Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
904 Pine St Sikeston, MO You do not want to miss out on this great property! Located in a highly desirable neighbor...	4 beds \| 3 baths \| 2,400 sq.ft.	$285,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.4% Airbnb Rental Income: $null Traditional Rental Income: $2610 Airbnb ROI: N/A Traditional ROI: 7.4%
1811 State Highway Z Sikeston, MO This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience....	3 beds \| 3 baths \| 1,774 sq.ft.	$259,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.06% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 9.06%
2011 State Highway H Sikeston, MO This one checks a LOT of boxes! 3 beds. 2 baths. Kelly School District. Updated kitchen. F...	3 beds \| 2 baths \| 2,147 sq.ft.	$270,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.65% Airbnb Rental Income: $null Traditional Rental Income: $2112 Airbnb ROI: N/A Traditional ROI: 6.65%
1011 N Ranney Street Sikeston, MO What a gorgeous, well maintained historic home! Letâs start with the kitchen. Itâs t...	4 beds \| 7 baths \| 7,356 sq.ft.	$670,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.11% Airbnb Rental Income: $null Traditional Rental Income: $4300 Airbnb ROI: N/A Traditional ROI: 5.11%
303 Greer Avenue Sikeston, MO Are you ready for a small home in Sikeston? You can sit on the covered, front porch and e...	3 beds \| 1 baths \| 1,335 sq.ft.	$99,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.9% Airbnb Rental Income: $null Traditional Rental Income: $953 Airbnb ROI: N/A Traditional ROI: 6.9%
911 S Prairie Street Sikeston, MO Welcome home to this charming ranch-style gem that perfectly balances cozy comfort with in...	3 beds \| 2 baths \| 1,600 sq.ft.	$145,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.9% Airbnb Rental Income: $null Traditional Rental Income: $1722 Airbnb ROI: N/A Traditional ROI: 9.9%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$188,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.05% Airbnb Rental Income: $null Traditional Rental Income: $2250 Airbnb ROI: N/A Traditional ROI: 10.05%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
126 Bradley Drive Sikeston, MO Recently remodeled and ready for Y-O-U! This great home is updated and move in ready! Impr...	3 beds \| 2 baths \| 1,828 sq.ft.	$259,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.16% Airbnb Rental Income: $null Traditional Rental Income: $2449 Airbnb ROI: N/A Traditional ROI: 8.16%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$344,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.43% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 7.43%
1201 Yosemite Sikeston, MO Welcome to this stunning 2023-built home offering the perfect blend of modern design, func...	3 beds \| 2 baths \| 1,800 sq.ft.	$309,500	Airbnb cash on cash: N/A Traditional cash on cash: 6.14% Airbnb Rental Income: $null Traditional Rental Income: $2410 Airbnb ROI: N/A Traditional ROI: 6.14%
133 Larue Lane Sikeston, MO Need space for family and pets in the Kelly School District? This totally renovated home ...	3 beds \| 3 baths \| N/A	$319,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.25% Airbnb Rental Income: $null Traditional Rental Income: $1962 Airbnb ROI: N/A Traditional ROI: 4.25%
103 Powers Sikeston, MO Charming 3-Bedroom All-Brick Home in Sikestonâs North End â 1,764 Sq Ft + 1.650 Sq Ft....	3 beds \| 3 baths \| N/A	$248,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.83% Airbnb Rental Income: $null Traditional Rental Income: $2387 Airbnb ROI: N/A Traditional ROI: 7.83%
1132 Pollard Plaza Sikeston, MO Welcome to this beautifully built 2024 home in Sikeston offering the perfect blend of mode...	4 beds \| 2 baths \| 2,004 sq.ft.	$340,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.11% Airbnb Rental Income: $null Traditional Rental Income: $1394 Airbnb ROI: N/A Traditional ROI: 2.11%
116 Hospitality Dr Sikeston, MO 116 Hospitality Dr, Sikeston, MO 63801 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.27% Airbnb Rental Income: $null Traditional Rental Income: $1062 Airbnb ROI: N/A Traditional ROI: 3.27%
109 Stallcup Dr Sikeston, MO 109 Stallcup Dr, Sikeston, MO 63801 \| Other	N/A beds \| N/A baths \| 0 sq.ft.	$400,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.62% Airbnb Rental Income: $null Traditional Rental Income: $1062 Airbnb ROI: N/A Traditional ROI: 0.62%
119 Depro Sikeston, MO Set on a spacious 0.72-acre corner lot just outside Sikeston, this property features a bra...	3 beds \| 3 baths \| 1,492 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.14% Airbnb Rental Income: $null Traditional Rental Income: $2006 Airbnb ROI: N/A Traditional ROI: 6.14%
312 Hardin Street Sikeston, MO Completely remodeled and ready to move into! Located near the center of Sikeston, close t...	3 beds \| 1 baths \| 1,296 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.47% Airbnb Rental Income: $null Traditional Rental Income: $1846 Airbnb ROI: N/A Traditional ROI: 8.47%
106 Jennings Lane Sikeston, MO Experience elevated living in this beautifully crafted 3,770-square-foot residence ideally...	4 beds \| 3 baths \| 3,770 sq.ft.	$549,995	Airbnb cash on cash: N/A Traditional cash on cash: 3.74% Airbnb Rental Income: $null Traditional Rental Income: $2760 Airbnb ROI: N/A Traditional ROI: 3.74%
628 Moore Avenue Sikeston, MO This charming bungalow in Sikeston's historic district has been beautifully updated and is...	2 beds \| 1 baths \| 910 sq.ft.	$119,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.92% Airbnb Rental Income: $null Traditional Rental Income: $1281 Airbnb ROI: N/A Traditional ROI: 8.92%
10 Dement Road Sikeston, MO This 3 bedroom, 1 & 3/4 bath home features a split bedroom floor plan and an eat-in kitche...	3 beds \| 2 baths \| 1,382 sq.ft.	$172,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.97% Airbnb Rental Income: $null Traditional Rental Income: $1798 Airbnb ROI: N/A Traditional ROI: 8.97%
209 Aletha Drive Sikeston, MO Looking for a home outside the city limits in a great neighborhood? This property offers t...	4 beds \| 2 baths \| 2,347 sq.ft.	$255,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.38% Airbnb Rental Income: $null Traditional Rental Income: $2196 Airbnb ROI: N/A Traditional ROI: 7.38%
2012 Ables Road Sikeston, MO Welcome to this cozy and inviting 2-bedroom, 1-bath home in Sikeston. It features a comfo...	2 beds \| 1 baths \| 1,002 sq.ft.	$120,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.26% Airbnb Rental Income: $null Traditional Rental Income: $1447 Airbnb ROI: N/A Traditional ROI: 10.26%
406 Broadway Street Sikeston, MO Charming and well-maintained 3-bedroom, 2-bath home with thoughtful updates and versatile ...	3 beds \| 2 baths \| 1,434 sq.ft.	$185,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.39% Airbnb Rental Income: $null Traditional Rental Income: $2170 Airbnb ROI: N/A Traditional ROI: 10.39%
116 Terrace Drive Sikeston, MO	3 beds \| 2 baths \| 1,302 sq.ft.	$169,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.2% Airbnb Rental Income: $null Traditional Rental Income: $1975 Airbnb ROI: N/A Traditional ROI: 10.2%
302 Marshall Sikeston, MO 302 Marshall, Sikeston, MO 63801 \| Single Family Residential	2 beds \| 1 baths \| 1,045 sq.ft.	$95,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.61% Airbnb Rental Income: $null Traditional Rental Income: $1349 Airbnb ROI: N/A Traditional ROI: 11.61%
903 Glenn Drive Sikeston, MO In a quiet subdivision, this well-maintained 3 bed, 2 bath home offers a comfortable layou...	3 beds \| 2 baths \| 1,434 sq.ft.	$210,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.66% Airbnb Rental Income: $null Traditional Rental Income: $2119 Airbnb ROI: N/A Traditional ROI: 8.66%
805 Sikes Avenue Sikeston, MO If space and functionality are at the top of your list, this is the one. This expansive 5...	5 beds \| 4 baths \| 4,387 sq.ft.	$355,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.91% Airbnb Rental Income: $null Traditional Rental Income: $4580 Airbnb ROI: N/A Traditional ROI: 11.91%
705 Linden Lane Sikeston, MO This one owner home is ready to go on the market for the first time since being built! Th...	3 beds \| 3 baths \| 1,566 sq.ft.	$180,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.18% Airbnb Rental Income: $null Traditional Rental Income: $2275 Airbnb ROI: N/A Traditional ROI: 11.18%

Real Estate investment in Sikeston, MO

There are 31 properties for sale in the city of Sikeston . The median list price in Sikeston is $108,000 and the average price per square foot is $92. In May 2026, the average monthly cash on cash return in Sikeston is 13.00%. The average monthly rental income in Sikeston is $1,740.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 31 investment properties available for sale in Sikeston.

In 2026, the best neighborhood to buy investment property is Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

904 Pine St

Sikeston, MO

4 beds | 3 baths | 2,400 sq.ft.

$285,500

Airbnb cash on cash: N/A

Traditional cash on cash: 7.4%

Airbnb Rental Income: $null

Traditional Rental Income: $2610

Airbnb ROI: N/A

Traditional ROI: 7.4%

1811 State Highway Z

Sikeston, MO

3 beds | 3 baths | 1,774 sq.ft.

$259,900

Airbnb cash on cash: N/A

Traditional cash on cash: 9.06%

Airbnb Rental Income: $null

Traditional Rental Income: $2621

Airbnb ROI: N/A

Traditional ROI: 9.06%

2011 State Highway H

Sikeston, MO

3 beds | 2 baths | 2,147 sq.ft.

$270,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.65%

Airbnb Rental Income: $null

Traditional Rental Income: $2112

Airbnb ROI: N/A

Traditional ROI: 6.65%

1011 N Ranney Street

Sikeston, MO

4 beds | 7 baths | 7,356 sq.ft.

$670,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.11%

Airbnb Rental Income: $null

Traditional Rental Income: $4300

Airbnb ROI: N/A

Traditional ROI: 5.11%

303 Greer Avenue

Sikeston, MO

3 beds | 1 baths | 1,335 sq.ft.

$99,900

Airbnb cash on cash: N/A

Traditional cash on cash: 6.9%

Airbnb Rental Income: $null

Traditional Rental Income: $953

Airbnb ROI: N/A

Traditional ROI: 6.9%

911 S Prairie Street

Sikeston, MO

3 beds | 2 baths | 1,600 sq.ft.

$145,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.9%

Airbnb Rental Income: $null

Traditional Rental Income: $1722

Airbnb ROI: N/A

Traditional ROI: 9.9%

605 N. Ranney Street

Sikeston, MO

3 beds | 2 baths | N/A

$188,900

Airbnb cash on cash: N/A

Traditional cash on cash: 10.05%

Airbnb Rental Income: $null

Traditional Rental Income: $2250

Airbnb ROI: N/A

Traditional ROI: 10.05%

3 Bel Air

Sikeston, MO

4 beds | 3 baths | N/A

$299,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.97%

Airbnb Rental Income: $null

Traditional Rental Income: $3451

Airbnb ROI: N/A