Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
847 Cambridge Drive Sikeston, MO Welcome to this charming three-bedroom, two-bath brick home that blends comfort and style ...	3 beds \| 2 baths \| 1,384 sq.ft.	$200,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.94% Airbnb Rental Income: $null Traditional Rental Income: $2093 Airbnb ROI: N/A Traditional ROI: 8.94%
1811 State Highway Z Sikeston, MO Rural living but not far from town. This 3 bedroom 2 1/2 bath home has a shop of 1,024 sq...	3 beds \| 3 baths \| N/A	$269,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.7% Airbnb Rental Income: $null Traditional Rental Income: $2621 Airbnb ROI: N/A Traditional ROI: 8.7%
911 Pine Street Sikeston, MO	3 beds \| 2 baths \| 1,432 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.28% Airbnb Rental Income: $null Traditional Rental Income: $2211 Airbnb ROI: N/A Traditional ROI: 7.28%
907 Taylor Street Sikeston, MO Welcome to 907 Taylor St in Sikeston â a spacious 3-bedroom, 2-bath brick home offering ...	3 beds \| 2 baths \| 2,113 sq.ft.	$279,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.92% Airbnb Rental Income: $null Traditional Rental Income: $2522 Airbnb ROI: N/A Traditional ROI: 7.92%
918 Hawthorn Drive Sikeston, MO Beautiful and charming move-in ready ranch home! This thoughtfully updated property featur...	3 beds \| 2 baths \| 1,750 sq.ft.	$210,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.89% Airbnb Rental Income: $null Traditional Rental Income: $2347 Airbnb ROI: N/A Traditional ROI: 9.89%
123 Holmes Drive Sikeston, MO This ALL BRICK home has many upgrades and is MOVE-IN-READY. The home has 3 bedrooms & 2 1/...	3 beds \| 3 baths \| 1,798 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.7% Airbnb Rental Income: $null Traditional Rental Income: $2439 Airbnb ROI: N/A Traditional ROI: 8.7%
819 E Kathleen Street Sikeston, MO Great opportunity for investors! This 2-bedroom property offers solid potential as a renta...	2 beds \| 1 baths \| 884 sq.ft.	$69,900	Airbnb cash on cash: 6.98% Traditional cash on cash: 11.9% Airbnb Rental Income: $1045 Traditional Rental Income: $1023 Airbnb ROI: 6.98% Traditional ROI: 11.9%
1304 William Street Sikeston, MO This 3 bedroom, 1 bath home has a spacious back yard for entertaining, BBQs or enjoying an...	3 beds \| 1 baths \| 1,100 sq.ft.	$110,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $1177 Airbnb ROI: N/A Traditional ROI: 8.83%
305 Ridge Drive Sikeston, MO Discover timeless elegance and modern convenience in this beautifully designed custom two-...	5 beds \| 5 baths \| 8,414 sq.ft.	$750,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.35% Airbnb Rental Income: $null Traditional Rental Income: $5005 Airbnb ROI: N/A Traditional ROI: 5.35%
1205 Northfield Ct. Sikeston, MO Welcome to your dream home! This beautiful brick two-story residence features an inviting ...	3 beds \| 4 baths \| N/A	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.49% Airbnb Rental Income: $null Traditional Rental Income: $3287 Airbnb ROI: N/A Traditional ROI: 7.49%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
701 Sikes Avenue Sikeston, MO	3 beds \| 2 baths \| 1,702 sq.ft.	$175,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.96% Airbnb Rental Income: $null Traditional Rental Income: $2322 Airbnb ROI: N/A Traditional ROI: 11.96%
243 N Ridge Road Sikeston, MO Tucked at the edge of town in a quiet, well-kept neighborhood, this home has the kind of s...	3 beds \| 5 baths \| 5,296 sq.ft.	$499,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.28% Airbnb Rental Income: $null Traditional Rental Income: $4243 Airbnb ROI: N/A Traditional ROI: 7.28%
850 Cambridge Dr Sikeston, MO Completely renovated 3-bedroom, 2-bath home in Sikeston city limits. This beautifully upda...	3 beds \| 2 baths \| 2,871 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.28% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 11.28%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$355,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.18% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 7.18%
866 Auburn Drive Sikeston, MO Welcome to your dream home in the heart of Sikeston on a corner lot. This beautifully upda...	4 beds \| 3 baths \| 3,610 sq.ft.	$325,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.38% Airbnb Rental Income: $null Traditional Rental Income: $3417 Airbnb ROI: N/A Traditional ROI: 9.38%
8 Elizabeth Road Sikeston, MO Just outside of Sikeston, this 3-bedroom, 2-bathroom home sits on a spacious half-acre lot...	3 beds \| 2 baths \| 1,592 sq.ft.	$244,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.57% Airbnb Rental Income: $null Traditional Rental Income: $2378 Airbnb ROI: N/A Traditional ROI: 8.57%
2163 County Highway 450 Sikeston, MO New Price Motivated Sellers... 3 bedroom/2 bath home located in Kelly School District, ...	3 beds \| 2 baths \| 1,538 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.22% Airbnb Rental Income: $null Traditional Rental Income: $1910 Airbnb ROI: N/A Traditional ROI: 6.22%
205 E Beech Street Sikeston, MO Step into charm and character with this beautifully maintained 2-bedroom, 1-bath Folk Vict...	2 beds \| 1 baths \| 980 sq.ft.	$124,900	Airbnb cash on cash: 3.65% Traditional cash on cash: 11.59% Airbnb Rental Income: $1045 Traditional Rental Income: $1637 Airbnb ROI: 3.65% Traditional ROI: 11.59%
608a State Highway H Sikeston, MO Looking for space, style, and function all in one? This brick home delivers. With 3 bedroo...	3 beds \| 2 baths \| 2,009 sq.ft.	$280,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.4% Airbnb Rental Income: $null Traditional Rental Income: $2435 Airbnb ROI: N/A Traditional ROI: 7.4%
1611 State Highway Z Sikeston, MO Surrounded by picturesque farmland, this beautifully maintained home offers the ultimate i...	3 beds \| 3 baths \| 2,015 sq.ft.	$244,900	Airbnb cash on cash: N/A Traditional cash on cash: 9.32% Airbnb Rental Income: $null Traditional Rental Income: $2569 Airbnb ROI: N/A Traditional ROI: 9.32%
926 Crescent Drive Sikeston, MO This beautifully maintained all-brick hoe is nestled in a quiet, family-friendly neighborh...	3 beds \| 2 baths \| 1,653 sq.ft.	$174,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.9% Airbnb Rental Income: $null Traditional Rental Income: $2312 Airbnb ROI: N/A Traditional ROI: 11.9%
1201 Yosemite Sikeston, MO Beautiful new 3-bedroom, 2-bath home featuring an open living area with tray ceilings and ...	3 beds \| 2 baths \| 1,800 sq.ft.	$309,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.26% Airbnb Rental Income: $null Traditional Rental Income: $2410 Airbnb ROI: N/A Traditional ROI: 6.26%
133 Larue Lane Sikeston, MO Need space for family and pets in the Kelly School District? This totally renovated home ...	3 beds \| 3 baths \| N/A	$319,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.25% Airbnb Rental Income: $null Traditional Rental Income: $1962 Airbnb ROI: N/A Traditional ROI: 4.25%
407 Virginia Street Sikeston, MO Completely remodeled! Let's start with appliances: water heater, range and dishwasher ar...	3 beds \| 1 baths \| 1,162 sq.ft.	$142,500	Airbnb cash on cash: N/A Traditional cash on cash: 11.9% Airbnb Rental Income: $null Traditional Rental Income: $1898 Airbnb ROI: N/A Traditional ROI: 11.9%

Real Estate investment in Sikeston, MO

There are 30 properties for sale in the city of Sikeston . The median list price in Sikeston is $137,250 and the average price per square foot is $77. In December 2025, the average monthly cash on cash return in Sikeston is 12.00%. The average monthly rental income in Sikeston is $2,093.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 30 investment properties available for sale in Sikeston.

In 2025, the best neighborhood to buy investment property is Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $1,045.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

847 Cambridge Drive

Sikeston, MO

3 beds | 2 baths | 1,384 sq.ft.

$200,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.94%

Airbnb Rental Income: $null

Traditional Rental Income: $2093

Airbnb ROI: N/A

Traditional ROI: 8.94%

1811 State Highway Z

Sikeston, MO

3 beds | 3 baths | N/A

$269,900

Airbnb cash on cash: N/A

Traditional cash on cash: 8.7%

Airbnb Rental Income: $null

Traditional Rental Income: $2621

Airbnb ROI: N/A

Traditional ROI: 8.7%

911 Pine Street

Sikeston, MO

3 beds | 2 baths | 1,432 sq.ft.

$250,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.28%

Airbnb Rental Income: $null

Traditional Rental Income: $2211

Airbnb ROI: N/A

Traditional ROI: 7.28%

907 Taylor Street

Sikeston, MO

3 beds | 2 baths | 2,113 sq.ft.

$279,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.92%

Airbnb Rental Income: $null

Traditional Rental Income: $2522

Airbnb ROI: N/A

Traditional ROI: 7.92%

918 Hawthorn Drive

Sikeston, MO

3 beds | 2 baths | 1,750 sq.ft.

$210,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.89%

Airbnb Rental Income: $null

Traditional Rental Income: $2347

Airbnb ROI: N/A

Traditional ROI: 9.89%

123 Holmes Drive

Sikeston, MO

3 beds | 3 baths | 1,798 sq.ft.

$245,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.7%

Airbnb Rental Income: $null

Traditional Rental Income: $2439

Airbnb ROI: N/A

Traditional ROI: 8.7%

819 E Kathleen Street

Sikeston, MO

2 beds | 1 baths | 884 sq.ft.

$69,900

Airbnb cash on cash: 6.98%

Traditional cash on cash: 11.9%

Airbnb Rental Income: $1045

Traditional Rental Income: $1023

Airbnb ROI: 6.98%

Traditional ROI: 11.9%

1304 William Street

Sikeston, MO

3 beds | 1 baths | 1,100 sq.ft.

$110,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.83%

Airbnb Rental Income: $null

Traditional Rental Income: $1177

Airbnb ROI: N/A