Real Estate Investment Properties for Sale in Seneca, SC

Looking for investment property in Seneca, SC with high ROI ?

Explore a variety of short-term homes & houses in Seneca, SC. Invest wisely with VRBO & Seneca, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1006 Kaye Street Seneca, SC Charming Brick Ranch on 1.55 Acres in Prime Seneca Location. Spacious home offering comfor...	3 beds \| 3 baths \| 1,889 sq.ft.	$335,000	Airbnb cash on cash: 2.4% Traditional cash on cash: 5.74% Airbnb Rental Income: $1666 Traditional Rental Income: $2251 Airbnb ROI: 2.4% Traditional ROI: 5.74%
4306 Ashford Bluff Drive Seneca, SC Ready for a new family and move-in ready. Welcome to 4306 Ashford Bluff Dr., Seneca, SC. A...	3 beds \| 3 baths \| 3,144 sq.ft.	$590,000	Airbnb cash on cash: 0.44% Traditional cash on cash: 2.58% Airbnb Rental Income: $1666 Traditional Rental Income: $2377 Airbnb ROI: 0.44% Traditional ROI: 2.58%
119 Oak Crest Circle Seneca, SC From the moment you drive down the long driveway surrounded by tall trees and greenery, it...	4 beds \| 6 baths \| N/A	$850,000	Airbnb cash on cash: 0.27% Traditional cash on cash: 6.69% Airbnb Rental Income: $1869 Traditional Rental Income: $6452 Airbnb ROI: 0.27% Traditional ROI: 6.69%
116 Deerfield Lane Seneca, SC Call Don Swearingen at 864-303-0345.Lake Hartwell living for under 1 million! This Log ho...	3 beds \| 3 baths \| N/A	$725,000	Airbnb cash on cash: 0.08% Traditional cash on cash: 1.77% Airbnb Rental Income: $1666 Traditional Rental Income: $2345 Airbnb ROI: 0.08% Traditional ROI: 1.77%
216 Riverbank Court Seneca, SC Don't miss this rare opportunity to own a beautifully crafted, Troyer built home in the de...	3 beds \| 3 baths \| 3,300 sq.ft.	$419,900	Airbnb cash on cash: 1.23% Traditional cash on cash: 3.61% Airbnb Rental Income: $1666 Traditional Rental Income: $2136 Airbnb ROI: 1.23% Traditional ROI: 3.61%
734 Tanglewood Drive Seneca, SC Location, location, location! Nestled in the heart of Oconee County, this charming 3-bedro...	3 beds \| 2 baths \| 1,559 sq.ft.	$249,900	Airbnb cash on cash: 3.09% Traditional cash on cash: 6.03% Airbnb Rental Income: $1666 Traditional Rental Income: $1894 Airbnb ROI: 3.09% Traditional ROI: 6.03%
106 Jason Drive Seneca, SC Listed by Lana Smith with Live Upstate SC- 864-608-8313 Seller is offering a concession t...	2 beds \| 1 baths \| N/A	$225,000	Airbnb cash on cash: 2.72% Traditional cash on cash: 3.63% Airbnb Rental Income: $1434 Traditional Rental Income: $1201 Airbnb ROI: 2.72% Traditional ROI: 3.63%
169 Campbell Bridge Road Seneca, SC Back on the market at no fault of the home/seller Welcome to 169 Campbell Bridge Rd. Thi...	3 beds \| 2 baths \| 1,512 sq.ft.	$305,000	Airbnb cash on cash: 2.68% Traditional cash on cash: 3.81% Airbnb Rental Income: $1666 Traditional Rental Income: $1525 Airbnb ROI: 2.68% Traditional ROI: 3.81%
322 Shorecrest Drive Seneca, SC Welcome to 322 Shorecrest Drive! This stunning 4-bedroom, 3-bath lakefront retreat nestled...	4 beds \| 3 baths \| N/A	$1,200,000	Airbnb cash on cash: 0.04% Traditional cash on cash: 1.09% Airbnb Rental Income: $1869 Traditional Rental Income: $2543 Airbnb ROI: 0.04% Traditional ROI: 1.09%
1473 E Tamassee Drive Seneca, SC Perfectly positioned between Clemson and Seneca, this updated 3-bedroom, 1.5-bath brick ra...	3 beds \| 2 baths \| 1,972 sq.ft.	$263,850	Airbnb cash on cash: 2.88% Traditional cash on cash: 6.68% Airbnb Rental Income: $1666 Traditional Rental Income: $2145 Airbnb ROI: 2.88% Traditional ROI: 6.68%
123 New Heritage Trail Seneca, SC Imagine coming home to this stunning brick beauty that's basically begging to become your ...	4 beds \| 4 baths \| 3,272 sq.ft.	$949,000	Airbnb cash on cash: -0.12% Traditional cash on cash: 1.99% Airbnb Rental Income: $1869 Traditional Rental Income: $3238 Airbnb ROI: -0.12% Traditional ROI: 1.99%
209 Amethyst Way Seneca, SC Lake Keowee Waterfront Perfection - Renovated Retreat with Private Dock & Shoreline Deck: ...	5 beds \| 4 baths \| N/A	$2,195,000	Airbnb cash on cash: -0.92% Traditional cash on cash: 0.03% Airbnb Rental Income: $2052 Traditional Rental Income: $3445 Airbnb ROI: -0.92% Traditional ROI: 0.03%
12010 W Camelia Lane Seneca, SC This home sits on a quiet culd-a-sac, perfectly Situated home in the heart of Seneca, nest...	4 beds \| 3 baths \| N/A	$400,000	Airbnb cash on cash: 1.94% Traditional cash on cash: 5.33% Airbnb Rental Income: $1869 Traditional Rental Income: $2640 Airbnb ROI: 1.94% Traditional ROI: 5.33%
505 Inlet Drive Seneca, SC Lakefront Living on Lake Keowee! For sale in Seneca, SC - this spacious 4BR/3.5BA home off...	4 beds \| 4 baths \| 3,200 sq.ft.	$559,000	Airbnb cash on cash: 1.27% Traditional cash on cash: 6.12% Airbnb Rental Income: $1869 Traditional Rental Income: $3902 Airbnb ROI: 1.27% Traditional ROI: 6.12%
127 Oak Ridge Circle Seneca, SC Beautifully updated and move-in ready! This 3-bedroom, 1.5-bath ranch in Seneca sits on a ...	3 beds \| 2 baths \| 1,008 sq.ft.	$199,990	Airbnb cash on cash: 4.26% Traditional cash on cash: 6.04% Airbnb Rental Income: $1666 Traditional Rental Income: $1538 Airbnb ROI: 4.26% Traditional ROI: 6.04%
516 Serria Way Seneca, SC Welcome Home to this Immaculate 4 Bedroom / 2.5 Bath with Bonus Room. Conveniently located...	4 beds \| 3 baths \| 2,471 sq.ft.	$474,900	Airbnb cash on cash: 1.58% Traditional cash on cash: 4.53% Airbnb Rental Income: $1869 Traditional Rental Income: $2677 Airbnb ROI: 1.58% Traditional ROI: 4.53%
426 South Cove Road Seneca, SC 426 South Cove Road \| Seneca Living at Its Best; Located just a half-mile from South Cove ...	4 beds \| 3 baths \| 2,599 sq.ft.	$425,000	Airbnb cash on cash: 1.96% Traditional cash on cash: 4.92% Airbnb Rental Income: $1869 Traditional Rental Income: $2548 Airbnb ROI: 1.96% Traditional ROI: 4.92%
116 Elliott Drive Seneca, SC Welcome home to this 3 bedroom, 2 bath retreat nestled on 0.65 acres. A spacious 2-car det...	3 beds \| 2 baths \| N/A	$340,000	Airbnb cash on cash: 1.89% Traditional cash on cash: 4.06% Airbnb Rental Income: $1666 Traditional Rental Income: $1891 Airbnb ROI: 1.89% Traditional ROI: 4.06%
217 Singing Pines Road Seneca, SC 2022 built 3 bed 2 bath FULLY FURNISHED Craftsman home with 1546 square feet of living spa...	3 beds \| 2 baths \| 1,546 sq.ft.	$339,000	Airbnb cash on cash: 1.91% Traditional cash on cash: 3.52% Airbnb Rental Income: $1666 Traditional Rental Income: $1713 Airbnb ROI: 1.91% Traditional ROI: 3.52%
213 Singing Pines Road Seneca, SC Fully furnished 3 bed 2 bath built in 2022. Seller is currently running as an Airbnb. Ever...	3 beds \| 2 baths \| 1,546 sq.ft.	$329,000	Airbnb cash on cash: 2.01% Traditional cash on cash: 3.67% Airbnb Rental Income: $1666 Traditional Rental Income: $1713 Airbnb ROI: 2.01% Traditional ROI: 3.67%
302 Meadowlark Lane Seneca, SC Donald Gardner beautiful custom style home on 2.96 acres and just a short drive to Lake Ke...	4 beds \| 4 baths \| 2,960 sq.ft.	$599,000	Airbnb cash on cash: 0.02% Traditional cash on cash: 3.42% Airbnb Rental Income: $1869 Traditional Rental Income: $3272 Airbnb ROI: 0.02% Traditional ROI: 3.42%
401 Promontory Ridge Seneca, SC Welcome to 401 Promontory Ridge, where Southern charm meets modern living, wrapped up in a...	4 beds \| 3 baths \| 2,748 sq.ft.	$759,000	Airbnb cash on cash: 0.16% Traditional cash on cash: 1.79% Airbnb Rental Income: $1869 Traditional Rental Income: $2518 Airbnb ROI: 0.16% Traditional ROI: 1.79%
505 Dalton Road Seneca, SC Discover this meticulous 3 bedroom, 2.5 bath Cape Cod home in Seneca, offering the perfect...	3 beds \| 3 baths \| 2,400 sq.ft.	$529,900	Airbnb cash on cash: 1.11% Traditional cash on cash: 2.36% Airbnb Rental Income: $1666 Traditional Rental Income: $1816 Airbnb ROI: 1.11% Traditional ROI: 2.36%
305 Wynswept Point Seneca, SC When the view matters more than anything else this is the home for you!With more than a mi...	4 beds \| 4 baths \| N/A	$2,500,000	Airbnb cash on cash: -0.63% Traditional cash on cash: -0.31% Airbnb Rental Income: $1869 Traditional Rental Income: $2119 Airbnb ROI: -0.63% Traditional ROI: -0.31%
1613 S Arlington Drive Seneca, SC Expansive Waterfront Location! A truly rare find on one of South Carolina's most sought-af...	4 beds \| 3 baths \| 3,193 sq.ft.	$1,250,000	Airbnb cash on cash: -0.48% Traditional cash on cash: 0.2% Airbnb Rental Income: $1869 Traditional Rental Income: $2156 Airbnb ROI: -0.48% Traditional ROI: 0.2%
317 balsa Way Seneca, SC Welcome to this large home with a small price tag for what your getting. This is a 5 bedro...	5 beds \| 3 baths \| 2,225 sq.ft.	$345,000	Airbnb cash on cash: 2.69% Traditional cash on cash: 5.4% Airbnb Rental Income: $2052 Traditional Rental Income: $2399 Airbnb ROI: 2.69% Traditional ROI: 5.4%
103 Fair Haven Court Seneca, SC Welcome to 103 Fair Haven Ct in Seneca, SCâa private lakefront retreat nestled on nearly...	5 beds \| 4 baths \| N/A	$785,000	Airbnb cash on cash: 0.39% Traditional cash on cash: 2.66% Airbnb Rental Income: $2052 Traditional Rental Income: $3181 Airbnb ROI: 0.39% Traditional ROI: 2.66%
506 Inlet Drive Seneca, SC Discover your perfect Lake Keowee getaway! This charming waterfront cottage comes with its...	4 beds \| 3 baths \| N/A	$1,650,000	Airbnb cash on cash: -0.43% Traditional cash on cash: 0.16% Airbnb Rental Income: $1869 Traditional Rental Income: $2268 Airbnb ROI: -0.43% Traditional ROI: 0.16%
403 Woodduck Drive Seneca, SC Welcome to your new HOME in Cross Creek! Purchased as brand-new construction earlier this ...	3 beds \| 3 baths \| 2,250 sq.ft.	$498,000	Airbnb cash on cash: 0.81% Traditional cash on cash: 2.94% Airbnb Rental Income: $1666 Traditional Rental Income: $2194 Airbnb ROI: 0.81% Traditional ROI: 2.94%
6 Ivy Court Seneca, SC Seeking privacy and wanting to stay near shopping, retail and Clemson University? Well loo...	3 beds \| 2 baths \| 1,298 sq.ft.	$270,000	Airbnb cash on cash: 3.12% Traditional cash on cash: 4.64% Airbnb Rental Income: $1666 Traditional Rental Income: $1588 Airbnb ROI: 3.12% Traditional ROI: 4.64%
270 Meridian Way Seneca, SC Welcome to Preston Ridge. Oconee County's most desirable townhome development. Maintenance...	3 beds \| 2 baths \| N/A	$379,000	Airbnb cash on cash: 0.97% Traditional cash on cash: 2.74% Airbnb Rental Income: $1666 Traditional Rental Income: $1830 Airbnb ROI: 0.97% Traditional ROI: 2.74%
260 Meridian Way Seneca, SC Welcome to Preston Ridge. Oconee County's most desirable townhome development. Maintenance...	3 beds \| 2 baths \| N/A	$379,000	Airbnb cash on cash: 0.97% Traditional cash on cash: 2.74% Airbnb Rental Income: $1666 Traditional Rental Income: $1830 Airbnb ROI: 0.97% Traditional ROI: 2.74%
14001 Rhine Court Seneca, SC This gem of a home is nestled into the lovely neighborhood of Saxony Forest. This communit...	5 beds \| 4 baths \| 2,600 sq.ft.	$549,000	Airbnb cash on cash: 1.6% Traditional cash on cash: 5.2% Airbnb Rental Income: $2052 Traditional Rental Income: $3368 Airbnb ROI: 1.6% Traditional ROI: 5.2%
11 Chippewa Court Seneca, SC This is the one you have been waiting for! The one that is an excellent choice for a prima...	3 beds \| 2 baths \| N/A	$296,500	Airbnb cash on cash: 2.39% Traditional cash on cash: 5.1% Airbnb Rental Income: $1666 Traditional Rental Income: $1956 Airbnb ROI: 2.39% Traditional ROI: 5.1%
150 Cedar Hill Drive Seneca, SC Great home built by a builder for a builder! Tucked away and private. This brick Ranch sty...	2 beds \| 2 baths \| 1,334 sq.ft.	$375,000	Airbnb cash on cash: 1.12% Traditional cash on cash: 2.87% Airbnb Rental Income: $1434 Traditional Rental Income: $1623 Airbnb ROI: 1.12% Traditional ROI: 2.87%
003 Harbin Acres Road Seneca, SC This Beautiful 3 Bedroom 2 Full Bath sits on more than 1 1/2 acres, and is an Amazing Oppo...	3 beds \| 2 baths \| N/A	$289,900	Airbnb cash on cash: 2.48% Traditional cash on cash: 5.26% Airbnb Rental Income: $1666 Traditional Rental Income: $1958 Airbnb ROI: 2.48% Traditional ROI: 5.26%
106 Laurel Lane Seneca, SC This spacious three or four bedroom home and three baths is situated in the heart of desir...	4 beds \| 3 baths \| 2,614 sq.ft.	$299,500	Airbnb cash on cash: 3.21% Traditional cash on cash: 7.69% Airbnb Rental Income: $1869 Traditional Rental Income: $2631 Airbnb ROI: 3.21% Traditional ROI: 7.69%
101 Lakeview Drive Seneca, SC BRICK RANCH on a beautiful corner lot in the city limits of Seneca. Older home that has be...	3 beds \| 2 baths \| 1,958 sq.ft.	$299,900	Airbnb cash on cash: 2.7% Traditional cash on cash: 4.94% Airbnb Rental Income: $1666 Traditional Rental Income: $1832 Airbnb ROI: 2.7% Traditional ROI: 4.94%

Real Estate investment in Seneca, SC

There are 129 properties for sale in the city of Seneca . The median list price in Seneca is $342,500 and the average price per square foot is $152. In October 2025, the average monthly cash on cash return in Seneca is 5.00%. The average monthly rental income in Seneca is $2,101.

Seneca, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 129 investment properties available for sale in Seneca.

In 2025, the best neighborhood to buy investment property is Seneca.

The ROI for Long-Term is higher than the Short-Term in Seneca with average rental income of $2,101.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, SC

1006 Kaye Street

Seneca, SC

3 beds | 3 baths | 1,889 sq.ft.

$335,000

Airbnb cash on cash: 2.4%

Traditional cash on cash: 5.74%

Airbnb Rental Income: $1666

Traditional Rental Income: $2251

Airbnb ROI: 2.4%

Traditional ROI: 5.74%

4306 Ashford Bluff Drive

Seneca, SC

3 beds | 3 baths | 3,144 sq.ft.

$590,000

Airbnb cash on cash: 0.44%

Traditional cash on cash: 2.58%

Airbnb Rental Income: $1666

Traditional Rental Income: $2377

Airbnb ROI: 0.44%

Traditional ROI: 2.58%

119 Oak Crest Circle

Seneca, SC

4 beds | 6 baths | N/A

$850,000

Airbnb cash on cash: 0.27%

Traditional cash on cash: 6.69%

Airbnb Rental Income: $1869

Traditional Rental Income: $6452

Airbnb ROI: 0.27%

Traditional ROI: 6.69%

116 Deerfield Lane

Seneca, SC

3 beds | 3 baths | N/A

$725,000

Airbnb cash on cash: 0.08%

Traditional cash on cash: 1.77%

Airbnb Rental Income: $1666

Traditional Rental Income: $2345

Airbnb ROI: 0.08%

Traditional ROI: 1.77%

216 Riverbank Court

Seneca, SC

3 beds | 3 baths | 3,300 sq.ft.

$419,900

Airbnb cash on cash: 1.23%

Traditional cash on cash: 3.61%

Airbnb Rental Income: $1666

Traditional Rental Income: $2136

Airbnb ROI: 1.23%

Traditional ROI: 3.61%

734 Tanglewood Drive

Seneca, SC

3 beds | 2 baths | 1,559 sq.ft.

$249,900

Airbnb cash on cash: 3.09%

Traditional cash on cash: 6.03%

Airbnb Rental Income: $1666

Traditional Rental Income: $1894

Airbnb ROI: 3.09%

Traditional ROI: 6.03%

106 Jason Drive

Seneca, SC

2 beds | 1 baths | N/A

$225,000

Airbnb cash on cash: 2.72%

Traditional cash on cash: 3.63%

Airbnb Rental Income: $1434

Traditional Rental Income: $1201

Airbnb ROI: 2.72%

Traditional ROI: 3.63%

169 Campbell Bridge Road

Seneca, SC

3 beds | 2 baths | 1,512 sq.ft.

$305,000

Airbnb cash on cash: 2.68%

Traditional cash on cash: 3.81%

Airbnb Rental Income: $1666

Traditional Rental Income: $1525

Airbnb ROI: 2.68%