Real Estate Investment Properties for Sale in Chamberlain, SD

Looking for investment property in Chamberlain, SD with high ROI ?

Explore a variety of short-term homes & houses in Chamberlain, SD. Invest wisely with VRBO & Chamberlain, SD Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chamberlain, SD

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1020 Lloyd Lane Chamberlain, SD Fabulous floor plan with large island and walk through pantry. Two necessary amenities tha...	3 beds \| 2 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.88% Airbnb Rental Income: $null Traditional Rental Income: $2519 Airbnb ROI: N/A Traditional ROI: 6.88%
301 S Main Street Chamberlain, SD Beautifully kept and with each room, the 1900's period brings back yesteryear. Solid inter...	3 beds \| N/A baths \| N/A	$224,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.62% Airbnb Rental Income: $null Traditional Rental Income: $2122 Airbnb ROI: N/A Traditional ROI: 7.62%
24269 State 50 Hwy Hwy Chamberlain, SD Located just outside of Chamberlain, this rustic log cabin offers peaceful privacy, incred...	3 beds \| 2 baths \| 2,015 sq.ft.	$590,000	Airbnb cash on cash: N/A Traditional cash on cash: 3% Airbnb Rental Income: $null Traditional Rental Income: $2557 Airbnb ROI: N/A Traditional ROI: 3%
300 E Stearns Ave Ave Chamberlain, SD This stunning Tudor-style home stands out with its steep rooflines, brick-and-stucco exter...	3 beds \| 1 baths \| 2,135 sq.ft.	$279,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.51% Airbnb Rental Income: $null Traditional Rental Income: $2570 Airbnb ROI: N/A Traditional ROI: 7.51%
208 Lakeview Ave Chamberlain, SD This home offers a very homey feeling with an easy traffic flow from room to room. Three b...	5 beds \| 2 baths \| N/A	$369,000	Airbnb cash on cash: 2.63% Traditional cash on cash: 5.5% Airbnb Rental Income: $2311 Traditional Rental Income: $2734 Airbnb ROI: 2.63% Traditional ROI: 5.5%
207 Cherry Ln Chamberlain, SD	3 beds \| 2 baths \| 2,700 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.23% Airbnb Rental Income: $null Traditional Rental Income: $2264 Airbnb ROI: N/A Traditional ROI: 6.23%
24889 343rd Ave Chamberlain, SD Ultimate retreat within minutes of Chamberlain and the Missouri River! This charming ranch...	3 beds \| 2 baths \| 1,568 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.9% Airbnb Rental Income: $null Traditional Rental Income: $2035 Airbnb ROI: N/A Traditional ROI: 5.9%
610 S Byron Blvd Chamberlain, SD	3 beds \| 2 baths \| 1,852 sq.ft.	$614,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.79% Airbnb Rental Income: $null Traditional Rental Income: $2440 Airbnb ROI: N/A Traditional ROI: 1.79%
304 E Beebe Ave Chamberlain, SD Charming home with wonderful space and many bedrooms. Main floor has a great flow to and f...	5 beds \| 3 baths \| N/A	$299,900	Airbnb cash on cash: 4.1% Traditional cash on cash: 6.92% Airbnb Rental Income: $2311 Traditional Rental Income: $2532 Airbnb ROI: 4.1% Traditional ROI: 6.92%
24565 345th Ave Ave Chamberlain, SD	3 beds \| 2 baths \| 1,664 sq.ft.	$425,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.7% Airbnb Rental Income: $null Traditional Rental Income: $2084 Airbnb ROI: N/A Traditional ROI: 2.7%
120 Wilderness Cove Dr Chamberlain, SD	N/A beds \| N/A baths \| N/A	$170,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.05% Airbnb Rental Income: $null Traditional Rental Income: $796 Airbnb ROI: N/A Traditional ROI: 2.05%
300 E Stearns Ave Chamberlain, SD This stunning Tudor-style home blends historic character with major recent updates. Whole-...	3 beds \| 2 baths \| 2,135 sq.ft.	$279,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.24% Airbnb Rental Income: $null Traditional Rental Income: $2500 Airbnb ROI: N/A Traditional ROI: 7.24%
24889 343rd Ave Ave Chamberlain, SD	3 beds \| 2 baths \| 1,568 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $2061 Airbnb ROI: N/A Traditional ROI: 5.43%
1209 S Main St Chamberlain, SD	4 beds \| 2 baths \| 2,322 sq.ft.	$265,000	Airbnb cash on cash: 7.48% Traditional cash on cash: 6.55% Airbnb Rental Income: $3271 Traditional Rental Income: $2304 Airbnb ROI: 7.48% Traditional ROI: 6.55%
417 N Sanborn St St Chamberlain, SD Spacious and well-appointed 5-bedroom, 5-bathroom home designed for comfort, entertaining,...	5 beds \| 4 baths \| 3,410 sq.ft.	$475,000	Airbnb cash on cash: 1.33% Traditional cash on cash: 8.97% Airbnb Rental Income: $2311 Traditional Rental Income: $5133 Airbnb ROI: 1.33% Traditional ROI: 8.97%
407 S River St St Chamberlain, SD	N/A beds \| N/A baths \| N/A	$160,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.73% Airbnb Rental Income: $null Traditional Rental Income: $860 Airbnb ROI: N/A Traditional ROI: 2.73%
205 Terrace Road Chamberlain, SD This home a lot to offer. Entry foyer with ceramic tile and large coat/umbrella closet. Im...	4 beds \| 3 baths \| 3,142 sq.ft.	$360,000	Airbnb cash on cash: 4.99% Traditional cash on cash: 5.93% Airbnb Rental Income: $3271 Traditional Rental Income: $2854 Airbnb ROI: 4.99% Traditional ROI: 5.93%
203 E Lawler Ave Chamberlain, SD	4 beds \| 3 baths \| 3,400 sq.ft.	$340,000	Airbnb cash on cash: 5.35% Traditional cash on cash: 7.14% Airbnb Rental Income: $3271 Traditional Rental Income: $3108 Airbnb ROI: 5.35% Traditional ROI: 7.14%
815 N Martin Chamberlain, SD This home offers a combination of affordability, practicality, and future potential that i...	2 beds \| 1 baths \| 864 sq.ft.	$173,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.11% Airbnb Rental Income: $null Traditional Rental Income: $1450 Airbnb ROI: N/A Traditional ROI: 6.11%
722 S Courtland Chamberlain, SD Owners have remodeled and built custom homes for years and it is exciting to see their tal...	4 beds \| 3 baths \| 1,463 sq.ft.	$309,000	Airbnb cash on cash: 6.66% Traditional cash on cash: 6.49% Airbnb Rental Income: $3271 Traditional Rental Income: $2488 Airbnb ROI: 6.66% Traditional ROI: 6.49%
101 S Byron Blvd Chamberlain, SD Looking for a business minded entrepreneur with a passion for children and a vision for gr...	4 beds \| 3 baths \| 3,212 sq.ft.	$319,000	Airbnb cash on cash: 5.85% Traditional cash on cash: 5.48% Airbnb Rental Income: $3271 Traditional Rental Income: $2425 Airbnb ROI: 5.85% Traditional ROI: 5.48%
110 S River St Chamberlain, SD Opportunities to purchase a home on Chamberlain's highly sought-after River Street are few...	4 beds \| 2 baths \| N/A	$310,000	Airbnb cash on cash: 6.32% Traditional cash on cash: 4.88% Airbnb Rental Income: $3271 Traditional Rental Income: $2117 Airbnb ROI: 6.32% Traditional ROI: 4.88%
210 N Club Street Chamberlain, SD Located on a cul-de-sac in the northeastern part of Chamberlain is the premium set up for ...	2 beds \| 1 baths \| 796 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.74% Airbnb Rental Income: $null Traditional Rental Income: $1394 Airbnb ROI: N/A Traditional ROI: 5.74%
205 E Beebe Ave Chamberlain, SD 1920's style home featuring 2 bedrooms with a large eat-in kitchen, a formal dining with h...	2 beds \| 1 baths \| 1,310 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.11% Airbnb Rental Income: $null Traditional Rental Income: $1606 Airbnb ROI: N/A Traditional ROI: 6.11%
208 E King St St Chamberlain, SD	5 beds \| 2 baths \| 2,354 sq.ft.	$365,000	Airbnb cash on cash: 2.5% Traditional cash on cash: 4.51% Airbnb Rental Income: $2311 Traditional Rental Income: $2426 Airbnb ROI: 2.5% Traditional ROI: 4.51%
1018 S Courtland St Chamberlain, SD	2 beds \| 2 baths \| 1,120 sq.ft.	$217,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.16% Airbnb Rental Income: $null Traditional Rental Income: $1626 Airbnb ROI: N/A Traditional ROI: 5.16%

Real Estate investment in Chamberlain, SD

There are 26 properties for sale in the city of Chamberlain . The median list price in Chamberlain is $323,500 and the average price per square foot is $159. In September 2026, the average monthly cash on cash return in Chamberlain is 6.00%. The average monthly rental income in Chamberlain is $2,276.

Chamberlain, SD Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 26 investment properties available for sale in Chamberlain.

In 2026, the best neighborhood to buy investment property is Chamberlain.

The ROI for Short-Term is higher than the Long-Term in Chamberlain with average rental income of $3,271.

Your search for investment property begins and ends here

Investment Property for Sale in Chamberlain, SD

1020 Lloyd Lane

Chamberlain, SD

3 beds | 2 baths | N/A

$299,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.88%

Airbnb Rental Income: $null

Traditional Rental Income: $2519

Airbnb ROI: N/A

Traditional ROI: 6.88%

301 S Main Street

Chamberlain, SD

3 beds | N/A baths | N/A

$224,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.62%

Airbnb Rental Income: $null

Traditional Rental Income: $2122

Airbnb ROI: N/A

Traditional ROI: 7.62%

24269 State 50 Hwy Hwy

Chamberlain, SD

3 beds | 2 baths | 2,015 sq.ft.

$590,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3%

Airbnb Rental Income: $null

Traditional Rental Income: $2557

Airbnb ROI: N/A

Traditional ROI: 3%

300 E Stearns Ave Ave

Chamberlain, SD

3 beds | 1 baths | 2,135 sq.ft.

$279,500

Airbnb cash on cash: N/A

Traditional cash on cash: 7.51%

Airbnb Rental Income: $null

Traditional Rental Income: $2570

Airbnb ROI: N/A

Traditional ROI: 7.51%

208 Lakeview Ave

Chamberlain, SD

5 beds | 2 baths | N/A

$369,000

Airbnb cash on cash: 2.63%

Traditional cash on cash: 5.5%

Airbnb Rental Income: $2311

Traditional Rental Income: $2734

Airbnb ROI: 2.63%

Traditional ROI: 5.5%

207 Cherry Ln

Chamberlain, SD

3 beds | 2 baths | 2,700 sq.ft.

$270,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.23%

Airbnb Rental Income: $null

Traditional Rental Income: $2264

Airbnb ROI: N/A

Traditional ROI: 6.23%

24889 343rd Ave

Chamberlain, SD

3 beds | 2 baths | 1,568 sq.ft.

$270,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.9%

Airbnb Rental Income: $null

Traditional Rental Income: $2035

Airbnb ROI: N/A

Traditional ROI: 5.9%

610 S Byron Blvd

Chamberlain, SD

3 beds | 2 baths | 1,852 sq.ft.

$614,900

Airbnb cash on cash: N/A

Traditional cash on cash: 1.79%

Airbnb Rental Income: $null

Traditional Rental Income: $2440

Airbnb ROI: N/A