Real Estate Investment Properties for Sale in Vermillion, SD

Looking for investment property in Vermillion, SD with high ROI ?

Explore a variety of short-term homes & houses in Vermillion, SD. Invest wisely with VRBO & Vermillion, SD Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Vermillion, SD

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1203 E Cherry Vermillion, SD Commercial zoning. Can be a residence or a business. Currently rented til 5/31/2026 for $1...	4 beds \| 2 baths \| 1,825 sq.ft.	$189,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.18% Airbnb Rental Income: $null Traditional Rental Income: $2625 Airbnb ROI: N/A Traditional ROI: 11.18%
1209 E Cherry Vermillion, SD Commercial zoning, can be a residence or a business. Seller can deliver it vacant for owne...	4 beds \| 2 baths \| 1,728 sq.ft.	$185,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.32% Airbnb Rental Income: $null Traditional Rental Income: $2467 Airbnb ROI: N/A Traditional ROI: 11.32%
2506 E Main St Vermillion, SD Charming Log Cabin Retreat Near Vermillion!! Nestled on nearly a half-acre just outside of...	3 beds \| 2 baths \| 1,647 sq.ft.	$379,499	Airbnb cash on cash: 1.32% Traditional cash on cash: 3.99% Airbnb Rental Income: $2107 Traditional Rental Income: $2518 Airbnb ROI: 1.32% Traditional ROI: 3.99%
103 N Pine Vermillion, SD Fantastic spot near USD Campus, this 4 bedroom, 2 bathroom home features a detached single...	4 beds \| 2 baths \| 1,632 sq.ft.	$209,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.88% Airbnb Rental Income: $null Traditional Rental Income: $1700 Airbnb ROI: N/A Traditional ROI: 5.88%
323 Wilder Vermillion, SD New construction!! Completion April 30, 2025 1741 sq ft on main with 2 bedrooms, 2 1/2 bat...	3 beds \| 4 baths \| 2,699 sq.ft.	$419,900	Airbnb cash on cash: 2.63% Traditional cash on cash: 5.24% Airbnb Rental Income: $2107 Traditional Rental Income: $2594 Airbnb ROI: 2.63% Traditional ROI: 5.24%
2410 E Main Vermillion, SD This property boasts numerous features: a double lot, a triple-car garage, and over 3,000+...	4 beds \| 2 baths \| 3,012 sq.ft.	$344,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.92% Airbnb Rental Income: $null Traditional Rental Income: $2856 Airbnb ROI: N/A Traditional ROI: 5.92%
1025 Madison St E Vermillion, SD Seller is offering a 2-1 interest rate buy down with full price offer on this home. Have y...	4 beds \| 4 baths \| 2,699 sq.ft.	$619,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.61% Airbnb Rental Income: $null Traditional Rental Income: $3526 Airbnb ROI: N/A Traditional ROI: 3.61%
1203-09 E Cherry Vermillion, SD 2 adjacent houses , all with commercial zoning. 144 frontage and 180 depth. Excellent traf...	N/A beds \| N/A baths \| 5,275 sq.ft.	$374,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.99% Airbnb Rental Income: $null Traditional Rental Income: $1633 Airbnb ROI: N/A Traditional ROI: 0.99%
316 S Norbeck St Vermillion, SD Welcome to 316?S Norbeck?St, a charming 4-bedroom, 2Â½-bath split-foyer home nestled in so...	4 beds \| 3 baths \| 1,762 sq.ft.	$259,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.21% Airbnb Rental Income: $null Traditional Rental Income: $2720 Airbnb ROI: N/A Traditional ROI: 8.21%
809 Carleton Circle Vermillion, SD Wonderful split foyer home, with a primary suite above the garage!! The kitchen offers up...	3 beds \| 2 baths \| 1,639 sq.ft.	$229,000	Airbnb cash on cash: 3.79% Traditional cash on cash: 7.65% Airbnb Rental Income: $2107 Traditional Rental Income: $2402 Airbnb ROI: 3.79% Traditional ROI: 7.65%
1305 OverDrive Vermillion, SD Welcome to this highly sought after neighborhood on the Westside of Vermillion. Quiet neig...	4 beds \| 3 baths \| 3,198 sq.ft.	$459,500	Airbnb cash on cash: N/A Traditional cash on cash: 4.13% Airbnb Rental Income: $null Traditional Rental Income: $2925 Airbnb ROI: N/A Traditional ROI: 4.13%
324 E Lewis St. Vermillion, SD This home is located in a wonderful historic part of Vermillion, SD. on a corner lot. The...	5 beds \| 3 baths \| 2,171 sq.ft.	$359,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.19% Airbnb Rental Income: $null Traditional Rental Income: $2906 Airbnb ROI: N/A Traditional ROI: 6.19%
121 Kidder Street Vermillion, SD Great investment opportunity on commercial building in downtown Vermillion. 2 long term t...	N/A beds \| N/A baths \| 10,800 sq.ft.	$750,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.3% Airbnb Rental Income: $null Traditional Rental Income: $1747 Airbnb ROI: N/A Traditional ROI: 0.3%
121 High Vermillion, SD This adorable 1-bedroom home with an extra office space is full of charm and updates! The ...	1 beds \| 1 baths \| 936 sq.ft.	$139,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.37% Airbnb Rental Income: $null Traditional Rental Income: $1351 Airbnb ROI: N/A Traditional ROI: 7.37%
722 E Main Street Vermillion, SD Wonderful starter home located on the corner of Main Street and Plum Street! This is a fo...	4 beds \| 3 baths \| 1,629 sq.ft.	$224,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.31% Airbnb Rental Income: $null Traditional Rental Income: $2521 Airbnb ROI: N/A Traditional ROI: 9.31%
30975 University Road Vermillion, SD This stunning country acreage is everything you have been looking for!! Well known by gues...	3 beds \| 2 baths \| 2,088 sq.ft.	$489,900	Airbnb cash on cash: 1.59% Traditional cash on cash: 3.74% Airbnb Rental Income: $2107 Traditional Rental Income: $2556 Airbnb ROI: 1.59% Traditional ROI: 3.74%
46586 Missouri Vermillion, SD River Life Starts Here! Looking for the perfect spot to relax, work, and play? This unique...	1 beds \| 1 baths \| 1,800 sq.ft.	$394,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.05% Airbnb Rental Income: $null Traditional Rental Income: $1719 Airbnb ROI: N/A Traditional ROI: 3.05%
1225 ValleyView Dr Vermillion, SD This stunning 4-bedroom, 3-bath multi-level home blends timeless mid-century charm with hi...	4 beds \| 3 baths \| 2,176 sq.ft.	$389,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.72% Airbnb Rental Income: $null Traditional Rental Income: $3042 Airbnb ROI: N/A Traditional ROI: 5.72%
19 S Yale Vermillion, SD Come see this beautiful 3 bedroom 2 bath house that comes with built-in character! It's on...	3 beds \| 2 baths \| 1,256 sq.ft.	$210,000	Airbnb cash on cash: 5.36% Traditional cash on cash: 8.32% Airbnb Rental Income: $2107 Traditional Rental Income: $2157 Airbnb ROI: 5.36% Traditional ROI: 8.32%
46653 Walkers place #14 Vermillion, SD Rare opportunity to own your own home on the Vermillion River, located at Walker Landing.....	3 beds \| 1 baths \| 740 sq.ft.	$199,900	Airbnb cash on cash: 5.65% Traditional cash on cash: 6.96% Airbnb Rental Income: $2107 Traditional Rental Income: $1815 Airbnb ROI: 5.65% Traditional ROI: 6.96%
46653 Walkers Place #15 Vermillion, SD Gorgeous custom home finished by local contractors, AMS. Vaulted ceiling, electric firepl...	2 beds \| 2 baths \| 900 sq.ft.	$239,000	Airbnb cash on cash: 8.14% Traditional cash on cash: 6.79% Airbnb Rental Income: $2991 Traditional Rental Income: $1999 Airbnb ROI: 8.14% Traditional ROI: 6.79%
9 N Pine Vermillion, SD Charming single-family home located on the corner of Main Street and Pine Street. Beautif...	5 beds \| 3 baths \| 2,681 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.9% Airbnb Rental Income: $null Traditional Rental Income: $3448 Airbnb ROI: N/A Traditional ROI: 10.9%
223 N Yale Vermillion, SD Here's a fun duplex on the south central edge of the University of South Dakota campus!! ...	N/A beds \| N/A baths \| 3,128 sq.ft.	$350,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.7% Airbnb Rental Income: $null Traditional Rental Income: $1903 Airbnb ROI: N/A Traditional ROI: 2.7%
4 W Clark Vermillion, SD Now, here`s a great duplex, just 1 block west of the University of South Dakota campus!! ...	N/A beds \| N/A baths \| 2,496 sq.ft.	$350,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.9% Airbnb Rental Income: $null Traditional Rental Income: $1878 Airbnb ROI: N/A Traditional ROI: 2.9%
1119 W Clark Vermillion, SD Nice 4~plex on the west edge of town by Bliss Pointe. All units are 2 bedroom, 1 bathroom...	N/A beds \| N/A baths \| 3,952 sq.ft.	$395,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.16% Airbnb Rental Income: $null Traditional Rental Income: $1778 Airbnb ROI: N/A Traditional ROI: 2.16%
716 Rose Vermillion, SD Here is a 4-plex located near the center of the University of South Dakota campus!! Each ...	N/A beds \| N/A baths \| 3,976 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.68% Airbnb Rental Income: $null Traditional Rental Income: $1905 Airbnb ROI: N/A Traditional ROI: 1.68%
1711 Vonnie St. Vermillion, SD The house in the neighborhood you have been waiting for is here for you to enjoy!! This ho...	3 beds \| 3 baths \| 2,760 sq.ft.	$315,000	Airbnb cash on cash: 2.81% Traditional cash on cash: 7.97% Airbnb Rental Income: $2107 Traditional Rental Income: $3095 Airbnb ROI: 2.81% Traditional ROI: 7.97%
121 S University Vermillion, SD Nestled on a generous .59-acre lot in the heart of Vermillion, this historic home boasts 5...	5 beds \| 3 baths \| 2,700 sq.ft.	$329,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.24% Airbnb Rental Income: $null Traditional Rental Income: $3130 Airbnb ROI: N/A Traditional ROI: 7.24%

Real Estate investment in Vermillion, SD

There are 28 properties for sale in the city of Vermillion . The median list price in Vermillion is $322,450 and the average price per square foot is $134. In September 2025, the average monthly cash on cash return in Vermillion is 6.00%. The average monthly rental income in Vermillion is $2,280.

Vermillion, SD Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 28 investment properties available for sale in Vermillion.

In 2025, the best neighborhood to buy investment property is Vermillion.

The ROI for Short-Term is higher than the Long-Term in Vermillion with average rental income of $2,107.

Your search for investment property begins and ends here

Investment Property for Sale in Vermillion, SD

1203 E Cherry

Vermillion, SD

4 beds | 2 baths | 1,825 sq.ft.

$189,500

Airbnb cash on cash: N/A

Traditional cash on cash: 11.18%

Airbnb Rental Income: $null

Traditional Rental Income: $2625

Airbnb ROI: N/A

Traditional ROI: 11.18%

1209 E Cherry

Vermillion, SD

4 beds | 2 baths | 1,728 sq.ft.

$185,500

Airbnb cash on cash: N/A

Traditional cash on cash: 11.32%

Airbnb Rental Income: $null

Traditional Rental Income: $2467

Airbnb ROI: N/A

Traditional ROI: 11.32%

2506 E Main St

Vermillion, SD

3 beds | 2 baths | 1,647 sq.ft.

$379,499

Airbnb cash on cash: 1.32%

Traditional cash on cash: 3.99%

Airbnb Rental Income: $2107

Traditional Rental Income: $2518

Airbnb ROI: 1.32%

Traditional ROI: 3.99%

103 N Pine

Vermillion, SD

4 beds | 2 baths | 1,632 sq.ft.

$209,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.88%

Airbnb Rental Income: $null

Traditional Rental Income: $1700

Airbnb ROI: N/A

Traditional ROI: 5.88%

323 Wilder

Vermillion, SD

3 beds | 4 baths | 2,699 sq.ft.

$419,900

Airbnb cash on cash: 2.63%

Traditional cash on cash: 5.24%

Airbnb Rental Income: $2107

Traditional Rental Income: $2594

Airbnb ROI: 2.63%

Traditional ROI: 5.24%

2410 E Main

Vermillion, SD

4 beds | 2 baths | 3,012 sq.ft.

$344,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.92%

Airbnb Rental Income: $null

Traditional Rental Income: $2856

Airbnb ROI: N/A

Traditional ROI: 5.92%

1025 Madison St E

Vermillion, SD

4 beds | 4 baths | 2,699 sq.ft.

$619,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.61%

Airbnb Rental Income: $null

Traditional Rental Income: $3526

Airbnb ROI: N/A

Traditional ROI: 3.61%

1203-09 E Cherry

Vermillion, SD

N/A beds | N/A baths | 5,275 sq.ft.

$374,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.99%

Airbnb Rental Income: $null

Traditional Rental Income: $1633

Airbnb ROI: N/A