Real Estate Investment Properties for Sale in Seneca, MO

Looking for investment property in Seneca, MO with high ROI ?

Explore a variety of short-term homes & houses in Seneca, MO. Invest wisely with VRBO & Seneca, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
7341 Bethel Road Seneca, MO Welcome to 7341 Bethel Rd-where modern luxury meets peaceful country living. Ideally posit...	5 beds \| 4 baths \| 4,138 sq.ft.	$650,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.5% Airbnb Rental Income: $null Traditional Rental Income: $2605 Airbnb ROI: N/A Traditional ROI: 2.5%
13453 Avalon Lane Seneca, MO Discover privacy, space, and charm with this traditional-style home nestled on 4.7 wooded ...	3 beds \| 2 baths \| 1,752 sq.ft.	$345,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.56% Airbnb Rental Income: $null Traditional Rental Income: $2371 Airbnb ROI: N/A Traditional ROI: 5.56%
12609 State Hwy 43 Seneca, MO Great investment property! Two mobile homes with storage that includes separate space for ...	3 beds \| 2 baths \| 1,216 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.59% Airbnb Rental Income: $null Traditional Rental Income: $1567 Airbnb ROI: N/A Traditional ROI: 5.59%
17981 Hottel Springs Rd Seneca, MO Tucked quietly along Hottel Springs Road, this home rises from the trees with a kind of gr...	5 beds \| 4 baths \| 5,557 sq.ft.	$574,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.19% Airbnb Rental Income: $null Traditional Rental Income: $3797 Airbnb ROI: N/A Traditional ROI: 5.19%
1020 Seneca Avenue Seneca, MO Cute little doll house! So many renovations have gone into this home. Central H/A, laminat...	2 beds \| 1 baths \| 1,000 sq.ft.	$119,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.6% Airbnb Rental Income: $null Traditional Rental Income: $1124 Airbnb ROI: N/A Traditional ROI: 7.6%
1418 Cherokee Avenue Seneca, MO Located right in front of the Seneca Fire Department. Conveniently located next restaurant...	4 beds \| 2 baths \| 1,737 sq.ft.	$179,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.74% Airbnb Rental Income: $null Traditional Rental Income: $1991 Airbnb ROI: N/A Traditional ROI: 9.74%
20540 HWY 43 Seneca, MO Welcome to your dream farmhouse retreat! This beautifully updated 3-bedroom, 2-bath home s...	3 beds \| 2 baths \| 1,504 sq.ft.	$255,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.85% Airbnb Rental Income: $null Traditional Rental Income: $1824 Airbnb ROI: N/A Traditional ROI: 5.85%
2004 Elm Street Seneca, MO Step inside and instantly feel at home in a cozy living room, where the fireplace creates ...	4 beds \| 3 baths \| 1,536 sq.ft.	$234,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.47% Airbnb Rental Income: $null Traditional Rental Income: $2061 Airbnb ROI: N/A Traditional ROI: 7.47%
431 Ottawa St Street Seneca, MO This adorable 3-bedroom, 1-bath home is full of updates and ready for new owners. Enjoy pe...	3 beds \| 1 baths \| 1,074 sq.ft.	$125,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.02% Airbnb Rental Income: $null Traditional Rental Income: $1327 Airbnb ROI: N/A Traditional ROI: 9.02%
5111 State Highway BB Seneca, MO Escape through the secure private gates of this 18.73-acre property, where a commanding 60...	5 beds \| 4 baths \| 2,562 sq.ft.	$724,900	Airbnb cash on cash: N/A Traditional cash on cash: 1.57% Airbnb Rental Income: $null Traditional Rental Income: $2033 Airbnb ROI: N/A Traditional ROI: 1.57%
608 Chippewa Street Seneca, MO Discover your perfect slice of small-town charm at 608 Chippewa St., Seneca, MO 64865! Nes...	2 beds \| 2 baths \| 1,085 sq.ft.	$174,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.52% Airbnb Rental Income: $null Traditional Rental Income: $1416 Airbnb ROI: N/A Traditional ROI: 6.52%
1809 Olive Street Seneca, MO 2BD 2BA Super Charming Home in Seneca. Property includes a 1 car detached garage, a chain ...	2 beds \| 2 baths \| 1,083 sq.ft.	$129,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.21% Airbnb Rental Income: $null Traditional Rental Income: $1424 Airbnb ROI: N/A Traditional ROI: 9.21%
21483 Antelope Road Seneca, MO This stunning 4-bedroom, 2-bathroom home has been completely remodeled to combine modern c...	4 beds \| 2 baths \| 1,590 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.06% Airbnb Rental Income: $null Traditional Rental Income: $2106 Airbnb ROI: N/A Traditional ROI: 8.06%
14289 Bethel Road Seneca, MO Check out this great 3-bedroom, 11/2-bathroom home offering 1937 sq ft of comfortable livi...	3 beds \| 2 baths \| 1,937 sq.ft.	$234,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.6% Airbnb Rental Income: $null Traditional Rental Income: $1655 Airbnb ROI: N/A Traditional ROI: 5.6%
2256 Holly Road Seneca, MO Cute, cozy, and efficient on 5 acres! Great open floor plan, high ceilings, 2 bedroom, 1 a...	2 beds \| 2 baths \| 1,080 sq.ft.	$247,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.31% Airbnb Rental Income: $null Traditional Rental Income: $1649 Airbnb ROI: N/A Traditional ROI: 5.31%
742 Cemetery Road Seneca, MO Charming 2-bedroom, 1-bath home featuring large rooms, a walk-in closet, and a spacious la...	2 beds \| 1 baths \| 1,088 sq.ft.	$120,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.42% Airbnb Rental Income: $null Traditional Rental Income: $1456 Airbnb ROI: N/A Traditional ROI: 10.42%
336 Rhonda Road Seneca, MO 336 Rhonda Road offers the best of both worlds - peaceful country living with the convenie...	3 beds \| 1 baths \| 1,066 sq.ft.	$212,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.31% Airbnb Rental Income: $null Traditional Rental Income: $1227 Airbnb ROI: N/A Traditional ROI: 4.31%
6496 Racine Street Seneca, MO Live in One, Rent the Other - Ideal Duplex Investment Opportunity! Discover the perfect bl...	N/A beds \| 3 baths \| 3,112 sq.ft.	$180,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.38% Airbnb Rental Income: $null Traditional Rental Income: $1979 Airbnb ROI: N/A Traditional ROI: 9.38%
13591 Abilene Seneca, MO In a small town, tucked in the woods down a quiet dirt road, you'll find 13591 Abilene Lan...	2 beds \| 1 baths \| 784 sq.ft.	$102,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.34% Airbnb Rental Income: $null Traditional Rental Income: $1356 Airbnb ROI: N/A Traditional ROI: 11.34%
13595 Abilene Seneca, MO Tucked among mature trees on 5.26 peaceful acres, this inviting 4-bedroom, 2-bath home off...	4 beds \| 2 baths \| 1,863 sq.ft.	$201,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.09% Airbnb Rental Income: $null Traditional Rental Income: $2093 Airbnb ROI: N/A Traditional ROI: 9.09%

Real Estate investment in Seneca, MO

There are 20 properties for sale in the city of Seneca . The median list price in Seneca is $218,450 and the average price per square foot is $119. In December 2025, the average monthly cash on cash return in Seneca is 7.00%. The average monthly rental income in Seneca is $1,740.

Seneca, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 20 investment properties available for sale in Seneca.

The ROI for Short-Term is higher than the Long-Term in Seneca with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, MO

7341 Bethel Road

Seneca, MO

5 beds | 4 baths | 4,138 sq.ft.

$650,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.5%

Airbnb Rental Income: $null

Traditional Rental Income: $2605

Airbnb ROI: N/A

Traditional ROI: 2.5%

13453 Avalon Lane

Seneca, MO

3 beds | 2 baths | 1,752 sq.ft.

$345,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.56%

Airbnb Rental Income: $null

Traditional Rental Income: $2371

Airbnb ROI: N/A

Traditional ROI: 5.56%

12609 State Hwy 43

Seneca, MO

3 beds | 2 baths | 1,216 sq.ft.

$225,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.59%

Airbnb Rental Income: $null

Traditional Rental Income: $1567

Airbnb ROI: N/A

Traditional ROI: 5.59%

17981 Hottel Springs Rd

Seneca, MO

5 beds | 4 baths | 5,557 sq.ft.

$574,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.19%

Airbnb Rental Income: $null

Traditional Rental Income: $3797

Airbnb ROI: N/A

Traditional ROI: 5.19%

1020 Seneca Avenue

Seneca, MO

2 beds | 1 baths | 1,000 sq.ft.

$119,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.6%

Airbnb Rental Income: $null

Traditional Rental Income: $1124

Airbnb ROI: N/A

Traditional ROI: 7.6%

1418 Cherokee Avenue

Seneca, MO

4 beds | 2 baths | 1,737 sq.ft.

$179,900

Airbnb cash on cash: N/A

Traditional cash on cash: 9.74%

Airbnb Rental Income: $null

Traditional Rental Income: $1991

Airbnb ROI: N/A

Traditional ROI: 9.74%

20540 HWY 43

Seneca, MO

3 beds | 2 baths | 1,504 sq.ft.

$255,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.85%

Airbnb Rental Income: $null

Traditional Rental Income: $1824

Airbnb ROI: N/A

Traditional ROI: 5.85%

2004 Elm Street

Seneca, MO

4 beds | 3 baths | 1,536 sq.ft.

$234,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.47%

Airbnb Rental Income: $null

Traditional Rental Income: $2061

Airbnb ROI: N/A