Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Single Family Homes for Sale in Sikeston, MO

Search for Single Family Residential for Sale in Sikeston, Missouri. Browse all of Mashvisor’s Single Family Residential listings and other investment property types including Single Family Homes, Multi Family Homes, Condos, Townhouses and Other Homes.

Showing 61 Single Family Residential listings of over 500,000 total investment properties for sale. Visit Mashvisor.com to all investment properties.

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1811 State Highway Z Sikeston, MO This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience....	3 beds \| 2 baths \| 1,774 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.87% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 8.87%
911 Pine Street Sikeston, MO	3 beds \| 2 baths \| 1,432 sq.ft.	$220,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.38% Airbnb Rental Income: $null Traditional Rental Income: $2211 Airbnb ROI: N/A Traditional ROI: 8.38%
829 Plantation Blvd Sikeston, MO Excellent home in an excellent neighborhood! Perfect for entertaining, the inviting great...	3 beds \| 2 baths \| 1,946 sq.ft.	$279,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $2111 Airbnb ROI: N/A Traditional ROI: 5.69%
2011 State Highway H Sikeston, MO STOP the car and check out this all brick home in Kelly School District!! Call and get an ...	3 beds \| 2 baths \| 2,147 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.53% Airbnb Rental Income: $null Traditional Rental Income: $2112 Airbnb ROI: N/A Traditional ROI: 6.53%
819 E Kathleen St Sikeston, MO Great opportunity for investors! This 2-bedroom property offers solid potential as a renta...	2 beds \| 1 baths \| 884 sq.ft.	$69,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.9% Airbnb Rental Income: $null Traditional Rental Income: $1023 Airbnb ROI: N/A Traditional ROI: 11.9%
917 Cambridge Drive Sikeston, MO This remodeled brick ranch offers modern convenience and comfortable living. Inside you'll...	3 beds \| 2 baths \| 1,256 sq.ft.	$159,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $1512 Airbnb ROI: N/A Traditional ROI: 7.81%
303 Greer Ave Sikeston, MO First time on the market for this home in Sikeston. It has two large bedrooms and one sma...	3 beds \| 1 baths \| 1,237 sq.ft.	$99,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.9% Airbnb Rental Income: $null Traditional Rental Income: $953 Airbnb ROI: N/A Traditional ROI: 6.9%
911 S Prairie St Sikeston, MO Want to live near all the "things" but be on a quiet dead end street? If so, th...	3 beds \| 2 baths \| 1,600 sq.ft.	$145,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.77% Airbnb Rental Income: $null Traditional Rental Income: $1722 Airbnb ROI: N/A Traditional ROI: 9.77%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$197,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.54% Airbnb Rental Income: $null Traditional Rental Income: $2250 Airbnb ROI: N/A Traditional ROI: 9.54%
1205 Northfield Ct. Sikeston, MO Welcome to your dream home! This beautiful brick two-story residence features an inviting ...	3 beds \| 4 baths \| N/A	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.49% Airbnb Rental Income: $null Traditional Rental Income: $3287 Airbnb ROI: N/A Traditional ROI: 7.49%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
721 Mimosa Dr Sikeston, MO NEW PRICE!!!<br> <br> Great quiet location! This 3 bedroom 2 bath brick home has 1485 sf ...	3 beds \| 2 baths \| 2,970 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.72% Airbnb Rental Income: $null Traditional Rental Income: $2516 Airbnb ROI: N/A Traditional ROI: 9.72%
850 Cambridge Dr Sikeston, MO Completely renovated 3-bedroom, 2-bath home in Sikeston city limits. This beautifully upda...	3 beds \| 2 baths \| 2,871 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.69% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 10.69%
901 Moore Ave Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$344,500	Airbnb cash on cash: N/A Traditional cash on cash: 7.43% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 7.43%
8 Elizabeth Rd Sikeston, MO Just outside of Sikeston, this 3-bedroom, 2-bathroom home sits on a spacious half-acre lot...	3 beds \| 2 baths \| 1,592 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.4% Airbnb Rental Income: $null Traditional Rental Income: $2378 Airbnb ROI: N/A Traditional ROI: 9.4%
608A State Highway H Sikeston, MO Looking for space, style, and function all in one? This brick home delivers. With 3 bedroo...	3 beds \| 2 baths \| 2,009 sq.ft.	$280,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.4% Airbnb Rental Income: $null Traditional Rental Income: $2435 Airbnb ROI: N/A Traditional ROI: 7.4%
1611 State Highway Z Sikeston, MO Surrounded by picturesque farmland, this beautifully maintained home offers the ultimate i...	3 beds \| 3 baths \| 2,015 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.98% Airbnb Rental Income: $null Traditional Rental Income: $2569 Airbnb ROI: N/A Traditional ROI: 9.98%
1201 Yosemite Sikeston, MO Beautiful new 3-bedroom, 2-bath home featuring an open living area with tray ceilings and ...	3 beds \| 2 baths \| 1,800 sq.ft.	$309,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.26% Airbnb Rental Income: $null Traditional Rental Income: $2410 Airbnb ROI: N/A Traditional ROI: 6.26%
139 Pharris Ridge Dr Sikeston, MO Well maintained, one owner home sitting on 2 acres outside city limits! The large family r...	2 beds \| 2 baths \| 2,490 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.43% Airbnb Rental Income: $null Traditional Rental Income: $2133 Airbnb ROI: N/A Traditional ROI: 7.43%
719 N West St Sikeston, MO Nice brick home with a family room added on the back. Wood burning fireplace. Huge walk ...	3 beds \| 2 baths \| 1,985 sq.ft.	$188,900	Airbnb cash on cash: N/A Traditional cash on cash: 11% Airbnb Rental Income: $null Traditional Rental Income: $2372 Airbnb ROI: N/A Traditional ROI: 11%
106 Holmes Dr Sikeston, MO Spacious, modern, updated, extremely well appointed. Enter into a large living room plus a...	3 beds \| 1 baths \| 2,034 sq.ft.	$250,999	Airbnb cash on cash: N/A Traditional cash on cash: 7.91% Airbnb Rental Income: $null Traditional Rental Income: $2369 Airbnb ROI: N/A Traditional ROI: 7.91%
734 Park Avenue Sikeston, MO This immaculate, move-in-ready home showcases multiple recent updates, including the kitch...	2 beds \| 1 baths \| 1,366 sq.ft.	$149,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.48% Airbnb Rental Income: $null Traditional Rental Income: $1787 Airbnb ROI: N/A Traditional ROI: 10.48%
216 Sherrie Dr Sikeston, MO 216 Sherrie Dr, Sikeston, MO 63801 \| Single Family Residential	5 beds \| 3 baths \| 2,800 sq.ft.	$279,999	Airbnb cash on cash: N/A Traditional cash on cash: 8.18% Airbnb Rental Income: $null Traditional Rental Income: $2768 Airbnb ROI: N/A Traditional ROI: 8.18%
312 Tanner St Sikeston, MO 312 Tanner St, Sikeston, MO 63801 \| Single Family Residential	5 beds \| 4 baths \| 6,095 sq.ft.	$790,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.06% Airbnb Rental Income: $null Traditional Rental Income: $4528 Airbnb ROI: N/A Traditional ROI: 4.06%
1304 Primrose Dr Sikeston, MO 1304 Primrose Dr, Sikeston, MO 63801 \| Single Family Residential	4 beds \| 4 baths \| 4,924 sq.ft.	$665,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.77% Airbnb Rental Income: $null Traditional Rental Income: $3032 Airbnb ROI: N/A Traditional ROI: 2.77%
402 Garner St Sikeston, MO 402 Garner St, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,965 sq.ft.	$264,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.96% Airbnb Rental Income: $null Traditional Rental Income: $2066 Airbnb ROI: N/A Traditional ROI: 5.96%
806 Innsbruck Lane Sikeston, MO Open House 1/18/26 2-4pm. Virtually Move-in Ready. New appliances, roof, backyard fence. l...	3 beds \| 2 baths \| 1,489 sq.ft.	$229,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.14% Airbnb Rental Income: $null Traditional Rental Income: $1856 Airbnb ROI: N/A Traditional ROI: 6.14%
2047 State Highway H Sikeston, MO 2047 State Highway H, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,367 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 6% Airbnb Rental Income: $null Traditional Rental Income: $1787 Airbnb ROI: N/A Traditional ROI: 6%
406 W Gladys St Sikeston, MO 406 W Gladys St, Sikeston, MO 63801 \| Single Family Residential	2 beds \| 1 baths \| 1,000 sq.ft.	$94,400	Airbnb cash on cash: N/A Traditional cash on cash: 10.02% Airbnb Rental Income: $null Traditional Rental Income: $1195 Airbnb ROI: N/A Traditional ROI: 10.02%
318 Kendall St Sikeston, MO 318 Kendall St, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 1 baths \| 1,080 sq.ft.	$119,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.56% Airbnb Rental Income: $null Traditional Rental Income: $1415 Airbnb ROI: N/A Traditional ROI: 9.56%
119 Depro Sikeston, MO Newly remodeled and move-in ready just outside Sikeston! Sitting on a spacious corner lot ...	3 beds \| 3 baths \| 1,492 sq.ft.	$260,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.84% Airbnb Rental Income: $null Traditional Rental Income: $2006 Airbnb ROI: N/A Traditional ROI: 5.84%
1205 Yosemite Sikeston, MO 1205 Yosemite, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,734 sq.ft.	$299,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $2178 Airbnb ROI: N/A Traditional ROI: 5.43%
312 Hardin St Sikeston, MO Completely remodeled and ready to move into! Located near the center of Sikeston, close t...	3 beds \| 1 baths \| 1,296 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.05% Airbnb Rental Income: $null Traditional Rental Income: $1846 Airbnb ROI: N/A Traditional ROI: 8.05%
2163 E County Highway 450 Sikeston, MO 2163 E County Highway 450, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.18% Airbnb Rental Income: $null Traditional Rental Income: $1676 Airbnb ROI: N/A Traditional ROI: 6.18%
202 N Brushwick Ave Sikeston, MO 202 N Brushwick Ave, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 2,495 sq.ft.	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.89% Airbnb Rental Income: $null Traditional Rental Income: $2125 Airbnb ROI: N/A Traditional ROI: 4.89%
707 Bayberry Dr Sikeston, MO 707 Bayberry Dr, Sikeston, MO 63801 \| Single Family Residential	3 beds \| 2 baths \| 1,674 sq.ft.	$225,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.96% Airbnb Rental Income: $null Traditional Rental Income: $1992 Airbnb ROI: N/A Traditional ROI: 6.96%
109 Lynn St Sikeston, MO	3 beds \| 1 baths \| 1,782 sq.ft.	$249,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.99% Airbnb Rental Income: $null Traditional Rental Income: $1498 Airbnb ROI: N/A Traditional ROI: 3.99%
105 Linda Dr Sikeston, MO	3 beds \| 2 baths \| 1,968 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.73% Airbnb Rental Income: $null Traditional Rental Income: $2064 Airbnb ROI: N/A Traditional ROI: 6.73%

Your search for investment property begins and ends here

Single Family Homes for Sale in Sikeston, MO

1811 State Highway Z

Sikeston, MO

3 beds | 2 baths | 1,774 sq.ft.

$265,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.87%

Airbnb Rental Income: $null

Traditional Rental Income: $2621

Airbnb ROI: N/A

Traditional ROI: 8.87%

911 Pine Street

Sikeston, MO

3 beds | 2 baths | 1,432 sq.ft.

$220,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.38%

Airbnb Rental Income: $null

Traditional Rental Income: $2211

Airbnb ROI: N/A

Traditional ROI: 8.38%

829 Plantation Blvd

Sikeston, MO

3 beds | 2 baths | 1,946 sq.ft.

$279,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.69%

Airbnb Rental Income: $null

Traditional Rental Income: $2111

Airbnb ROI: N/A

Traditional ROI: 5.69%

2011 State Highway H

Sikeston, MO

3 beds | 2 baths | 2,147 sq.ft.

$275,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.53%

Airbnb Rental Income: $null

Traditional Rental Income: $2112

Airbnb ROI: N/A

Traditional ROI: 6.53%

819 E Kathleen St

Sikeston, MO

2 beds | 1 baths | 884 sq.ft.

$69,900

Airbnb cash on cash: N/A

Traditional cash on cash: 11.9%

Airbnb Rental Income: $null

Traditional Rental Income: $1023

Airbnb ROI: N/A

Traditional ROI: 11.9%

917 Cambridge Drive

Sikeston, MO

3 beds | 2 baths | 1,256 sq.ft.

$159,900

Airbnb cash on cash: N/A

Traditional cash on cash: 7.81%

Airbnb Rental Income: $null

Traditional Rental Income: $1512

Airbnb ROI: N/A

Traditional ROI: 7.81%

303 Greer Ave

Sikeston, MO

3 beds | 1 baths | 1,237 sq.ft.

$99,900

Airbnb cash on cash: N/A

Traditional cash on cash: 6.9%

Airbnb Rental Income: $null

Traditional Rental Income: $953

Airbnb ROI: N/A

Traditional ROI: 6.9%

911 S Prairie St

Sikeston, MO

3 beds | 2 baths | 1,600 sq.ft.

$145,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.77%

Airbnb Rental Income: $null

Traditional Rental Income: $1722

Airbnb ROI: N/A