Real Estate Investment Properties for Sale in Doniphan, MO

Looking for investment property in Doniphan, MO with high ROI ?

Explore a variety of short-term homes & houses in Doniphan, MO. Invest wisely with VRBO & Doniphan, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Doniphan, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
670 Ripley Y-3 Doniphan, MO Potential only limited by your imagination. VERY nice 4 bedroom cabin with loft area sitti...	4 beds \| 2 baths \| 2,110 sq.ft.	$319,000	Airbnb cash on cash: 4.28% Traditional cash on cash: 5.28% Airbnb Rental Income: $2343 Traditional Rental Income: $2065 Airbnb ROI: 4.28% Traditional ROI: 5.28%
1901 River Valley Road Doniphan, MO CURRRENT RIVER SPLENDOR! This immaculate river cabin sits on two acres & is only about 5 m...	3 beds \| 3 baths \| 1,834 sq.ft.	$685,000	Airbnb cash on cash: -0.76% Traditional cash on cash: 2.65% Airbnb Rental Income: $663 Traditional Rental Income: $2540 Airbnb ROI: -0.76% Traditional ROI: 2.65%
81 Southern Comfort Doniphan, MO $575,000; 81 Southern Comfort, Doniphan, MO 63935; Beautiful 3 bedroom 2 bathroom river ca...	3 beds \| 2 baths \| 1,440 sq.ft.	$575,000	Airbnb cash on cash: -0.68% Traditional cash on cash: 1.91% Airbnb Rental Income: $663 Traditional Rental Income: $1750 Airbnb ROI: -0.68% Traditional ROI: 1.91%
1866 Ripley 21n-4 Doniphan, MO Looking for a house in a rural area? This one is for you. 3 bedroom, 2 bath brick home wit...	3 beds \| 2 baths \| 1,080 sq.ft.	$155,000	Airbnb cash on cash: 0.55% Traditional cash on cash: 8.46% Airbnb Rental Income: $663 Traditional Rental Income: $1535 Airbnb ROI: 0.55% Traditional ROI: 8.46%
76 Ripley 142E-2B Doniphan, MO SELLER WILL HELP WITH SOME OF THE CLOSING FEES AT CLOSING-Fully Renovated 5-Bedroom Home w...	5 beds \| 3 baths \| 2,500 sq.ft.	$249,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.76% Airbnb Rental Income: $null Traditional Rental Income: $2465 Airbnb ROI: N/A Traditional ROI: 8.76%
10343 ST Hwy 142W Doniphan, MO Come sit on the front porch and you'll be hooked! This property features 2 homes, 3 bar...	3 beds \| 2 baths \| 2,424 sq.ft.	$265,000	Airbnb cash on cash: -0.13% Traditional cash on cash: 8.32% Airbnb Rental Income: $663 Traditional Rental Income: $2477 Airbnb ROI: -0.13% Traditional ROI: 8.32%
6029 Ripley Rt V Doniphan, MO Breath-taking, fully furnishe home on 64 acres (m/l) on top of the hill! You have to see t...	3 beds \| 3 baths \| 3,067 sq.ft.	$559,000	Airbnb cash on cash: -0.7% Traditional cash on cash: 3.62% Airbnb Rental Income: $663 Traditional Rental Income: $2619 Airbnb ROI: -0.7% Traditional ROI: 3.62%
451 Riverway Dr. Doniphan, MO This updated 4-bedroom, 3-bath cabin on 0.5 +/- acres offers waterfront views, a brand new...	4 beds \| 3 baths \| 2,726 sq.ft.	$649,000	Airbnb cash on cash: 1.48% Traditional cash on cash: 3.31% Airbnb Rental Income: $2343 Traditional Rental Income: $2873 Airbnb ROI: 1.48% Traditional ROI: 3.31%
232 Confederate Ridge Rd Doniphan, MO Discover this stunning custom-designed Craftsman home, built in 2013, offering breathtakin...	3 beds \| 2 baths \| 2,080 sq.ft.	$348,000	Airbnb cash on cash: -0.48% Traditional cash on cash: 5.98% Airbnb Rental Income: $663 Traditional Rental Income: $2475 Airbnb ROI: -0.48% Traditional ROI: 5.98%
529 Ripley 142E-20A Doniphan, MO Income opportunity awaits! Look at this recently remodeled 2,400 sq. ft. building that now...	N/A beds \| N/A baths \| 2,400 sq.ft.	$229,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.76% Airbnb Rental Income: $null Traditional Rental Income: $1549 Airbnb ROI: N/A Traditional ROI: 4.76%
805 Walnut St Doniphan, MO	3 beds \| 2 baths \| 1,000 sq.ft.	$129,900	Airbnb cash on cash: 0.92% Traditional cash on cash: 11.56% Airbnb Rental Income: $663 Traditional Rental Income: $1692 Airbnb ROI: 0.92% Traditional ROI: 11.56%
936 Crawdad Lane Doniphan, MO Private 75-Acre Estate with Lake, 3 Homes & Government Forest Border Private Lakefront P...	4 beds \| 2 baths \| 2,997 sq.ft.	$899,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 1.93% Airbnb Rental Income: $2343 Traditional Rental Income: $2677 Airbnb ROI: 0.84% Traditional ROI: 1.93%
167 Ripley Co Rd Y-3 Doniphan, MO Hereâs an amazing opportunity to own four neighboring parcels totaling 33.1 acres m/l ju...	2 beds \| 2 baths \| 1,404 sq.ft.	$349,500	Airbnb cash on cash: -0.7% Traditional cash on cash: 3.14% Airbnb Rental Income: $563 Traditional Rental Income: $1541 Airbnb ROI: -0.7% Traditional ROI: 3.14%
206 E Spring Street Doniphan, MO Updated 3 bedrooms 2 bath home with shop and carport for the toys. This one has new metal...	3 beds \| 2 baths \| 1,312 sq.ft.	$149,000	Airbnb cash on cash: 0.55% Traditional cash on cash: 9.52% Airbnb Rental Income: $663 Traditional Rental Income: $1642 Airbnb ROI: 0.55% Traditional ROI: 9.52%
1103 Cherry Street Doniphan, MO This is the listing that everyone will be talking about. It's a Doniphan landmark. Sitting...	4 beds \| 3 baths \| 6,280 sq.ft.	$449,000	Airbnb cash on cash: 2.53% Traditional cash on cash: 4.89% Airbnb Rental Income: $2343 Traditional Rental Income: $2757 Airbnb ROI: 2.53% Traditional ROI: 4.89%
1300 River Valley Road Doniphan, MO Discover the perfect blend of luxury and nature in this stunning 4 bedroom, 3 bath modern ...	4 beds \| 3 baths \| 1,768 sq.ft.	$649,900	Airbnb cash on cash: 1.61% Traditional cash on cash: 3.2% Airbnb Rental Income: $2343 Traditional Rental Income: $2732 Airbnb ROI: 1.61% Traditional ROI: 3.2%
129 Ripley 142E-24C Doniphan, MO This is the home everybody has been looking for! Check out this super nice split level hom...	3 beds \| 3 baths \| 2,013 sq.ft.	$225,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 8.68% Airbnb Rental Income: $663 Traditional Rental Income: $2234 Airbnb ROI: -0.1% Traditional ROI: 8.68%
9 Green Meadows Doniphan, MO Check out the character in this beautiful one of a kind, stone exterior home in Doniphan o...	3 beds \| 2 baths \| 3,492 sq.ft.	$229,500	Airbnb cash on cash: -0.34% Traditional cash on cash: 6.06% Airbnb Rental Income: $663 Traditional Rental Income: $1753 Airbnb ROI: -0.34% Traditional ROI: 6.06%
3936 State Highway 142 E Doniphan, MO Step into this beautifully renovated three bedroom, two bath modern brick home that blends...	5 beds \| 3 baths \| 2,464 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.06% Airbnb Rental Income: $null Traditional Rental Income: $2271 Airbnb ROI: N/A Traditional ROI: 7.06%
574 Ripley 160E-8 Doniphan, MO Country home offers 3 bedroom, 1 bath with a bonus room for sale in southeast Missouri. Ho...	3 beds \| 1 baths \| 1,245 sq.ft.	$145,000	Airbnb cash on cash: 0.57% Traditional cash on cash: 8.25% Airbnb Rental Income: $663 Traditional Rental Income: $1431 Airbnb ROI: 0.57% Traditional ROI: 8.25%
1457 Riverway Drive Doniphan, MO Escape to modern luxury in this Riverfront Cabin Retreat! Welcome to your dream getaway - ...	5 beds \| 2 baths \| 2,480 sq.ft.	$599,500	Airbnb cash on cash: N/A Traditional cash on cash: 3.26% Airbnb Rental Income: $null Traditional Rental Income: $2605 Airbnb ROI: N/A Traditional ROI: 3.26%
1120 Ripley 142E-4 Doniphan, MO This Charming 3bed/2ba traditional brick ranch offers 1,900 sqft. of comfortable living sp...	3 beds \| 2 baths \| 1,900 sq.ft.	$209,000	Airbnb cash on cash: -0.04% Traditional cash on cash: 8.34% Airbnb Rental Income: $663 Traditional Rental Income: $2024 Airbnb ROI: -0.04% Traditional ROI: 8.34%
2402 Ripley Route A Doniphan, MO Discover this spacious and beautifully designed 3,497 sq ft home nestled on the banks of t...	3 beds \| 3 baths \| 3,497 sq.ft.	$1,400,000	Airbnb cash on cash: -0.91% Traditional cash on cash: 0.93% Airbnb Rental Income: $663 Traditional Rental Income: $2765 Airbnb ROI: -0.91% Traditional ROI: 0.93%
1461 River Valley Road Doniphan, MO Looking for the perfect River House on the lower Current River? This 4-bedroom 2- bath hom...	4 beds \| 2 baths \| 2,200 sq.ft.	$849,900	Airbnb cash on cash: 0.87% Traditional cash on cash: 1.46% Airbnb Rental Income: $2343 Traditional Rental Income: $2237 Airbnb ROI: 0.87% Traditional ROI: 1.46%
225 Ripley 21s-1B Doniphan, MO Looking for affordable housing, this is the one. Large 1664 sq ft modular home on 1.5 acre...	3 beds \| 2 baths \| 1,664 sq.ft.	$149,000	Airbnb cash on cash: 0.58% Traditional cash on cash: 10.04% Airbnb Rental Income: $663 Traditional Rental Income: $1712 Airbnb ROI: 0.58% Traditional ROI: 10.04%
3971 State Highway 142 E Doniphan, MO Located just 4 miles outside Doniphan, this 3 bedroom, 1 bath home has 1,476 square feet (...	3 beds \| 1 baths \| 1,476 sq.ft.	$149,900	Airbnb cash on cash: 0.62% Traditional cash on cash: 7.96% Airbnb Rental Income: $663 Traditional Rental Income: $1416 Airbnb ROI: 0.62% Traditional ROI: 7.96%
15 Summerfield Estate Doniphan, MO Welcome to 15 Summerfield Estate, a beautifully renovated home located in the desirable Su...	4 beds \| 4 baths \| 2,660 sq.ft.	$375,000	Airbnb cash on cash: 3.51% Traditional cash on cash: 8.04% Airbnb Rental Income: $2343 Traditional Rental Income: $3358 Airbnb ROI: 3.51% Traditional ROI: 8.04%
9765 Highway 21 Doniphan, MO Immaculate Single wide home setting on 20 acres +/- roughly 10 miles outside the town of D...	3 beds \| 2 baths \| 1,280 sq.ft.	$154,900	Airbnb cash on cash: 0.7% Traditional cash on cash: 9.12% Airbnb Rental Income: $663 Traditional Rental Income: $1609 Airbnb ROI: 0.7% Traditional ROI: 9.12%
9609 State Highway 21S Doniphan, MO Log home with 3 bedrooms, 2 baths located in a secluded area only 10 miles from Doniphan. ...	3 beds \| 2 baths \| 1,200 sq.ft.	$319,900	Airbnb cash on cash: -0.23% Traditional cash on cash: 3.41% Airbnb Rental Income: $663 Traditional Rental Income: $1459 Airbnb ROI: -0.23% Traditional ROI: 3.41%
110 Muskrat Lane Doniphan, MO 3 bed, 1 3/4 bath home just minutes from Doniphan and Current River. The home is on a quie...	3 beds \| 2 baths \| 1,920 sq.ft.	$149,500	Airbnb cash on cash: 0.52% Traditional cash on cash: 11.81% Airbnb Rental Income: $663 Traditional Rental Income: $1980 Airbnb ROI: 0.52% Traditional ROI: 11.81%
10088 Ripley Route -Y Doniphan, MO Have you ever wanted to be hidden from everyone, yet have the modern conveniences and only...	5 beds \| 3 baths \| 3,052 sq.ft.	$449,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.36% Airbnb Rental Income: $null Traditional Rental Income: $2789 Airbnb ROI: N/A Traditional ROI: 5.36%
220 160E-8 Doniphan, MO This beautifully renovated and well-maintained 2000 Sq. foot brick home offers the perfect...	3 beds \| 3 baths \| 2,000 sq.ft.	$249,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 9.02% Airbnb Rental Income: $663 Traditional Rental Income: $2510 Airbnb ROI: -0.1% Traditional ROI: 9.02%
113 Ripley 142E-17 Doniphan, MO Tucked away just east of Doniphan at the end of a quiet dead-end road, this charming 3 bed...	3 beds \| 2 baths \| 1,444 sq.ft.	$230,000	Airbnb cash on cash: -0.14% Traditional cash on cash: 6.54% Airbnb Rental Income: $663 Traditional Rental Income: $1817 Airbnb ROI: -0.14% Traditional ROI: 6.54%

Real Estate investment in Doniphan, MO

There are 35 properties for sale in the city of Doniphan . The median list price in Doniphan is $249,000 and the average price per square foot is $117. In September 2025, the average monthly cash on cash return in Doniphan is 8.00%. The average monthly rental income in Doniphan is $2,045.

Doniphan, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 35 investment properties available for sale in Doniphan.

In 2025, the best neighborhood to buy investment property is Doniphan.

The ROI for Long-Term is higher than the Short-Term in Doniphan with average rental income of $2,045.

Your search for investment property begins and ends here

Investment Property for Sale in Doniphan, MO

670 Ripley Y-3

Doniphan, MO

4 beds | 2 baths | 2,110 sq.ft.

$319,000

Airbnb cash on cash: 4.28%

Traditional cash on cash: 5.28%

Airbnb Rental Income: $2343

Traditional Rental Income: $2065

Airbnb ROI: 4.28%

Traditional ROI: 5.28%

1901 River Valley Road

Doniphan, MO

3 beds | 3 baths | 1,834 sq.ft.

$685,000

Airbnb cash on cash: -0.76%

Traditional cash on cash: 2.65%

Airbnb Rental Income: $663

Traditional Rental Income: $2540

Airbnb ROI: -0.76%

Traditional ROI: 2.65%

81 Southern Comfort

Doniphan, MO

3 beds | 2 baths | 1,440 sq.ft.

$575,000

Airbnb cash on cash: -0.68%

Traditional cash on cash: 1.91%

Airbnb Rental Income: $663

Traditional Rental Income: $1750

Airbnb ROI: -0.68%

Traditional ROI: 1.91%

1866 Ripley 21n-4

Doniphan, MO

3 beds | 2 baths | 1,080 sq.ft.

$155,000

Airbnb cash on cash: 0.55%

Traditional cash on cash: 8.46%

Airbnb Rental Income: $663

Traditional Rental Income: $1535

Airbnb ROI: 0.55%

Traditional ROI: 8.46%

76 Ripley 142E-2B

Doniphan, MO

5 beds | 3 baths | 2,500 sq.ft.

$249,900

Airbnb cash on cash: N/A

Traditional cash on cash: 8.76%

Airbnb Rental Income: $null

Traditional Rental Income: $2465

Airbnb ROI: N/A

Traditional ROI: 8.76%

10343 ST Hwy 142W

Doniphan, MO

3 beds | 2 baths | 2,424 sq.ft.

$265,000

Airbnb cash on cash: -0.13%

Traditional cash on cash: 8.32%

Airbnb Rental Income: $663

Traditional Rental Income: $2477

Airbnb ROI: -0.13%

Traditional ROI: 8.32%

6029 Ripley Rt V

Doniphan, MO

3 beds | 3 baths | 3,067 sq.ft.

$559,000

Airbnb cash on cash: -0.7%

Traditional cash on cash: 3.62%

Airbnb Rental Income: $663

Traditional Rental Income: $2619

Airbnb ROI: -0.7%

Traditional ROI: 3.62%

451 Riverway Dr.

Doniphan, MO

4 beds | 3 baths | 2,726 sq.ft.

$649,000

Airbnb cash on cash: 1.48%

Traditional cash on cash: 3.31%

Airbnb Rental Income: $2343

Traditional Rental Income: $2873

Airbnb ROI: 1.48%