Real Estate Investment Properties for Sale in Lake City, SC

Looking for investment property in Lake City, SC with high ROI ?

Explore a variety of short-term homes & houses in Lake City, SC. Invest wisely with VRBO & Lake City, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Lake City, SC

separator

PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
2260 Old Spring Rd LAKE CITY, SC Great starter home or home for the buyer ready to down size! Located btwn Lake City and Jo...	3 beds \| 2 baths \| 1,350 sq.ft.	$104,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.41% Airbnb Rental Income: $null Traditional Rental Income: $1414 Airbnb ROI: N/A Traditional ROI: 11.41%
520 E Main Street LAKE CITY, SC Welcome to peaceful living and stylish functionality! This 3 bedroom, 2 bath home is brimm...	3 beds \| 2 baths \| 2,620 sq.ft.	$329,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.24% Airbnb Rental Income: $null Traditional Rental Income: $2662 Airbnb ROI: N/A Traditional ROI: 6.24%
1484 Fitch Rd. LAKE CITY, SC Luxurious 3-Bedroom Retreat on 3 Lush Acres â Your Private Oasis Awaits! Escape to elega...	3 beds \| 4 baths \| 4,089 sq.ft.	$599,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.55% Airbnb Rental Income: $null Traditional Rental Income: $2207 Airbnb ROI: N/A Traditional ROI: 2.55%
1309 N Matthews Road LAKE CITY, SC SOLD "AS IS". This beautiful property has 4.29 acres. The downstairs is heated and coole...	2 beds \| 3 baths \| 1,659 sq.ft.	$207,000	Airbnb cash on cash: 0.54% Traditional cash on cash: 8.96% Airbnb Rental Income: $834 Traditional Rental Income: $2159 Airbnb ROI: 0.54% Traditional ROI: 8.96%
822 Twin Oaks Circle LAKE CITY, SC Discover this stunning residence nestled in the sought-after Twin Oaks Community! This rem...	4 beds \| 2 baths \| 1,402 sq.ft.	$211,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.91% Airbnb Rental Income: $null Traditional Rental Income: $2618 Airbnb ROI: N/A Traditional ROI: 9.91%
722 Twin Oaks Circle LAKE CITY, SC NEW LISTING ALERT! 722 Twin Oaks Circle Lake City, SC $225,000\| 3 Bedrooms \| 2 1/2 Bat...	3 beds \| 3 baths \| 1,603 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.95% Airbnb Rental Income: $null Traditional Rental Income: $2535 Airbnb ROI: N/A Traditional ROI: 8.95%
52 Acres-TBD Vox Hwy LAKE CITY, SC 52 Acres-TBD Vox Hwy, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$221,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.01% Airbnb Rental Income: $null Traditional Rental Income: $843 Airbnb ROI: N/A Traditional ROI: 2.01%
217 Smith St LAKE CITY, SC 217 Smith St, LAKE CITY, SC 29560 \| Single Family Residential	4 beds \| 2 baths \| 2,216 sq.ft.	$249,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.68% Airbnb Rental Income: $null Traditional Rental Income: $1563 Airbnb ROI: N/A Traditional ROI: 4.68%
900 S Morris St LAKE CITY, SC 900 S Morris St, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 1,549 sq.ft.	$170,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.57% Airbnb Rental Income: $null Traditional Rental Income: $2061 Airbnb ROI: N/A Traditional ROI: 10.57%
116 S Second Ave LAKE CITY, SC 116 S Second Ave, LAKE CITY, SC 29560 \| Single Family Residential	4 beds \| 2 baths \| 3,510 sq.ft.	$319,999	Airbnb cash on cash: N/A Traditional cash on cash: 3.32% Airbnb Rental Income: $null Traditional Rental Income: $1563 Airbnb ROI: N/A Traditional ROI: 3.32%
3728 W Turbeville Hwy LAKE CITY, SC 3728 W Turbeville Hwy, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,100 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.57% Airbnb Rental Income: $null Traditional Rental Income: $1414 Airbnb ROI: N/A Traditional ROI: 1.57%
310 Elm St LAKE CITY, SC 310 Elm St, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 1,176 sq.ft.	$160,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.08% Airbnb Rental Income: $null Traditional Rental Income: $1414 Airbnb ROI: N/A Traditional ROI: 7.08%
220 Brantley St LAKE CITY, SC 220 Brantley St, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,578 sq.ft.	$323,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.44% Airbnb Rental Income: $null Traditional Rental Income: $2221 Airbnb ROI: N/A Traditional ROI: 5.44%
506 Taylor St LAKE CITY, SC 506 Taylor St, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 1 baths \| 1,456 sq.ft.	$149,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.69% Airbnb Rental Income: $null Traditional Rental Income: $1414 Airbnb ROI: N/A Traditional ROI: 7.69%
120 Rodgers Ave LAKE CITY, SC 120 Rodgers Ave, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 3 baths \| 1,902 sq.ft.	$115,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.31% Airbnb Rental Income: $null Traditional Rental Income: $1414 Airbnb ROI: N/A Traditional ROI: 10.31%
739 & 741 Jones Rd LAKE CITY, SC 739 & 741 Jones Rd, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 2,500 sq.ft.	$3,500,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.93% Airbnb Rental Income: $null Traditional Rental Income: $2157 Airbnb ROI: N/A Traditional ROI: -0.93%
4520 Huggins Rd LAKE CITY, SC 4520 Huggins Rd, LAKE CITY, SC 29560 \| Manufactured Home	3 beds \| 2 baths \| 1,734 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.34% Airbnb Rental Income: $null Traditional Rental Income: $2159 Airbnb ROI: N/A Traditional ROI: 8.34%
115 Carolina Ave LAKE CITY, SC 115 Carolina Ave, LAKE CITY, SC 29560 \| Single Family Residential	3 beds \| 2 baths \| 1,919 sq.ft.	$168,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.61% Airbnb Rental Income: $null Traditional Rental Income: $2204 Airbnb ROI: N/A Traditional ROI: 11.61%
319 Scott St LAKE CITY, SC 319 Scott St, LAKE CITY, SC 29560 \| Single Family Residential	2 beds \| 1 baths \| 750 sq.ft.	$89,900	Airbnb cash on cash: 3.12% Traditional cash on cash: 9.65% Airbnb Rental Income: $834 Traditional Rental Income: $1080 Airbnb ROI: 3.12% Traditional ROI: 9.65%
5.9AC W Main St LAKE CITY, SC 5.9AC W Main St, LAKE CITY, SC 29560 \| Other	N/A beds \| N/A baths \| N/A	$109,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.53% Airbnb Rental Income: $null Traditional Rental Income: $843 Airbnb ROI: N/A Traditional ROI: 5.53%
254 Lockwood Drive LAKE CITY, SC Brand new Yarmouth model at Hamilton Grove in Bluffton, SC, is a 2,505-square-foot, two-st...	4 beds \| 3 baths \| 2,505 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.52% Airbnb Rental Income: $null Traditional Rental Income: $2736 Airbnb ROI: N/A Traditional ROI: 4.52%

Real Estate investment in Lake-city, SC

There are 21 properties for sale in the city of Lake City . The median list price in Lake City is $262,450 and the average price per square foot is $142. In January 2026, the average monthly cash on cash return in Lake City is 11.00%. The average monthly rental income in Lake City is $1,414.

Lake-city, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 21 investment properties available for sale in Lake-city.

In 2026, the best neighborhood to buy investment property is LAKE CITY.

The ROI for Short-Term is higher than the Long-Term in Lake-city with average rental income of $834.

Your search for investment property begins and ends here

Investment Property for Sale in Lake City, SC

2260 Old Spring Rd

LAKE CITY, SC

3 beds | 2 baths | 1,350 sq.ft.

$104,900

Airbnb cash on cash: N/A

Traditional cash on cash: 11.41%

Airbnb Rental Income: $null

Traditional Rental Income: $1414

Airbnb ROI: N/A

Traditional ROI: 11.41%

520 E Main Street

LAKE CITY, SC

3 beds | 2 baths | 2,620 sq.ft.

$329,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.24%

Airbnb Rental Income: $null

Traditional Rental Income: $2662

Airbnb ROI: N/A

Traditional ROI: 6.24%

1484 Fitch Rd.

LAKE CITY, SC

3 beds | 4 baths | 4,089 sq.ft.

$599,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.55%

Airbnb Rental Income: $null

Traditional Rental Income: $2207

Airbnb ROI: N/A

Traditional ROI: 2.55%

1309 N Matthews Road

LAKE CITY, SC

2 beds | 3 baths | 1,659 sq.ft.

$207,000

Airbnb cash on cash: 0.54%

Traditional cash on cash: 8.96%

Airbnb Rental Income: $834

Traditional Rental Income: $2159

Airbnb ROI: 0.54%

Traditional ROI: 8.96%

822 Twin Oaks Circle

LAKE CITY, SC

4 beds | 2 baths | 1,402 sq.ft.

$211,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.91%

Airbnb Rental Income: $null

Traditional Rental Income: $2618

Airbnb ROI: N/A

Traditional ROI: 9.91%

722 Twin Oaks Circle

LAKE CITY, SC

3 beds | 3 baths | 1,603 sq.ft.

$225,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.95%

Airbnb Rental Income: $null

Traditional Rental Income: $2535

Airbnb ROI: N/A

Traditional ROI: 8.95%

52 Acres-TBD Vox Hwy

LAKE CITY, SC

N/A beds | N/A baths | N/A

$221,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.01%

Airbnb Rental Income: $null

Traditional Rental Income: $843

Airbnb ROI: N/A

Traditional ROI: 2.01%

217 Smith St

LAKE CITY, SC

4 beds | 2 baths | 2,216 sq.ft.

$249,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.68%

Airbnb Rental Income: $null

Traditional Rental Income: $1563

Airbnb ROI: N/A