Real Estate Investment Properties for Sale in De Soto, MO

Looking for investment property in De Soto, MO with high ROI ?

Explore a variety of short-term homes & houses in De Soto, MO. Invest wisely with VRBO & De Soto, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
13819 State Route 21 De Soto, MO Charming 3-bedroom, 1-bath ranch home situated on 2.96 peaceful acres in the DeSoto School...	3 beds \| 1 baths \| 1,692 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.29% Airbnb Rental Income: $null Traditional Rental Income: $1068 Airbnb ROI: N/A Traditional ROI: 2.29%
2902 Clay Street De Soto, MO Caesar's Country Acres is an all-age community located in De Soto, Missouri, approximately...	N/A beds \| N/A baths \| N/A	$530,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.92% Airbnb Rental Income: $null Traditional Rental Income: $1430 Airbnb ROI: N/A Traditional ROI: 0.92%
3589 State Route 110 De Soto, MO Come and visit this rare opportunity just south of the Gateway City and on the doorstep of...	4 beds \| 4 baths \| 3,899 sq.ft.	$1,690,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.74% Airbnb Rental Income: $null Traditional Rental Income: $3360 Airbnb ROI: N/A Traditional ROI: 0.74%
615 Perry St De Soto, MO Welcome home to this cozy home right in the heart of De Soto. This two bed one bath home m...	2 beds \| 1 baths \| 775 sq.ft.	$159,900	Airbnb cash on cash: 0.23% Traditional cash on cash: 3.88% Airbnb Rental Income: $661 Traditional Rental Income: $919 Airbnb ROI: 0.23% Traditional ROI: 3.88%
4319 Flucom Road De Soto, MO A Rare Country Retreat on 6.99 Acres in De Soto! Looking for privacy, space, and endless p...	4 beds \| 3 baths \| 2,556 sq.ft.	$439,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.48% Airbnb Rental Income: $null Traditional Rental Income: $3085 Airbnb ROI: N/A Traditional ROI: 5.48%
5528 Hillsboro Hematite Road De Soto, MO HILLSBORO SCHOOLS - Enjoy peaceful country living in this beautifully maintained ranch on ...	3 beds \| 2 baths \| 2,016 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.94% Airbnb Rental Income: $null Traditional Rental Income: $2070 Airbnb ROI: N/A Traditional ROI: 6.94%
709 S 2nd St De Soto, MO Buy through Auction.com. This foreclosure property is a great opportunity to invest in thi...	3 beds \| 2 baths \| 1,100 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.86% Airbnb Rental Income: $null Traditional Rental Income: $1373 Airbnb ROI: N/A Traditional ROI: 4.86%
1323 S 5th St De Soto, MO Take a look at everything this affordable DeSoto ranch is offering: nearly one-third of an...	2 beds \| 1 baths \| 936 sq.ft.	$169,900	Airbnb cash on cash: 0.15% Traditional cash on cash: 4.32% Airbnb Rental Income: $661 Traditional Rental Income: $1038 Airbnb ROI: 0.15% Traditional ROI: 4.32%
514 S 2nd St De Soto, MO Solid bungalow in the heart of town. The yard is fully fenced and has a few shade trees in...	2 beds \| 1 baths \| 910 sq.ft.	$130,000	Airbnb cash on cash: 0.64% Traditional cash on cash: 5.12% Airbnb Rental Income: $661 Traditional Rental Income: $922 Airbnb ROI: 0.64% Traditional ROI: 5.12%
2151 Lake Park Trl De Soto, MO Beautiful acreage with a lake. Totaling 24.85 acres of seclusion. Looking for someone with...	N/A beds \| N/A baths \| N/A	$234,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.51% Airbnb Rental Income: $null Traditional Rental Income: $1742 Airbnb ROI: N/A Traditional ROI: 5.51%
3772 GOLDENROD LN De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 768 sq.ft.	$130,000	Airbnb cash on cash: 0.49% Traditional cash on cash: 5.5% Airbnb Rental Income: $661 Traditional Rental Income: $989 Airbnb ROI: 0.49% Traditional ROI: 5.5%
3401 FLUCOM RD De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 780 sq.ft.	$181,000	Airbnb cash on cash: 0.14% Traditional cash on cash: 4.66% Airbnb Rental Income: $661 Traditional Rental Income: $1141 Airbnb ROI: 0.14% Traditional ROI: 4.66%
422 N 2nd St De Soto, MO Lot of possibilities with this home/property which sits on a huge lot. Could be set up as ...	3 beds \| 2 baths \| 2,000 sq.ft.	$359,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.17% Airbnb Rental Income: $null Traditional Rental Income: $835 Airbnb ROI: N/A Traditional ROI: 1.17%
700 Lovett St De Soto, MO Step inside! This Two-bedroom, one-bathroom home offers significant potential and was prev...	2 beds \| 1 baths \| 858 sq.ft.	$114,900	Airbnb cash on cash: 0.76% Traditional cash on cash: 7.16% Airbnb Rental Income: $661 Traditional Rental Income: $1073 Airbnb ROI: 0.76% Traditional ROI: 7.16%
206 E Clement St De Soto, MO Enjoy your morning coffee or evening beverages on the charming, covered front porch of thi...	3 beds \| 1 baths \| 1,208 sq.ft.	$199,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.58% Airbnb Rental Income: $null Traditional Rental Income: $1013 Airbnb ROI: N/A Traditional ROI: 3.58%
1539 Hickory Lndg De Soto, MO Welcome home to 1539 Hickory Landing, a beautiful ranch-style Villa built in 2024. This 3-...	3 beds \| 2 baths \| 1,604 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $1944 Airbnb ROI: N/A Traditional ROI: 4.45%
1553 Hickory Lndg De Soto, MO 2 Bedroom and 2 full Bathrooms, Welcome to the Villas at West Ridge. What a great opportu...	2 beds \| 2 baths \| 1,460 sq.ft.	$290,000	Airbnb cash on cash: -1.71% Traditional cash on cash: 3.18% Airbnb Rental Income: $661 Traditional Rental Income: $1698 Airbnb ROI: -1.71% Traditional ROI: 3.18%
618 Woods End Trl De Soto, MO Calling all investors. Lots of potential in this lake front property on over 3 acres. 3 Be...	2 beds \| 1 baths \| 2,052 sq.ft.	$339,000	Airbnb cash on cash: -0.64% Traditional cash on cash: 2.91% Airbnb Rental Income: $661 Traditional Rental Income: $1495 Airbnb ROI: -0.64% Traditional ROI: 2.91%
129 E Pratt St De Soto, MO This remodeled bungalow is move in ready and beaming with charm. A nice size level yard m...	1 beds \| 1 baths \| 616 sq.ft.	$89,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.57% Airbnb Rental Income: $null Traditional Rental Income: $709 Airbnb ROI: N/A Traditional ROI: 5.57%
5336 Morse Ave De Soto, MO Enter this beautifully updated 3-bedroom, 1-bath home featuring stylish new flooring and f...	3 beds \| 1 baths \| 392 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.56% Airbnb Rental Income: $null Traditional Rental Income: $1371 Airbnb ROI: N/A Traditional ROI: 5.56%
1545 Hickory Lndg De Soto, MO This is the newest development within city limits and it is a great opportunity to own a b...	3 beds \| 2 baths \| 1,606 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.94% Airbnb Rental Income: $null Traditional Rental Income: $2010 Airbnb ROI: N/A Traditional ROI: 4.94%
13619 Mount Olive Road De Soto, MO Nestled on approximately 4 beautiful acres in the Desoto countryside, this well-maintained...	3 beds \| 2 baths \| 2,052 sq.ft.	$279,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.47% Airbnb Rental Income: $null Traditional Rental Income: $2242 Airbnb ROI: N/A Traditional ROI: 6.47%
Lot 1B of Hawks Retreat De Soto, MO Lot 1B of Hawks Retreat, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.71% Airbnb Rental Income: $null Traditional Rental Income: $724 Airbnb ROI: N/A Traditional ROI: 0.71%
0 State Route 21 De Soto, MO 0 State Route 21, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.57% Airbnb Rental Income: $null Traditional Rental Income: $712 Airbnb ROI: N/A Traditional ROI: -0.57%
13670 Mammoth Rd De Soto, MO 13670 Mammoth Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,968 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.81% Airbnb Rental Income: $null Traditional Rental Income: $1853 Airbnb ROI: N/A Traditional ROI: 1.81%
709 Eberhardt Ln De Soto, MO 709 Eberhardt Ln, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 7,660 sq.ft.	$1,749,000	Airbnb cash on cash: N/A Traditional cash on cash: -1.2% Airbnb Rental Income: $null Traditional Rental Income: $1335 Airbnb ROI: N/A Traditional ROI: -1.2%
400 Hill Side Rd De Soto, MO 400 Hill Side Rd, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$55,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.47% Airbnb Rental Income: $null Traditional Rental Income: $857 Airbnb ROI: N/A Traditional ROI: 11.47%
14641 Engledow Springs Rd De Soto, MO 14641 Engledow Springs Rd, De Soto, MO 63020 \| Single Family Residential	N/A beds \| 1 baths \| 900 sq.ft.	$415,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.64% Airbnb Rental Income: $null Traditional Rental Income: $606 Airbnb ROI: N/A Traditional ROI: -0.64%
2942 Marathon Dr De Soto, MO 2942 Marathon Dr, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,259 sq.ft.	$274,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.16% Airbnb Rental Income: $null Traditional Rental Income: $1419 Airbnb ROI: N/A Traditional ROI: 3.16%
4305 Park Dr De Soto, MO Opportunity knocks at 4305 Park Dr in De Soto! Located in a desirable lake community, this...	2 beds \| 1 baths \| 1,050 sq.ft.	$94,500	Airbnb cash on cash: -0.02% Traditional cash on cash: 5.3% Airbnb Rental Income: $661 Traditional Rental Income: $852 Airbnb ROI: -0.02% Traditional ROI: 5.3%
5270 US Highway 67 De Soto, MO 5270 US Highway 67, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$385,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.19% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: -0.19%
53 HIGHWAY E (vererans Dr) Dr De Soto, MO 53 HIGHWAY E (vererans Dr) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$50,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.63% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: 10.63%
4640 Dylan (lot 11) Dr De Soto, MO 4640 Dylan (lot 11) Dr, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$60,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.35% Airbnb Rental Income: $null Traditional Rental Income: $722 Airbnb ROI: N/A Traditional ROI: 8.35%
49 Monte Rosa Dr De Soto, MO 49 Monte Rosa Dr, De Soto, MO 63020 \| Single Family Residential	4 beds \| 3 baths \| 2,664 sq.ft.	$369,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.96% Airbnb Rental Income: $null Traditional Rental Income: $2224 Airbnb ROI: N/A Traditional ROI: 3.96%
2712 Creon De Soto, MO 2712 Creon, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,456 sq.ft.	$129,700	Airbnb cash on cash: N/A Traditional cash on cash: 7.98% Airbnb Rental Income: $null Traditional Rental Income: $1332 Airbnb ROI: N/A Traditional ROI: 7.98%
1559 Berry Dairy Rd De Soto, MO 1559 Berry Dairy Rd, De Soto, MO 63020 \| Single Family Residential	3 beds \| 3 baths \| 2,402 sq.ft.	$329,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.21% Airbnb Rental Income: $null Traditional Rental Income: $2002 Airbnb ROI: N/A Traditional ROI: 4.21%
4155 Highway 67 De Soto, MO 4155 Highway 67, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| N/A	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: -0.75% Airbnb Rental Income: $null Traditional Rental Income: $773 Airbnb ROI: N/A Traditional ROI: -0.75%
328 Sirius Rd De Soto, MO 328 Sirius Rd, De Soto, MO 63020 \| Manufactured Home	3 beds \| 2 baths \| 1,792 sq.ft.	$150,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.24% Airbnb Rental Income: $null Traditional Rental Income: $1556 Airbnb ROI: N/A Traditional ROI: 8.24%

Real Estate investment in De-soto, MO

There are 86 properties for sale in the city of De Soto . The median list price in De Soto is $199,880 and the average price per square foot is $129. In July 2026, the average monthly cash on cash return in De Soto is 6.00%. The average monthly rental income in De Soto is $989.

De-soto, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 86 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Short-Term is higher than the Long-Term in De-soto with average rental income of $661.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, MO

13819 State Route 21

De Soto, MO

3 beds | 1 baths | 1,692 sq.ft.

$265,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.29%

Airbnb Rental Income: $null

Traditional Rental Income: $1068

Airbnb ROI: N/A

Traditional ROI: 2.29%

2902 Clay Street

De Soto, MO

N/A beds | N/A baths | N/A

$530,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.92%

Airbnb Rental Income: $null

Traditional Rental Income: $1430

Airbnb ROI: N/A

Traditional ROI: 0.92%

3589 State Route 110

De Soto, MO

4 beds | 4 baths | 3,899 sq.ft.

$1,690,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.74%

Airbnb Rental Income: $null

Traditional Rental Income: $3360

Airbnb ROI: N/A

Traditional ROI: 0.74%

615 Perry St

De Soto, MO

2 beds | 1 baths | 775 sq.ft.

$159,900

Airbnb cash on cash: 0.23%

Traditional cash on cash: 3.88%

Airbnb Rental Income: $661

Traditional Rental Income: $919

Airbnb ROI: 0.23%

Traditional ROI: 3.88%

4319 Flucom Road

De Soto, MO

4 beds | 3 baths | 2,556 sq.ft.

$439,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.48%

Airbnb Rental Income: $null

Traditional Rental Income: $3085

Airbnb ROI: N/A

Traditional ROI: 5.48%

5528 Hillsboro Hematite Road

De Soto, MO

3 beds | 2 baths | 2,016 sq.ft.

$250,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.94%

Airbnb Rental Income: $null

Traditional Rental Income: $2070

Airbnb ROI: N/A

Traditional ROI: 6.94%

709 S 2nd St

De Soto, MO

3 beds | 2 baths | 1,100 sq.ft.

$224,900

Airbnb cash on cash: N/A

Traditional cash on cash: 4.86%

Airbnb Rental Income: $null

Traditional Rental Income: $1373

Airbnb ROI: N/A

Traditional ROI: 4.86%

1323 S 5th St

De Soto, MO

2 beds | 1 baths | 936 sq.ft.

$169,900

Airbnb cash on cash: 0.15%

Traditional cash on cash: 4.32%

Airbnb Rental Income: $661

Traditional Rental Income: $1038

Airbnb ROI: 0.15%