2 baths | 1,568 sq.ft.

$270,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.9%

Airbnb Rental Income: $null

Traditional Rental Income: $2035

Airbnb ROI: N/A

Traditional ROI: 5.9%

610 S Byron Blvd

Chamberlain, SD

3 beds | 2 baths | 1,852 sq.ft.

$614,900

Airbnb cash on cash: N/A

Traditional cash on cash: 1.79%

Airbnb Rental Income: $null

Traditional Rental Income: $2440

Airbnb ROI: N/A