Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1811 State Highway Z Sikeston, MO This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience....	3 beds \| 3 baths \| 1,774 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.87% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 8.87%
911 Pine Street Sikeston, MO	3 beds \| 2 baths \| 1,432 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.38% Airbnb Rental Income: $null Traditional Rental Income: $2211 Airbnb ROI: N/A Traditional ROI: 8.38%
918 Hawthorn Drive Sikeston, MO Back on the Market- No Fault to Sellers! Beautiful and charming move-in ready ranch home!...	3 beds \| 2 baths \| 1,750 sq.ft.	$200,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.42% Airbnb Rental Income: $null Traditional Rental Income: $2347 Airbnb ROI: N/A Traditional ROI: 10.42%
123 Holmes Drive Sikeston, MO This ALL BRICK home has many upgrades and is MOVE-IN-READY. The home has 3 bedrooms & 2 1/...	3 beds \| 3 baths \| 1,798 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.9% Airbnb Rental Income: $null Traditional Rental Income: $2439 Airbnb ROI: N/A Traditional ROI: 8.9%
819 E Kathleen Street Sikeston, MO Great opportunity for investors! This 2-bedroom property offers solid potential as a renta...	2 beds \| 1 baths \| 884 sq.ft.	$69,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.9% Airbnb Rental Income: $null Traditional Rental Income: $1023 Airbnb ROI: N/A Traditional ROI: 11.9%
917 Cambridge Drive Sikeston, MO This remodeled brick ranch offers modern convenience and comfortable living. Inside you'll...	3 beds \| 2 baths \| 1,256 sq.ft.	$159,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $1512 Airbnb ROI: N/A Traditional ROI: 7.81%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$197,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.54% Airbnb Rental Income: $null Traditional Rental Income: $2250 Airbnb ROI: N/A Traditional ROI: 9.54%
1205 Northfield Ct. Sikeston, MO Welcome to your dream home! This beautiful brick two-story residence features an inviting ...	3 beds \| 4 baths \| N/A	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.49% Airbnb Rental Income: $null Traditional Rental Income: $3287 Airbnb ROI: N/A Traditional ROI: 7.49%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
701 Sikes Avenue Sikeston, MO	3 beds \| 2 baths \| 1,702 sq.ft.	$175,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.96% Airbnb Rental Income: $null Traditional Rental Income: $2322 Airbnb ROI: N/A Traditional ROI: 11.96%
721 Mimosa Dr Sikeston, MO NEW PRICE!!!<br> <br> Great quiet location! This 3 bedroom 2 bath brick home has 1485 sf ...	3 beds \| 2 baths \| 2,970 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.72% Airbnb Rental Income: $null Traditional Rental Income: $2516 Airbnb ROI: N/A Traditional ROI: 9.72%
850 Cambridge Dr Sikeston, MO Completely renovated 3-bedroom, 2-bath home in Sikeston city limits. This beautifully upda...	3 beds \| 2 baths \| 2,871 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.69% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 10.69%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$344,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.43% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 7.43%
8 Elizabeth Road Sikeston, MO Just outside of Sikeston, this 3-bedroom, 2-bathroom home sits on a spacious half-acre lot...	3 beds \| 2 baths \| 1,592 sq.ft.	$234,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.97% Airbnb Rental Income: $null Traditional Rental Income: $2378 Airbnb ROI: N/A Traditional ROI: 8.97%
205 E Beech Street Sikeston, MO Step into charm and character with this beautifully maintained 2-bedroom, 1-bath Folk Vict...	2 beds \| 1 baths \| 980 sq.ft.	$124,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.59% Airbnb Rental Income: $null Traditional Rental Income: $1637 Airbnb ROI: N/A Traditional ROI: 11.59%
608a State Highway H Sikeston, MO Looking for space, style, and function all in one? This brick home delivers. With 3 bedroo...	3 beds \| 2 baths \| 2,009 sq.ft.	$280,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.4% Airbnb Rental Income: $null Traditional Rental Income: $2435 Airbnb ROI: N/A Traditional ROI: 7.4%
1611 State Highway Z Sikeston, MO Surrounded by picturesque farmland, this beautifully maintained home offers the ultimate i...	3 beds \| 3 baths \| 2,015 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.98% Airbnb Rental Income: $null Traditional Rental Income: $2569 Airbnb ROI: N/A Traditional ROI: 9.98%
139 Pharris Ridge Drive Sikeston, MO Well maintained, one owner home sitting on 2 acres outside city limits! The large family r...	2 beds \| 2 baths \| 2,490 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.43% Airbnb Rental Income: $null Traditional Rental Income: $2133 Airbnb ROI: N/A Traditional ROI: 7.43%
719 N West Street Sikeston, MO Nice brick home with a family room added on the back. Wood burning fireplace. Huge walk ...	3 beds \| 2 baths \| 1,985 sq.ft.	$188,900	Airbnb cash on cash: N/A Traditional cash on cash: 11% Airbnb Rental Income: $null Traditional Rental Income: $2372 Airbnb ROI: N/A Traditional ROI: 11%
106 Holmes Drive Sikeston, MO Spacious, modern, updated, extremely well appointed. Enter into a large living room plus a...	3 beds \| 2 baths \| 2,034 sq.ft.	$260,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.61% Airbnb Rental Income: $null Traditional Rental Income: $2369 Airbnb ROI: N/A Traditional ROI: 7.61%
734 Park Avenue Sikeston, MO This immaculate, move-in-ready home showcases multiple recent updates, including the kitch...	2 beds \| 1 baths \| 1,366 sq.ft.	$149,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.48% Airbnb Rental Income: $null Traditional Rental Income: $1787 Airbnb ROI: N/A Traditional ROI: 10.48%
806 Innsbruck Lane Sikeston, MO Open House 1/18/26 2-4pm. Virtually Move-in Ready. New appliances, roof, backyard fence. l...	3 beds \| 2 baths \| 1,489 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.14% Airbnb Rental Income: $null Traditional Rental Income: $1856 Airbnb ROI: N/A Traditional ROI: 6.14%
119 Depro Sikeston, MO Newly remodeled and move-in ready just outside Sikeston! Sitting on a spacious corner lot ...	3 beds \| 3 baths \| 1,492 sq.ft.	$260,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.84% Airbnb Rental Income: $null Traditional Rental Income: $2006 Airbnb ROI: N/A Traditional ROI: 5.84%
312 Hardin Street Sikeston, MO Completely remodeled and ready to move into! Located near the center of Sikeston, close t...	3 beds \| 1 baths \| 1,296 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.05% Airbnb Rental Income: $null Traditional Rental Income: $1846 Airbnb ROI: N/A Traditional ROI: 8.05%
707 Bayberry Dr Sikeston, MO 707 Bayberry Dr, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,674 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.96% Airbnb Rental Income: $null Traditional Rental Income: $1992 Airbnb ROI: N/A Traditional ROI: 6.96%
105 Linda Dr Sikeston, MO	3 beds \| 2 baths \| 1,968 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.73% Airbnb Rental Income: $null Traditional Rental Income: $2064 Airbnb ROI: N/A Traditional ROI: 6.73%
1401 N Main St Sikeston, MO 1401 N Main St, Sikeston, MO 63801 \| Other	N/A beds \| N/A baths \| N/A	$244,500	Airbnb cash on cash: N/A Traditional cash on cash: 2.19% Airbnb Rental Income: $null Traditional Rental Income: $1053 Airbnb ROI: N/A Traditional ROI: 2.19%

Real Estate investment in Sikeston, MO

There are 28 properties for sale in the city of Sikeston . The median list price in Sikeston is $137,750 and the average price per square foot is $107. In February 2026, the average monthly cash on cash return in Sikeston is 11.00%. The average monthly rental income in Sikeston is $2,035.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 28 investment properties available for sale in Sikeston.

In 2026, the best neighborhood to buy investment property is Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

1811 State Highway Z

Sikeston, MO

3 beds | 3 baths | 1,774 sq.ft.

$265,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.87%

Airbnb Rental Income: $null

Traditional Rental Income: $2621

Airbnb ROI: N/A

Traditional ROI: 8.87%

911 Pine Street

Sikeston, MO

3 beds | 2 baths | 1,432 sq.ft.

$220,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.38%

Airbnb Rental Income: $null

Traditional Rental Income: $2211

Airbnb ROI: N/A

Traditional ROI: 8.38%

918 Hawthorn Drive

Sikeston, MO

3 beds | 2 baths | 1,750 sq.ft.

$200,000

Airbnb cash on cash: N/A

Traditional cash on cash: 10.42%

Airbnb Rental Income: $null

Traditional Rental Income: $2347

Airbnb ROI: N/A

Traditional ROI: 10.42%

123 Holmes Drive

Sikeston, MO

3 beds | 3 baths | 1,798 sq.ft.

$239,900

Airbnb cash on cash: N/A

Traditional cash on cash: 8.9%

Airbnb Rental Income: $null

Traditional Rental Income: $2439

Airbnb ROI: N/A

Traditional ROI: 8.9%

819 E Kathleen Street

Sikeston, MO

2 beds | 1 baths | 884 sq.ft.

$69,900

Airbnb cash on cash: N/A

Traditional cash on cash: 11.9%

Airbnb Rental Income: $null

Traditional Rental Income: $1023

Airbnb ROI: N/A

Traditional ROI: 11.9%

917 Cambridge Drive

Sikeston, MO

3 beds | 2 baths | 1,256 sq.ft.

$159,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.81%

Airbnb Rental Income: $null

Traditional Rental Income: $1512

Airbnb ROI: N/A

Traditional ROI: 7.81%

605 N. Ranney Street

Sikeston, MO

3 beds | 2 baths | N/A

$197,500

Airbnb cash on cash: N/A

Traditional cash on cash: 9.54%

Airbnb Rental Income: $null

Traditional Rental Income: $2250

Airbnb ROI: N/A

Traditional ROI: 9.54%

1205 Northfield Ct.

Sikeston, MO

3 beds | 4 baths | N/A

$360,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.49%

Airbnb Rental Income: $null

Traditional Rental Income: $3287

Airbnb ROI: N/A