Real Estate Investment Properties for Sale in De Soto, MO

Looking for investment property in De Soto, MO with high ROI ?

Explore a variety of short-term homes & houses in De Soto, MO. Invest wisely with VRBO & De Soto, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in De Soto, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
4445 Cedar Tree Lane De Soto, MO Welcome to your dream retreat! This spectacular 5-bedroom, 5.1/2-bath estate offers more t...	5 beds \| 6 baths \| 5,073 sq.ft.	$580,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.21% Airbnb Rental Income: $null Traditional Rental Income: $6006 Airbnb ROI: N/A Traditional ROI: 9.21%
801 Boyd St De Soto, MO This tidy 3 bedroom ranch home is ready for your family. Nice big back yard featuring a de...	3 beds \| 1 baths \| 1,028 sq.ft.	$144,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.29% Airbnb Rental Income: $null Traditional Rental Income: $1014 Airbnb ROI: N/A Traditional ROI: 5.29%
5522 Hillsboro Hematite Rd De Soto, MO 3 Bedroom, 2 bath ranch on 2 acres in the Hillsboro School District. New windows installed...	3 beds \| 2 baths \| 1,092 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.92% Airbnb Rental Income: $null Traditional Rental Income: $1178 Airbnb ROI: N/A Traditional ROI: 2.92%
2151 Lake Park Trl De Soto, MO Beautiful acreage with a lake. Totaling 24.85 acres of seclusion. Looking for someone with...	N/A beds \| N/A baths \| N/A	$239,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.38% Airbnb Rental Income: $null Traditional Rental Income: $1742 Airbnb ROI: N/A Traditional ROI: 5.38%
507 Mckissock St De Soto, MO Cozy cottage in the heart of DeSoto perfect for a small family or rental property. All el...	2 beds \| 1 baths \| 616 sq.ft.	$140,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.7% Airbnb Rental Income: $null Traditional Rental Income: $900 Airbnb ROI: N/A Traditional ROI: 4.7%
4302 Easy St De Soto, MO Buy through Auction.com. This foreclosure property is a great opportunity to invest in thi...	2 beds \| 1 baths \| 960 sq.ft.	$99,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.4% Airbnb Rental Income: $null Traditional Rental Income: $954 Airbnb ROI: N/A Traditional ROI: 7.4%
3772 GOLDENROD LN De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 768 sq.ft.	$130,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.5% Airbnb Rental Income: $null Traditional Rental Income: $989 Airbnb ROI: N/A Traditional ROI: 5.5%
3401 FLUCOM RD De Soto, MO Invest with success and buy through Auction.com. This bank-owned investment property is a ...	2 beds \| 1 baths \| 780 sq.ft.	$181,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.66% Airbnb Rental Income: $null Traditional Rental Income: $1141 Airbnb ROI: N/A Traditional ROI: 4.66%
14147 Timberline Dr De Soto, MO Introducing a freshly spruced-up gem nestled in the tranquil Valle Lake neighborhood! This...	2 beds \| 1 baths \| 1,000 sq.ft.	$158,700	Airbnb cash on cash: N/A Traditional cash on cash: 4.08% Airbnb Rental Income: $null Traditional Rental Income: $973 Airbnb ROI: N/A Traditional ROI: 4.08%
1123 Moulton Street De Soto, MO Step into this brand-new ranch home thatâs ready for you to move right in. With 3 bedroo...	3 beds \| 2 baths \| 1,200 sq.ft.	$272,950	Airbnb cash on cash: N/A Traditional cash on cash: 3.15% Airbnb Rental Income: $null Traditional Rental Income: $1173 Airbnb ROI: N/A Traditional ROI: 3.15%
221 W Miller St De Soto, MO Price Improved! Needing a large 4 bed 2 bath home, this might be the one! Beautifully ren...	3 beds \| 3 baths \| 1,940 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.41% Airbnb Rental Income: $null Traditional Rental Income: $2108 Airbnb ROI: N/A Traditional ROI: 9.41%
1539 Hickory Lndg De Soto, MO Welcome home to 1539 Hickory Landing, a beautiful ranch-style Villa built in 2024. This 3-...	3 beds \| 2 baths \| 1,604 sq.ft.	$295,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.45% Airbnb Rental Income: $null Traditional Rental Income: $1944 Airbnb ROI: N/A Traditional ROI: 4.45%
300 Valley Place De Soto, MO Nestled in a serene neighborhood, this charming split-level home offers the perfect blend ...	4 beds \| 2 baths \| 1,300 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.13% Airbnb Rental Income: $null Traditional Rental Income: $1921 Airbnb ROI: N/A Traditional ROI: 7.13%
1575 Hickory Lndg De Soto, MO Charming Villa in the Heart of De Soto! This beautifully maintained 2-bedroom, 2-bath home...	2 beds \| 2 baths \| 1,460 sq.ft.	$264,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.59% Airbnb Rental Income: $null Traditional Rental Income: $1918 Airbnb ROI: N/A Traditional ROI: 4.59%
407 N 11th St De Soto, MO Welcome to this beautifully maintained 3-bedroom, 2-bathroom home nestled right in the hea...	3 beds \| 2 baths \| 1,293 sq.ft.	$199,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.82% Airbnb Rental Income: $null Traditional Rental Income: $1894 Airbnb ROI: N/A Traditional ROI: 7.82%
1551 Hickory Landing De Soto, MO This is the newest development within city limits and it is a great opportunity to own a b...	3 beds \| 2 baths \| 1,604 sq.ft.	$287,270	Airbnb cash on cash: N/A Traditional cash on cash: 4.55% Airbnb Rental Income: $null Traditional Rental Income: $1812 Airbnb ROI: N/A Traditional ROI: 4.55%
211 Easy St De Soto, MO USDA ELIGIBLELife really is easier on Easy Street. This brand-new 3 bedroom, 2 bath ho...	3 beds \| 2 baths \| 1,600 sq.ft.	$310,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.16% Airbnb Rental Income: $null Traditional Rental Income: $1945 Airbnb ROI: N/A Traditional ROI: 5.16%
4126 Fountain City Rd De Soto, MO This all brick home is a rare find on almost 4 acres on the outskirts of downtown De Soto....	4 beds \| 3 baths \| 2,625 sq.ft.	$539,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.68% Airbnb Rental Income: $null Traditional Rental Income: $2713 Airbnb ROI: N/A Traditional ROI: 3.68%
123 E 2nd St De Soto, MO Discover an Affordable 2 bedroom, 1 bath home in the heart of De Soto! this Charming Prope...	2 beds \| 1 baths \| 869 sq.ft.	$135,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.21% Airbnb Rental Income: $null Traditional Rental Income: $1206 Airbnb ROI: N/A Traditional ROI: 7.21%
4844 Cabernet Avenue De Soto, MO PRICED TO SELL!!!! 4 bedroom, 2.5 bath country living on private 5 acres - is waiting for...	4 beds \| 3 baths \| 2,352 sq.ft.	$289,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.12% Airbnb Rental Income: $null Traditional Rental Income: $2479 Airbnb ROI: N/A Traditional ROI: 7.12%
0 Bogy St De Soto, MO 0 Bogy St, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$99,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.69% Airbnb Rental Income: $null Traditional Rental Income: $733 Airbnb ROI: N/A Traditional ROI: 4.69%
Lot 1B of Hawks Retreat De Soto, MO Lot 1B of Hawks Retreat, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.71% Airbnb Rental Income: $null Traditional Rental Income: $724 Airbnb ROI: N/A Traditional ROI: 0.71%
0 State Route 21 De Soto, MO 0 State Route 21, De Soto, MO 63020 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$699,900	Airbnb cash on cash: N/A Traditional cash on cash: -1.02% Airbnb Rental Income: $null Traditional Rental Income: $712 Airbnb ROI: N/A Traditional ROI: -1.02%
401 Bunker Hill Dr De Soto, MO 401 Bunker Hill Dr, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,092 sq.ft.	$159,999	Airbnb cash on cash: N/A Traditional cash on cash: 4.62% Airbnb Rental Income: $null Traditional Rental Income: $1145 Airbnb ROI: N/A Traditional ROI: 4.62%
1621 N 6th St De Soto, MO 1621 N 6th St, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,893 sq.ft.	$293,750	Airbnb cash on cash: N/A Traditional cash on cash: 4.1% Airbnb Rental Income: $null Traditional Rental Income: $1769 Airbnb ROI: N/A Traditional ROI: 4.1%
416 Yorktown Dr De Soto, MO 416 Yorktown Dr, De Soto, MO 63020 \| Single Family Residential	3 beds \| 2 baths \| 1,712 sq.ft.	$359,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.01% Airbnb Rental Income: $null Traditional Rental Income: $1512 Airbnb ROI: N/A Traditional ROI: 2.01%
2141 Big River Trl De Soto, MO 2141 Big River Trl, De Soto, MO 63020 \| Single Family Residential	1 beds \| 1 baths \| 288 sq.ft.	$63,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.91% Airbnb Rental Income: $null Traditional Rental Income: $937 Airbnb ROI: N/A Traditional ROI: 10.91%

Real Estate investment in De-soto, MO

There are 70 properties for sale in the city of De Soto . The median list price in De Soto is $148,950 and the average price per square foot is $102. In February 2026, the average monthly cash on cash return in De Soto is 7.00%. The average monthly rental income in De Soto is $1,002.

De-soto, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 70 investment properties available for sale in De-soto.

In 2026, the best neighborhood to buy investment property is De Soto.

The ROI for Short-Term is higher than the Long-Term in De-soto with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in De Soto, MO

4445 Cedar Tree Lane

De Soto, MO

5 beds | 6 baths | 5,073 sq.ft.

$580,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.21%

Airbnb Rental Income: $null

Traditional Rental Income: $6006

Airbnb ROI: N/A

Traditional ROI: 9.21%

801 Boyd St

De Soto, MO

3 beds | 1 baths | 1,028 sq.ft.

$144,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.29%

Airbnb Rental Income: $null

Traditional Rental Income: $1014

Airbnb ROI: N/A

Traditional ROI: 5.29%

5522 Hillsboro Hematite Rd

De Soto, MO

3 beds | 2 baths | 1,092 sq.ft.

$265,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.92%

Airbnb Rental Income: $null

Traditional Rental Income: $1178

Airbnb ROI: N/A

Traditional ROI: 2.92%

2151 Lake Park Trl

De Soto, MO

N/A beds | N/A baths | N/A

$239,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.38%

Airbnb Rental Income: $null

Traditional Rental Income: $1742

Airbnb ROI: N/A

Traditional ROI: 5.38%

507 Mckissock St

De Soto, MO

2 beds | 1 baths | 616 sq.ft.

$140,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.7%

Airbnb Rental Income: $null

Traditional Rental Income: $900

Airbnb ROI: N/A

Traditional ROI: 4.7%

4302 Easy St

De Soto, MO

2 beds | 1 baths | 960 sq.ft.

$99,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.4%

Airbnb Rental Income: $null

Traditional Rental Income: $954

Airbnb ROI: N/A

Traditional ROI: 7.4%

3772 GOLDENROD LN

De Soto, MO

2 beds | 1 baths | 768 sq.ft.

$130,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.5%

Airbnb Rental Income: $null

Traditional Rental Income: $989

Airbnb ROI: N/A

Traditional ROI: 5.5%

3401 FLUCOM RD

De Soto, MO

2 beds | 1 baths | 780 sq.ft.

$181,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.66%

Airbnb Rental Income: $null

Traditional Rental Income: $1141

Airbnb ROI: N/A