Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Single Family Homes for Sale in Santee, SC

Search for Single Family Residential for Sale in Santee, South Carolina. Browse all of Mashvisor’s Single Family Residential listings and other investment property types including Single Family Homes, Multi Family Homes, Condos, Townhouses and Other Homes.

Showing 54 Single Family Residential listings of over 500,000 total investment properties for sale. Visit Mashvisor.com to all investment properties.

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
104 Cooper Dr Santee, SC In Santee Cooper Resort, you purchase more than a home, you purchase a lifestyle. Nothing ...	4 beds \| 3 baths \| 3,564 sq.ft.	$384,000	Airbnb cash on cash: 6.73% Traditional cash on cash: 6.9% Airbnb Rental Income: $4116 Traditional Rental Income: $3300 Airbnb ROI: 6.73% Traditional ROI: 6.9%
370 Chapel Creek Drive Santee, SC Welcome to 370 Chapel Creek Drive in Santee, SC-a beautifully crafted 4-bedroom, 4-bathroo...	4 beds \| 4 baths \| 3,720 sq.ft.	$575,000	Airbnb cash on cash: 4.26% Traditional cash on cash: 5.6% Airbnb Rental Income: $4116 Traditional Rental Income: $3957 Airbnb ROI: 4.26% Traditional ROI: 5.6%
126 Wateree Drive Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 3 baths \| 3,204 sq.ft.	$549,000	Airbnb cash on cash: -1.47% Traditional cash on cash: 1.28% Airbnb Rental Income: $921 Traditional Rental Income: $1986 Airbnb ROI: -1.47% Traditional ROI: 1.28%
127 Cooper Cir Santee, SC Located in Santee Cooper Resort on Lake Marion. This home has 14 rooms (laundry room, uti...	4 beds \| 3 baths \| 3,386 sq.ft.	$499,900	Airbnb cash on cash: 3.33% Traditional cash on cash: 1.51% Airbnb Rental Income: $4116 Traditional Rental Income: $2394 Airbnb ROI: 3.33% Traditional ROI: 1.51%
229 Cooper Dr Santee, SC Welcome home to this sanctuary nestled under a canopy of towering pine trees. The winding ...	3 beds \| 2 baths \| 1,692 sq.ft.	$314,999	Airbnb cash on cash: -0.04% Traditional cash on cash: 3.68% Airbnb Rental Income: $921 Traditional Rental Income: $1682 Airbnb ROI: -0.04% Traditional ROI: 3.68%
1 John Fothergill Circle Santee, SC Beautifully maintained single story home located in Bradford Village a 55 & older gated co...	2 beds \| 2 baths \| 1,501 sq.ft.	$219,900	Airbnb cash on cash: 0.61% Traditional cash on cash: 6.13% Airbnb Rental Income: $1030 Traditional Rental Income: $1819 Airbnb ROI: 0.61% Traditional ROI: 6.13%
125 Congaree Ct Santee, SC This home is a short sale! Come Fall in love with this beautiful move-in-ready 2023-built ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,000	Airbnb cash on cash: 0.35% Traditional cash on cash: 4.88% Airbnb Rental Income: $921 Traditional Rental Income: $1615 Airbnb ROI: 0.35% Traditional ROI: 4.88%
472 Santee Drive Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 4 baths \| 4,046 sq.ft.	$575,000	Airbnb cash on cash: 0.22% Traditional cash on cash: 4.6% Airbnb Rental Income: $1672 Traditional Rental Income: $3558 Airbnb ROI: 0.22% Traditional ROI: 4.6%
119 Saluda Dr Santee, SC Experience the ultimate lake and golf lifestyle at 119 Saluda Drive, located in the sought...	4 beds \| 2 baths \| 3,055 sq.ft.	$499,900	Airbnb cash on cash: 4.75% Traditional cash on cash: 3.09% Airbnb Rental Income: $4116 Traditional Rental Income: $2466 Airbnb ROI: 4.75% Traditional ROI: 3.09%
220 Green Street Santee, SC Welcome to this charming manufactured home offering comfort, style, and modern upgrades. F...	3 beds \| 2 baths \| 1,375 sq.ft.	$199,900	Airbnb cash on cash: 1.21% Traditional cash on cash: 6.83% Airbnb Rental Income: $921 Traditional Rental Income: $1646 Airbnb ROI: 1.21% Traditional ROI: 6.83%
208 Avocada Dr Santee, SC NO HOA with a FRONT AND BACK YARD.3 bedroom , 2 bathroom with a front porch followed by a ...	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 0.81% Traditional cash on cash: 5.97% Airbnb Rental Income: $921 Traditional Rental Income: $1774 Airbnb ROI: 0.81% Traditional ROI: 5.97%
230 Oak Hollow Drive Santee, SC Your Lake Home Near Lake Marion! Embrace the perfect blend of comfort, and nature with thi...	3 beds \| 2 baths \| N/A	$230,000	Airbnb cash on cash: 1.14% Traditional cash on cash: 7.31% Airbnb Rental Income: $921 Traditional Rental Income: $1921 Airbnb ROI: 1.14% Traditional ROI: 7.31%
192 Avocada Dr Santee, SC 192 Avocada Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$260,000	Airbnb cash on cash: 0.41% Traditional cash on cash: 3.65% Airbnb Rental Income: $921 Traditional Rental Income: $1375 Airbnb ROI: 0.41% Traditional ROI: 3.65%
190 Avocada Drive Dr Santee, SC 190 Avocada Drive Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 0.53% Traditional cash on cash: 3.97% Airbnb Rental Income: $921 Traditional Rental Income: $1375 Airbnb ROI: 0.53% Traditional ROI: 3.97%
214 Avocada Dr Santee, SC 214 Avocada Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 0.53% Traditional cash on cash: 3.97% Airbnb Rental Income: $921 Traditional Rental Income: $1375 Airbnb ROI: 0.53% Traditional ROI: 3.97%
Spruce Plan Santee, SC Spruce Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,296 sq.ft.	$253,990	Airbnb cash on cash: 0.45% Traditional cash on cash: 3.59% Airbnb Rental Income: $921 Traditional Rental Income: $1331 Airbnb ROI: 0.45% Traditional ROI: 3.59%
121 Congaree Ct Ct Santee, SC 121 Congaree Ct Ct, Santee, SC 29142 \| Single Family Residential	4 beds \| 2 baths \| 1,774 sq.ft.	$295,000	Airbnb cash on cash: 9.57% Traditional cash on cash: 4.24% Airbnb Rental Income: $4116 Traditional Rental Income: $1759 Airbnb ROI: 9.57% Traditional ROI: 4.24%
Aspen Plan Santee, SC Aspen Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,440 sq.ft.	$249,990	Airbnb cash on cash: 0.49% Traditional cash on cash: 4.03% Airbnb Rental Income: $921 Traditional Rental Income: $1414 Airbnb ROI: 0.49% Traditional ROI: 4.03%
Fairview Plan Santee, SC Fairview Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 1,910 sq.ft.	$299,990	Airbnb cash on cash: 0.15% Traditional cash on cash: 4.24% Airbnb Rental Income: $921 Traditional Rental Income: $1732 Airbnb ROI: 0.15% Traditional ROI: 4.24%
Tupelo Plan Santee, SC Tupelo Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,517 sq.ft.	$274,990	Airbnb cash on cash: 0.3% Traditional cash on cash: 3.66% Airbnb Rental Income: $921 Traditional Rental Income: $1449 Airbnb ROI: 0.3% Traditional ROI: 3.66%
106 Santee Cooper Anx Santee, SC 106 Santee Cooper Anx, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 2,771 sq.ft.	$460,000	Airbnb cash on cash: -0.88% Traditional cash on cash: 2.69% Airbnb Rental Income: $921 Traditional Rental Income: $2116 Airbnb ROI: -0.88% Traditional ROI: 2.69%
156 William Clark Blvd Santee, SC 156 William Clark Blvd, Santee, SC 29142 \| Single Family Residential	5 beds \| 3 baths \| 2,646 sq.ft.	$359,000	Airbnb cash on cash: 1.59% Traditional cash on cash: 4.92% Airbnb Rental Income: $1672 Traditional Rental Income: $2327 Airbnb ROI: 1.59% Traditional ROI: 4.92%
118 William Clark Blvd Santee, SC 118 William Clark Blvd, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 2,507 sq.ft.	$350,000	Airbnb cash on cash: -1.83% Traditional cash on cash: 2.97% Airbnb Rental Income: $921 Traditional Rental Income: $2155 Airbnb ROI: -1.83% Traditional ROI: 2.97%
724 Striped Bass Ct Santee, SC 724 Striped Bass Ct, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,517 sq.ft.	$255,000	Airbnb cash on cash: 0.25% Traditional cash on cash: 4.36% Airbnb Rental Income: $921 Traditional Rental Income: $1567 Airbnb ROI: 0.25% Traditional ROI: 4.36%
SULLIVAN Plan Santee, SC	3 beds \| 2 baths \| 1,183 sq.ft.	$207,080	Airbnb cash on cash: 0.91% Traditional cash on cash: 4.56% Airbnb Rental Income: $921 Traditional Rental Income: $1297 Airbnb ROI: 0.91% Traditional ROI: 4.56%
BRANDON Plan Santee, SC	3 beds \| 2 baths \| 1,518 sq.ft.	$244,370	Airbnb cash on cash: 0.53% Traditional cash on cash: 4.3% Airbnb Rental Income: $921 Traditional Rental Income: $1449 Airbnb ROI: 0.53% Traditional ROI: 4.3%
RACHEL Plan Santee, SC	3 beds \| 2 baths \| 1,360 sq.ft.	$223,435	Airbnb cash on cash: 0.73% Traditional cash on cash: 4.45% Airbnb Rental Income: $921 Traditional Rental Income: $1367 Airbnb ROI: 0.73% Traditional ROI: 4.45%
130 2nd Street Santee, SC Steps to Lake Marion! This fully renovated 3-bedroom, 2-bath ranch offers turnkey living i...	3 beds \| 2 baths \| 1,580 sq.ft.	$234,000	Airbnb cash on cash: 0.73% Traditional cash on cash: 6.12% Airbnb Rental Income: $921 Traditional Rental Income: $1772 Airbnb ROI: 0.73% Traditional ROI: 6.12%
612 Santee Drive Santee, SC Are you looking for a second home? If so, this is the home for you! It is being sold compl...	3 beds \| 3 baths \| 2,019 sq.ft.	$375,000	Airbnb cash on cash: -1.29% Traditional cash on cash: 2.95% Airbnb Rental Income: $921 Traditional Rental Income: $2071 Airbnb ROI: -1.29% Traditional ROI: 2.95%
605 Perch Ln Santee, SC 605 Perch Ln, Santee, SC 29142 \| Single Family Residential	4 beds \| 2 baths \| 1,774 sq.ft.	$302,705	Airbnb cash on cash: 9.31% Traditional cash on cash: 4.32% Airbnb Rental Income: $4116 Traditional Rental Income: $1819 Airbnb ROI: 9.31% Traditional ROI: 4.32%
443 Santee Dr Santee, SC 443 Santee Dr, Santee, SC 29142 \| Single Family Residential	6 beds \| 4 baths \| 5,723 sq.ft.	$1,300,000	Airbnb cash on cash: -0.78% Traditional cash on cash: 0.69% Airbnb Rental Income: $1672 Traditional Rental Income: $2973 Airbnb ROI: -0.78% Traditional ROI: 0.69%
601 Perch Ln Santee, SC 601 Perch Ln, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,183 sq.ft.	$219,000	Airbnb cash on cash: 0.54% Traditional cash on cash: 4.77% Airbnb Rental Income: $921 Traditional Rental Income: $1455 Airbnb ROI: 0.54% Traditional ROI: 4.77%
645 Perch Ln Santee, SC 645 Perch Ln, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,183 sq.ft.	$221,500	Airbnb cash on cash: 0.52% Traditional cash on cash: 4.69% Airbnb Rental Income: $921 Traditional Rental Income: $1453 Airbnb ROI: 0.52% Traditional ROI: 4.69%
700 Striped Bass Ct Santee, SC 700 Striped Bass Ct, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,518 sq.ft.	$257,500	Airbnb cash on cash: 0.23% Traditional cash on cash: 4.55% Airbnb Rental Income: $921 Traditional Rental Income: $1627 Airbnb ROI: 0.23% Traditional ROI: 4.55%
700 Perch Ln Santee, SC 700 Perch Ln, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,517 sq.ft.	$291,620	Airbnb cash on cash: 0.02% Traditional cash on cash: 3.84% Airbnb Rental Income: $921 Traditional Rental Income: $1626 Airbnb ROI: 0.02% Traditional ROI: 3.84%
713 Striped Bass Ct Santee, SC 713 Striped Bass Ct, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,183 sq.ft.	$216,500	Airbnb cash on cash: 0.56% Traditional cash on cash: 4.83% Airbnb Rental Income: $921 Traditional Rental Income: $1453 Airbnb ROI: 0.56% Traditional ROI: 4.83%
603 Santee Dr Santee, SC 603 Santee Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 2,700 sq.ft.	$625,000	Airbnb cash on cash: -1.05% Traditional cash on cash: 1.14% Airbnb Rental Income: $921 Traditional Rental Income: $1857 Airbnb ROI: -1.05% Traditional ROI: 1.14%
609 Perch Ln Santee, SC 609 Perch Ln, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,360 sq.ft.	$241,830	Airbnb cash on cash: 0.35% Traditional cash on cash: 4.53% Airbnb Rental Income: $921 Traditional Rental Income: $1535 Airbnb ROI: 0.35% Traditional ROI: 4.53%
207 Cooper Dr Santee, SC 207 Cooper Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 2,112 sq.ft.	$389,000	Airbnb cash on cash: -0.74% Traditional cash on cash: 2.63% Airbnb Rental Income: $921 Traditional Rental Income: $1807 Airbnb ROI: -0.74% Traditional ROI: 2.63%
1075 Chapel Branch Rd Santee, SC 1075 Chapel Branch Rd, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,892 sq.ft.	$550,000	Airbnb cash on cash: -0.68% Traditional cash on cash: 1.56% Airbnb Rental Income: $921 Traditional Rental Income: $1728 Airbnb ROI: -0.68% Traditional ROI: 1.56%

Your search for investment property begins and ends here

Single Family Homes for Sale in Santee, SC

104 Cooper Dr

Santee, SC

4 beds | 3 baths | 3,564 sq.ft.

$384,000

Airbnb cash on cash: 6.73%

Traditional cash on cash: 6.9%

Airbnb Rental Income: $4116

Traditional Rental Income: $3300

Airbnb ROI: 6.73%

Traditional ROI: 6.9%

370 Chapel Creek Drive

Santee, SC

4 beds | 4 baths | 3,720 sq.ft.

$575,000

Airbnb cash on cash: 4.26%

Traditional cash on cash: 5.6%

Airbnb Rental Income: $4116

Traditional Rental Income: $3957

Airbnb ROI: 4.26%

Traditional ROI: 5.6%

126 Wateree Drive

Santee, SC

3 beds | 3 baths | 3,204 sq.ft.

$549,000

Airbnb cash on cash: -1.47%

Traditional cash on cash: 1.28%

Airbnb Rental Income: $921

Traditional Rental Income: $1986

Airbnb ROI: -1.47%

Traditional ROI: 1.28%

127 Cooper Cir

Santee, SC

4 beds | 3 baths | 3,386 sq.ft.

$499,900

Airbnb cash on cash: 3.33%

Traditional cash on cash: 1.51%

Airbnb Rental Income: $4116

Traditional Rental Income: $2394

Airbnb ROI: 3.33%

Traditional ROI: 1.51%

229 Cooper Dr

Santee, SC

3 beds | 2 baths | 1,692 sq.ft.

$314,999

Airbnb cash on cash: -0.04%

Traditional cash on cash: 3.68%

Airbnb Rental Income: $921

Traditional Rental Income: $1682

Airbnb ROI: -0.04%

Traditional ROI: 3.68%

1 John Fothergill Circle

Santee, SC

2 beds | 2 baths | 1,501 sq.ft.

$219,900

Airbnb cash on cash: 0.61%

Traditional cash on cash: 6.13%

Airbnb Rental Income: $1030

Traditional Rental Income: $1819

Airbnb ROI: 0.61%

Traditional ROI: 6.13%

125 Congaree Ct

Santee, SC

3 beds | 2 baths | 1,183 sq.ft.

$242,000

Airbnb cash on cash: 0.35%

Traditional cash on cash: 4.88%

Airbnb Rental Income: $921

Traditional Rental Income: $1615

Airbnb ROI: 0.35%

Traditional ROI: 4.88%

472 Santee Drive

Santee, SC

5 beds | 4 baths | 4,046 sq.ft.

$575,000

Airbnb cash on cash: 0.22%

Traditional cash on cash: 4.6%

Airbnb Rental Income: $1672

Traditional Rental Income: $3558

Airbnb ROI: 0.22%