Real Estate Investment Properties for Sale in Chillicothe, OH

Looking for investment property in Chillicothe, OH with high ROI ?

Explore a variety of short-term homes & houses in Chillicothe, OH. Invest wisely with VRBO & Chillicothe, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chillicothe, OH

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
411 Church St Chillicothe, OH Spacious German brick home with large rooms throughout. Two closed fireplaces, wood floor...	4 beds \| 2 baths \| 2,350 sq.ft.	$399,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.02% Airbnb Rental Income: $null Traditional Rental Income: $1806 Airbnb ROI: N/A Traditional ROI: 2.02%
631 Cherokee Rd Chillicothe, OH This one and a half story home located in Chillicothe's Story Place will charm you with it...	2 beds \| 2 baths \| 1,170 sq.ft.	$254,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.27% Airbnb Rental Income: $null Traditional Rental Income: $1245 Airbnb ROI: N/A Traditional ROI: 2.27%
187 Madeira Ave Chillicothe, OH Walking distance to Downtown Chillicothe, the Historic District and Poland Park!! This h...	2 beds \| 1 baths \| 1,512 sq.ft.	$129,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.7% Airbnb Rental Income: $null Traditional Rental Income: $1120 Airbnb ROI: N/A Traditional ROI: 5.7%
1303 SANDY RD Chillicothe, OH Invest with success and buy through Auction.com. This bank-owned investment property is a ...	3 beds \| 2 baths \| 1,728 sq.ft.	$174,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.48% Airbnb Rental Income: $null Traditional Rental Income: $1950 Airbnb ROI: N/A Traditional ROI: 9.48%
15 Shawnee Dr Chillicothe, OH Nestled in the highly desirable Brewer Heights neighborhood, 15 Shawnee Drive is perfect f...	3 beds \| 2 baths \| 1,840 sq.ft.	$369,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.24% Airbnb Rental Income: $null Traditional Rental Income: $1750 Airbnb ROI: N/A Traditional ROI: 3.24%
194 Plyleys Ln Chillicothe, OH $179,900 - Reduced! Move-in-ready 3 bed, 1 bath ranch with large eat-in kitchen and functi...	3 beds \| 1 baths \| 1,050 sq.ft.	$179,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.98% Airbnb Rental Income: $null Traditional Rental Income: $1093 Airbnb ROI: N/A Traditional ROI: 3.98%
11524 US Highway 50 Chillicothe, OH Welcome to this charming two-story home that perfectly blends comfort and style. Boasting ...	4 beds \| 1 baths \| 1,671 sq.ft.	$249,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.99% Airbnb Rental Income: $null Traditional Rental Income: $1557 Airbnb ROI: N/A Traditional ROI: 4.99%
20702 N US Highway 23 Chillicothe, OH One-of-a-Kind Estate Featuring Ohio's Largest Private Indoor Pool! Welcome to 20702 US Hig...	2 beds \| 5 baths \| 8,195 sq.ft.	$1,300,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.14% Airbnb Rental Income: $null Traditional Rental Income: $3876 Airbnb ROI: N/A Traditional ROI: 1.14%
1667 Stone Rd Lot 59 Chillicothe, OH Wow-so much space! This newer doublewide features 5 bedrooms and 3 full baths with an open...	5 beds \| 3 baths \| 2,040 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $2524 Airbnb ROI: N/A Traditional ROI: 7.81%
90 2nd St Chillicothe, OH Step back in time with this stunning Victorian gem in the heart of downtown Chillicothe. T...	4 beds \| 2 baths \| 3,720 sq.ft.	$400,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.87% Airbnb Rental Income: $null Traditional Rental Income: $1990 Airbnb ROI: N/A Traditional ROI: 3.87%
20 Club Dr Chillicothe, OH Welcome to 20 Club Drive an inviting 4-bed, 3.5-bath home in one of Chillicothe's most des...	4 beds \| 3 baths \| 2,486 sq.ft.	$349,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.09% Airbnb Rental Income: $null Traditional Rental Income: $3106 Airbnb ROI: N/A Traditional ROI: 7.09%
35 Pickett Ct Chillicothe, OH Welcome to your BRAND NEW sanctuary! This stunning 3-bed, 2-bath haven in a vibrant commun...	3 beds \| 2 baths \| 1,484 sq.ft.	$389,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.64% Airbnb Rental Income: $null Traditional Rental Income: $1989 Airbnb ROI: N/A Traditional ROI: 2.64%
1271 Porter Dr. Chillicothe, OH Recently updated & available for immediate occupancy! Be sure to see this well-located 3 ...	3 beds \| 2 baths \| 1,390 sq.ft.	$269,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.93% Airbnb Rental Income: $null Traditional Rental Income: $1803 Airbnb ROI: N/A Traditional ROI: 4.93%
245 Madeira Chillicothe, OH Welcome to 245 Madeira Ave, ideally located on a quiet no-outlet street close distance to ...	3 beds \| 1 baths \| 1,702 sq.ft.	$147,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.89% Airbnb Rental Income: $null Traditional Rental Income: $1419 Airbnb ROI: N/A Traditional ROI: 6.89%
10217 County Road 550 Chillicothe, OH 10217 County Road 550, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 2,142 sq.ft.	$314,900	Airbnb cash on cash: N/A Traditional cash on cash: 0.9% Airbnb Rental Income: $null Traditional Rental Income: $1113 Airbnb ROI: N/A Traditional ROI: 0.9%
16673 State Route 28 Chillicothe, OH 16673 State Route 28, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 2 baths \| 2,591 sq.ft.	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.2% Airbnb Rental Income: $null Traditional Rental Income: $1794 Airbnb ROI: N/A Traditional ROI: 3.2%
675 Allen Ave Chillicothe, OH 675 Allen Ave, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 2 baths \| 1,429 sq.ft.	$325,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.74% Airbnb Rental Income: $null Traditional Rental Income: $1402 Airbnb ROI: N/A Traditional ROI: 1.74%
675 Cox Ave Chillicothe, OH 675 Cox Ave, Chillicothe, OH 45601 \| Single Family Residential	4 beds \| 1 baths \| 1,050 sq.ft.	$165,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.24% Airbnb Rental Income: $null Traditional Rental Income: $1002 Airbnb ROI: N/A Traditional ROI: 3.24%
94 Applewood Dr Chillicothe, OH 94 Applewood Dr, Chillicothe, OH 45601 \| Single Family Residential	5 beds \| 3 baths \| 1,516 sq.ft.	$479,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.44% Airbnb Rental Income: $null Traditional Rental Income: $1880 Airbnb ROI: N/A Traditional ROI: 1.44%
657 E 2nd St Chillicothe, OH 657 E 2nd St, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 1,432 sq.ft.	$169,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.53% Airbnb Rental Income: $null Traditional Rental Income: $1075 Airbnb ROI: N/A Traditional ROI: 3.53%
23 Shawnee Dr Chillicothe, OH 23 Shawnee Dr, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 1,283 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.04% Airbnb Rental Income: $null Traditional Rental Income: $1280 Airbnb ROI: N/A Traditional ROI: 2.04%
42 Warner Ave Chillicothe, OH 42 Warner Ave, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 924 sq.ft.	$154,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.91% Airbnb Rental Income: $null Traditional Rental Income: $898 Airbnb ROI: N/A Traditional ROI: 2.91%
965 Graves Rd Chillicothe, OH 965 Graves Rd, Chillicothe, OH 45601 \| Other	N/A beds \| N/A baths \| N/A	$114,900	Airbnb cash on cash: N/A Traditional cash on cash: 0.17% Airbnb Rental Income: $null Traditional Rental Income: $391 Airbnb ROI: N/A Traditional ROI: 0.17%
535 Cedar St Chillicothe, OH 535 Cedar St, Chillicothe, OH 45601 \| Single Family Residential	3 beds \| 1 baths \| 1,472 sq.ft.	$189,999	Airbnb cash on cash: N/A Traditional cash on cash: 2.9% Airbnb Rental Income: $null Traditional Rental Income: $1075 Airbnb ROI: N/A Traditional ROI: 2.9%

Real Estate investment in Chillicothe, OH

There are 107 properties for sale in the city of Chillicothe . The median list price in Chillicothe is $199,900 and the average price per square foot is $120. In February 2026, the average monthly cash on cash return in Chillicothe is 3.00%. The average monthly rental income in Chillicothe is $1,222.

Chillicothe, OH Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 107 investment properties available for sale in Chillicothe.

In 2026, the best neighborhood to buy investment property is Chillicothe.

The ROI for Short-Term is higher than the Long-Term in Chillicothe with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Chillicothe, OH

411 Church St

Chillicothe, OH

4 beds | 2 baths | 2,350 sq.ft.

$399,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.02%

Airbnb Rental Income: $null

Traditional Rental Income: $1806

Airbnb ROI: N/A

Traditional ROI: 2.02%

631 Cherokee Rd

Chillicothe, OH

2 beds | 2 baths | 1,170 sq.ft.

$254,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.27%

Airbnb Rental Income: $null

Traditional Rental Income: $1245

Airbnb ROI: N/A

Traditional ROI: 2.27%

187 Madeira Ave

Chillicothe, OH

2 beds | 1 baths | 1,512 sq.ft.

$129,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.7%

Airbnb Rental Income: $null

Traditional Rental Income: $1120

Airbnb ROI: N/A

Traditional ROI: 5.7%

1303 SANDY RD

Chillicothe, OH

3 beds | 2 baths | 1,728 sq.ft.

$174,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.48%

Airbnb Rental Income: $null

Traditional Rental Income: $1950

Airbnb ROI: N/A

Traditional ROI: 9.48%

15 Shawnee Dr

Chillicothe, OH

3 beds | 2 baths | 1,840 sq.ft.

$369,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.24%

Airbnb Rental Income: $null

Traditional Rental Income: $1750

Airbnb ROI: N/A

Traditional ROI: 3.24%

194 Plyleys Ln

Chillicothe, OH

3 beds | 1 baths | 1,050 sq.ft.

$179,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.98%

Airbnb Rental Income: $null

Traditional Rental Income: $1093

Airbnb ROI: N/A

Traditional ROI: 3.98%

11524 US Highway 50

Chillicothe, OH

4 beds | 1 baths | 1,671 sq.ft.

$249,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.99%

Airbnb Rental Income: $null

Traditional Rental Income: $1557

Airbnb ROI: N/A

Traditional ROI: 4.99%

20702 N US Highway 23

Chillicothe, OH

2 beds | 5 baths | 8,195 sq.ft.

$1,300,000

Airbnb cash on cash: N/A

Traditional cash on cash: 1.14%

Airbnb Rental Income: $null

Traditional Rental Income: $3876

Airbnb ROI: N/A