Real Estate Investment Properties for Sale in Florence, SC

Looking for investment property in Florence, SC with high ROI ?

Explore a variety of short-term homes & houses in Florence, SC. Invest wisely with VRBO & Florence, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Florence, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2729 Winterbrook Drive Florence, SC This traditional brick and vinyl home located in Winterbrook subdivision was built in 1999...	3 beds \| 2 baths \| 1,277 sq.ft.	$205,000	Airbnb cash on cash: 1.77% Traditional cash on cash: 7.6% Airbnb Rental Income: $1116 Traditional Rental Income: $1875 Airbnb ROI: 1.77% Traditional ROI: 7.6%
1307 Jackson Avenue Florence, SC Welcome to 1307 Jackson Avenue â a beautifully updated 2,800 sq. ft. home in the heart o...	3 beds \| 3 baths \| 2,812 sq.ft.	$349,000	Airbnb cash on cash: 0.41% Traditional cash on cash: 6.61% Airbnb Rental Income: $1116 Traditional Rental Income: $2775 Airbnb ROI: 0.41% Traditional ROI: 6.61%
2317 Lampley Way Florence, SC Welcome to this beautifully maintained 4-bedroom, 2.5-bath home located in the sought-afte...	4 beds \| 3 baths \| 1,967 sq.ft.	$299,900	Airbnb cash on cash: 3.01% Traditional cash on cash: 6.83% Airbnb Rental Income: $1889 Traditional Rental Income: $2463 Airbnb ROI: 3.01% Traditional ROI: 6.83%
2502 Lakeview Dr. Florence, SC Beautiful 4 Bedroom, 2 Bath Split-Level Home with Large Fenced-In Backyard Welcome home t...	4 beds \| 2 baths \| 2,236 sq.ft.	$259,900	Airbnb cash on cash: 3.7% Traditional cash on cash: 7.95% Airbnb Rental Income: $1889 Traditional Rental Income: $2427 Airbnb ROI: 3.7% Traditional ROI: 7.95%
1914 Deerwood Place Florence, SC Welcome to 1914 Deerwood Place, a beautifully updated home tucked away on a quiet cul-de-s...	4 beds \| 3 baths \| 2,696 sq.ft.	$439,900	Airbnb cash on cash: 2.01% Traditional cash on cash: 5.49% Airbnb Rental Income: $1889 Traditional Rental Income: $2819 Airbnb ROI: 2.01% Traditional ROI: 5.49%
3109 Duchess Ln. Florence, SC Welcome to the desirable Kingsgate neighborhood! This 4-bedroom home (plus a large bonus r...	4 beds \| 4 baths \| 2,856 sq.ft.	$525,000	Airbnb cash on cash: 1.59% Traditional cash on cash: 4.82% Airbnb Rental Income: $1889 Traditional Rental Income: $2969 Airbnb ROI: 1.59% Traditional ROI: 4.82%
3107 Duchess Lane Florence, SC Discover Your Dream Home in Florence's Premier Neighborhood Welcome to a stunning four-be...	4 beds \| 4 baths \| 3,705 sq.ft.	$739,900	Airbnb cash on cash: 0.85% Traditional cash on cash: 3.65% Airbnb Rental Income: $1889 Traditional Rental Income: $3320 Airbnb ROI: 0.85% Traditional ROI: 3.65%
906/908 Sherwood Drive Florence, SC Brick duplex. Each side has 2 bedrooms and 1 bathroom. Large great room. Outside storage ...	N/A beds \| N/A baths \| N/A	$207,000	Airbnb cash on cash: 4.93% Traditional cash on cash: 4.63% Airbnb Rental Income: $1889 Traditional Rental Income: $1327 Airbnb ROI: 4.93% Traditional ROI: 4.63%
1915 Damon Drive Florence, SC Well maintained home situated on corner lot in established neighborhood. Spacious step d...	3 beds \| 3 baths \| 1,900 sq.ft.	$259,900	Airbnb cash on cash: 1.41% Traditional cash on cash: 7.07% Airbnb Rental Income: $1116 Traditional Rental Income: $2129 Airbnb ROI: 1.41% Traditional ROI: 7.07%
418 Chippenham Lane Florence, SC Updated 3 bedrooms 2 bath house in West Florence neighborhood, Foxcroft. Conveniently loc...	3 beds \| 2 baths \| 1,710 sq.ft.	$244,900	Airbnb cash on cash: 1.23% Traditional cash on cash: 6.45% Airbnb Rental Income: $1116 Traditional Rental Income: $1948 Airbnb ROI: 1.23% Traditional ROI: 6.45%
808 Cloisters Drive Florence, SC Beautifully Maintained Home located in the Cloisters Subdivision in Florence SC. Large Liv...	3 beds \| 3 baths \| 2,340 sq.ft.	$319,900	Airbnb cash on cash: 0.59% Traditional cash on cash: 6.38% Airbnb Rental Income: $1116 Traditional Rental Income: $2485 Airbnb ROI: 0.59% Traditional ROI: 6.38%
3241 Lakeshore Drive Florence, SC Discover your perfect 4000 sq-ft, lakefront sanctuary in this stunning four-bedroom, four-...	4 beds \| 5 baths \| 4,000 sq.ft.	$849,900	Airbnb cash on cash: 0.07% Traditional cash on cash: 5.01% Airbnb Rental Income: $1889 Traditional Rental Income: $5299 Airbnb ROI: 0.07% Traditional ROI: 5.01%
1305 Virginia Acres Florence, SC A must see well maintained brick home with 3 bedrooms and 2 baths all on a 1/2 acre lot lo...	3 beds \| 2 baths \| 1,646 sq.ft.	$214,000	Airbnb cash on cash: 1.63% Traditional cash on cash: 7.59% Airbnb Rental Income: $1116 Traditional Rental Income: $1950 Airbnb ROI: 1.63% Traditional ROI: 7.59%
3406 Sussex Court Florence, SC Welcome to this fabulous home and what it offers. Beautiful traditional floor plan with l...	4 beds \| 4 baths \| 3,477 sq.ft.	$439,500	Airbnb cash on cash: 1.57% Traditional cash on cash: 6.4% Airbnb Rental Income: $1889 Traditional Rental Income: $3374 Airbnb ROI: 1.57% Traditional ROI: 6.4%
844 Ventura Court Florence, SC New Construction by Golden Construction. Conveniently located in Clark Place subdivision. ...	3 beds \| 2 baths \| 1,367 sq.ft.	$195,000	Airbnb cash on cash: 1.93% Traditional cash on cash: 8.11% Airbnb Rental Income: $1116 Traditional Rental Income: $1886 Airbnb ROI: 1.93% Traditional ROI: 8.11%
1007 W. Palmetto St Florence, SC This charming 1933 property offers flexibility for a single-family home or an income-produ...	4 beds \| 4 baths \| 4,236 sq.ft.	$340,000	Airbnb cash on cash: 2.48% Traditional cash on cash: 10.05% Airbnb Rental Income: $1889 Traditional Rental Income: $3806 Airbnb ROI: 2.48% Traditional ROI: 10.05%
1460 Chandler Circle Florence, SC	3 beds \| 3 baths \| 1,904 sq.ft.	$299,000	Airbnb cash on cash: 0.27% Traditional cash on cash: 5.5% Airbnb Rental Income: $1116 Traditional Rental Income: $2213 Airbnb ROI: 0.27% Traditional ROI: 5.5%
2910 Redwood Dr Florence, SC This 4-bedroom, 2.5-bathroom home offers an incredible opportunity to make it your own. Ne...	4 beds \| 3 baths \| 2,027 sq.ft.	$179,900	Airbnb cash on cash: 5.65% Traditional cash on cash: 9.42% Airbnb Rental Income: $1889 Traditional Rental Income: $2030 Airbnb ROI: 5.65% Traditional ROI: 9.42%
238 Lester Ave Florence, SC Well-built brick home located in a quiet, well-maintained neighborhood. The property offer...	3 beds \| 2 baths \| 1,539 sq.ft.	$159,000	Airbnb cash on cash: 2.69% Traditional cash on cash: 11.21% Airbnb Rental Income: $1116 Traditional Rental Income: $2034 Airbnb ROI: 2.69% Traditional ROI: 11.21%
1205 S Riverdale Avenue Florence, SC Full of character and natural light, this move-in-ready 3-bedroom home offers a welcoming ...	3 beds \| 1 baths \| 1,242 sq.ft.	$200,000	Airbnb cash on cash: 1.84% Traditional cash on cash: 7.13% Airbnb Rental Income: $1116 Traditional Rental Income: $1744 Airbnb ROI: 1.84% Traditional ROI: 7.13%
904 Beverly Drive Florence, SC	3 beds \| 2 baths \| 2,268 sq.ft.	$289,000	Airbnb cash on cash: 1.08% Traditional cash on cash: 5.06% Airbnb Rental Income: $1116 Traditional Rental Income: $1826 Airbnb ROI: 1.08% Traditional ROI: 5.06%
708 Muirfield Place Florence, SC Welcome to 708 Muirfield Place, a stunning all-brick home nestled on the water in prestigi...	4 beds \| 4 baths \| 3,809 sq.ft.	$579,500	Airbnb cash on cash: -0.17% Traditional cash on cash: 2.54% Airbnb Rental Income: $1889 Traditional Rental Income: $2852 Airbnb ROI: -0.17% Traditional ROI: 2.54%
3000 Willett Ct. Florence, SC Looking for space, style, and a great location? This 4-bedroom, 2.5-bath corner lot home h...	4 beds \| 3 baths \| 2,312 sq.ft.	$435,000	Airbnb cash on cash: 1.6% Traditional cash on cash: 3.66% Airbnb Rental Income: $1889 Traditional Rental Income: $2222 Airbnb ROI: 1.6% Traditional ROI: 3.66%
1244 Strada Amore #3 Florence, SC Welcome to 1244 Strada Amore! This well maintained 2-bedroom, 2-bathroom second floor cond...	2 beds \| 2 baths \| 1,475 sq.ft.	$160,000	Airbnb cash on cash: 0.65% Traditional cash on cash: 5.57% Airbnb Rental Income: $1052 Traditional Rental Income: $1439 Airbnb ROI: 0.65% Traditional ROI: 5.57%
213 Creek Drive Florence, SC Well maintained home located in established neighborhood. This charming 2 bedroom, 1 bath ...	2 beds \| 1 baths \| 1,389 sq.ft.	$164,400	Airbnb cash on cash: 2.22% Traditional cash on cash: 5.99% Airbnb Rental Income: $1052 Traditional Rental Income: $1279 Airbnb ROI: 2.22% Traditional ROI: 5.99%
130 Mustang Rd Florence, SC 2 Brick Ranch Homes---1) Home 3/1 Super Nice inside & 1 - Brick Ranch Home 3/...	3 beds \| 1 baths \| 1,316 sq.ft.	$449,900	Airbnb cash on cash: 0.17% Traditional cash on cash: 1.63% Airbnb Rental Income: $1116 Traditional Rental Income: $1356 Airbnb ROI: 0.17% Traditional ROI: 1.63%
2600 Kingston Dr. Florence, SC Welcome to 2600 Kingston Drive in the Parkwood neighborhood!?This charming single-story ho...	3 beds \| 2 baths \| 1,428 sq.ft.	$229,900	Airbnb cash on cash: 1.91% Traditional cash on cash: 5.22% Airbnb Rental Income: $1116 Traditional Rental Income: $1461 Airbnb ROI: 1.91% Traditional ROI: 5.22%
3155 S Cashua Drive, #11 Florence, SC WELCOME HOME to this cozy and beautiful two bedroom, two bath condo in Pine Lakes Subdivis...	2 beds \| 2 baths \| 1,200 sq.ft.	$133,900	Airbnb cash on cash: 2.2% Traditional cash on cash: 6.25% Airbnb Rental Income: $1052 Traditional Rental Income: $1208 Airbnb ROI: 2.2% Traditional ROI: 6.25%
1189 Waxwing Drive Apt A Florence, SC Located in the desirable Marsh Pointe Subdivision, this spacious, move in ready 1,450 sqft...	2 beds \| 2 baths \| 1,450 sq.ft.	$159,500	Airbnb cash on cash: 2.33% Traditional cash on cash: 7.52% Airbnb Rental Income: $1052 Traditional Rental Income: $1478 Airbnb ROI: 2.33% Traditional ROI: 7.52%
313 S Gaillard St Florence, SC Three bedroom oand one bathroom home in Florence, SC is seconds from McLeod Hospital. With...	3 beds \| 1 baths \| 1,074 sq.ft.	$165,000	Airbnb cash on cash: 2.82% Traditional cash on cash: 6.99% Airbnb Rental Income: $1116 Traditional Rental Income: $1396 Airbnb ROI: 2.82% Traditional ROI: 6.99%
1110-G Third Loop Road Florence, SC Location, location, location, located off 3rd Loop near center of town/Desirable Brick Bon...	3 beds \| 2 baths \| 1,300 sq.ft.	$132,000	Airbnb cash on cash: 3.81% Traditional cash on cash: 11.78% Airbnb Rental Income: $1116 Traditional Rental Income: $1752 Airbnb ROI: 3.81% Traditional ROI: 11.78%
2220 Oakwood Lane APT A8 Florence, SC Welcome to your new home. Nestled within the quiet Foxboro Subdivision this beautiful 2 be...	2 beds \| 2 baths \| 1,088 sq.ft.	$127,900	Airbnb cash on cash: 3.26% Traditional cash on cash: 9.66% Airbnb Rental Income: $1052 Traditional Rental Income: $1475 Airbnb ROI: 3.26% Traditional ROI: 9.66%
1002 Romsey Place Florence, SC What a fantastic property overlooking Lake Oakdaleâpacked with updates and ready to impr...	3 beds \| 3 baths \| 2,385 sq.ft.	$365,000	Airbnb cash on cash: 0.58% Traditional cash on cash: 5.09% Airbnb Rental Income: $1116 Traditional Rental Income: $2285 Airbnb ROI: 0.58% Traditional ROI: 5.09%
1451 Gregg Ave. Florence, SC A lovely little bungalow on a large corner lot in W Florence with lots of quaint charm. Co...	3 beds \| 1 baths \| 990 sq.ft.	$155,850	Airbnb cash on cash: 2.63% Traditional cash on cash: 8.34% Airbnb Rental Income: $1116 Traditional Rental Income: $1591 Airbnb ROI: 2.63% Traditional ROI: 8.34%
2797 Leola Hill Drive Florence, SC Nestled on the outskirts of Florence, SC, this beautifully updated 3-bedroom, 2-full bathr...	3 beds \| 2 baths \| 1,680 sq.ft.	$189,000	Airbnb cash on cash: 2.4% Traditional cash on cash: 8.01% Airbnb Rental Income: $1116 Traditional Rental Income: $1750 Airbnb ROI: 2.4% Traditional ROI: 8.01%
2207 S Vance Drive Florence, SC Welcome to this inviting 3-bedroom, 2-bathroom home situated in the heart of Florence, SC....	3 beds \| 2 baths \| 1,620 sq.ft.	$249,000	Airbnb cash on cash: 1.5% Traditional cash on cash: 6.43% Airbnb Rental Income: $1116 Traditional Rental Income: $1901 Airbnb ROI: 1.5% Traditional ROI: 6.43%
404 W Vista St Florence, SC New Construction two story home for sale in the City of Florence, S.C. Nice three bedrooms...	3 beds \| 2 baths \| 1,600 sq.ft.	$240,000	Airbnb cash on cash: 1.73% Traditional cash on cash: 6.65% Airbnb Rental Income: $1116 Traditional Rental Income: $1856 Airbnb ROI: 1.73% Traditional ROI: 6.65%
941 Rice Planters Ln Florence, SC Stunning 4-Bed, 3.5-bath home with upstairs living room is perfect for modern living! Thi...	4 beds \| 4 baths \| 3,745 sq.ft.	$550,000	Airbnb cash on cash: 1.27% Traditional cash on cash: 5.12% Airbnb Rental Income: $1889 Traditional Rental Income: $3366 Airbnb ROI: 1.27% Traditional ROI: 5.12%
3415 Sussex Court Florence, SC Welcome to this charming, traditional, well-maintained 4-bedroom, 3.5-bathroom home nestle...	4 beds \| 4 baths \| 4,177 sq.ft.	$599,900	Airbnb cash on cash: 1.04% Traditional cash on cash: 4.59% Airbnb Rental Income: $1889 Traditional Rental Income: $3374 Airbnb ROI: 1.04% Traditional ROI: 4.59%
7411 E National Cemetery Road Florence, SC Southern Comfort Meets Modern Elegance Welcome to your dream retreat! This thoughtfully re...	3 beds \| 3 baths \| 1,829 sq.ft.	$317,000	Airbnb cash on cash: 0.97% Traditional cash on cash: 6% Airbnb Rental Income: $1116 Traditional Rental Income: $2241 Airbnb ROI: 0.97% Traditional ROI: 6%

Real Estate investment in Florence, SC

There are 233 properties for sale in the city of Florence . The median list price in Florence is $284,500 and the average price per square foot is $135. In December 2025, the average monthly cash on cash return in Florence is 6.00%. The average monthly rental income in Florence is $2,132.

Florence, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 233 investment properties available for sale in Florence.

In 2025, the best neighborhood to buy investment property is Florence.

The ROI for Long-Term is higher than the Short-Term in Florence with average rental income of $2,132.

Your search for investment property begins and ends here

Investment Property for Sale in Florence, SC

2729 Winterbrook Drive

Florence, SC

3 beds | 2 baths | 1,277 sq.ft.

$205,000

Airbnb cash on cash: 1.77%

Traditional cash on cash: 7.6%

Airbnb Rental Income: $1116

Traditional Rental Income: $1875

Airbnb ROI: 1.77%

Traditional ROI: 7.6%

1307 Jackson Avenue

Florence, SC

3 beds | 3 baths | 2,812 sq.ft.

$349,000

Airbnb cash on cash: 0.41%

Traditional cash on cash: 6.61%

Airbnb Rental Income: $1116

Traditional Rental Income: $2775

Airbnb ROI: 0.41%

Traditional ROI: 6.61%

2317 Lampley Way

Florence, SC

4 beds | 3 baths | 1,967 sq.ft.

$299,900

Airbnb cash on cash: 3.01%

Traditional cash on cash: 6.83%

Airbnb Rental Income: $1889

Traditional Rental Income: $2463

Airbnb ROI: 3.01%

Traditional ROI: 6.83%

2502 Lakeview Dr.

Florence, SC

4 beds | 2 baths | 2,236 sq.ft.

$259,900

Airbnb cash on cash: 3.7%

Traditional cash on cash: 7.95%

Airbnb Rental Income: $1889

Traditional Rental Income: $2427

Airbnb ROI: 3.7%

Traditional ROI: 7.95%

1914 Deerwood Place

Florence, SC

4 beds | 3 baths | 2,696 sq.ft.

$439,900

Airbnb cash on cash: 2.01%

Traditional cash on cash: 5.49%

Airbnb Rental Income: $1889

Traditional Rental Income: $2819

Airbnb ROI: 2.01%

Traditional ROI: 5.49%

3109 Duchess Ln.

Florence, SC

4 beds | 4 baths | 2,856 sq.ft.

$525,000

Airbnb cash on cash: 1.59%

Traditional cash on cash: 4.82%

Airbnb Rental Income: $1889

Traditional Rental Income: $2969

Airbnb ROI: 1.59%

Traditional ROI: 4.82%

3107 Duchess Lane

Florence, SC

4 beds | 4 baths | 3,705 sq.ft.

$739,900

Airbnb cash on cash: 0.85%

Traditional cash on cash: 3.65%

Airbnb Rental Income: $1889

Traditional Rental Income: $3320

Airbnb ROI: 0.85%

Traditional ROI: 3.65%

906/908 Sherwood Drive

Florence, SC

N/A beds | N/A baths | N/A

$207,000

Airbnb cash on cash: 4.93%

Traditional cash on cash: 4.63%

Airbnb Rental Income: $1889

Traditional Rental Income: $1327

Airbnb ROI: 4.93%