Real Estate Investment Properties for Sale in Seneca, SC

Looking for investment property in Seneca, SC with high ROI ?

Explore a variety of short-term homes & houses in Seneca, SC. Invest wisely with VRBO & Seneca, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Seneca, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
104 Knollwood Drive Seneca, SC Discover unparalleled comfort and expansive living in this remarkable residence, perfectly...	5 beds \| 4 baths \| 6,000 sq.ft.	$625,000	Airbnb cash on cash: 1.16% Traditional cash on cash: 4.94% Airbnb Rental Income: $2246 Traditional Rental Income: $3887 Airbnb ROI: 1.16% Traditional ROI: 4.94%
520 Serria Way Seneca, SC Motivated Seller! 520 Serria Way is the home you have been waiting on! Placed on .58 +/- a...	3 beds \| 2 baths \| 2,129 sq.ft.	$365,000	Airbnb cash on cash: 1.76% Traditional cash on cash: 3.77% Airbnb Rental Income: $1704 Traditional Rental Income: $1921 Airbnb ROI: 1.76% Traditional ROI: 3.77%
111 N Grant Road Seneca, SC Home and 12 acres in a highly desired location just minutes from the new Target shopping c...	4 beds \| 5 baths \| 3,390 sq.ft.	$899,900	Airbnb cash on cash: 1.25% Traditional cash on cash: 3.97% Airbnb Rental Income: $2676 Traditional Rental Income: $4319 Airbnb ROI: 1.25% Traditional ROI: 3.97%
136 Loran Pointe Circle Seneca, SC Welcome to 136 Loran Pointe Circle, a remarkable Seneca property that truly redefines vers...	4 beds \| 3 baths \| N/A	$599,900	Airbnb cash on cash: 2.26% Traditional cash on cash: 3.21% Airbnb Rental Income: $2676 Traditional Rental Income: $2573 Airbnb ROI: 2.26% Traditional ROI: 3.21%
609 Providence Point Drive Seneca, SC Welcome home to this spacious 4-bedroom, 2.5 bath residence situated on a desirable corner...	4 beds \| 3 baths \| 2,500 sq.ft.	$479,000	Airbnb cash on cash: 2.73% Traditional cash on cash: 3.52% Airbnb Rental Income: $2676 Traditional Rental Income: $2395 Airbnb ROI: 2.73% Traditional ROI: 3.52%
109 Oak Crest Circle Seneca, SC Beautiful Home in prestige's subdivision of Stillwater, 5 minutes from Clemson University....	3 beds \| 2 baths \| 1,943 sq.ft.	$480,000	Airbnb cash on cash: 1.24% Traditional cash on cash: 3.14% Airbnb Rental Income: $1704 Traditional Rental Income: $2087 Airbnb ROI: 1.24% Traditional ROI: 3.14%
905 N Crestview Drive Seneca, SC This beautiful four-bedroom three bath home in Woodland Acres welcomes you with a spacious...	4 beds \| 3 baths \| 2,200 sq.ft.	$289,900	Airbnb cash on cash: 5.57% Traditional cash on cash: 7.29% Airbnb Rental Income: $2676 Traditional Rental Income: $2512 Airbnb ROI: 5.57% Traditional ROI: 7.29%
1298 Carradine Road Seneca, SC A RARE opportunity - A peaceful retreat just 9 min to Clemson (avoiding Tiger Blvd), with ...	3 beds \| 3 baths \| N/A	$359,000	Airbnb cash on cash: 1.91% Traditional cash on cash: 4.54% Airbnb Rental Income: $1704 Traditional Rental Income: $2118 Airbnb ROI: 1.91% Traditional ROI: 4.54%
209 New Timber Trail Seneca, SC 209 New Timber Trail is a turnkey home ideal for part-time living and an excellent income ...	3 beds \| 3 baths \| 2,023 sq.ft.	$1,250,000	Airbnb cash on cash: -0.7% Traditional cash on cash: 0.35% Airbnb Rental Income: $1704 Traditional Rental Income: $2452 Airbnb ROI: -0.7% Traditional ROI: 0.35%
851 Louie Lane Seneca, SC Newer roof, windows, and appliances! Welcome to this charming, single-level residence in t...	4 beds \| 2 baths \| 1,335 sq.ft.	$235,000	Airbnb cash on cash: 7.2% Traditional cash on cash: 5.42% Airbnb Rental Income: $2676 Traditional Rental Income: $1646 Airbnb ROI: 7.2% Traditional ROI: 5.42%
510 Return Church Road Seneca, SC Newly renovated three bedroom three bath home on 2 acres! Open floor plan with vaulted cei...	3 beds \| 3 baths \| N/A	$369,900	Airbnb cash on cash: 2.14% Traditional cash on cash: 4.96% Airbnb Rental Income: $1704 Traditional Rental Income: $2209 Airbnb ROI: 2.14% Traditional ROI: 4.96%
116 oak ridge Circle Seneca, SC Discover unparalleled value and opportunity at 116 Oak Ridge Circle, a charming single-sto...	3 beds \| 2 baths \| 912 sq.ft.	$214,900	Airbnb cash on cash: 4.36% Traditional cash on cash: 5.97% Airbnb Rental Income: $1704 Traditional Rental Income: $1558 Airbnb ROI: 4.36% Traditional ROI: 5.97%
1279 Coneross Point Drive Seneca, SC Are you seeking a move in ready 3 bedroom home tucked away in quiet seclusion with privacy...	3 beds \| 2 baths \| 1,417 sq.ft.	$459,000	Airbnb cash on cash: 1.44% Traditional cash on cash: 3.28% Airbnb Rental Income: $1704 Traditional Rental Income: $2024 Airbnb ROI: 1.44% Traditional ROI: 3.28%
1210 Cane Creek Drive Seneca, SC Lake life can be charming... and it is just around the corner at 1210 Cane Creek Drive on ...	3 beds \| 3 baths \| 2,584 sq.ft.	$775,000	Airbnb cash on cash: -0.01% Traditional cash on cash: 2.12% Airbnb Rental Income: $1704 Traditional Rental Income: $2775 Airbnb ROI: -0.01% Traditional ROI: 2.12%
209 Amethyst Way Seneca, SC Lake days come easy here, with a private covered dock, a rare shoreline entertaining deck,...	5 beds \| 4 baths \| N/A	$2,195,000	Airbnb cash on cash: -0.84% Traditional cash on cash: 0.03% Airbnb Rental Income: $2246 Traditional Rental Income: $3445 Airbnb ROI: -0.84% Traditional ROI: 0.03%
109 Lanford Drive Seneca, SC Fully renovated & move-in ready, this spacious 4-bedroom, 3-bath brick ranch offers approx...	4 beds \| 3 baths \| 2,300 sq.ft.	$400,000	Airbnb cash on cash: 3.59% Traditional cash on cash: 4.25% Airbnb Rental Income: $2676 Traditional Rental Income: $2288 Airbnb ROI: 3.59% Traditional ROI: 4.25%
227 Serenity Bay Drive Seneca, SC Welcome to your laid-back lake escape at 227 Serenity Bay on Lake Keowee -a warm, inviting...	4 beds \| 4 baths \| 2,755 sq.ft.	$865,000	Airbnb cash on cash: 0.28% Traditional cash on cash: 1.83% Airbnb Rental Income: $2676 Traditional Rental Income: $3293 Airbnb ROI: 0.28% Traditional ROI: 1.83%
2011 Ridgeview Lane Seneca, SC Tucked away in a peaceful wooded setting, this inviting 4-bedroom, 2-bath home blends priv...	4 beds \| 2 baths \| 1,568 sq.ft.	$294,900	Airbnb cash on cash: 5.74% Traditional cash on cash: 5.23% Airbnb Rental Income: $2676 Traditional Rental Income: $1900 Airbnb ROI: 5.74% Traditional ROI: 5.23%
212 Winding Lane Seneca, SC Welcome home! This 3 bedroom, 3.5 bath home sits on 2.3 fully fenced acres just minutes fr...	3 beds \| 4 baths \| N/A	$588,000	Airbnb cash on cash: 0.88% Traditional cash on cash: 3.47% Airbnb Rental Income: $1704 Traditional Rental Income: $2654 Airbnb ROI: 0.88% Traditional ROI: 3.47%
3607 Rocky Creek Drive Seneca, SC Welcome to this spacious and beautifully maintained one-level home, perfectly suited for t...	3 beds \| 2 baths \| 2,200 sq.ft.	$375,000	Airbnb cash on cash: 1.93% Traditional cash on cash: 4.35% Airbnb Rental Income: $1704 Traditional Rental Income: $2085 Airbnb ROI: 1.93% Traditional ROI: 4.35%
420 Sherwood Drive Seneca, SC Discover a harmonious blend of comfort and modern living in this delightful single-family ...	4 beds \| 2 baths \| 1,578 sq.ft.	$279,000	Airbnb cash on cash: 5.84% Traditional cash on cash: 5.26% Airbnb Rental Income: $2676 Traditional Rental Income: $1888 Airbnb ROI: 5.84% Traditional ROI: 5.26%
805 Goddard Avenue Seneca, SC If you've been looking for a solid, completely updated home that is easy to take care of, ...	3 beds \| 2 baths \| 1,232 sq.ft.	$174,900	Airbnb cash on cash: 5.54% Traditional cash on cash: 8.79% Airbnb Rental Income: $1704 Traditional Rental Income: $1772 Airbnb ROI: 5.54% Traditional ROI: 8.79%
1200 Loran Pointe Circle Seneca, SC This stunning three-bedroom, two-and-a-half-bath home on Lake Keowee offers a rare opportu...	3 beds \| 4 baths \| N/A	$899,000	Airbnb cash on cash: -0.75% Traditional cash on cash: 1.57% Airbnb Rental Income: $1704 Traditional Rental Income: $3172 Airbnb ROI: -0.75% Traditional ROI: 1.57%
100 Willow Creek Circle Seneca, SC Location! Location! Location! 100 Willow Creek Circle is the place you want to be! Jus...	3 beds \| 2 baths \| 2,210 sq.ft.	$275,000	Airbnb cash on cash: 2.82% Traditional cash on cash: 6.5% Airbnb Rental Income: $1704 Traditional Rental Income: $2186 Airbnb ROI: 2.82% Traditional ROI: 6.5%
323 Meldau Road Seneca, SC Lakefront on a quite cove on Hartwell with a dock in place, and only minutes from Clemson ...	4 beds \| 3 baths \| N/A	$699,000	Airbnb cash on cash: 1.42% Traditional cash on cash: 1.54% Airbnb Rental Income: $2676 Traditional Rental Income: $2120 Airbnb ROI: 1.42% Traditional ROI: 1.54%
110 S Fairplay Street Seneca, SC Come experience the charm of this historical home located in the heart of downtown Seneca....	4 beds \| 4 baths \| N/A	$514,900	Airbnb cash on cash: 2.92% Traditional cash on cash: 5.18% Airbnb Rental Income: $2676 Traditional Rental Income: $3128 Airbnb ROI: 2.92% Traditional ROI: 5.18%
401 S Cherry Street Seneca, SC Modern Quadplex in Prime Location! Excellent opportunity with this newly renovated quadple...	N/A beds \| N/A baths \| 3,740 sq.ft.	$749,000	Airbnb cash on cash: -1.47% Traditional cash on cash: 0.3% Airbnb Rental Income: $417 Traditional Rental Income: $1397 Airbnb ROI: -1.47% Traditional ROI: 0.3%
1125 Friendship Road Seneca, SC BACK ON THE MARKET AT NO FAULT TO THE SELLER Assumable loan opportunity with an incredible...	4 beds \| 2 baths \| 2,096 sq.ft.	$339,900	Airbnb cash on cash: 4.72% Traditional cash on cash: 5.39% Airbnb Rental Income: $2676 Traditional Rental Income: $2253 Airbnb ROI: 4.72% Traditional ROI: 5.39%
1133 Harts Ridge Drive Seneca, SC Calling All Investors, Clemson University Students, Parents & Fans! Don't miss this opport...	3 beds \| 3 baths \| N/A	$259,000	Airbnb cash on cash: 2.07% Traditional cash on cash: 5.44% Airbnb Rental Income: $1704 Traditional Rental Income: $2054 Airbnb ROI: 2.07% Traditional ROI: 5.44%
305 N Chestnut Street Seneca, SC Welcome to 305 N Chestnut Street in the heart of Seneca! This spacious 4-bedroom, 2.5-bath...	4 beds \| 3 baths \| 2,340 sq.ft.	$282,000	Airbnb cash on cash: 5.77% Traditional cash on cash: 6.74% Airbnb Rental Income: $2676 Traditional Rental Income: $2299 Airbnb ROI: 5.77% Traditional ROI: 6.74%
310 E South 5th Street Seneca, SC Charming Brick Craftsman with one level living in the historic district of Seneca. This is...	2 beds \| 2 baths \| 1,026 sq.ft.	$238,500	Airbnb cash on cash: 1.19% Traditional cash on cash: 5.57% Airbnb Rental Income: $1087 Traditional Rental Income: $1704 Airbnb ROI: 1.19% Traditional ROI: 5.57%

Real Estate investment in Seneca, SC

There are 177 properties for sale in the city of Seneca . The median list price in Seneca is $254,847 and the average price per square foot is $98. In July 2026, the average monthly cash on cash return in Seneca is 3.00%. The average monthly rental income in Seneca is $2,053.

Seneca, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 177 investment properties available for sale in Seneca.

In 2026, the best neighborhood to buy investment property is Seneca.

The ROI for Long-Term is higher than the Short-Term in Seneca with average rental income of $2,053.

Your search for investment property begins and ends here

Investment Property for Sale in Seneca, SC

104 Knollwood Drive

Seneca, SC

5 beds | 4 baths | 6,000 sq.ft.

$625,000

Airbnb cash on cash: 1.16%

Traditional cash on cash: 4.94%

Airbnb Rental Income: $2246

Traditional Rental Income: $3887

Airbnb ROI: 1.16%

Traditional ROI: 4.94%

520 Serria Way

Seneca, SC

3 beds | 2 baths | 2,129 sq.ft.

$365,000

Airbnb cash on cash: 1.76%

Traditional cash on cash: 3.77%

Airbnb Rental Income: $1704

Traditional Rental Income: $1921

Airbnb ROI: 1.76%

Traditional ROI: 3.77%

111 N Grant Road

Seneca, SC

4 beds | 5 baths | 3,390 sq.ft.

$899,900

Airbnb cash on cash: 1.25%

Traditional cash on cash: 3.97%

Airbnb Rental Income: $2676

Traditional Rental Income: $4319

Airbnb ROI: 1.25%

Traditional ROI: 3.97%

136 Loran Pointe Circle

Seneca, SC

4 beds | 3 baths | N/A

$599,900

Airbnb cash on cash: 2.26%

Traditional cash on cash: 3.21%

Airbnb Rental Income: $2676

Traditional Rental Income: $2573

Airbnb ROI: 2.26%

Traditional ROI: 3.21%

609 Providence Point Drive

Seneca, SC

4 beds | 3 baths | 2,500 sq.ft.

$479,000

Airbnb cash on cash: 2.73%

Traditional cash on cash: 3.52%

Airbnb Rental Income: $2676

Traditional Rental Income: $2395

Airbnb ROI: 2.73%

Traditional ROI: 3.52%

109 Oak Crest Circle

Seneca, SC

3 beds | 2 baths | 1,943 sq.ft.

$480,000

Airbnb cash on cash: 1.24%

Traditional cash on cash: 3.14%

Airbnb Rental Income: $1704

Traditional Rental Income: $2087

Airbnb ROI: 1.24%

Traditional ROI: 3.14%

905 N Crestview Drive

Seneca, SC

4 beds | 3 baths | 2,200 sq.ft.

$289,900

Airbnb cash on cash: 5.57%

Traditional cash on cash: 7.29%

Airbnb Rental Income: $2676

Traditional Rental Income: $2512

Airbnb ROI: 5.57%

Traditional ROI: 7.29%

1298 Carradine Road

Seneca, SC

3 beds | 3 baths | N/A

$359,000

Airbnb cash on cash: 1.91%

Traditional cash on cash: 4.54%

Airbnb Rental Income: $1704

Traditional Rental Income: $2118

Airbnb ROI: 1.91%