Real Estate Investment Properties for Sale in De Soto, MO

Looking for investment property in De Soto, MO with high ROI ?

Explore a variety of short-term homes & houses in De Soto, MO. Invest wisely with VRBO & De Soto, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
904 N 2nd Street De Soto, MO Highlight of the block and impossible to miss, this modern craftsman steals the curb appea...	2 beds \| 2 baths \| 1,440 sq.ft.	$200,000	Airbnb cash on cash: 1.75% Traditional cash on cash: 4.18% Airbnb Rental Income: $1105 Traditional Rental Income: $1193 Airbnb ROI: 1.75% Traditional ROI: 4.18%
2902 Clay Street De Soto, MO Caesar's Country Acres is an all-age community located in De Soto, Missouri, approximately...	N/A beds \| N/A baths \| N/A	$530,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.92% Airbnb Rental Income: $null Traditional Rental Income: $1430 Airbnb ROI: N/A Traditional ROI: 0.92%
3589 State Route 110 De Soto, MO Rare opportunity just south of the Gateway City and on the doorstep of the Ozarks â the ...	4 beds \| 4 baths \| 3,899 sq.ft.	$1,690,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.74% Airbnb Rental Income: $null Traditional Rental Income: $3360 Airbnb ROI: N/A Traditional ROI: 0.74%
13723 Willow Wind Drive De Soto, MO Welcome Home!! You will fall in love with this newer 6 year old home!! It boasts 4 Bedro...	4 beds \| 2 baths \| 1,597 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.19% Airbnb Rental Income: $null Traditional Rental Income: $1847 Airbnb ROI: N/A Traditional ROI: 2.19%
3772 GOLDENROD LN De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 768 sq.ft.	$130,000	Airbnb cash on cash: 3.45% Traditional cash on cash: 5.5% Airbnb Rental Income: $1105 Traditional Rental Income: $989 Airbnb ROI: 3.45% Traditional ROI: 5.5%
3401 FLUCOM RD De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 780 sq.ft.	$181,000	Airbnb cash on cash: 2.29% Traditional cash on cash: 4.66% Airbnb Rental Income: $1105 Traditional Rental Income: $1141 Airbnb ROI: 2.29% Traditional ROI: 4.66%
700 Lovett Street De Soto, MO Step inside! This Two-bedroom, one-bathroom home offers significant potential and was prev...	2 beds \| 1 baths \| 858 sq.ft.	$125,000	Airbnb cash on cash: 3.69% Traditional cash on cash: 6.53% Airbnb Rental Income: $1105 Traditional Rental Income: $1073 Airbnb ROI: 3.69% Traditional ROI: 6.53%
107 Morgan Lake Road De Soto, MO Welcome Home, to this Custom Built 1.5 Story Victorian Style Home with solid limestone tur...	4 beds \| 4 baths \| 4,260 sq.ft.	$869,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.54% Airbnb Rental Income: $null Traditional Rental Income: $3546 Airbnb ROI: N/A Traditional ROI: 2.54%
211 Easy Street De Soto, MO USDA ELIGIBLELife really is easier on Easy Street. This brand-new 3 bedroom, 2 bath ho...	3 beds \| 2 baths \| 1,600 sq.ft.	$305,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.26% Airbnb Rental Income: $null Traditional Rental Income: $1945 Airbnb ROI: N/A Traditional ROI: 5.26%
123 E 2nd Street De Soto, MO Discover an Affordable 2 bedroom, 1 bath home in the heart of De Soto! this Charming Prope...	2 beds \| 1 baths \| 869 sq.ft.	$135,000	Airbnb cash on cash: 3.56% Traditional cash on cash: 7.21% Airbnb Rental Income: $1105 Traditional Rental Income: $1206 Airbnb ROI: 3.56% Traditional ROI: 7.21%
3700 State Road V De Soto, MO Set on approximately 6.75 acres, this custom-built 2,700 sq ft home is just 5 years old an...	4 beds \| 3 baths \| 2,698 sq.ft.	$725,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.08% Airbnb Rental Income: $null Traditional Rental Income: $2578 Airbnb ROI: N/A Traditional ROI: 2.08%
14079 Charter Church Road De Soto, MO Imagine the possibilities! Log cabin sitting on 26+ acres. You could fix and flip, create ...	3 beds \| 3 baths \| 960 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.54% Airbnb Rental Income: $null Traditional Rental Income: $1101 Airbnb ROI: N/A Traditional ROI: 2.54%
14274 S Lake Drive De Soto, MO Waterfront Living at Its Best! Nestled on a peaceful lakefront lot, this well-maintained, ...	3 beds \| 2 baths \| 1,792 sq.ft.	$265,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.27% Airbnb Rental Income: $null Traditional Rental Income: $1563 Airbnb ROI: N/A Traditional ROI: 4.27%
1650 Brandywine Drive De Soto, MO Recently constructed 3 bedroom 2 bath home with many features! The 3 car garage is fully ...	3 beds \| 2 baths \| 1,600 sq.ft.	$384,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.01% Airbnb Rental Income: $null Traditional Rental Income: $1597 Airbnb ROI: N/A Traditional ROI: 3.01%
300 Wild Creek Court De Soto, MO Beautiful 3-bedroom, 2-bath home nestled in a gorgeous lakeview setting on a quiet cul-de-...	3 beds \| 2 baths \| 1,512 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.07% Airbnb Rental Income: $null Traditional Rental Income: $1353 Airbnb ROI: N/A Traditional ROI: 4.07%
3973 Zell Circle De Soto, MO Come enjoy lake living on a 1.323 Acre triple lot! 2025 Roof! 3bd 1ba, pantry, no carpet, ...	3 beds \| 1 baths \| 1,281 sq.ft.	$149,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.04% Airbnb Rental Income: $null Traditional Rental Income: $1114 Airbnb ROI: N/A Traditional ROI: 5.04%
1612 N 6th Street De Soto, MO Old Town De Soto living at its best! Mature trees, beautiful sage-colored siding, and rece...	4 beds \| 2 baths \| 1,848 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.1% Airbnb Rental Income: $null Traditional Rental Income: $1696 Airbnb ROI: N/A Traditional ROI: 6.1%
600 W Clement De Soto, MO Step inside this spacious and well-maintained 3 bed, 2 bath raised ranch offering comfort ...	3 beds \| 2 baths \| 1,196 sq.ft.	$244,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.84% Airbnb Rental Income: $null Traditional Rental Income: $1614 Airbnb ROI: N/A Traditional ROI: 4.84%
4455 Cedar Tree Lane De Soto, MO 10 acres with pond â¢ Outbuilding with lean-tos â¢ Main floor primary suite â¢ Walk-out...	2 beds \| 2 baths \| 1,328 sq.ft.	$330,000	Airbnb cash on cash: 0.13% Traditional cash on cash: 4.24% Airbnb Rental Income: $1105 Traditional Rental Income: $2007 Airbnb ROI: 0.13% Traditional ROI: 4.24%
508 S 2nd Street De Soto, MO WOW! Fall in love with this freshly renovated 4 bed 2 full bath & 1 half bath w/ a primary...	4 beds \| 3 baths \| 1,726 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.37% Airbnb Rental Income: $null Traditional Rental Income: $2266 Airbnb ROI: N/A Traditional ROI: 8.37%

Real Estate investment in De-soto, MO

There are 25 properties for sale in the city of De Soto . The median list price in De Soto is $234,900 and the average price per square foot is $145. In April 2026, the average monthly cash on cash return in De Soto is 4.00%. The average monthly rental income in De Soto is $1,528.

De-soto, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 25 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Long-Term is higher than the Short-Term in De-soto with average rental income of $1,528.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, MO

904 N 2nd Street

De Soto, MO

2 beds | 2 baths | 1,440 sq.ft.

$200,000

Airbnb cash on cash: 1.75%

Traditional cash on cash: 4.18%

Airbnb Rental Income: $1105

Traditional Rental Income: $1193

Airbnb ROI: 1.75%

Traditional ROI: 4.18%

2902 Clay Street

De Soto, MO

N/A beds | N/A baths | N/A

$530,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.92%

Airbnb Rental Income: $null

Traditional Rental Income: $1430

Airbnb ROI: N/A

Traditional ROI: 0.92%

3589 State Route 110

De Soto, MO

4 beds | 4 baths | 3,899 sq.ft.

$1,690,000

Airbnb cash on cash: N/A

Traditional cash on cash: 0.74%

Airbnb Rental Income: $null

Traditional Rental Income: $3360

Airbnb ROI: N/A

Traditional ROI: 0.74%

13723 Willow Wind Drive

De Soto, MO

4 beds | 2 baths | 1,597 sq.ft.

$475,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.19%

Airbnb Rental Income: $null

Traditional Rental Income: $1847

Airbnb ROI: N/A

Traditional ROI: 2.19%

3772 GOLDENROD LN

De Soto, MO

2 beds | 1 baths | 768 sq.ft.

$130,000

Airbnb cash on cash: 3.45%

Traditional cash on cash: 5.5%

Airbnb Rental Income: $1105

Traditional Rental Income: $989

Airbnb ROI: 3.45%

Traditional ROI: 5.5%

3401 FLUCOM RD

De Soto, MO

2 beds | 1 baths | 780 sq.ft.

$181,000

Airbnb cash on cash: 2.29%

Traditional cash on cash: 4.66%

Airbnb Rental Income: $1105

Traditional Rental Income: $1141

Airbnb ROI: 2.29%

Traditional ROI: 4.66%

700 Lovett Street

De Soto, MO

2 beds | 1 baths | 858 sq.ft.

$125,000

Airbnb cash on cash: 3.69%

Traditional cash on cash: 6.53%

Airbnb Rental Income: $1105

Traditional Rental Income: $1073

Airbnb ROI: 3.69%

Traditional ROI: 6.53%

107 Morgan Lake Road

De Soto, MO

4 beds | 4 baths | 4,260 sq.ft.

$869,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.54%

Airbnb Rental Income: $null

Traditional Rental Income: $3546

Airbnb ROI: N/A