Real Estate Investment Properties for Sale in Seneca, SC

Looking for investment property in Seneca, SC with high ROI ?

Explore a variety of short-term homes & houses in Seneca, SC. Invest wisely with VRBO & Seneca, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
4306 Ashford Bluff Drive Seneca, SC Ready for a new family and move-in ready. Welcome to 4306 Ashford Bluff Dr., Seneca, SC. A...	3 beds \| 3 baths \| 3,144 sq.ft.	$610,000	Airbnb cash on cash: 0.31% Traditional cash on cash: 2.44% Airbnb Rental Income: $1623 Traditional Rental Income: $2377 Airbnb ROI: 0.31% Traditional ROI: 2.44%
208 Holleman Street Seneca, SC Back on the market No fault of the seller! Investor Special! As is! Don't miss this charmi...	2 beds \| 2 baths \| 1,094 sq.ft.	$120,000	Airbnb cash on cash: 7.58% Traditional cash on cash: 11.93% Airbnb Rental Income: $1609 Traditional Rental Income: $1656 Airbnb ROI: 7.58% Traditional ROI: 11.93%
119 Oak Crest Circle Seneca, SC From the moment you drive down the long driveway surrounded by tall trees and greenery, it...	4 beds \| 6 baths \| N/A	$889,900	Airbnb cash on cash: 0.5% Traditional cash on cash: 6.35% Airbnb Rental Income: $2150 Traditional Rental Income: $6452 Airbnb ROI: 0.5% Traditional ROI: 6.35%
405 Keith Lane Seneca, SC Welcome Home to 405 Keith Lane, Seneca, SC!Discover this charming 3-bedroom, 2-bath home n...	3 beds \| 2 baths \| 1,260 sq.ft.	$224,000	Airbnb cash on cash: 3.8% Traditional cash on cash: 6.08% Airbnb Rental Income: $1623 Traditional Rental Income: $1646 Airbnb ROI: 3.8% Traditional ROI: 6.08%
125 Shadowood Court Seneca, SC UPDATE: SELLER IS OFFERING $10,000 TOWARDS BUYERS CLOSING COSTS. Welcome to 125 Shadowood ...	3 beds \| 2 baths \| 1,653 sq.ft.	$335,000	Airbnb cash on cash: 2.04% Traditional cash on cash: 4.15% Airbnb Rental Income: $1623 Traditional Rental Income: $1829 Airbnb ROI: 2.04% Traditional ROI: 4.15%
116 Deerfield Lane Seneca, SC Call Don Swearingen at 864-303-0345.Lake Hartwell living for under 1 million! This Log ho...	3 beds \| 3 baths \| N/A	$725,000	Airbnb cash on cash: 0.02% Traditional cash on cash: 1.77% Airbnb Rental Income: $1623 Traditional Rental Income: $2345 Airbnb ROI: 0.02% Traditional ROI: 1.77%
216 Riverbank Court Seneca, SC Don't miss this rare opportunity to own a beautifully crafted, Troyer built home in the de...	3 beds \| 3 baths \| 3,300 sq.ft.	$429,900	Airbnb cash on cash: 1.07% Traditional cash on cash: 3.49% Airbnb Rental Income: $1623 Traditional Rental Income: $2136 Airbnb ROI: 1.07% Traditional ROI: 3.49%
106 Jason Drive Seneca, SC Listed by Lana Smith with Live Upstate SC- 864-608-8313 Welcome to this beautifully update...	2 beds \| 1 baths \| N/A	$232,700	Airbnb cash on cash: 3.24% Traditional cash on cash: 3.46% Airbnb Rental Income: $1609 Traditional Rental Income: $1201 Airbnb ROI: 3.24% Traditional ROI: 3.46%
169 Campbell Bridge Road Seneca, SC Welcome to 169 Campbell Bridge Rd. This 3 bed, 2 bath home has a 2-car garage, detached 18...	3 beds \| 2 baths \| 1,512 sq.ft.	$315,000	Airbnb cash on cash: 2.44% Traditional cash on cash: 3.66% Airbnb Rental Income: $1623 Traditional Rental Income: $1525 Airbnb ROI: 2.44% Traditional ROI: 3.66%
1473 E Tamassee Drive Seneca, SC Perfectly positioned between Clemson and Seneca, this updated 3-bedroom, 1.5-bath brick ra...	3 beds \| 2 baths \| 1,972 sq.ft.	$268,500	Airbnb cash on cash: 2.66% Traditional cash on cash: 6.53% Airbnb Rental Income: $1623 Traditional Rental Income: $2145 Airbnb ROI: 2.66% Traditional ROI: 6.53%
123 New Heritage Trail Seneca, SC Imagine coming home to this stunning brick beauty that's basically begging to become your ...	4 beds \| 4 baths \| 3,272 sq.ft.	$990,000	Airbnb cash on cash: 0.07% Traditional cash on cash: 1.85% Airbnb Rental Income: $2150 Traditional Rental Income: $3238 Airbnb ROI: 0.07% Traditional ROI: 1.85%
154 Northshores Drive Seneca, SC The modern Lake Keowee waterfront home you've been waiting for. Located in the prestigious...	4 beds \| 4 baths \| 3,077 sq.ft.	$1,950,000	Airbnb cash on cash: -0.35% Traditional cash on cash: 0.95% Airbnb Rental Income: $2150 Traditional Rental Income: $3951 Airbnb ROI: -0.35% Traditional ROI: 0.95%
209 Amethyst Way Seneca, SC Lake Keowee Waterfront Perfection - Renovated Retreat with Private Dock & Shoreline Deck: ...	5 beds \| 4 baths \| N/A	$2,230,000	Airbnb cash on cash: -0.75% Traditional cash on cash: 0.01% Airbnb Rental Income: $2467 Traditional Rental Income: $3445 Airbnb ROI: -0.75% Traditional ROI: 0.01%
3076 Brookfield Drive Seneca, SC CUTE AS CAN BE Three Bedroom / 1 Bath in Seneca close to downtown, shopping, restaurants, ...	3 beds \| 1 baths \| 1,348 sq.ft.	$220,000	Airbnb cash on cash: 3.95% Traditional cash on cash: 6.14% Airbnb Rental Income: $1623 Traditional Rental Income: $1620 Airbnb ROI: 3.95% Traditional ROI: 6.14%
505 Inlet Drive Seneca, SC Lakefront Living on Lake Keowee! For sale in Seneca, SC - this spacious 4BR/3.5BA home off...	4 beds \| 4 baths \| 3,200 sq.ft.	$559,000	Airbnb cash on cash: 1.72% Traditional cash on cash: 6.12% Airbnb Rental Income: $2150 Traditional Rental Income: $3902 Airbnb ROI: 1.72% Traditional ROI: 6.12%
112 Whippoorwill Drive Seneca, SC Welcome to this beautifully maintained 4-bedroom, 3-bath tri-level lakefront home with ove...	4 beds \| 3 baths \| 3,336 sq.ft.	$1,400,000	Airbnb cash on cash: -0.66% Traditional cash on cash: 0.35% Airbnb Rental Income: $2150 Traditional Rental Income: $2921 Airbnb ROI: -0.66% Traditional ROI: 0.35%
128 Hickory Cove Road Seneca, SC Back on Market, no fault of the seller. Waterfront access to one of the Southeastâs mo...	5 beds \| 4 baths \| N/A	$1,200,000	Airbnb cash on cash: 0.26% Traditional cash on cash: 2.05% Airbnb Rental Income: $2467 Traditional Rental Income: $3866 Airbnb ROI: 0.26% Traditional ROI: 2.05%
704 Bogey Boulevard Seneca, SC Step inside this stunning 4-bedroom, 3.5-bath home, built in 2021, and immediately feel at...	4 beds \| 4 baths \| N/A	$532,000	Airbnb cash on cash: 1.39% Traditional cash on cash: 4.68% Airbnb Rental Income: $2150 Traditional Rental Income: $3238 Airbnb ROI: 1.39% Traditional ROI: 4.68%
1104 Little River View Drive Seneca, SC Welcome to this beautifully crafted custom Craftsman-style home, nestled in the prestigiou...	3 beds \| 3 baths \| 1,824 sq.ft.	$720,000	Airbnb cash on cash: -0.3% Traditional cash on cash: 1.36% Airbnb Rental Income: $1623 Traditional Rental Income: $2282 Airbnb ROI: -0.3% Traditional ROI: 1.36%
426 South Cove Road Seneca, SC 426 South Cove Road \| Seneca Living at Its Best; Located just a half-mile from South Cove ...	4 beds \| 3 baths \| 2,599 sq.ft.	$425,000	Airbnb cash on cash: 2.55% Traditional cash on cash: 4.92% Airbnb Rental Income: $2150 Traditional Rental Income: $2548 Airbnb ROI: 2.55% Traditional ROI: 4.92%
116 Elliott Drive Seneca, SC Welcome home to this 3 bedroom, 2 bath retreat nestled on 0.65 acres. A spacious 2-car det...	3 beds \| 2 baths \| N/A	$340,000	Airbnb cash on cash: 1.78% Traditional cash on cash: 3.04% Airbnb Rental Income: $1623 Traditional Rental Income: $1566 Airbnb ROI: 1.78% Traditional ROI: 3.04%
214 Fisherman Lane Seneca, SC TRUE SOUTHERN CHARM ON THE LAKE - YOUR DREAM RETREAT AWAITS WITH AN EXTRA LOT INCLUDED! Mo...	3 beds \| 3 baths \| 2,526 sq.ft.	$674,900	Airbnb cash on cash: 0.25% Traditional cash on cash: 1.85% Airbnb Rental Income: $1623 Traditional Rental Income: $2172 Airbnb ROI: 0.25% Traditional ROI: 1.85%
302 Meadowlark Lane Seneca, SC Donald Gardner beautiful custom style home on 2.96 acres and just a short drive to Lake Ke...	4 beds \| 4 baths \| 2,960 sq.ft.	$650,000	Airbnb cash on cash: 0.32% Traditional cash on cash: 3.08% Airbnb Rental Income: $2150 Traditional Rental Income: $3272 Airbnb ROI: 0.32% Traditional ROI: 3.08%
505 Dalton Road Seneca, SC Discover this meticulous 3 bedroom, 2.5 bath Cape Cod home in Seneca, offering the perfect...	3 beds \| 3 baths \| 2,400 sq.ft.	$539,900	Airbnb cash on cash: 1% Traditional cash on cash: 2.3% Airbnb Rental Income: $1623 Traditional Rental Income: $1816 Airbnb ROI: 1% Traditional ROI: 2.3%
305 Wynswept Point Seneca, SC When the view matters more than anything else this is the home for you!With more than a mi...	4 beds \| 4 baths \| N/A	$2,700,000	Airbnb cash on cash: -0.57% Traditional cash on cash: -0.36% Airbnb Rental Income: $2150 Traditional Rental Income: $2119 Airbnb ROI: -0.57% Traditional ROI: -0.36%
1613 S Arlington Drive Seneca, SC Expansive Waterfront Location! A truly rare find on one of South Carolina's most sought-af...	4 beds \| 3 baths \| 3,193 sq.ft.	$1,250,000	Airbnb cash on cash: -0.28% Traditional cash on cash: 0.2% Airbnb Rental Income: $2150 Traditional Rental Income: $2156 Airbnb ROI: -0.28% Traditional ROI: 0.2%
413 Sonoma Court Seneca, SC This property is "the one" if you are looking for a home with the primary bedroom on the m...	3 beds \| 3 baths \| N/A	$315,000	Airbnb cash on cash: 1.88% Traditional cash on cash: 4% Airbnb Rental Income: $1623 Traditional Rental Income: $1791 Airbnb ROI: 1.88% Traditional ROI: 4%
317 balsa Way Seneca, SC Welcome to this large home with a small price tag for what your getting. This is a 5 bedro...	5 beds \| 3 baths \| 2,225 sq.ft.	$345,000	Airbnb cash on cash: 3.76% Traditional cash on cash: 5.4% Airbnb Rental Income: $2467 Traditional Rental Income: $2399 Airbnb ROI: 3.76% Traditional ROI: 5.4%
314 Holland Avenue Seneca, SC Owner Financing Available! Welcome home to this charming renovated 4 bedroom, 2 bath home ...	4 beds \| 2 baths \| 1,318 sq.ft.	$239,000	Airbnb cash on cash: 5.11% Traditional cash on cash: 5.43% Airbnb Rental Income: $2150 Traditional Rental Income: $1674 Airbnb ROI: 5.11% Traditional ROI: 5.43%
6 Ivy Court Seneca, SC Open concept, one level living is realized in this home! Interior features include 3 bedro...	3 beds \| 2 baths \| 1,298 sq.ft.	$274,950	Airbnb cash on cash: 2.91% Traditional cash on cash: 4.54% Airbnb Rental Income: $1623 Traditional Rental Income: $1588 Airbnb ROI: 2.91% Traditional ROI: 4.54%
731 E Main Street Seneca, SC Rent to own, owner financing preferred. This charming three-bedroom, two-bathroom home sea...	3 beds \| 2 baths \| 1,641 sq.ft.	$195,900	Airbnb cash on cash: 4.19% Traditional cash on cash: 7.29% Airbnb Rental Income: $1623 Traditional Rental Income: $1741 Airbnb ROI: 4.19% Traditional ROI: 7.29%
270 Meridian Way Seneca, SC Welcome to Preston Ridge. Oconee County's most desirable townhome development. Maintenance...	3 beds \| 2 baths \| N/A	$379,000	Airbnb cash on cash: 0.87% Traditional cash on cash: 2.74% Airbnb Rental Income: $1623 Traditional Rental Income: $1830 Airbnb ROI: 0.87% Traditional ROI: 2.74%
260 Meridian Way Seneca, SC Welcome to Preston Ridge. Oconee County's most desirable townhome development. Maintenance...	3 beds \| 2 baths \| N/A	$379,000	Airbnb cash on cash: 0.87% Traditional cash on cash: 2.74% Airbnb Rental Income: $1623 Traditional Rental Income: $1830 Airbnb ROI: 0.87% Traditional ROI: 2.74%
14001 Rhine Court Seneca, SC This gem of a home is nestled into the lovely neighborhood of Saxony Forest. This communit...	5 beds \| 4 baths \| 2,600 sq.ft.	$549,000	Airbnb cash on cash: 2.27% Traditional cash on cash: 5.2% Airbnb Rental Income: $2467 Traditional Rental Income: $3368 Airbnb ROI: 2.27% Traditional ROI: 5.2%
1212 Stillwater Drive Seneca, SC Welcome to 1212 Stillwater Drive in coveted Stillwater Subdivision. Located just a few min...	4 beds \| 5 baths \| N/A	$1,595,000	Airbnb cash on cash: -0.55% Traditional cash on cash: 1.32% Airbnb Rental Income: $2150 Traditional Rental Income: $4370 Airbnb ROI: -0.55% Traditional ROI: 1.32%
122 Fair Heaven Court Seneca, SC	4 beds \| 4 baths \| N/A	$1,395,900	Airbnb cash on cash: -0.4% Traditional cash on cash: 1.02% Airbnb Rental Income: $2150 Traditional Rental Income: $3450 Airbnb ROI: -0.4% Traditional ROI: 1.02%
150 Cedar Hill Drive Seneca, SC Great home built by a builder for a builder! Tucked away and private. This brick Ranch sty...	2 beds \| 2 baths \| 1,334 sq.ft.	$375,000	Airbnb cash on cash: 1.53% Traditional cash on cash: 2.87% Airbnb Rental Income: $1609 Traditional Rental Income: $1623 Airbnb ROI: 1.53% Traditional ROI: 2.87%
003 Harbin Acres Road Seneca, SC This Beautiful 3 Bedroom 2 Full Bath sits on more than 1 1/2 acres, and is an Amazing Oppo...	3 beds \| 2 baths \| N/A	$289,900	Airbnb cash on cash: 2.35% Traditional cash on cash: 5.26% Airbnb Rental Income: $1623 Traditional Rental Income: $1958 Airbnb ROI: 2.35% Traditional ROI: 5.26%

Real Estate investment in Seneca, SC

There are 135 properties for sale in the city of Seneca . The median list price in Seneca is $383,700 and the average price per square foot is $162. In September 2025, the average monthly cash on cash return in Seneca is 4.00%. The average monthly rental income in Seneca is $2,140.

Seneca, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 135 investment properties available for sale in Seneca.

In 2025, the best neighborhood to buy investment property is Seneca.

The ROI for Long-Term is higher than the Short-Term in Seneca with average rental income of $2,140.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, SC

4306 Ashford Bluff Drive

Seneca, SC

3 beds | 3 baths | 3,144 sq.ft.

$610,000

Airbnb cash on cash: 0.31%

Traditional cash on cash: 2.44%

Airbnb Rental Income: $1623

Traditional Rental Income: $2377

Airbnb ROI: 0.31%

Traditional ROI: 2.44%

208 Holleman Street

Seneca, SC

2 beds | 2 baths | 1,094 sq.ft.

$120,000

Airbnb cash on cash: 7.58%

Traditional cash on cash: 11.93%

Airbnb Rental Income: $1609

Traditional Rental Income: $1656

Airbnb ROI: 7.58%

Traditional ROI: 11.93%

119 Oak Crest Circle

Seneca, SC

4 beds | 6 baths | N/A

$889,900

Airbnb cash on cash: 0.5%

Traditional cash on cash: 6.35%

Airbnb Rental Income: $2150

Traditional Rental Income: $6452

Airbnb ROI: 0.5%

Traditional ROI: 6.35%

405 Keith Lane

Seneca, SC

3 beds | 2 baths | 1,260 sq.ft.

$224,000

Airbnb cash on cash: 3.8%

Traditional cash on cash: 6.08%

Airbnb Rental Income: $1623

Traditional Rental Income: $1646

Airbnb ROI: 3.8%

Traditional ROI: 6.08%

125 Shadowood Court

Seneca, SC

3 beds | 2 baths | 1,653 sq.ft.

$335,000

Airbnb cash on cash: 2.04%

Traditional cash on cash: 4.15%

Airbnb Rental Income: $1623

Traditional Rental Income: $1829

Airbnb ROI: 2.04%

Traditional ROI: 4.15%

116 Deerfield Lane

Seneca, SC

3 beds | 3 baths | N/A

$725,000

Airbnb cash on cash: 0.02%

Traditional cash on cash: 1.77%

Airbnb Rental Income: $1623

Traditional Rental Income: $2345

Airbnb ROI: 0.02%

Traditional ROI: 1.77%

216 Riverbank Court

Seneca, SC

3 beds | 3 baths | 3,300 sq.ft.

$429,900

Airbnb cash on cash: 1.07%

Traditional cash on cash: 3.49%

Airbnb Rental Income: $1623

Traditional Rental Income: $2136

Airbnb ROI: 1.07%

Traditional ROI: 3.49%

106 Jason Drive

Seneca, SC

2 beds | 1 baths | N/A

$232,700

Airbnb cash on cash: 3.24%

Traditional cash on cash: 3.46%

Airbnb Rental Income: $1609

Traditional Rental Income: $1201

Airbnb ROI: 3.24%