Real Estate Investment Properties for Sale in Chillicothe, OH

Looking for investment property in Chillicothe, OH with high ROI ?

Explore a variety of short-term homes & houses in Chillicothe, OH. Invest wisely with VRBO & Chillicothe, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chillicothe, OH

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
411 Church St Chillicothe, OH Spacious German brick home with large rooms throughout. Two closed fireplaces, wood floor...	4 beds \| 2 baths \| 2,350 sq.ft.	$399,900	Airbnb cash on cash: -1.15% Traditional cash on cash: 2.02% Airbnb Rental Income: $966 Traditional Rental Income: $1806 Airbnb ROI: -1.15% Traditional ROI: 2.02%
320 Vine St Chillicothe, OH Nice one story conveniently located near downtown, city park and shopping. One and half c...	2 beds \| 1 baths \| 1,188 sq.ft.	$182,000	Airbnb cash on cash: 0.24% Traditional cash on cash: 3.67% Airbnb Rental Income: $915 Traditional Rental Income: $1168 Airbnb ROI: 0.24% Traditional ROI: 3.67%
726 Beechwood St Chillicothe, OH Are you ready to get a great deal on a piece of real estate? This is an Online Only Forecl...	3 beds \| 1 baths \| 1,197 sq.ft.	$179,900	Airbnb cash on cash: 1.73% Traditional cash on cash: 4.13% Airbnb Rental Income: $1028 Traditional Rental Income: $1078 Airbnb ROI: 1.73% Traditional ROI: 4.13%
760 E 4th St Chillicothe, OH Invest with success and buy through Auction.com. This foreclosure investment property is a...	3 beds \| 2 baths \| 1,120 sq.ft.	$175,000	Airbnb cash on cash: 2.07% Traditional cash on cash: 4.99% Airbnb Rental Income: $1028 Traditional Rental Income: $1155 Airbnb ROI: 2.07% Traditional ROI: 4.99%
593 Cedar St Chillicothe, OH Charming 1.5 story home on the West End of town. Close to shopping and schools. Nice curb ...	3 beds \| 1 baths \| 1,053 sq.ft.	$162,000	Airbnb cash on cash: 1.83% Traditional cash on cash: 6.77% Airbnb Rental Income: $1028 Traditional Rental Income: $1432 Airbnb ROI: 1.83% Traditional ROI: 6.77%
3768 Musgrove Rd Chillicothe, OH Nice location is off Musgrove Rd back a private shared drive (with easement/maintenance ag...	3 beds \| 2 baths \| 1,456 sq.ft.	$321,900	Airbnb cash on cash: 0.79% Traditional cash on cash: 3.9% Airbnb Rental Income: $1028 Traditional Rental Income: $1607 Airbnb ROI: 0.79% Traditional ROI: 3.9%
1303 SANDY RD Chillicothe, OH Invest with success and buy through Auction.com. This bank-owned investment property is a ...	3 beds \| 2 baths \| 1,728 sq.ft.	$174,000	Airbnb cash on cash: 1.74% Traditional cash on cash: 9.48% Airbnb Rental Income: $1028 Traditional Rental Income: $1950 Airbnb ROI: 1.74% Traditional ROI: 9.48%
5 Shawnee Dr Chillicothe, OH This Brewer Heights home is a classic example of a mid-century home. It is in excellent mo...	3 beds \| 2 baths \| 1,607 sq.ft.	$365,000	Airbnb cash on cash: -0.06% Traditional cash on cash: 3.06% Airbnb Rental Income: $1028 Traditional Rental Income: $1735 Airbnb ROI: -0.06% Traditional ROI: 3.06%
703 Piney Crk Chillicothe, OH Great 3 bedroom home with bonus area by main bedroom could be office or nursery. Kitchen i...	3 beds \| 2 baths \| 1,836 sq.ft.	$229,900	Airbnb cash on cash: 0.1% Traditional cash on cash: 4.46% Airbnb Rental Income: $1028 Traditional Rental Income: $1615 Airbnb ROI: 0.1% Traditional ROI: 4.46%
239 Almahurst Dr Chillicothe, OH Welcome to this beautifully updated 3,804 sq ft home featuring 4 bedrooms and 2 full/2 hal...	4 beds \| 2 baths \| 3,804 sq.ft.	$475,000	Airbnb cash on cash: -0.72% Traditional cash on cash: 4.56% Airbnb Rental Income: $966 Traditional Rental Income: $2961 Airbnb ROI: -0.72% Traditional ROI: 4.56%
23 N Brownell St Chillicothe, OH Adorable home with 3 bedrooms ,1 bath, main level laundry/mud room, fenced yard and 2 car ...	3 beds \| 1 baths \| 910 sq.ft.	$149,900	Airbnb cash on cash: 2.58% Traditional cash on cash: 4.11% Airbnb Rental Income: $1028 Traditional Rental Income: $888 Airbnb ROI: 2.58% Traditional ROI: 4.11%
191 Sullivan Rd Chillicothe, OH This unique property built from repurposed shipping containers boasts 3 bedrooms and 2 ful...	3 beds \| 2 baths \| 1,488 sq.ft.	$350,000	Airbnb cash on cash: -0.8% Traditional cash on cash: 2.32% Airbnb Rental Income: $1028 Traditional Rental Income: $1692 Airbnb ROI: -0.8% Traditional ROI: 2.32%
15 Windsor Dr Chillicothe, OH Welcome to your dream home! Located less than an hour outside of Columbus, This home has e...	5 beds \| 3 baths \| 5,184 sq.ft.	$1,295,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.98% Airbnb Rental Income: $null Traditional Rental Income: $4491 Airbnb ROI: N/A Traditional ROI: 1.98%
1011 Lee Hollow Rd Chillicothe, OH Very unique opportunity! Log cabin in the woods, on about 2.5 acress (3 parcels), PLUS a s...	1 beds \| 1 baths \| 728 sq.ft.	$150,000	Airbnb cash on cash: 0.21% Traditional cash on cash: 8.56% Airbnb Rental Income: $558 Traditional Rental Income: $1474 Airbnb ROI: 0.21% Traditional ROI: 8.56%
623 Glencroft Ave Chillicothe, OH Welcome to 623 Glencoft Avenue! This brand-new, single-level home offers 3 bedrooms and 1 ...	3 beds \| 1 baths \| 1,056 sq.ft.	$145,000	Airbnb cash on cash: 3.04% Traditional cash on cash: 7.87% Airbnb Rental Income: $1028 Traditional Rental Income: $1339 Airbnb ROI: 3.04% Traditional ROI: 7.87%
485 Springer Rd Chillicothe, OH Picture this... A real LOG CABIN, nestled at the back of 5 acres surrounded by woods and p...	3 beds \| 1 baths \| 632 sq.ft.	$250,000	Airbnb cash on cash: 1.33% Traditional cash on cash: 3.44% Airbnb Rental Income: $1028 Traditional Rental Income: $1168 Airbnb ROI: 1.33% Traditional ROI: 3.44%
4557 State Route 159 Chillicothe, OH Public Remarks: Here is your chance at a rare opp. to own 5.12 acres in Green Twp with NO ...	3 beds \| 3 baths \| 3,909 sq.ft.	$425,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 3.57% Airbnb Rental Income: $1028 Traditional Rental Income: $2129 Airbnb ROI: -0.1% Traditional ROI: 3.57%
7178 State Route 159 Chillicothe, OH Cozy 3 bedroom, 1 full bath home nestled on 6 beautiful acres, offering both privacy and c...	3 beds \| 1 baths \| 1,304 sq.ft.	$250,000	Airbnb cash on cash: 0.86% Traditional cash on cash: 4.08% Airbnb Rental Income: $1028 Traditional Rental Income: $1427 Airbnb ROI: 0.86% Traditional ROI: 4.08%
559 Golfview Dr Chillicothe, OH Move-in ready 2-story home in the desirable Golfview neighborhood featuring 3 bedrooms, 2....	3 beds \| 2 baths \| 1,864 sq.ft.	$374,900	Airbnb cash on cash: -0.06% Traditional cash on cash: 4.51% Airbnb Rental Income: $1028 Traditional Rental Income: $2276 Airbnb ROI: -0.06% Traditional ROI: 4.51%
20702 N US Highway 23 Chillicothe, OH One-of-a-Kind Estate Featuring Ohio's Largest Private Indoor Pool! Welcome to 20702 US Hig...	2 beds \| 5 baths \| 8,195 sq.ft.	$1,200,000	Airbnb cash on cash: -1.64% Traditional cash on cash: 1.32% Airbnb Rental Income: $915 Traditional Rental Income: $3876 Airbnb ROI: -1.64% Traditional ROI: 1.32%
1456 Debord Rd Chillicothe, OH Newly built retreat with 13.24 acres. Located in the beautiful, southern hills of Ross Cou...	3 beds \| 1 baths \| 1,207 sq.ft.	$439,900	Airbnb cash on cash: -1.15% Traditional cash on cash: 1.6% Airbnb Rental Income: $1028 Traditional Rental Income: $1799 Airbnb ROI: -1.15% Traditional ROI: 1.6%
1667 Stone Rd Lot 59 Chillicothe, OH Wow-so much space! This newer doublewide features 5 bedrooms and 3 full baths with an open...	5 beds \| 3 baths \| 2,040 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $2524 Airbnb ROI: N/A Traditional ROI: 7.81%
90 2nd St Chillicothe, OH Step back in time with this stunning Victorian gem in the heart of downtown Chillicothe. T...	4 beds \| 2 baths \| 3,720 sq.ft.	$400,000	Airbnb cash on cash: 0.21% Traditional cash on cash: 3.87% Airbnb Rental Income: $966 Traditional Rental Income: $1990 Airbnb ROI: 0.21% Traditional ROI: 3.87%
222 Saint Claire Dr Chillicothe, OH Experience easy living in this turn-key, three-story condo featuring two spacious bedrooms...	2 beds \| 1 baths \| 1,382 sq.ft.	$189,400	Airbnb cash on cash: -1.28% Traditional cash on cash: 5.3% Airbnb Rental Income: $915 Traditional Rental Income: $1757 Airbnb ROI: -1.28% Traditional ROI: 5.3%
35 Pickett Ct Chillicothe, OH Welcome to your BRAND NEW sanctuary! This stunning 3-bed, 2-bath haven in a vibrant commun...	3 beds \| 2 baths \| 1,484 sq.ft.	$369,900	Airbnb cash on cash: -0.89% Traditional cash on cash: 2.92% Airbnb Rental Income: $1028 Traditional Rental Income: $1989 Airbnb ROI: -0.89% Traditional ROI: 2.92%
90 E 2nd St Chillicothe, OH Step back in time with this stunning Victorian gem in the heart of downtown Chillicothe. T...	4 beds \| 2 baths \| 3,720 sq.ft.	$400,000	Airbnb cash on cash: -0.01% Traditional cash on cash: 2.79% Airbnb Rental Income: $966 Traditional Rental Income: $1664 Airbnb ROI: -0.01% Traditional ROI: 2.79%
1071 Marietta Rd Chillicothe, OH Come and visit the opportunity of a lifetime with this beautifully kept rustic barn that w...	4 beds \| 4 baths \| 2,550 sq.ft.	$550,000	Airbnb cash on cash: -0.28% Traditional cash on cash: 3.69% Airbnb Rental Income: $966 Traditional Rental Income: $2654 Airbnb ROI: -0.28% Traditional ROI: 3.69%
1271 Porter Dr. Chillicothe, OH Recently updated & available for immediate occupancy! Be sure to see this well-located 3 ...	3 beds \| 2 baths \| 1,390 sq.ft.	$269,000	Airbnb cash on cash: 0.45% Traditional cash on cash: 4.93% Airbnb Rental Income: $1028 Traditional Rental Income: $1803 Airbnb ROI: 0.45% Traditional ROI: 4.93%
9 Overlook Dr Chillicothe, OH Discover this rare mid-century modern home tucked on a quiet cul-de-sac with beautiful sun...	5 beds \| 3 baths \| 3,679 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.39% Airbnb Rental Income: $null Traditional Rental Income: $5964 Airbnb ROI: N/A Traditional ROI: 11.39%
245 Madeira Chillicothe, OH Welcome to 245 Madeira Ave, ideally located on a quiet no-outlet street close distance to ...	3 beds \| 1 baths \| 1,702 sq.ft.	$147,000	Airbnb cash on cash: 1.56% Traditional cash on cash: 6.89% Airbnb Rental Income: $1028 Traditional Rental Income: $1419 Airbnb ROI: 1.56% Traditional ROI: 6.89%
10217 County Road 550 Chillicothe, OH 10217 County Road 550, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 2,142 sq.ft.	$299,900	Airbnb cash on cash: -0.51% Traditional cash on cash: 1.07% Airbnb Rental Income: $1028 Traditional Rental Income: $1113 Airbnb ROI: -0.51% Traditional ROI: 1.07%
255 Caldwell St Chillicothe, OH Step into timeless charm with this beautiful historic 4-bedroom, 2-bath home, rich in char...	4 beds \| 2 baths \| 2,054 sq.ft.	$215,000	Airbnb cash on cash: 0.03% Traditional cash on cash: 7.49% Airbnb Rental Income: $966 Traditional Rental Income: $2137 Airbnb ROI: 0.03% Traditional ROI: 7.49%
16673 State Route 28 Chillicothe, OH 16673 State Route 28, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 2 baths \| 2,591 sq.ft.	$295,000	Airbnb cash on cash: -0.47% Traditional cash on cash: 3.58% Airbnb Rental Income: $1028 Traditional Rental Income: $1794 Airbnb ROI: -0.47% Traditional ROI: 3.58%
675 Allen Ave Chillicothe, OH 675 Allen Ave, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 2 baths \| 1,429 sq.ft.	$325,000	Airbnb cash on cash: -0.66% Traditional cash on cash: 1.74% Airbnb Rental Income: $1028 Traditional Rental Income: $1402 Airbnb ROI: -0.66% Traditional ROI: 1.74%
3272 Black Run Rd Chillicothe, OH 3272 Black Run Rd, Chillicothe, OH 45601 \| Other	N/A beds \| N/A baths \| N/A	$105,000	Airbnb cash on cash: 0.71% Traditional cash on cash: 0.57% Airbnb Rental Income: $734 Traditional Rental Income: $408 Airbnb ROI: 0.71% Traditional ROI: 0.57%
675 Cox Ave Chillicothe, OH 675 Cox Ave, Chillicothe, OH 45601 \| Single Family Residential	4 beds \| 1 baths \| 1,050 sq.ft.	$165,000	Airbnb cash on cash: 0.79% Traditional cash on cash: 3.24% Airbnb Rental Income: $966 Traditional Rental Income: $1002 Airbnb ROI: 0.79% Traditional ROI: 3.24%
94 Applewood Dr Chillicothe, OH 94 Applewood Dr, Chillicothe, OH 45601 \| Single Family Residential	5 beds \| 3 baths \| 1,516 sq.ft.	$479,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.44% Airbnb Rental Income: $null Traditional Rental Income: $1880 Airbnb ROI: N/A Traditional ROI: 1.44%
128 Maplewood Dr Chillicothe, OH 128 Maplewood Dr, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 2 baths \| 1,695 sq.ft.	$279,900	Airbnb cash on cash: -0.36% Traditional cash on cash: 3.16% Airbnb Rental Income: $1028 Traditional Rental Income: $1596 Airbnb ROI: -0.36% Traditional ROI: 3.16%
637 Vernon Dr Chillicothe, OH 637 Vernon Dr, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 1,056 sq.ft.	$258,000	Airbnb cash on cash: -0.18% Traditional cash on cash: 1.01% Airbnb Rental Income: $1028 Traditional Rental Income: $956 Airbnb ROI: -0.18% Traditional ROI: 1.01%
320 Summerhill Dr Chillicothe, OH 320 Summerhill Dr, Chillicothe, OH 45601 \| Single Family Residential	7 beds \| 3 baths \| N/A	$990,000	Airbnb cash on cash: N/A Traditional cash on cash: -0.28% Airbnb Rental Income: $null Traditional Rental Income: $2322 Airbnb ROI: N/A Traditional ROI: -0.28%

Real Estate investment in Chillicothe, OH

There are 136 properties for sale in the city of Chillicothe . The median list price in Chillicothe is $224,900 and the average price per square foot is $133. In March 2026, the average monthly cash on cash return in Chillicothe is 3.00%. The average monthly rental income in Chillicothe is $1,321.

Chillicothe, OH Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 136 investment properties available for sale in Chillicothe.

In 2026, the best neighborhood to buy investment property is Chillicothe.

The ROI for Short-Term is higher than the Long-Term in Chillicothe with average rental income of $966.

Your search for investment property begins and ends here

Investment Property for Sale in Chillicothe, OH

411 Church St

Chillicothe, OH

4 beds | 2 baths | 2,350 sq.ft.

$399,900

Airbnb cash on cash: -1.15%

Traditional cash on cash: 2.02%

Airbnb Rental Income: $966

Traditional Rental Income: $1806

Airbnb ROI: -1.15%

Traditional ROI: 2.02%

320 Vine St

Chillicothe, OH

2 beds | 1 baths | 1,188 sq.ft.

$182,000

Airbnb cash on cash: 0.24%

Traditional cash on cash: 3.67%

Airbnb Rental Income: $915

Traditional Rental Income: $1168

Airbnb ROI: 0.24%

Traditional ROI: 3.67%

726 Beechwood St

Chillicothe, OH

3 beds | 1 baths | 1,197 sq.ft.

$179,900

Airbnb cash on cash: 1.73%

Traditional cash on cash: 4.13%

Airbnb Rental Income: $1028

Traditional Rental Income: $1078

Airbnb ROI: 1.73%

Traditional ROI: 4.13%

760 E 4th St

Chillicothe, OH

3 beds | 2 baths | 1,120 sq.ft.

$175,000

Airbnb cash on cash: 2.07%

Traditional cash on cash: 4.99%

Airbnb Rental Income: $1028

Traditional Rental Income: $1155

Airbnb ROI: 2.07%

Traditional ROI: 4.99%

593 Cedar St

Chillicothe, OH

3 beds | 1 baths | 1,053 sq.ft.

$162,000

Airbnb cash on cash: 1.83%

Traditional cash on cash: 6.77%

Airbnb Rental Income: $1028

Traditional Rental Income: $1432

Airbnb ROI: 1.83%

Traditional ROI: 6.77%

3768 Musgrove Rd

Chillicothe, OH

3 beds | 2 baths | 1,456 sq.ft.

$321,900

Airbnb cash on cash: 0.79%

Traditional cash on cash: 3.9%

Airbnb Rental Income: $1028

Traditional Rental Income: $1607

Airbnb ROI: 0.79%

Traditional ROI: 3.9%

1303 SANDY RD

Chillicothe, OH

3 beds | 2 baths | 1,728 sq.ft.

$174,000

Airbnb cash on cash: 1.74%

Traditional cash on cash: 9.48%

Airbnb Rental Income: $1028

Traditional Rental Income: $1950

Airbnb ROI: 1.74%

Traditional ROI: 9.48%

5 Shawnee Dr

Chillicothe, OH

3 beds | 2 baths | 1,607 sq.ft.

$365,000

Airbnb cash on cash: -0.06%

Traditional cash on cash: 3.06%

Airbnb Rental Income: $1028

Traditional Rental Income: $1735

Airbnb ROI: -0.06%