Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
370 Chapel Creek Drive Santee, SC Welcome to 370 Chapel Creek Drive in Santee, SC, where golf, lake living, and Lowcountry c...	4 beds \| 4 baths \| 3,720 sq.ft.	$570,000	Airbnb cash on cash: 5.08% Traditional cash on cash: 5.66% Airbnb Rental Income: $4603 Traditional Rental Income: $3957 Airbnb ROI: 5.08% Traditional ROI: 5.66%
126 Wateree Drive Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 3 baths \| 3,204 sq.ft.	$549,000	Airbnb cash on cash: -1.3% Traditional cash on cash: 1.28% Airbnb Rental Income: $1024 Traditional Rental Income: $1986 Airbnb ROI: -1.3% Traditional ROI: 1.28%
105 Ballard Lane Santee, SC Turnkey waterfront condo overlooking Lake Marion--South Carolina's largest lake with acces...	2 beds \| 2 baths \| 1,298 sq.ft.	$267,000	Airbnb cash on cash: -0.6% Traditional cash on cash: 3.64% Airbnb Rental Income: $1068 Traditional Rental Income: $1768 Airbnb ROI: -0.6% Traditional ROI: 3.64%
8495 Old Number Six Highway Santee, SC Half Acre Charming Lake Retreat Near Golf & Santee State Park! Don't miss this opportunity...	2 beds \| 1 baths \| 800 sq.ft.	$209,900	Airbnb cash on cash: 1.49% Traditional cash on cash: 5.65% Airbnb Rental Income: $1068 Traditional Rental Income: $1530 Airbnb ROI: 1.49% Traditional ROI: 5.65%
106 Broad River Drive Santee, SC Easy home build process. PROPOSED CONSTRUCTION on DEEP WATER. ** Vacant Land/Lot also list...	4 beds \| 3 baths \| 2,600 sq.ft.	$743,000	Airbnb cash on cash: 3.57% Traditional cash on cash: 2.49% Airbnb Rental Income: $4603 Traditional Rental Income: $2903 Airbnb ROI: 3.57% Traditional ROI: 2.49%
472 Santee Drive Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 4 baths \| 4,046 sq.ft.	$550,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.88% Airbnb Rental Income: $null Traditional Rental Income: $3558 Airbnb ROI: N/A Traditional ROI: 4.88%
457 Santee Drive Santee, SC Welcome to luxury living on Lake Marion! Situated on the serene shores of Lake Marion this...	4 beds \| 5 baths \| 3,778 sq.ft.	$1,450,000	Airbnb cash on cash: 0.96% Traditional cash on cash: 1.22% Airbnb Rental Income: $4603 Traditional Rental Income: $4006 Airbnb ROI: 0.96% Traditional ROI: 1.22%
107 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton This is a limit...	3 beds \| 3 baths \| 1,473 sq.ft.	$251,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 5.16% Airbnb Rental Income: $1024 Traditional Rental Income: $1687 Airbnb ROI: 0.84% Traditional ROI: 5.16%
109 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton This is a limit...	3 beds \| 3 baths \| 1,524 sq.ft.	$256,000	Airbnb cash on cash: 0.79% Traditional cash on cash: 4.81% Airbnb Rental Income: $1024 Traditional Rental Income: $1636 Airbnb ROI: 0.79% Traditional ROI: 4.81%
156 William Clark Boulevard Santee, SC Welcome to Center Pointe, where golf, fishing, and lake life are just minutes away! Conven...	5 beds \| 4 baths \| 2,646 sq.ft.	$349,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.1% Airbnb Rental Income: $null Traditional Rental Income: $2327 Airbnb ROI: N/A Traditional ROI: 5.1%
724 Striped Bass Court Santee, SC Spacious New Home Near Lake Marion Welcome home to 724 Striped Bass Court, located in the ...	3 beds \| 3 baths \| 1,518 sq.ft.	$245,900	Airbnb cash on cash: 0.68% Traditional cash on cash: 4.57% Airbnb Rental Income: $1024 Traditional Rental Income: $1567 Airbnb ROI: 0.68% Traditional ROI: 4.57%
122 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Welcome to Mari...	3 beds \| 3 baths \| 1,524 sq.ft.	$254,000	Airbnb cash on cash: 0.81% Traditional cash on cash: 4.6% Airbnb Rental Income: $1024 Traditional Rental Income: $1573 Airbnb ROI: 0.81% Traditional ROI: 4.6%
126 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Don't miss this...	3 beds \| 3 baths \| 1,524 sq.ft.	$267,000	Airbnb cash on cash: 0.7% Traditional cash on cash: 4.31% Airbnb Rental Income: $1024 Traditional Rental Income: $1573 Airbnb ROI: 0.7% Traditional ROI: 4.31%
116 Cypress Hollow Way Santee, SC Don't miss this limited opportunity to own an end-unit townhome in Marion Village, one of ...	3 beds \| 3 baths \| 1,473 sq.ft.	$251,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 4.51% Airbnb Rental Income: $1024 Traditional Rental Income: $1533 Airbnb ROI: 0.84% Traditional ROI: 4.51%
120 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Welcome to Mari...	3 beds \| 3 baths \| 1,524 sq.ft.	$250,000	Airbnb cash on cash: 0.85% Traditional cash on cash: 4.53% Airbnb Rental Income: $1024 Traditional Rental Income: $1533 Airbnb ROI: 0.85% Traditional ROI: 4.53%
118 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Welcome to Mari...	3 beds \| 3 baths \| 1,524 sq.ft.	$255,000	Airbnb cash on cash: 0.81% Traditional cash on cash: 4.58% Airbnb Rental Income: $1024 Traditional Rental Income: $1573 Airbnb ROI: 0.81% Traditional ROI: 4.58%
124 Cypress Hollow Way Santee, SC Special interest rates available with closing cost assistance paid by the builder. Welcome...	3 beds \| 3 baths \| 1,473 sq.ft.	$251,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 4.51% Airbnb Rental Income: $1024 Traditional Rental Income: $1533 Airbnb ROI: 0.84% Traditional ROI: 4.51%
612 Santee Drive Santee, SC Are you looking for a second home? If so, this is the home for you! It is being sold compl...	3 beds \| 3 baths \| 2,019 sq.ft.	$350,000	Airbnb cash on cash: -1.05% Traditional cash on cash: 3.23% Airbnb Rental Income: $1024 Traditional Rental Income: $2071 Airbnb ROI: -1.05% Traditional ROI: 3.23%
609 Perch Lane Santee, SC Welcome home to 609 Perch Lane, set on an oversized lot in the heart of the Center Pointe ...	3 beds \| 3 baths \| 1,360 sq.ft.	$241,830	Airbnb cash on cash: 0.72% Traditional cash on cash: 4.53% Airbnb Rental Income: $1024 Traditional Rental Income: $1535 Airbnb ROI: 0.72% Traditional ROI: 4.53%
23 Peter Collinson Road Santee, SC Charming 3-bedroom, 2-bath ranch in the quiet, gated 55+ community of Bradford Village. Th...	3 beds \| 2 baths \| 2,276 sq.ft.	$279,900	Airbnb cash on cash: 0.36% Traditional cash on cash: 5.96% Airbnb Rental Income: $1024 Traditional Rental Income: $2140 Airbnb ROI: 0.36% Traditional ROI: 5.96%
613 Ballard Lane Santee, SC Waterfront 2nd floor furnished condo overlooking the Big Waters of Lake Marion. Close to c...	2 beds \| 2 baths \| 1,232 sq.ft.	$219,000	Airbnb cash on cash: -1.72% Traditional cash on cash: 4.8% Airbnb Rental Income: $1068 Traditional Rental Income: $2053 Airbnb ROI: -1.72% Traditional ROI: 4.8%
724 Sinker Lane Santee, SC Welcome home to this this 10 month young single level retirement or starter home located a...	2 beds \| 2 baths \| 1,181 sq.ft.	$286,888	Airbnb cash on cash: 0.38% Traditional cash on cash: 4.4% Airbnb Rental Income: $1068 Traditional Rental Income: $1786 Airbnb ROI: 0.38% Traditional ROI: 4.4%
363 Legend Court Santee, SC Experience the best of Lake Marion living at 363 Legend Court, a beautifully maintained wa...	3 beds \| 2 baths \| 1,550 sq.ft.	$460,000	Airbnb cash on cash: -0.63% Traditional cash on cash: 1.6% Airbnb Rental Income: $1024 Traditional Rental Income: $1623 Airbnb ROI: -0.63% Traditional ROI: 1.6%
725 Striped Bass Court Santee, SC Welcome home to 725 Striped Bass Court, where comfort, connection, and Lowcountry living c...	3 beds \| 3 baths \| 1,518 sq.ft.	$245,900	Airbnb cash on cash: 0.68% Traditional cash on cash: 4.82% Airbnb Rental Income: $1024 Traditional Rental Income: $1626 Airbnb ROI: 0.68% Traditional ROI: 4.82%
600 Perch Lane Santee, SC Lowcountry Living in Centerpoint Welcome to 600 Perch Lane in the Center Pointe community ...	3 beds \| 2 baths \| 1,183 sq.ft.	$219,000	Airbnb cash on cash: 1.2% Traditional cash on cash: 5.93% Airbnb Rental Income: $1024 Traditional Rental Income: $1645 Airbnb ROI: 1.2% Traditional ROI: 5.93%
704 Striped Bass Court Santee, SC Centerpoint Ravenel SC New Home Opportunity Center Pointe is conveniently located in the h...	3 beds \| 3 baths \| 1,360 sq.ft.	$234,000	Airbnb cash on cash: 0.85% Traditional cash on cash: 4.77% Airbnb Rental Income: $1024 Traditional Rental Income: $1532 Airbnb ROI: 0.85% Traditional ROI: 4.77%
115 Wateree Drive Santee, SC Luxury meets lakeside living in this fully custom new construction home located in the pre...	5 beds \| 4 baths \| 2,633 sq.ft.	$699,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.71% Airbnb Rental Income: $null Traditional Rental Income: $2388 Airbnb ROI: N/A Traditional ROI: 1.71%
138 Heatleys End Road Santee, SC Enjoy country living on this 10-acre property with two homes. Move-in ready - main brick h...	3 beds \| 2 baths \| 2,269 sq.ft.	$834,900	Airbnb cash on cash: -0.83% Traditional cash on cash: 0.67% Airbnb Rental Income: $1024 Traditional Rental Income: $1829 Airbnb ROI: -0.83% Traditional ROI: 0.67%
140 Edisto Drive Santee, SC Looking for a peaceful country setting with room for your horses? This approximately 1.4 a...	3 beds \| 2 baths \| 980 sq.ft.	$230,000	Airbnb cash on cash: 0.69% Traditional cash on cash: 4.75% Airbnb Rental Income: $1024 Traditional Rental Income: $1548 Airbnb ROI: 0.69% Traditional ROI: 4.75%
520 Trillium Court Santee, SC Lake life is calling! Owning a Lake Marion condo puts you in the sweet spot of low-mainten...	3 beds \| 2 baths \| 1,720 sq.ft.	$300,000	Airbnb cash on cash: -2.59% Traditional cash on cash: 3.02% Airbnb Rental Income: $1024 Traditional Rental Income: $2248 Airbnb ROI: -2.59% Traditional ROI: 3.02%
130 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$341,400	Airbnb cash on cash: 0.21% Traditional cash on cash: 4.38% Airbnb Rental Income: $1024 Traditional Rental Income: $2000 Airbnb ROI: 0.21% Traditional ROI: 4.38%
145 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$349,965	Airbnb cash on cash: 0.17% Traditional cash on cash: 4.26% Airbnb Rental Income: $1024 Traditional Rental Income: $2009 Airbnb ROI: 0.17% Traditional ROI: 4.26%
905 Bream Circle Santee, SC Newly Released! Looking for that spacious backyard? This lot with the Brandon floorplan ha...	3 beds \| 3 baths \| 1,518 sq.ft.	$293,120	Airbnb cash on cash: 0.68% Traditional cash on cash: 5.27% Airbnb Rental Income: $1024 Traditional Rental Income: $1933 Airbnb ROI: 0.68% Traditional ROI: 5.27%
605 Perch Lane Santee, SC New Construction in Santee SC \|Near Lake Marion & Golf Courses Welcome home to 605 Perch L...	2 beds \| 3 baths \| 1,360 sq.ft.	$289,900	Airbnb cash on cash: 0.48% Traditional cash on cash: 4.58% Airbnb Rental Income: $1068 Traditional Rental Income: $1819 Airbnb ROI: 0.48% Traditional ROI: 4.58%
601 Perch Lane Santee, SC Lowcountry Living in Centerpoint Welcome to 601 Perch Lane in the Center Pointe community ...	3 beds \| 2 baths \| 1,183 sq.ft.	$219,000	Airbnb cash on cash: 0.96% Traditional cash on cash: 4.77% Airbnb Rental Income: $1024 Traditional Rental Income: $1455 Airbnb ROI: 0.96% Traditional ROI: 4.77%
645 Perch Lane Santee, SC Santee SC 3-Bedroom Home for Sale \| Modern Living Near Lake Marion & Golf Welcome to 645 P...	3 beds \| 2 baths \| 1,183 sq.ft.	$221,500	Airbnb cash on cash: 0.93% Traditional cash on cash: 4.69% Airbnb Rental Income: $1024 Traditional Rental Income: $1453 Airbnb ROI: 0.93% Traditional ROI: 4.69%
700 Striped Bass Court Santee, SC Welcome home to 700 Striped Bass Court, where comfort, connection, and Lowcountry living c...	3 beds \| 3 baths \| 1,518 sq.ft.	$257,500	Airbnb cash on cash: 0.59% Traditional cash on cash: 4.55% Airbnb Rental Income: $1024 Traditional Rental Income: $1627 Airbnb ROI: 0.59% Traditional ROI: 4.55%
713 Striped Bass Court Santee, SC Welcome to 713 Striped Bass Lane, in the Center Pointe community of Santee, South Carolina...	3 beds \| 2 baths \| 1,183 sq.ft.	$216,500	Airbnb cash on cash: 0.98% Traditional cash on cash: 4.83% Airbnb Rental Income: $1024 Traditional Rental Income: $1453 Airbnb ROI: 0.98% Traditional ROI: 4.83%

Real Estate investment in Santee, SC

There are 41 properties for sale in the city of Santee . The median list price in Santee is $294,024 and the average price per square foot is $190. In July 2026, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $1,728.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 41 investment properties available for sale in Santee.

In 2026, the best neighborhood to buy investment property is Santee.

The ROI for Long-Term is higher than the Short-Term in Santee with average rental income of $1,728.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

370 Chapel Creek Drive

Santee, SC

4 beds | 4 baths | 3,720 sq.ft.

$570,000

Airbnb cash on cash: 5.08%

Traditional cash on cash: 5.66%

Airbnb Rental Income: $4603

Traditional Rental Income: $3957

Airbnb ROI: 5.08%

Traditional ROI: 5.66%

126 Wateree Drive

Santee, SC

3 beds | 3 baths | 3,204 sq.ft.

$549,000

Airbnb cash on cash: -1.3%

Traditional cash on cash: 1.28%

Airbnb Rental Income: $1024

Traditional Rental Income: $1986

Airbnb ROI: -1.3%

Traditional ROI: 1.28%

105 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$267,000

Airbnb cash on cash: -0.6%

Traditional cash on cash: 3.64%

Airbnb Rental Income: $1068

Traditional Rental Income: $1768

Airbnb ROI: -0.6%

Traditional ROI: 3.64%

8495 Old Number Six Highway

Santee, SC

2 beds | 1 baths | 800 sq.ft.

$209,900

Airbnb cash on cash: 1.49%

Traditional cash on cash: 5.65%

Airbnb Rental Income: $1068

Traditional Rental Income: $1530

Airbnb ROI: 1.49%

Traditional ROI: 5.65%

106 Broad River Drive

Santee, SC

4 beds | 3 baths | 2,600 sq.ft.

$743,000

Airbnb cash on cash: 3.57%

Traditional cash on cash: 2.49%

Airbnb Rental Income: $4603

Traditional Rental Income: $2903

Airbnb ROI: 3.57%

Traditional ROI: 2.49%

472 Santee Drive

Santee, SC

5 beds | 4 baths | 4,046 sq.ft.

$550,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.88%

Airbnb Rental Income: $null

Traditional Rental Income: $3558

Airbnb ROI: N/A

Traditional ROI: 4.88%

457 Santee Drive

Santee, SC

4 beds | 5 baths | 3,778 sq.ft.

$1,450,000

Airbnb cash on cash: 0.96%

Traditional cash on cash: 1.22%

Airbnb Rental Income: $4603

Traditional Rental Income: $4006

Airbnb ROI: 0.96%

Traditional ROI: 1.22%

107 Cypress Hollow Way

Santee, SC

3 beds | 3 baths | 1,473 sq.ft.

$251,000

Airbnb cash on cash: 0.84%

Traditional cash on cash: 5.16%

Airbnb Rental Income: $1024

Traditional Rental Income: $1687

Airbnb ROI: 0.84%