Real Estate Investment Properties for Sale in Clayton, MO

Looking for investment property in Clayton, MO with high ROI ?

Explore a variety of short-term homes & houses in Clayton, MO. Invest wisely with VRBO & Clayton, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Clayton, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
710 S Hanley Road #10B Clayton, MO Welcome to The Whitehall, one of Claytonâs premier high-rise condominium communities and...	2 beds \| 2 baths \| 1,697 sq.ft.	$499,900	Airbnb cash on cash: -3.57% Traditional cash on cash: -1.06% Airbnb Rental Income: $1297 Traditional Rental Income: $2067 Airbnb ROI: -3.57% Traditional ROI: -1.06%
7545 Wellington Way #1A Clayton, MO Welcome to this beautifully updated condo in the heart of Clayton, set in a well-maintaine...	2 beds \| 2 baths \| 1,417 sq.ft.	$365,000	Airbnb cash on cash: -0.98% Traditional cash on cash: 2.11% Airbnb Rental Income: $1297 Traditional Rental Income: $1953 Airbnb ROI: -0.98% Traditional ROI: 2.11%
6320 Northwood Avenue #3 Clayton, MO Welcome home to the award winning Clayton School District, where you can watch your child ...	3 beds \| 2 baths \| 1,526 sq.ft.	$449,900	Airbnb cash on cash: 0.33% Traditional cash on cash: 1.23% Airbnb Rental Income: $2106 Traditional Rental Income: $1945 Airbnb ROI: 0.33% Traditional ROI: 1.23%
900 S Hanley Road #11B Clayton, MO Discover effortless condo living in this inviting 1-bedroom residence, conveniently locate...	1 beds \| 1 baths \| 1,110 sq.ft.	$145,000	Airbnb cash on cash: -9.27% Traditional cash on cash: -4.62% Airbnb Rental Income: $967 Traditional Rental Income: $1263 Airbnb ROI: -9.27% Traditional ROI: -4.62%
925 S Hanley Road #F Clayton, MO For Sale \| 1,080 Sq Ft \| Art Deco Masterpiece in the Heart of Clayton Own a piece of Clayt...	2 beds \| 1 baths \| 1,080 sq.ft.	$189,900	Airbnb cash on cash: -1.58% Traditional cash on cash: 0.84% Airbnb Rental Income: $1297 Traditional Rental Income: $1328 Airbnb ROI: -1.58% Traditional ROI: 0.84%
7570 Byron Place #3W Clayton, MO PRICE REDUCED- Motivated Seller! Located in the highly sought-after Clayton School Distri...	2 beds \| 1 baths \| 1,074 sq.ft.	$229,900	Airbnb cash on cash: -0.8% Traditional cash on cash: 1.07% Airbnb Rental Income: $1297 Traditional Rental Income: $1298 Airbnb ROI: -0.8% Traditional ROI: 1.07%
7529 Wellington Way #1 Clayton, MO Perfectly positioned in the heart of the Moorlands, 7529 Wellington Way #1 offers the idea...	3 beds \| 2 baths \| 1,778 sq.ft.	$429,000	Airbnb cash on cash: 0.29% Traditional cash on cash: 3.22% Airbnb Rental Income: $2106 Traditional Rental Income: $2745 Airbnb ROI: 0.29% Traditional ROI: 3.22%
8250 Forsyth Boulevard #302 Clayton, MO Completed custom 3 bed, 3.5 bath 3243 sq ft unit overlooking Forsyth and Maryland. The cu...	3 beds \| 4 baths \| 3,243 sq.ft.	$2,329,000	Airbnb cash on cash: -1.42% Traditional cash on cash: -0.6% Airbnb Rental Income: $2106 Traditional Rental Income: $3349 Airbnb ROI: -1.42% Traditional ROI: -0.6%
900 S Hanley Road #6C Clayton, MO Welcome to unit 6C in the desirable Hanley Towers, ideally located in the heart of Clayton...	2 beds \| 2 baths \| 1,633 sq.ft.	$289,000	Airbnb cash on cash: -6.22% Traditional cash on cash: -2.36% Airbnb Rental Income: $1297 Traditional Rental Income: $1943 Airbnb ROI: -6.22% Traditional ROI: -2.36%
8130 Westmoreland Avenue Clayton, MO Executive estate in the heart of Clayton, just a block from the financial center of St. Lo...	4 beds \| 6 baths \| 7,023 sq.ft.	$2,590,000	Airbnb cash on cash: -1.64% Traditional cash on cash: 0.41% Airbnb Rental Income: $1897 Traditional Rental Income: $6322 Airbnb ROI: -1.64% Traditional ROI: 0.41%
665 W Polo Drive Clayton, MO Welcome to 665 W Polo Drive, a distinguished French Norman residence on one of Clayton's m...	5 beds \| 4 baths \| 4,366 sq.ft.	$1,775,000	Airbnb cash on cash: -0.16% Traditional cash on cash: 0.64% Airbnb Rental Income: $3363 Traditional Rental Income: $3936 Airbnb ROI: -0.16% Traditional ROI: 0.64%
7532 Cromwell Dr. #2N Clayton, MO Discover the charm of this highly sought after Moorlands condo, a well maintained second f...	2 beds \| 1 baths \| 1,120 sq.ft.	$232,400	Airbnb cash on cash: -0.68% Traditional cash on cash: 1.47% Airbnb Rental Income: $1297 Traditional Rental Income: $1365 Airbnb ROI: -0.68% Traditional ROI: 1.47%
150 Carondelet Plaza #1301 Clayton, MO Experience elevated living at the most coveted address in town- The Plaza in Clayton. This...	2 beds \| 3 baths \| 3,744 sq.ft.	$2,395,000	Airbnb cash on cash: -3.13% Traditional cash on cash: -2.51% Airbnb Rental Income: $1297 Traditional Rental Income: $2275 Airbnb ROI: -3.13% Traditional ROI: -2.51%
214 Topton Way Clayton, MO Rare Opportunity in the Heart of Clayton Gardens! Unlock the potential of this solid 4-si...	3 beds \| 3 baths \| 1,922 sq.ft.	$899,900	Airbnb cash on cash: -0.39% Traditional cash on cash: 0.78% Airbnb Rental Income: $2106 Traditional Rental Income: $2539 Airbnb ROI: -0.39% Traditional ROI: 0.78%
6619 San Bonita Avenue Clayton, MO Located in the heart of Clayton, this spacious three-story brick multifamily property offe...	N/A beds \| N/A baths \| 2,806 sq.ft.	$909,000	Airbnb cash on cash: -1.9% Traditional cash on cash: -0.11% Airbnb Rental Income: $263 Traditional Rental Income: $1545 Airbnb ROI: -1.9% Traditional ROI: -0.11%
250 S Brentwood Boulevard #1F Clayton, MO Rare opportunity to own an exceptionally spacious and affordable condo offering more than ...	3 beds \| 3 baths \| 2,249 sq.ft.	$325,000	Airbnb cash on cash: -1.28% Traditional cash on cash: 2.79% Airbnb Rental Income: $2106 Traditional Rental Income: $2811 Airbnb ROI: -1.28% Traditional ROI: 2.79%
136 N Brentwood Boulevard Clayton, MO Experience elevated living in this exemplary residence in the heart of Clayton, just minut...	4 beds \| 7 baths \| 6,407 sq.ft.	$6,200,000	Airbnb cash on cash: -1.33% Traditional cash on cash: -1.06% Airbnb Rental Income: $1897 Traditional Rental Income: $2918 Airbnb ROI: -1.33% Traditional ROI: -1.06%
900 S Hanley Road #3D Clayton, MO Welcome to 900 S. Hanley Road, Unit 3D, ideally located in the heart of Clayton with easy ...	3 beds \| 3 baths \| 2,025 sq.ft.	$299,000	Airbnb cash on cash: -5.23% Traditional cash on cash: -2.32% Airbnb Rental Income: $2106 Traditional Rental Income: $2386 Airbnb ROI: -5.23% Traditional ROI: -2.32%
31 Brighton Way #3 Clayton, MO The entire third floor is yours. This extraordinary 4,000-square-foot residence redefines ...	3 beds \| 4 baths \| 4,087 sq.ft.	$2,500,000	Airbnb cash on cash: -1.77% Traditional cash on cash: -1.69% Airbnb Rental Income: $2106 Traditional Rental Income: $1759 Airbnb ROI: -1.77% Traditional ROI: -1.69%
630 Westwood Drive #2S Clayton, MO Location, location, location! Fabulous Clayton condo in sought after Moorlands neighborhoo...	2 beds \| 1 baths \| 1,289 sq.ft.	$259,900	Airbnb cash on cash: -0.87% Traditional cash on cash: -0.28% Airbnb Rental Income: $1297 Traditional Rental Income: $1036 Airbnb ROI: -0.87% Traditional ROI: -0.28%
200 S Brentwood Boulevard #13F Clayton, MO Welcome to the 13th floor of the highly sought-after Park Tower, where luxury, privacy, an...	2 beds \| 2 baths \| 1,204 sq.ft.	$225,000	Airbnb cash on cash: -5.53% Traditional cash on cash: -4.26% Airbnb Rental Income: $1297 Traditional Rental Income: $1162 Airbnb ROI: -5.53% Traditional ROI: -4.26%
7743 Kingsbury Boulevard #21 Clayton, MO One-of-a-kind Clayton condo offering a rare combination of space, convenience, and style! ...	2 beds \| 3 baths \| 1,713 sq.ft.	$475,000	Airbnb cash on cash: -1.63% Traditional cash on cash: 1.4% Airbnb Rental Income: $1297 Traditional Rental Income: $2238 Airbnb ROI: -1.63% Traditional ROI: 1.4%
312 N Brentwood Boulevard #3 Clayton, MO Beautifully renovated 3-bedroom, 3.5-bath townhome in the sought-after Brentwood Commons e...	3 beds \| 4 baths \| 3,327 sq.ft.	$1,200,000	Airbnb cash on cash: -2.22% Traditional cash on cash: -1.12% Airbnb Rental Income: $2106 Traditional Rental Income: $2800 Airbnb ROI: -2.22% Traditional ROI: -1.12%
520 S Brentwood Boulevard #2D Clayton, MO Presenting an exceptional opportunity at 520 S Brentwood BLVD 2D, CLYTN, MO 63105. This di...	2 beds \| 2 baths \| 1,590 sq.ft.	$299,999	Airbnb cash on cash: -2.32% Traditional cash on cash: 1.84% Airbnb Rental Income: $1297 Traditional Rental Income: $2068 Airbnb ROI: -2.32% Traditional ROI: 1.84%
6636 San Bonita Avenue #2W Clayton, MO Nestled in the heart of the sought-after DeMun neighborhood and within the prestigious Cla...	2 beds \| 1 baths \| 1,328 sq.ft.	$305,000	Airbnb cash on cash: -0.43% Traditional cash on cash: 3.88% Airbnb Rental Income: $1297 Traditional Rental Income: $2128 Airbnb ROI: -0.43% Traditional ROI: 3.88%
8104 Stratford Drive Clayton, MO Stretch out in this Clayton Gardens gem on a rare oversized lot! The main floor features l...	3 beds \| 4 baths \| 3,593 sq.ft.	$1,190,000	Airbnb cash on cash: -0.66% Traditional cash on cash: 0.9% Airbnb Rental Income: $2106 Traditional Rental Income: $3302 Airbnb ROI: -0.66% Traditional ROI: 0.9%
205 Brighton Way Clayton, MO Located in Clayton Gardens, this home was in pristine condition with modern finishes throu...	4 beds \| 4 baths \| 3,316 sq.ft.	$1,749,000	Airbnb cash on cash: -1.05% Traditional cash on cash: 0.12% Airbnb Rental Income: $1897 Traditional Rental Income: $3295 Airbnb ROI: -1.05% Traditional ROI: 0.12%
712 Francis Place Clayton, MO Fresh New Price! Tucked in an incredibly walkable location near Shaw Park, downtown Clayto...	3 beds \| 2 baths \| 1,737 sq.ft.	$575,000	Airbnb cash on cash: 0.98% Traditional cash on cash: 2.12% Airbnb Rental Income: $2106 Traditional Rental Income: $2181 Airbnb ROI: 0.98% Traditional ROI: 2.12%
7456 Parkdale Avenue Clayton, MO This gracious home offers a lifestyle that is both comfortable and refined. A beautifully ...	4 beds \| 3 baths \| 2,752 sq.ft.	$899,500	Airbnb cash on cash: -0.61% Traditional cash on cash: 1.34% Airbnb Rental Income: $1897 Traditional Rental Income: $3027 Airbnb ROI: -0.61% Traditional ROI: 1.34%
7246 Wydown Boulevard Clayton, MO The gorgeous curb appeal and an inviting foyer set the tone for this beautiful home, offer...	4 beds \| 4 baths \| 4,750 sq.ft.	$2,185,000	Airbnb cash on cash: -1.4% Traditional cash on cash: -0.17% Airbnb Rental Income: $1897 Traditional Rental Income: $3903 Airbnb ROI: -1.4% Traditional ROI: -0.17%
8124 Halifax Drive Clayton, MO The curb appeal sets the tone for this beautifully renovated Clayton property! Step insid...	3 beds \| 3 baths \| 2,544 sq.ft.	$624,900	Airbnb cash on cash: 0.72% Traditional cash on cash: 2.94% Airbnb Rental Income: $2106 Traditional Rental Income: $2857 Airbnb ROI: 0.72% Traditional ROI: 2.94%

Real Estate investment in Clayton, MO

There are 32 properties for sale in the city of Clayton . The median list price in Clayton is $734,311 and the average price per square foot is $324. In July 2026, the average monthly cash on cash return in Clayton is 1.00%. The average monthly rental income in Clayton is $2,169.

Clayton, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 32 investment properties available for sale in Clayton.

In 2026, the best neighborhood to buy investment property is Clayton.

The ROI for Long-Term is higher than the Short-Term in Clayton with average rental income of $2,169.

Your search for investment property begins and ends here

Investment Property for Sale in Clayton, MO

710 S Hanley Road #10B

Clayton, MO

2 beds | 2 baths | 1,697 sq.ft.

$499,900

Airbnb cash on cash: -3.57%

Traditional cash on cash: -1.06%

Airbnb Rental Income: $1297

Traditional Rental Income: $2067

Airbnb ROI: -3.57%

Traditional ROI: -1.06%

7545 Wellington Way #1A

Clayton, MO

2 beds | 2 baths | 1,417 sq.ft.

$365,000

Airbnb cash on cash: -0.98%

Traditional cash on cash: 2.11%

Airbnb Rental Income: $1297

Traditional Rental Income: $1953

Airbnb ROI: -0.98%

Traditional ROI: 2.11%

6320 Northwood Avenue #3

Clayton, MO

3 beds | 2 baths | 1,526 sq.ft.

$449,900

Airbnb cash on cash: 0.33%

Traditional cash on cash: 1.23%

Airbnb Rental Income: $2106

Traditional Rental Income: $1945

Airbnb ROI: 0.33%

Traditional ROI: 1.23%

900 S Hanley Road #11B

Clayton, MO

1 beds | 1 baths | 1,110 sq.ft.

$145,000

Airbnb cash on cash: -9.27%

Traditional cash on cash: -4.62%

Airbnb Rental Income: $967

Traditional Rental Income: $1263

Airbnb ROI: -9.27%

Traditional ROI: -4.62%

925 S Hanley Road #F

Clayton, MO

2 beds | 1 baths | 1,080 sq.ft.

$189,900

Airbnb cash on cash: -1.58%

Traditional cash on cash: 0.84%

Airbnb Rental Income: $1297

Traditional Rental Income: $1328

Airbnb ROI: -1.58%

Traditional ROI: 0.84%

7570 Byron Place #3W

Clayton, MO

2 beds | 1 baths | 1,074 sq.ft.

$229,900

Airbnb cash on cash: -0.8%

Traditional cash on cash: 1.07%

Airbnb Rental Income: $1297

Traditional Rental Income: $1298

Airbnb ROI: -0.8%

Traditional ROI: 1.07%

7529 Wellington Way #1

Clayton, MO

3 beds | 2 baths | 1,778 sq.ft.

$429,000

Airbnb cash on cash: 0.29%

Traditional cash on cash: 3.22%

Airbnb Rental Income: $2106

Traditional Rental Income: $2745

Airbnb ROI: 0.29%

Traditional ROI: 3.22%

8250 Forsyth Boulevard #302

Clayton, MO

3 beds | 4 baths | 3,243 sq.ft.

$2,329,000

Airbnb cash on cash: -1.42%

Traditional cash on cash: -0.6%

Airbnb Rental Income: $2106

Traditional Rental Income: $3349

Airbnb ROI: -1.42%