Real Estate Investment Properties for Sale in Chillicothe, OH

Looking for investment property in Chillicothe, OH with high ROI ?

Explore a variety of short-term homes & houses in Chillicothe, OH. Invest wisely with VRBO & Chillicothe, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Single Family Homes for Sale in Chillicothe, OH

Search for Single Family Residential for Sale in Chillicothe, Ohio. Browse all of Mashvisor’s Single Family Residential listings and other investment property types including Single Family Homes, Multi Family Homes, Condos, Townhouses and Other Homes.

Showing 31 Single Family Residential listings of over 500,000 total investment properties for sale. Visit Mashvisor.com to all investment properties.

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
320 Hough Road Chillicothe, OH Welcome to 320 Hough Rd! This well-kept 3 bedroom, 2 full bath home sits on 1 acre, offeri...	3 beds \| 2 baths \| 2,240 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.51% Airbnb Rental Income: $null Traditional Rental Income: $2240 Airbnb ROI: N/A Traditional ROI: 9.51%
14220 State Route 772 Chillicothe, OH Welcome to this 4 bedroom, 2.5 bathroom. raised ranch retreat just three minutes from down...	4 beds \| 2 baths \| 3,296 sq.ft.	$449,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.21% Airbnb Rental Income: $null Traditional Rental Income: $2647 Airbnb ROI: N/A Traditional ROI: 4.21%
1303 SANDY RD Chillicothe, OH Invest with success and buy through Auction.com. This bank-owned investment property is a ...	3 beds \| 2 baths \| 1,728 sq.ft.	$174,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.48% Airbnb Rental Income: $null Traditional Rental Income: $1950 Airbnb ROI: N/A Traditional ROI: 9.48%
239 Almahurst Drive Chillicothe, OH Welcome to this beautifully updated 3,804 sq ft home featuring 4 bedrooms and 2 full/2 hal...	4 beds \| 4 baths \| 3,804 sq.ft.	$480,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.5% Airbnb Rental Income: $null Traditional Rental Income: $2961 Airbnb ROI: N/A Traditional ROI: 4.5%
194 Plyleys Lane Chillicothe, OH ***New photos just added-home is now empty and ready for your personal touch! Plus, enjoy ...	3 beds \| 1 baths \| 1,050 sq.ft.	$183,900	Airbnb cash on cash: N/A Traditional cash on cash: 3.88% Airbnb Rental Income: $null Traditional Rental Income: $1093 Airbnb ROI: N/A Traditional ROI: 3.88%
631 Orange Street Chillicothe, OH Owner Needs an Offer! Great first home or for downsizing! Has large yard, part of it fen...	2 beds \| 1 baths \| 845 sq.ft.	$189,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.8% Airbnb Rental Income: $null Traditional Rental Income: $1056 Airbnb ROI: N/A Traditional ROI: 2.8%
1011 Lee Hollow Road Chillicothe, OH Very unique opportunity! Log cabin in the woods, on about 2.5 acress (3 parcels), PLUS a s...	1 beds \| 1 baths \| 728 sq.ft.	$150,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.56% Airbnb Rental Income: $null Traditional Rental Income: $1474 Airbnb ROI: N/A Traditional ROI: 8.56%
14933 US Highway 50 Chillicothe, OH Character Galore! Beautiful farm house with original wood work , wood burning fireplace, a...	3 beds \| 2 baths \| 1,840 sq.ft.	$259,995	Airbnb cash on cash: N/A Traditional cash on cash: 7.87% Airbnb Rental Income: $null Traditional Rental Income: $2377 Airbnb ROI: N/A Traditional ROI: 7.87%
178 Applewood Drive Chillicothe, OH Exceptional custom-built home in Hesswood Hills offering 5 bedrooms, 3 full baths, and lar...	5 beds \| 3 baths \| 2,954 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.82% Airbnb Rental Income: $null Traditional Rental Income: $2775 Airbnb ROI: N/A Traditional ROI: 3.82%
485 Springer Road Chillicothe, OH Picture this... A real LOG CABIN, nestled at the back of 5 acres surrounded by woods and p...	3 beds \| 1 baths \| 632 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.44% Airbnb Rental Income: $null Traditional Rental Income: $1168 Airbnb ROI: N/A Traditional ROI: 3.44%
308 Oak Lane Chillicothe, OH Don't miss this well cared for brick ranch with 3 bedrooms, 2 full baths and partially fin...	3 beds \| 2 baths \| 1,325 sq.ft.	$309,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.94% Airbnb Rental Income: $null Traditional Rental Income: $1688 Airbnb ROI: N/A Traditional ROI: 2.94%
1857 Patton Hill Road Chillicothe, OH New Roof August 2025 See updated pictures Come check out this beautifully updated 4 be...	4 beds \| 2 baths \| 1,200 sq.ft.	$269,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.04% Airbnb Rental Income: $null Traditional Rental Income: $1845 Airbnb ROI: N/A Traditional ROI: 5.04%
299 N High Street Chillicothe, OH Investor opportunity in the heart of Chillicothe. This 5-bedroom, 3-bath home is mid-renov...	5 beds \| 3 baths \| 2,292 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.12% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 11.12%
4557 State Route 159 Chillicothe, OH Discover a unique opportunity in Green Township with 5.12 acres and no zoning restrictions...	3 beds \| 3 baths \| 3,909 sq.ft.	$525,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.71% Airbnb Rental Income: $null Traditional Rental Income: $2129 Airbnb ROI: N/A Traditional ROI: 2.71%
7178 State Route 159 Chillicothe, OH Cozy 3 bedroom, 1 full bath home nestled on 6 beautiful acres, offering both privacy and c...	3 beds \| 1 baths \| 1,304 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.08% Airbnb Rental Income: $null Traditional Rental Income: $1427 Airbnb ROI: N/A Traditional ROI: 4.08%
20702 N US Highway 23 Chillicothe, OH One-of-a-Kind Estate Featuring Ohio's Largest Private Indoor Pool! Welcome to 20702 US Hig...	2 beds \| 5 baths \| 8,195 sq.ft.	$1,300,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.14% Airbnb Rental Income: $null Traditional Rental Income: $3876 Airbnb ROI: N/A Traditional ROI: 1.14%
1456 Debord Road Chillicothe, OH Newly built retreat with 13.24 acres. Located in the beautiful, southern hills of Ross Cou...	3 beds \| 2 baths \| 1,250 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.5% Airbnb Rental Income: $null Traditional Rental Income: $1799 Airbnb ROI: N/A Traditional ROI: 1.5%
265 N High Street Chillicothe, OH Check out this charming craftsman style home with 5 bedrooms, 2 bathrooms, refinished hard...	5 beds \| 2 baths \| 1,912 sq.ft.	$209,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.89% Airbnb Rental Income: $null Traditional Rental Income: $2582 Airbnb ROI: N/A Traditional ROI: 10.89%
17 Briarcliff Drive Chillicothe, OH Luxurious and Spacious Custom Built Home situated on a large corner lot in Hesswood Hills....	4 beds \| 4 baths \| 4,382 sq.ft.	$429,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.22% Airbnb Rental Income: $null Traditional Rental Income: $3047 Airbnb ROI: N/A Traditional ROI: 5.22%
90 2ND ST Chillicothe, OH Step back in time with this stunning Victorian gem in the heart of downtown Chillicothe. T...	4 beds \| 2 baths \| 3,720 sq.ft.	$430,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.54% Airbnb Rental Income: $null Traditional Rental Income: $1990 Airbnb ROI: N/A Traditional ROI: 3.54%
184 E 7TH ST Chillicothe, OH This 3-bedroom, 1-bath home offers great potential for those looking to invest in a proper...	3 beds \| 1 baths \| 1,310 sq.ft.	$106,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.51% Airbnb Rental Income: $null Traditional Rental Income: $1541 Airbnb ROI: N/A Traditional ROI: 11.51%
258 Logan View Drive Chillicothe, OH Welcome home to this beautifully updated three-bedroom, one-level home offering effortless...	3 beds \| 1 baths \| 1,128 sq.ft.	$249,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.29% Airbnb Rental Income: $null Traditional Rental Income: $1442 Airbnb ROI: N/A Traditional ROI: 4.29%
20 Club Drive Chillicothe, OH Welcome to 20 Club Drive an inviting 4-bed, 3.5-bath home in one of Chillicothe's most des...	4 beds \| 4 baths \| 1,865 sq.ft.	$349,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.09% Airbnb Rental Income: $null Traditional Rental Income: $3106 Airbnb ROI: N/A Traditional ROI: 7.09%
35 Pickett Court Chillicothe, OH OPEN HOUSE SUNDAY, NOVEMBER 30th FROM 11 - 3! Welcome to your BRAND NEW sanctuary! This s...	3 beds \| 2 baths \| 1,484 sq.ft.	$399,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.51% Airbnb Rental Income: $null Traditional Rental Income: $1989 Airbnb ROI: N/A Traditional ROI: 2.51%
2956 Egypt Pike Chillicothe, OH For those who appreciate privacy and the great outdoors, welcome to 2956 Egypt Pike, a per...	3 beds \| 2 baths \| 2,538 sq.ft.	$325,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.25% Airbnb Rental Income: $null Traditional Rental Income: $2261 Airbnb ROI: N/A Traditional ROI: 5.25%
42 Yaples Orchard Drive Chillicothe, OH Welcome to this beautiful single-family residence located in the highly desirable Yaples O...	4 beds \| 4 baths \| 2,880 sq.ft.	$524,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.62% Airbnb Rental Income: $null Traditional Rental Income: $3286 Airbnb ROI: N/A Traditional ROI: 4.62%
200 Winona Boulevard Chillicothe, OH Welcome to 200 Winona Boulevard in Chillicothe. This one-level, 3-bedroom, 2-bath home wit...	3 beds \| 2 baths \| 1,632 sq.ft.	$289,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.31% Airbnb Rental Income: $null Traditional Rental Income: $1777 Airbnb ROI: N/A Traditional ROI: 4.31%
41 Grabill Court Chillicothe, OH Spacious 4-bedroom home offering over 3,000 square feet of finished living space across th...	4 beds \| 3 baths \| 2,518 sq.ft.	$375,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.64% Airbnb Rental Income: $null Traditional Rental Income: $2681 Airbnb ROI: N/A Traditional ROI: 5.64%
24 Northfork Drive Chillicothe, OH Turn-key and ready to welcome you home, this charming one-story property offers comfort, c...	3 beds \| 1 baths \| 864 sq.ft.	$199,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.07% Airbnb Rental Income: $null Traditional Rental Income: $1187 Airbnb ROI: N/A Traditional ROI: 4.07%
182 Hirn Street Chillicothe, OH Turn of the century home offers comfortable living to the new owner. Spring and summer lan...	2 beds \| 1 baths \| 1,162 sq.ft.	$135,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.94% Airbnb Rental Income: $null Traditional Rental Income: $1327 Airbnb ROI: N/A Traditional ROI: 7.94%
5686 Blain Highway Chillicothe, OH Welcome to 5686 Blain Highway! Check out this one story well maintained property. You will...	3 beds \| 2 baths \| 1,804 sq.ft.	$425,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.07% Airbnb Rental Income: $null Traditional Rental Income: $2012 Airbnb ROI: N/A Traditional ROI: 3.07%

Your search for investment property begins and ends here

Single Family Homes for Sale in Chillicothe, OH

320 Hough Road

Chillicothe, OH

3 beds | 2 baths | 2,240 sq.ft.

$205,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.51%

Airbnb Rental Income: $null

Traditional Rental Income: $2240

Airbnb ROI: N/A

Traditional ROI: 9.51%

14220 State Route 772

Chillicothe, OH

4 beds | 2 baths | 3,296 sq.ft.

$449,900

Airbnb cash on cash: N/A

Traditional cash on cash: 4.21%

Airbnb Rental Income: $null

Traditional Rental Income: $2647

Airbnb ROI: N/A

Traditional ROI: 4.21%

1303 SANDY RD

Chillicothe, OH

3 beds | 2 baths | 1,728 sq.ft.

$174,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.48%

Airbnb Rental Income: $null

Traditional Rental Income: $1950

Airbnb ROI: N/A

Traditional ROI: 9.48%

239 Almahurst Drive

Chillicothe, OH

4 beds | 4 baths | 3,804 sq.ft.

$480,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.5%

Airbnb Rental Income: $null

Traditional Rental Income: $2961

Airbnb ROI: N/A

Traditional ROI: 4.5%

194 Plyleys Lane

Chillicothe, OH

3 beds | 1 baths | 1,050 sq.ft.

$183,900

Airbnb cash on cash: N/A

Traditional cash on cash: 3.88%

Airbnb Rental Income: $null

Traditional Rental Income: $1093

Airbnb ROI: N/A

Traditional ROI: 3.88%

631 Orange Street

Chillicothe, OH

2 beds | 1 baths | 845 sq.ft.

$189,900

Airbnb cash on cash: N/A

Traditional cash on cash: 2.8%

Airbnb Rental Income: $null

Traditional Rental Income: $1056

Airbnb ROI: N/A

Traditional ROI: 2.8%

1011 Lee Hollow Road

Chillicothe, OH

1 beds | 1 baths | 728 sq.ft.

$150,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.56%

Airbnb Rental Income: $null

Traditional Rental Income: $1474

Airbnb ROI: N/A

Traditional ROI: 8.56%

14933 US Highway 50

Chillicothe, OH

3 beds | 2 baths | 1,840 sq.ft.

$259,995

Airbnb cash on cash: N/A

Traditional cash on cash: 7.87%

Airbnb Rental Income: $null

Traditional Rental Income: $2377

Airbnb ROI: N/A