Real Estate Investment Properties for Sale in Clayton, MO

Looking for investment property in Clayton, MO with high ROI ?

Explore a variety of short-term homes & houses in Clayton, MO. Invest wisely with VRBO & Clayton, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Clayton, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
150 Carondelet Plaza #2801 Clayton, MO Welcome to the crown jewel of luxury living: this full-floor penthouse features 2800 squar...	3 beds \| 5 baths \| 7,719 sq.ft.	$7,495,000	Airbnb cash on cash: -2.25% Traditional cash on cash: -1.86% Airbnb Rental Income: $1532 Traditional Rental Income: $3842 Airbnb ROI: -2.25% Traditional ROI: -1.86%
907 S Hanley Road #5 Clayton, MO LOCATION, location, location! Interesting architectural building with easy access to all t...	1 beds \| 1 baths \| 837 sq.ft.	$152,000	Airbnb cash on cash: -1.8% Traditional cash on cash: 2.58% Airbnb Rental Income: $838 Traditional Rental Income: $1146 Airbnb ROI: -1.8% Traditional ROI: 2.58%
7544 York Drive #3W Clayton, MO From the Art Deco exterior to an interior where a perfect blend of old meets new, this bea...	2 beds \| 2 baths \| 1,369 sq.ft.	$295,000	Airbnb cash on cash: -1% Traditional cash on cash: 3.68% Airbnb Rental Income: $1086 Traditional Rental Income: $2016 Airbnb ROI: -1% Traditional ROI: 3.68%
7521 Byron Place #3E Clayton, MO Beautifully updated 2-bedroom, 1-bath condo located in the heart of Claytonâs desirable ...	2 beds \| 1 baths \| 1,185 sq.ft.	$282,000	Airbnb cash on cash: -1.48% Traditional cash on cash: 1.16% Airbnb Rental Income: $1086 Traditional Rental Income: $1419 Airbnb ROI: -1.48% Traditional ROI: 1.16%
900 S Hanley Road #15B Clayton, MO Live in the clouds over Clayton! Beautifully updated condo with granite stainless kitchen,...	1 beds \| 1 baths \| 1,100 sq.ft.	$230,000	Airbnb cash on cash: -6.17% Traditional cash on cash: -3.91% Airbnb Rental Income: $838 Traditional Rental Income: $1002 Airbnb ROI: -6.17% Traditional ROI: -3.91%
8333 Kingsbury Boulevard Clayton, MO Lovely sprawling ranch in a very desired area of Clayton. This corner lot ranch is almo...	4 beds \| 4 baths \| 3,197 sq.ft.	$1,750,000	Airbnb cash on cash: -1.4% Traditional cash on cash: 0.6% Airbnb Rental Income: $1519 Traditional Rental Income: $4322 Airbnb ROI: -1.4% Traditional ROI: 0.6%
20 Ridgemoor Drive Clayton, MO NEW PRICE!Discover the stunning updates in this remarkable 5-bedroom, 3 full bath, 2 half ...	5 beds \| 5 baths \| 5,336 sq.ft.	$1,899,900	Airbnb cash on cash: -0.92% Traditional cash on cash: 0.97% Airbnb Rental Income: $2348 Traditional Rental Income: $5085 Airbnb ROI: -0.92% Traditional ROI: 0.97%
710 S Hanley Road #18B Clayton, MO The Whitehall at Its Finest â Spacious, Sophisticated, and Truly One of a Kind. Welcome ...	3 beds \| 4 baths \| 3,300 sq.ft.	$890,000	Airbnb cash on cash: -4.71% Traditional cash on cash: -2.34% Airbnb Rental Income: $1532 Traditional Rental Income: $3054 Airbnb ROI: -4.71% Traditional ROI: -2.34%
8130 Roxburgh Drive Clayton, MO This beautiful 4 family apartment building is located in Clayshire Neighborhood just acros...	N/A beds \| N/A baths \| 4,480 sq.ft.	$850,000	Airbnb cash on cash: -1.67% Traditional cash on cash: -0.37% Airbnb Rental Income: $731 Traditional Rental Income: $1451 Airbnb ROI: -1.67% Traditional ROI: -0.37%
314 S Hanley Road #1N Clayton, MO Great opportunity, with incredible new price $250K for Clayton condo! Charming condo in th...	2 beds \| 1 baths \| 1,390 sq.ft.	$250,000	Airbnb cash on cash: -1.06% Traditional cash on cash: 2.18% Airbnb Rental Income: $1086 Traditional Rental Income: $1480 Airbnb ROI: -1.06% Traditional ROI: 2.18%
710 S Hanley Road #17C Clayton, MO A very rare opportunity to purchase a nearly 4,000 sq. ft. penthouse in the sky on the 17t...	3 beds \| 3 baths \| 3,811 sq.ft.	$975,000	Airbnb cash on cash: -4.31% Traditional cash on cash: -2.54% Airbnb Rental Income: $1532 Traditional Rental Income: $2693 Airbnb ROI: -4.31% Traditional ROI: -2.54%
132 N Brentwood Boulevard Clayton, MO This extraordinary 2024 Slavin Homes built residence offers a lifestyle of refined luxury ...	4 beds \| 7 baths \| 7,383 sq.ft.	$9,950,000	Airbnb cash on cash: -1.18% Traditional cash on cash: -0.58% Airbnb Rental Income: $1519 Traditional Rental Income: $6590 Airbnb ROI: -1.18% Traditional ROI: -0.58%
900 S Hanley Road #6E Clayton, MO Sophisticated Urban Living in Clayton. Step into this elegant and spacious 2-bedroom, 2-ba...	2 beds \| 2 baths \| 1,620 sq.ft.	$265,000	Airbnb cash on cash: -5.96% Traditional cash on cash: -0.4% Airbnb Rental Income: $1086 Traditional Rental Income: $2106 Airbnb ROI: -5.96% Traditional ROI: -0.4%
212 Gay Avenue Clayton, MO On one of Claytonâs most coveted streets, this end unit residence stands out with a rare...	3 beds \| 4 baths \| 3,026 sq.ft.	$1,350,000	Airbnb cash on cash: -1.37% Traditional cash on cash: 0.1% Airbnb Rental Income: $1532 Traditional Rental Income: $2930 Airbnb ROI: -1.37% Traditional ROI: 0.1%
8166 Whitburn Drive Clayton, MO A 15-unit property located in the wonderful Clayton neighborhood. There are 12 two-bedroom...	3 beds \| 2 baths \| 1,250 sq.ft.	$3,295,000	Airbnb cash on cash: -1.76% Traditional cash on cash: -1.41% Airbnb Rental Income: $731 Traditional Rental Income: $1480 Airbnb ROI: -1.76% Traditional ROI: -1.41%
150 Carondelet Plaza #302 Clayton, MO This 2,800 SF Condominium offers a lifestyle of luxury and convenience in Clayton's premie...	2 beds \| 3 baths \| 2,817 sq.ft.	$1,350,000	Airbnb cash on cash: -3.8% Traditional cash on cash: -2.41% Airbnb Rental Income: $1086 Traditional Rental Income: $2457 Airbnb ROI: -3.8% Traditional ROI: -2.41%
7788 Pershing Avenue Clayton, MO The Jewel behind the door. Old Town Clayton's BEST! 7788 Pershing Avenue draws its inspira...	3 beds \| 5 baths \| 4,284 sq.ft.	$1,750,000	Airbnb cash on cash: -1.38% Traditional cash on cash: 0.3% Airbnb Rental Income: $1532 Traditional Rental Income: $3830 Airbnb ROI: -1.38% Traditional ROI: 0.3%
224 N Bemiston Avenue Clayton, MO Constructed of brick and limestone, this newer home evokes the timeless charm of historic ...	5 beds \| 5 baths \| 4,473 sq.ft.	$2,495,000	Airbnb cash on cash: -1.05% Traditional cash on cash: 0.19% Airbnb Rental Income: $2348 Traditional Rental Income: $4629 Airbnb ROI: -1.05% Traditional ROI: 0.19%
23 Topton Way #2B Clayton, MO Stylish Living in the Heart of Clayton! Welcome to this beautifully appointed 2bed/2.5 ba...	2 beds \| 3 baths \| 2,365 sq.ft.	$979,000	Airbnb cash on cash: -2.92% Traditional cash on cash: -0.86% Airbnb Rental Income: $1086 Traditional Rental Income: $2592 Airbnb ROI: -2.92% Traditional ROI: -0.86%
7642 Carswold Drive Clayton, MO Back On Market - No Fault of Seller. Located on a quiet street in Wydown Forest, this stat...	3 beds \| 3 baths \| 1,700 sq.ft.	$629,000	Airbnb cash on cash: -0.47% Traditional cash on cash: 1.5% Airbnb Rental Income: $1532 Traditional Rental Income: $2241 Airbnb ROI: -0.47% Traditional ROI: 1.5%
127 N Bemiston Avenue Clayton, MO Situated in the heart of Old Town Clayton, this exceptional condominium offers a rare blen...	3 beds \| 5 baths \| 3,775 sq.ft.	$1,250,000	Airbnb cash on cash: -1.81% Traditional cash on cash: 0.37% Airbnb Rental Income: $1532 Traditional Rental Income: $3626 Airbnb ROI: -1.81% Traditional ROI: 0.37%
6312 Southwood Avenue #1W Clayton, MO Step into this light-filled condo that seamlessly blends classic charm with modern updates...	3 beds \| 2 baths \| 1,497 sq.ft.	$374,900	Airbnb cash on cash: -0.79% Traditional cash on cash: 1.69% Airbnb Rental Income: $1532 Traditional Rental Income: $1959 Airbnb ROI: -0.79% Traditional ROI: 1.69%

Real Estate investment in Clayton, MO

There are 24 properties for sale in the city of Clayton . The median list price in Clayton is $977,000 and the average price per square foot is $205. In October 2025, the average monthly cash on cash return in Clayton is N/A%. The average monthly rental income in Clayton is $2,525.

Clayton, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 24 investment properties available for sale in Clayton.

In 2025, the best neighborhood to buy investment property is Clayton.

The ROI for Long-Term is higher than the Short-Term in Clayton with average rental income of $2,525.

Your search for investment property begins and ends here

Investment Property for Sale in Clayton, MO

150 Carondelet Plaza #2801

Clayton, MO

3 beds | 5 baths | 7,719 sq.ft.

$7,495,000

Airbnb cash on cash: -2.25%

Traditional cash on cash: -1.86%

Airbnb Rental Income: $1532

Traditional Rental Income: $3842

Airbnb ROI: -2.25%

Traditional ROI: -1.86%

907 S Hanley Road #5

Clayton, MO

1 beds | 1 baths | 837 sq.ft.

$152,000

Airbnb cash on cash: -1.8%

Traditional cash on cash: 2.58%

Airbnb Rental Income: $838

Traditional Rental Income: $1146

Airbnb ROI: -1.8%

Traditional ROI: 2.58%

7544 York Drive #3W

Clayton, MO

2 beds | 2 baths | 1,369 sq.ft.

$295,000

Airbnb cash on cash: -1%

Traditional cash on cash: 3.68%

Airbnb Rental Income: $1086

Traditional Rental Income: $2016

Airbnb ROI: -1%

Traditional ROI: 3.68%

7521 Byron Place #3E

Clayton, MO

2 beds | 1 baths | 1,185 sq.ft.

$282,000

Airbnb cash on cash: -1.48%

Traditional cash on cash: 1.16%

Airbnb Rental Income: $1086

Traditional Rental Income: $1419

Airbnb ROI: -1.48%

Traditional ROI: 1.16%

900 S Hanley Road #15B

Clayton, MO

1 beds | 1 baths | 1,100 sq.ft.

$230,000

Airbnb cash on cash: -6.17%

Traditional cash on cash: -3.91%

Airbnb Rental Income: $838

Traditional Rental Income: $1002

Airbnb ROI: -6.17%

Traditional ROI: -3.91%

8333 Kingsbury Boulevard

Clayton, MO

4 beds | 4 baths | 3,197 sq.ft.

$1,750,000

Airbnb cash on cash: -1.4%

Traditional cash on cash: 0.6%

Airbnb Rental Income: $1519

Traditional Rental Income: $4322

Airbnb ROI: -1.4%

Traditional ROI: 0.6%

20 Ridgemoor Drive

Clayton, MO

5 beds | 5 baths | 5,336 sq.ft.

$1,899,900

Airbnb cash on cash: -0.92%

Traditional cash on cash: 0.97%

Airbnb Rental Income: $2348

Traditional Rental Income: $5085

Airbnb ROI: -0.92%

Traditional ROI: 0.97%

710 S Hanley Road #18B

Clayton, MO

3 beds | 4 baths | 3,300 sq.ft.

$890,000

Airbnb cash on cash: -4.71%

Traditional cash on cash: -2.34%

Airbnb Rental Income: $1532

Traditional Rental Income: $3054

Airbnb ROI: -4.71%