Real Estate Investment Properties for Sale in Chillicothe, OH

Looking for investment property in Chillicothe, OH with high ROI ?

Explore a variety of short-term homes & houses in Chillicothe, OH. Invest wisely with VRBO & Chillicothe, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chillicothe, OH

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
395 Fyffe Hollow Road Chillicothe, OH Spacious ranch on scenic wooded lot; open living, dining and family rooms accented by woo...	3 beds \| 2 baths \| 2,240 sq.ft.	$285,000	Airbnb cash on cash: 3.84% Traditional cash on cash: 6.5% Airbnb Rental Income: $2076 Traditional Rental Income: $2255 Airbnb ROI: 3.84% Traditional ROI: 6.5%
1011 Lee Hollow Road Chillicothe, OH Very unique opportunity! Log cabin in the woods, on about 2.5 acress (3 parcels), PLUS a s...	1 beds \| 1 baths \| 728 sq.ft.	$150,000	Airbnb cash on cash: 2.54% Traditional cash on cash: 8.56% Airbnb Rental Income: $959 Traditional Rental Income: $1474 Airbnb ROI: 2.54% Traditional ROI: 8.56%
389-391 E 2nd Street #389 Chillicothe, OH Opportunity knocks with this beautiful maintained multi-family duplex located in the desir...	N/A beds \| N/A baths \| 1,480 sq.ft.	$179,900	Airbnb cash on cash: 1.16% Traditional cash on cash: 3.08% Airbnb Rental Income: $959 Traditional Rental Income: $938 Airbnb ROI: 1.16% Traditional ROI: 3.08%
1335 Mingo Road Chillicothe, OH Experience the perfect blend of comfort & nature at this private wooded retreat which offe...	4 beds \| 2 baths \| 1,536 sq.ft.	$337,500	Airbnb cash on cash: N/A Traditional cash on cash: 4.07% Airbnb Rental Income: $null Traditional Rental Income: $1903 Airbnb ROI: N/A Traditional ROI: 4.07%
503-505 E 2nd Street #503 Chillicothe, OH *Seller is offering $5,000 credit towards buyer closing costs* Situated conveniently i...	N/A beds \| N/A baths \| N/A	$135,000	Airbnb cash on cash: 0.48% Traditional cash on cash: 8.39% Airbnb Rental Income: $790 Traditional Rental Income: $1494 Airbnb ROI: 0.48% Traditional ROI: 8.39%
1959 Chapel Creek Road Chillicothe, OH MOTIVATED SELLER!!! Welcome to 1959 Chapel Creek Road, a charming two-story all electric h...	3 beds \| 3 baths \| 2,068 sq.ft.	$289,000	Airbnb cash on cash: 3.44% Traditional cash on cash: 6.27% Airbnb Rental Income: $2076 Traditional Rental Income: $2312 Airbnb ROI: 3.44% Traditional ROI: 6.27%
3040 Seney Road #912 Chillicothe, OH Absolutely perfect home for the wood worker, car collector or tradesman who needs a very c...	3 beds \| 2 baths \| 1,940 sq.ft.	$439,888	Airbnb cash on cash: 1.93% Traditional cash on cash: 3.31% Airbnb Rental Income: $2076 Traditional Rental Income: $2107 Airbnb ROI: 1.93% Traditional ROI: 3.31%
2680 Biers Run Rd Road Chillicothe, OH Motivated Sellers! Welcome to your dream home! Set back from the road for added privacy, c...	4 beds \| 3 baths \| 2,768 sq.ft.	$565,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.29% Airbnb Rental Income: $null Traditional Rental Income: $2748 Airbnb ROI: N/A Traditional ROI: 3.29%
485 Springer Road Chillicothe, OH Picture this... A real LOG CABIN, nestled at the back of 9.7 acres surrounded by woods and...	2 beds \| 1 baths \| 632 sq.ft.	$299,900	Airbnb cash on cash: 1.88% Traditional cash on cash: 2.72% Airbnb Rental Income: $1344 Traditional Rental Income: $1168 Airbnb ROI: 1.88% Traditional ROI: 2.72%
4557 State Route 159 Chillicothe, OH Discover a unique opportunity in Green Township with this versatile two-parcel property to...	3 beds \| 3 baths \| 3,909 sq.ft.	$749,900	Airbnb cash on cash: 0.77% Traditional cash on cash: 1.61% Airbnb Rental Income: $2076 Traditional Rental Income: $2129 Airbnb ROI: 0.77% Traditional ROI: 1.61%
368 Mingo Road Chillicothe, OH Discover this stunning 15.64 wooded acres featuring a spacious 4-bedroom, 2-bathroom home....	4 beds \| 2 baths \| 1,968 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.82% Airbnb Rental Income: $null Traditional Rental Income: $2301 Airbnb ROI: N/A Traditional ROI: 6.82%
3857 US Highway 23 Chillicothe, OH Here is your chance to live on 33+ wooded acres. This stunning 3 bed 2 bath home is a slic...	3 beds \| 2 baths \| 2,835 sq.ft.	$474,900	Airbnb cash on cash: 1.67% Traditional cash on cash: 3.31% Airbnb Rental Income: $2076 Traditional Rental Income: $2269 Airbnb ROI: 1.67% Traditional ROI: 3.31%
1230 Polk Hollow Road Chillicothe, OH Come experience your perfect country getaway! Situated on 3 acres of land, this charming h...	3 beds \| 2 baths \| 1,516 sq.ft.	$325,000	Airbnb cash on cash: 3.25% Traditional cash on cash: 4.15% Airbnb Rental Income: $2076 Traditional Rental Income: $1816 Airbnb ROI: 3.25% Traditional ROI: 4.15%
299 N High Street Chillicothe, OH Investor opportunity in the heart of Chillicothe. This 5-bedroom, 3-bath home is mid-renov...	5 beds \| 3 baths \| 2,292 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.36% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 10.36%
1857 Patton Hill Road Chillicothe, OH New Roof August 2025 See updated pictures Come check out this beautifully updated 4...	4 beds \| 2 baths \| 1,200 sq.ft.	$279,999	Airbnb cash on cash: N/A Traditional cash on cash: 4.83% Airbnb Rental Income: $null Traditional Rental Income: $1845 Airbnb ROI: N/A Traditional ROI: 4.83%
629 W 5th Street Chillicothe, OH This 3-bedroom, 2-bath home offers a solid, spacious floor plan in a well-established neig...	3 beds \| 2 baths \| 1,855 sq.ft.	$349,000	Airbnb cash on cash: 2.62% Traditional cash on cash: 4.36% Airbnb Rental Income: $2076 Traditional Rental Income: $2112 Airbnb ROI: 2.62% Traditional ROI: 4.36%
213 Sulphur Spring Road Chillicothe, OH This unique 4,336 sq ft home is set on 3.72 scenic acres with shared pond & offers excepti...	3 beds \| 3 baths \| 4,336 sq.ft.	$625,000	Airbnb cash on cash: 0.78% Traditional cash on cash: 2.57% Airbnb Rental Income: $2076 Traditional Rental Income: $2585 Airbnb ROI: 0.78% Traditional ROI: 2.57%
14933 US Highway 50 Chillicothe, OH Character Galore! Beautiful farm house with original wood work , wood burning fireplace, a...	3 beds \| 2 baths \| 1,840 sq.ft.	$289,995	Airbnb cash on cash: 3.91% Traditional cash on cash: 6.97% Airbnb Rental Income: $2076 Traditional Rental Income: $2377 Airbnb ROI: 3.91% Traditional ROI: 6.97%
215 W 2nd Street Chillicothe, OH Welcome to this beautifully maintained 4-bedroom, 1.5-bath home on the edge of historic Ch...	4 beds \| 2 baths \| 2,916 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.29% Airbnb Rental Income: $null Traditional Rental Income: $2388 Airbnb ROI: N/A Traditional ROI: 7.29%
7178 State Route 159 Chillicothe, OH Cozy 3 bedroom, 1 full bath home nestled on 6 beautiful acres, offering both privacy and c...	3 beds \| 1 baths \| 1,304 sq.ft.	$275,000	Airbnb cash on cash: 4.06% Traditional cash on cash: 3.62% Airbnb Rental Income: $2076 Traditional Rental Income: $1427 Airbnb ROI: 4.06% Traditional ROI: 3.62%
29 Applewood Drive Chillicothe, OH Well-maintained and updated throughout, this spacious 3-bedroom, 2.5-bath home offers stun...	3 beds \| 3 baths \| 3,063 sq.ft.	$314,900	Airbnb cash on cash: 2.79% Traditional cash on cash: 6.77% Airbnb Rental Income: $2076 Traditional Rental Income: $2721 Airbnb ROI: 2.79% Traditional ROI: 6.77%
194 Plyleys Lane Chillicothe, OH Welcome to this charming west side ranch-style home, ideally located near shopping, dining...	3 beds \| 1 baths \| 1,050 sq.ft.	$184,900	Airbnb cash on cash: 6.4% Traditional cash on cash: 3.85% Airbnb Rental Income: $2076 Traditional Rental Income: $1093 Airbnb ROI: 6.4% Traditional ROI: 3.85%
1323 Alum Cliff Road Chillicothe, OH Escape to this one-of-a-kind cabin retreat on 2 acres along Paint Creek! Whether you're se...	2 beds \| 1 baths \| 672 sq.ft.	$199,000	Airbnb cash on cash: 3.19% Traditional cash on cash: 4.32% Airbnb Rental Income: $1344 Traditional Rental Income: $1143 Airbnb ROI: 3.19% Traditional ROI: 4.32%
299 High Street Chillicothe, OH Investor opportunity in the heart of Chillicothe. This 5-bedroom, 3-bath home is mid-renov...	5 beds \| 3 baths \| 2,292 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.31% Airbnb Rental Income: $null Traditional Rental Income: $2611 Airbnb ROI: N/A Traditional ROI: 10.31%
629 Fifth Street Chillicothe, OH This 3-bedroom, 2-bath home offers a solid, spacious floor plan in a well-established neig...	3 beds \| 2 baths \| 3,092 sq.ft.	$349,000	Airbnb cash on cash: 2.62% Traditional cash on cash: 5.16% Airbnb Rental Income: $2076 Traditional Rental Income: $2374 Airbnb ROI: 2.62% Traditional ROI: 5.16%
100 Camelin Hill Road Chillicothe, OH Visit the cozy front porch, the updated interiors and exterior and a glimpse of that expan...	3 beds \| 1 baths \| 1,248 sq.ft.	$258,500	Airbnb cash on cash: 4.58% Traditional cash on cash: 4.31% Airbnb Rental Income: $2076 Traditional Rental Income: $1473 Airbnb ROI: 4.58% Traditional ROI: 4.31%
178 Applewood Drive Chillicothe, OH Exceptional custom-built home in Hesswood Hills offering 5 bedrooms, 3 full baths, and lar...	5 beds \| 3 baths \| 2,954 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.82% Airbnb Rental Income: $null Traditional Rental Income: $2775 Airbnb ROI: N/A Traditional ROI: 3.82%
95 Walnut Street, S. Chillicothe, OH Charming home in the Historic Downtown District-tons of potential! 3 bedrooms, 2 baths. Fe...	3 beds \| 2 baths \| 1,862 sq.ft.	$165,000	Airbnb cash on cash: 7.67% Traditional cash on cash: 9.99% Airbnb Rental Income: $2076 Traditional Rental Income: $1906 Airbnb ROI: 7.67% Traditional ROI: 9.99%
268 Clayburne Blvd. Chillicothe, OH Charming Cape Cod Home with In-Law Suite \| 4 Bed \| 3.5 Bath \| Bonus Room , Office Nestled ...	4 beds \| 4 baths \| 1,764 sq.ft.	$375,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.21% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 4.21%
12690 Pleasant Valley Road Chillicothe, OH Discover the Untapped Potential of 12690 Pleasant Valley Rd. This 1,840 sq ft. two-story r...	3 beds \| 1 baths \| 1,840 sq.ft.	$128,900	Airbnb cash on cash: 9.15% Traditional cash on cash: 8.14% Airbnb Rental Income: $2076 Traditional Rental Income: $1416 Airbnb ROI: 9.15% Traditional ROI: 8.14%
2275 Rozelle Creek Chillicothe, OH Spacious 3BR/2BA Home on Over 8 Acres with Outbuildings This beautifully converted double...	3 beds \| 2 baths \| 1,242 sq.ft.	$310,000	Airbnb cash on cash: 3.31% Traditional cash on cash: 4.11% Airbnb Rental Income: $2076 Traditional Rental Income: $1772 Airbnb ROI: 3.31% Traditional ROI: 4.11%
4 John Street Chillicothe, OH One owner condo was the model home for Phase of 3 Rosewood villas. Nice area as you walk ...	2 beds \| 2 baths \| 1,344 sq.ft.	$244,900	Airbnb cash on cash: 1.09% Traditional cash on cash: 4.63% Airbnb Rental Income: $1344 Traditional Rental Income: $1751 Airbnb ROI: 1.09% Traditional ROI: 4.63%
25 Woodland Way Chillicothe, OH This stunning split-level 3-4 bedroom, 3-bathroom home is located in a neighborhood on a d...	3 beds \| 3 baths \| 2,254 sq.ft.	$399,000	Airbnb cash on cash: 2.37% Traditional cash on cash: 5.02% Airbnb Rental Income: $2076 Traditional Rental Income: $2533 Airbnb ROI: 2.37% Traditional ROI: 5.02%
114 Eastview Drive Chillicothe, OH Discover this charming 3-bedroom, 1.5-bath home at the bottom of Hesswood Hill, offering g...	3 beds \| 2 baths \| 1,015 sq.ft.	$245,000	Airbnb cash on cash: 3.71% Traditional cash on cash: 3.45% Airbnb Rental Income: $2076 Traditional Rental Income: $1479 Airbnb ROI: 3.71% Traditional ROI: 3.45%
59 Limestone Blvd. Chillicothe, OH This stunning 5-bedroom, 3-bath home features new high-definition plank flooring throughou...	5 beds \| 3 baths \| 1,776 sq.ft.	$325,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.81% Airbnb Rental Income: $null Traditional Rental Income: $2408 Airbnb ROI: N/A Traditional ROI: 5.81%
559 Golfview Drive Chillicothe, OH Move-in ready 2-story home in the desirable Golfview neighborhood featuring 3 bedrooms, 2....	3 beds \| 3 baths \| 1,864 sq.ft.	$420,000	Airbnb cash on cash: 2.06% Traditional cash on cash: 3.93% Airbnb Rental Income: $2076 Traditional Rental Income: $2276 Airbnb ROI: 2.06% Traditional ROI: 3.93%
11524 US Highway 50 Chillicothe, OH Welcome to this charming two-story home that perfectly blends comfort and style. Boasting...	4 beds \| 1 baths \| 1,671 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.44% Airbnb Rental Income: $null Traditional Rental Income: $1557 Airbnb ROI: N/A Traditional ROI: 4.44%
618 E 2nd Street Chillicothe, OH Charming and renovated 2BR/1BA home featuring modern accents throughout! Enjoy a spacious ...	2 beds \| 1 baths \| 1,391 sq.ft.	$179,900	Airbnb cash on cash: 3.69% Traditional cash on cash: 6.52% Airbnb Rental Income: $1344 Traditional Rental Income: $1415 Airbnb ROI: 3.69% Traditional ROI: 6.52%
1303 SANDY RD Chillicothe, OH Invest with success and buy through Auction.com. This bank-owned investment property is a ...	3 beds \| 2 baths \| 1,728 sq.ft.	$174,000	Airbnb cash on cash: 7.01% Traditional cash on cash: 9.48% Airbnb Rental Income: $2076 Traditional Rental Income: $1950 Airbnb ROI: 7.01% Traditional ROI: 9.48%
16 Turnberry Lane Chillicothe, OH Spacious 5-bedroom, 4-bath home offering over 3,400 square feet of comfortable living spac...	5 beds \| 4 baths \| 2,598 sq.ft.	$499,999	Airbnb cash on cash: N/A Traditional cash on cash: 4.32% Airbnb Rental Income: $null Traditional Rental Income: $2999 Airbnb ROI: N/A Traditional ROI: 4.32%

Real Estate investment in Chillicothe, OH

There are 49 properties for sale in the city of Chillicothe . The median list price in Chillicothe is $277,500 and the average price per square foot is $143. In September 2025, the average monthly cash on cash return in Chillicothe is 5.00%. The average monthly rental income in Chillicothe is $2,110.

Chillicothe, OH Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 49 investment properties available for sale in Chillicothe.

In 2025, the best neighborhood to buy investment property is Chillicothe.

The ROI for Long-Term is higher than the Short-Term in Chillicothe with average rental income of $2,110.

Your search for investment property begins and ends here

Investment Property for Sale in Chillicothe, OH

395 Fyffe Hollow Road

Chillicothe, OH

3 beds | 2 baths | 2,240 sq.ft.

$285,000

Airbnb cash on cash: 3.84%

Traditional cash on cash: 6.5%

Airbnb Rental Income: $2076

Traditional Rental Income: $2255

Airbnb ROI: 3.84%

Traditional ROI: 6.5%

1011 Lee Hollow Road

Chillicothe, OH

1 beds | 1 baths | 728 sq.ft.

$150,000

Airbnb cash on cash: 2.54%

Traditional cash on cash: 8.56%

Airbnb Rental Income: $959

Traditional Rental Income: $1474

Airbnb ROI: 2.54%

Traditional ROI: 8.56%

389-391 E 2nd Street #389

Chillicothe, OH

N/A beds | N/A baths | 1,480 sq.ft.

$179,900

Airbnb cash on cash: 1.16%

Traditional cash on cash: 3.08%

Airbnb Rental Income: $959

Traditional Rental Income: $938

Airbnb ROI: 1.16%

Traditional ROI: 3.08%

1335 Mingo Road

Chillicothe, OH

4 beds | 2 baths | 1,536 sq.ft.

$337,500

Airbnb cash on cash: N/A

Traditional cash on cash: 4.07%

Airbnb Rental Income: $null

Traditional Rental Income: $1903

Airbnb ROI: N/A

Traditional ROI: 4.07%

503-505 E 2nd Street #503

Chillicothe, OH

N/A beds | N/A baths | N/A

$135,000

Airbnb cash on cash: 0.48%

Traditional cash on cash: 8.39%

Airbnb Rental Income: $790

Traditional Rental Income: $1494

Airbnb ROI: 0.48%

Traditional ROI: 8.39%

1959 Chapel Creek Road

Chillicothe, OH

3 beds | 3 baths | 2,068 sq.ft.

$289,000

Airbnb cash on cash: 3.44%

Traditional cash on cash: 6.27%

Airbnb Rental Income: $2076

Traditional Rental Income: $2312

Airbnb ROI: 3.44%

Traditional ROI: 6.27%

3040 Seney Road #912

Chillicothe, OH

3 beds | 2 baths | 1,940 sq.ft.

$439,888

Airbnb cash on cash: 1.93%

Traditional cash on cash: 3.31%

Airbnb Rental Income: $2076

Traditional Rental Income: $2107

Airbnb ROI: 1.93%

Traditional ROI: 3.31%

2680 Biers Run Rd Road

Chillicothe, OH

4 beds | 3 baths | 2,768 sq.ft.

$565,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3.29%

Airbnb Rental Income: $null

Traditional Rental Income: $2748

Airbnb ROI: N/A