Real Estate Investment Properties for Sale in Vermillion, SD

Looking for investment property in Vermillion, SD with high ROI ?

Explore a variety of short-term homes & houses in Vermillion, SD. Invest wisely with VRBO & Vermillion, SD Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Vermillion, SD

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
847 Eastgate Vermillion, SD This inviting ranch~style home offers the perfect blend of comfort, functionality, and loc...	4 beds \| 3 baths \| 2,284 sq.ft.	$329,900	Airbnb cash on cash: 1.37% Traditional cash on cash: 7.38% Airbnb Rental Income: $1782 Traditional Rental Income: $3159 Airbnb ROI: 1.37% Traditional ROI: 7.38%
220 Catalina Vermillion, SD Great starter home!! Closes to High School, Prentis Park, Saint Agnes School. This 3 bedro...	3 beds \| 2 baths \| 1,724 sq.ft.	$239,900	Airbnb cash on cash: 2.61% Traditional cash on cash: 8.14% Airbnb Rental Income: $1681 Traditional Rental Income: $2465 Airbnb ROI: 2.61% Traditional ROI: 8.14%
216-216 1/2 High Vermillion, SD Lots of potential with this property. its on 2 lots , so there is room to expand if desire...	5 beds \| 3 baths \| 1,676 sq.ft.	$199,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.98% Airbnb Rental Income: $null Traditional Rental Income: $1846 Airbnb ROI: N/A Traditional ROI: 5.98%
216-218 W Cedar Vermillion, SD This up and down duplex is close to downtown, schools and park. Upper unit is a 2 bdrm , 1...	4 beds \| 2 baths \| 1,924 sq.ft.	$169,900	Airbnb cash on cash: 4.37% Traditional cash on cash: 7.17% Airbnb Rental Income: $1782 Traditional Rental Income: $1749 Airbnb ROI: 4.37% Traditional ROI: 7.17%
103 N Pine Vermillion, SD Fantastic spot near USD Campus, this 4 bedroom, 2 bathroom home features a detached single...	4 beds \| 2 baths \| 1,632 sq.ft.	$189,900	Airbnb cash on cash: 4.22% Traditional cash on cash: 6.46% Airbnb Rental Income: $1782 Traditional Rental Income: $1700 Airbnb ROI: 4.22% Traditional ROI: 6.46%
722 E MAIN Vermillion, SD ATTRACTIVE 2 STORY ACROSS FROM PRENTIS PARK . CLOSE TO USD, HIGH SCHOOL, HOSPITAL AND DOWN...	4 beds \| 3 baths \| 1,629 sq.ft.	$215,000	Airbnb cash on cash: 3.72% Traditional cash on cash: 9.73% Airbnb Rental Income: $1782 Traditional Rental Income: $2521 Airbnb ROI: 3.72% Traditional ROI: 9.73%
1222 Zitkala-Sa Trl. Vermillion, SD Step into style and comfort with this stunning, brand-new construction twin home, featurin...	3 beds \| 2 baths \| 1,696 sq.ft.	$359,900	Airbnb cash on cash: 2.22% Traditional cash on cash: 6.32% Airbnb Rental Income: $1681 Traditional Rental Income: $2597 Airbnb ROI: 2.22% Traditional ROI: 6.32%
15 E Duke St. Vermillion, SD Welcome to North42!! This beautiful townhome is part of Phase 1 of an exciting new develop...	3 beds \| 3 baths \| 2,059 sq.ft.	$389,900	Airbnb cash on cash: 0.76% Traditional cash on cash: 5.43% Airbnb Rental Income: $1681 Traditional Rental Income: $2919 Airbnb ROI: 0.76% Traditional ROI: 5.43%
17 E Duke St. Vermillion, SD Welcome to North42! This beautiful townhome is part of Phase 1 of an exciting new developm...	3 beds \| 3 baths \| 1,990 sq.ft.	$369,900	Airbnb cash on cash: 0.93% Traditional cash on cash: 5.77% Airbnb Rental Income: $1681 Traditional Rental Income: $2893 Airbnb ROI: 0.93% Traditional ROI: 5.77%
21 E Duke St. Vermillion, SD Welcome to North42!! This beautiful townhome is part of Phase 1 of an exciting new develop...	3 beds \| 3 baths \| 1,990 sq.ft.	$369,900	Airbnb cash on cash: 0.93% Traditional cash on cash: 5.77% Airbnb Rental Income: $1681 Traditional Rental Income: $2893 Airbnb ROI: 0.93% Traditional ROI: 5.77%
23 E Duke St. Vermillion, SD Welcome to North42! This beautiful townhome is part of Phase 1 of an exciting new developm...	3 beds \| 3 baths \| 2,026 sq.ft.	$389,900	Airbnb cash on cash: 0.76% Traditional cash on cash: 5.41% Airbnb Rental Income: $1681 Traditional Rental Income: $2911 Airbnb ROI: 0.76% Traditional ROI: 5.41%
1540 Rockwell Trail Vermillion, SD Welcome home to the beautifully maintained 5-bedroom, 3-bath residence built in 2016, offe...	5 beds \| 3 baths \| 2,655 sq.ft.	$444,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.5% Airbnb Rental Income: $null Traditional Rental Income: $3079 Airbnb ROI: N/A Traditional ROI: 4.5%
406 N Crawford Vermillion, SD This home has a huge amount of common area: spacious living room, 416 square foot main flo...	4 beds \| 3 baths \| 12,554 sq.ft.	$329,900	Airbnb cash on cash: 1.16% Traditional cash on cash: 7.46% Airbnb Rental Income: $1782 Traditional Rental Income: $3249 Airbnb ROI: 1.16% Traditional ROI: 7.46%
918 James Vermillion, SD This spacious ranch~style home features three bedrooms and two bathrooms, offering ample l...	3 beds \| 2 baths \| 2,433 sq.ft.	$275,000	Airbnb cash on cash: 1.94% Traditional cash on cash: 7.44% Airbnb Rental Income: $1681 Traditional Rental Income: $2637 Airbnb ROI: 1.94% Traditional ROI: 7.44%
326 wilder Vermillion, SD Welcome to this stunning custom-built home in the highly desirable Bliss Pointe developmen...	5 beds \| 3 baths \| 3,085 sq.ft.	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.22% Airbnb Rental Income: $null Traditional Rental Income: $3214 Airbnb ROI: N/A Traditional ROI: 3.22%
534 Valley View Vermillion, SD Welcome to this charming brick home, ideally situated in a prime location and ready for it...	3 beds \| 2 baths \| 1,914 sq.ft.	$245,900	Airbnb cash on cash: 1.99% Traditional cash on cash: 6.72% Airbnb Rental Income: $1681 Traditional Rental Income: $2310 Airbnb ROI: 1.99% Traditional ROI: 6.72%
32103 Saginaw Vermillion, SD This well-maintained ranch home with numerous updates is situated on a large 2.15-acre lot...	3 beds \| 3 baths \| 2,056 sq.ft.	$389,900	Airbnb cash on cash: 0.72% Traditional cash on cash: 3.92% Airbnb Rental Income: $1681 Traditional Rental Income: $2383 Airbnb ROI: 0.72% Traditional ROI: 3.92%
1913 DePaul Ave. Vermillion, SD Exceptional opportunity for acreage lovers to own a 3~bedroom, 2~bathroom ranch home built...	3 beds \| 2 baths \| 1,860 sq.ft.	$357,900	Airbnb cash on cash: 0.77% Traditional cash on cash: 4.26% Airbnb Rental Income: $1681 Traditional Rental Income: $2384 Airbnb ROI: 0.77% Traditional ROI: 4.26%
1000 Deerfield Rd. Vermillion, SD This grand home comes with a grand interior, a grand exterior, and a grand address, 1000 D...	4 beds \| 2 baths \| 1,880 sq.ft.	$619,500	Airbnb cash on cash: -0.09% Traditional cash on cash: 2.27% Airbnb Rental Income: $1782 Traditional Rental Income: $2661 Airbnb ROI: -0.09% Traditional ROI: 2.27%
13 W National Vermillion, SD Excellent location between downtown and campus. Lowest priced single family home in Vermil...	3 beds \| 2 baths \| 1,100 sq.ft.	$140,000	Airbnb cash on cash: 5.86% Traditional cash on cash: 10.32% Airbnb Rental Income: $1681 Traditional Rental Income: $1811 Airbnb ROI: 5.86% Traditional ROI: 10.32%
1103 Hwy 50 Vermillion, SD This 8+ acre property is an eye catcher!! The two-story home has original and beautiful wo...	5 beds \| 3 baths \| 3,497 sq.ft.	$495,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.01% Airbnb Rental Income: $null Traditional Rental Income: $3102 Airbnb ROI: N/A Traditional ROI: 4.01%
316 Prentis Ave. Vermillion, SD So much to offer here!! Built in 1960 with sleek mid-century architecture, this home combi...	4 beds \| 2 baths \| 2,184 sq.ft.	$289,000	Airbnb cash on cash: 2.72% Traditional cash on cash: 7.04% Airbnb Rental Income: $1782 Traditional Rental Income: $2472 Airbnb ROI: 2.72% Traditional ROI: 7.04%
209 N Harvard Vermillion, SD 5 bedroom , 2 bath home with fenced back yard and garage, on block from USD campus. Always...	5 beds \| 2 baths \| 1,526 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.96% Airbnb Rental Income: $null Traditional Rental Income: $2383 Airbnb ROI: N/A Traditional ROI: 7.96%
723 N Norbeck St. Vermillion, SD Beautiful 1620 square foot Champion manufactured home, on footings, built on a half-acre!!...	3 beds \| 2 baths \| 1,620 sq.ft.	$229,000	Airbnb cash on cash: 3.47% Traditional cash on cash: 8.38% Airbnb Rental Income: $1681 Traditional Rental Income: $2275 Airbnb ROI: 3.47% Traditional ROI: 8.38%
107 S Crawford Rd Vermillion, SD Turnkey duplex-potential ranch-style house in the desirable southeast part of Vermillion! ...	4 beds \| 2 baths \| 2,537 sq.ft.	$250,000	Airbnb cash on cash: 2.26% Traditional cash on cash: 7.39% Airbnb Rental Income: $1782 Traditional Rental Income: $2507 Airbnb ROI: 2.26% Traditional ROI: 7.39%
1819 De Paul Ave. Vermillion, SD This fantastic ranch style home located on an acre just on the north edge of Vermillion!! ...	4 beds \| 4 baths \| 2,406 sq.ft.	$459,000	Airbnb cash on cash: 0.32% Traditional cash on cash: 3.72% Airbnb Rental Income: $1782 Traditional Rental Income: $2756 Airbnb ROI: 0.32% Traditional ROI: 3.72%
441 N Pine St. Vermillion, SD Don't miss this beautifully updated 3~bedroom, 1.5~bath home offering 1,710 square feet of...	3 beds \| 2 baths \| 1,749 sq.ft.	$274,900	Airbnb cash on cash: 2.35% Traditional cash on cash: 4.59% Airbnb Rental Income: $1681 Traditional Rental Income: $1793 Airbnb ROI: 2.35% Traditional ROI: 4.59%
1878 Constance Dr Vermillion, SD Here is truly a rare opportunity to own a home in a prime, quiet Vermillion neighborhood w...	3 beds \| 3 baths \| 2,765 sq.ft.	$384,900	Airbnb cash on cash: 0.73% Traditional cash on cash: 5.43% Airbnb Rental Income: $1681 Traditional Rental Income: $2909 Airbnb ROI: 0.73% Traditional ROI: 5.43%
3 E Duke St. Vermillion, SD Welcome to North42! This beautiful townhome is part of Phase 1 of an exciting new developm...	3 beds \| 3 baths \| 2,026 sq.ft.	$389,900	Airbnb cash on cash: 0.76% Traditional cash on cash: 4.75% Airbnb Rental Income: $1681 Traditional Rental Income: $2670 Airbnb ROI: 0.76% Traditional ROI: 4.75%
5 E Duke St. Vermillion, SD Welcome to North42!! This beautiful townhome is part of Phase 1 of an exciting new develop...	3 beds \| 3 baths \| 1,990 sq.ft.	$369,900	Airbnb cash on cash: 0.93% Traditional cash on cash: 5.12% Airbnb Rental Income: $1681 Traditional Rental Income: $2667 Airbnb ROI: 0.93% Traditional ROI: 5.12%
9 E Duke St. Vermillion, SD Welcome to North42! This beautiful townhome is part of Phase 1 of an exciting new developm...	3 beds \| 3 baths \| 1,990 sq.ft.	$369,900	Airbnb cash on cash: 0.93% Traditional cash on cash: 5.12% Airbnb Rental Income: $1681 Traditional Rental Income: $2667 Airbnb ROI: 0.93% Traditional ROI: 5.12%
1016 Valley View Dr. Vermillion, SD PRICE IMPROVEMENT!! Fresh updates, corner lot, and ready to move in Don't miss this one!! ...	3 beds \| 2 baths \| 1,716 sq.ft.	$239,900	Airbnb cash on cash: 2.23% Traditional cash on cash: 7.18% Airbnb Rental Income: $1681 Traditional Rental Income: $2333 Airbnb ROI: 2.23% Traditional ROI: 7.18%
1313 Cornell Vermillion, SD Brand new and ready to welcome you home!! Built by Mart Brothers Construction in Vermillio...	3 beds \| 2 baths \| 1,413 sq.ft.	$390,500	Airbnb cash on cash: 0.76% Traditional cash on cash: 3.62% Airbnb Rental Income: $1681 Traditional Rental Income: $2261 Airbnb ROI: 0.76% Traditional ROI: 3.62%
46653 Walkers #14 Vermillion, SD Riverfront cabin in Walker's Landing, on leased land. Enjoy fishing from your backyard!! B...	3 beds \| 1 baths \| 956 sq.ft.	$150,000	Airbnb cash on cash: 5.81% Traditional cash on cash: 10.48% Airbnb Rental Income: $1681 Traditional Rental Income: $1883 Airbnb ROI: 5.81% Traditional ROI: 10.48%
11 E Duke St. Vermillion, SD Welcome to North42!! This beautiful townhome is part of Phase 1 of an exciting new develop...	3 beds \| 3 baths \| 2,026 sq.ft.	$389,900	Airbnb cash on cash: 0.76% Traditional cash on cash: 5.42% Airbnb Rental Income: $1681 Traditional Rental Income: $2916 Airbnb ROI: 0.76% Traditional ROI: 5.42%
23 Muirfield Crt. Vermillion, SD This is a gorgeous home, located on the Bluffs Golf Course, hole #9! New 6" baseboards, fr...	5 beds \| 3 baths \| 4,428 sq.ft.	$569,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.2% Airbnb Rental Income: $null Traditional Rental Income: $3238 Airbnb ROI: N/A Traditional ROI: 3.2%
211 W Duke Vermillion, SD Beautiful zero entry townhouse! This 1296 sq ft townhouse is perfect fit for the person wh...	2 beds \| 2 baths \| 1,296 sq.ft.	$259,000	Airbnb cash on cash: 1.43% Traditional cash on cash: 5.28% Airbnb Rental Income: $1454 Traditional Rental Income: $1963 Airbnb ROI: 1.43% Traditional ROI: 5.28%
1525 Crestview Vermillion, SD Welcome home to this beautifully updated 5-bedroom, 3-bathroom residence perfectly situate...	5 beds \| 3 baths \| 2,836 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.9% Airbnb Rental Income: $null Traditional Rental Income: $3262 Airbnb ROI: N/A Traditional ROI: 4.9%

Real Estate investment in Vermillion, SD

There are 39 properties for sale in the city of Vermillion . The median list price in Vermillion is $269,839 and the average price per square foot is $124. In November 2026, the average monthly cash on cash return in Vermillion is 6.00%. The average monthly rental income in Vermillion is $2,490.

Vermillion, SD Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 39 investment properties available for sale in Vermillion.

In 2026, the best neighborhood to buy investment property is Vermillion.

The ROI for Long-Term is higher than the Short-Term in Vermillion with average rental income of $2,490.

Your search for investment property begins and ends here

Investment Property for Sale in Vermillion, SD

847 Eastgate

Vermillion, SD

4 beds | 3 baths | 2,284 sq.ft.

$329,900

Airbnb cash on cash: 1.37%

Traditional cash on cash: 7.38%

Airbnb Rental Income: $1782

Traditional Rental Income: $3159

Airbnb ROI: 1.37%

Traditional ROI: 7.38%

220 Catalina

Vermillion, SD

3 beds | 2 baths | 1,724 sq.ft.

$239,900

Airbnb cash on cash: 2.61%

Traditional cash on cash: 8.14%

Airbnb Rental Income: $1681

Traditional Rental Income: $2465

Airbnb ROI: 2.61%

Traditional ROI: 8.14%

216-216 1/2 High

Vermillion, SD

5 beds | 3 baths | 1,676 sq.ft.

$199,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.98%

Airbnb Rental Income: $null

Traditional Rental Income: $1846

Airbnb ROI: N/A

Traditional ROI: 5.98%

216-218 W Cedar

Vermillion, SD

4 beds | 2 baths | 1,924 sq.ft.

$169,900

Airbnb cash on cash: 4.37%

Traditional cash on cash: 7.17%

Airbnb Rental Income: $1782

Traditional Rental Income: $1749

Airbnb ROI: 4.37%

Traditional ROI: 7.17%

103 N Pine

Vermillion, SD

4 beds | 2 baths | 1,632 sq.ft.

$189,900

Airbnb cash on cash: 4.22%

Traditional cash on cash: 6.46%

Airbnb Rental Income: $1782

Traditional Rental Income: $1700

Airbnb ROI: 4.22%

Traditional ROI: 6.46%

722 E MAIN

Vermillion, SD

4 beds | 3 baths | 1,629 sq.ft.

$215,000

Airbnb cash on cash: 3.72%

Traditional cash on cash: 9.73%

Airbnb Rental Income: $1782

Traditional Rental Income: $2521

Airbnb ROI: 3.72%

Traditional ROI: 9.73%

1222 Zitkala-Sa Trl.

Vermillion, SD

3 beds | 2 baths | 1,696 sq.ft.

$359,900

Airbnb cash on cash: 2.22%

Traditional cash on cash: 6.32%

Airbnb Rental Income: $1681

Traditional Rental Income: $2597

Airbnb ROI: 2.22%

Traditional ROI: 6.32%

15 E Duke St.

Vermillion, SD

3 beds | 3 baths | 2,059 sq.ft.

$389,900

Airbnb cash on cash: 0.76%

Traditional cash on cash: 5.43%

Airbnb Rental Income: $1681

Traditional Rental Income: $2919

Airbnb ROI: 0.76%