Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1811 State Highway Z Sikeston, MO This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience....	3 beds \| 3 baths \| 1,774 sq.ft.	$259,900	Airbnb cash on cash: -0.57% Traditional cash on cash: 9.06% Airbnb Rental Income: $539 Traditional Rental Income: $2621 Airbnb ROI: -0.57% Traditional ROI: 9.06%
604 Park Avenue Sikeston, MO Step into the charm of yesterday with the comfort of today in this stunning brick beauty. ...	3 beds \| 2 baths \| 2,048 sq.ft.	$199,000	Airbnb cash on cash: -0.77% Traditional cash on cash: 11.62% Airbnb Rental Income: $539 Traditional Rental Income: $2600 Airbnb ROI: -0.77% Traditional ROI: 11.62%
1011 N Ranney Street Sikeston, MO What a gorgeous, well maintained historic home! Letâs start with the kitchen. Itâs t...	4 beds \| 7 baths \| 7,356 sq.ft.	$670,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.11% Airbnb Rental Income: $null Traditional Rental Income: $4300 Airbnb ROI: N/A Traditional ROI: 5.11%
1300 N Main Sikeston, MO Donât miss an opportunity â condos like these donât come available often! Move-in re...	3 beds \| 3 baths \| N/A	$225,000	Airbnb cash on cash: -1.18% Traditional cash on cash: 9.62% Airbnb Rental Income: $539 Traditional Rental Income: $2559 Airbnb ROI: -1.18% Traditional ROI: 9.62%
126 Bradley Drive Sikeston, MO Recently remodeled and ready for Y-O-U! This great home is updated and move in ready! Impr...	3 beds \| 2 baths \| 1,828 sq.ft.	$259,000	Airbnb cash on cash: -0.79% Traditional cash on cash: 8.16% Airbnb Rental Income: $539 Traditional Rental Income: $2449 Airbnb ROI: -0.79% Traditional ROI: 8.16%
1201 Yosemite Sikeston, MO Welcome to this stunning 2023-built home offering the perfect blend of modern design, func...	3 beds \| 2 baths \| 1,800 sq.ft.	$309,500	Airbnb cash on cash: -1.25% Traditional cash on cash: 6.14% Airbnb Rental Income: $539 Traditional Rental Income: $2410 Airbnb ROI: -1.25% Traditional ROI: 6.14%
133 Larue Lane Sikeston, MO Need space for family and pets in the Kelly School District? This totally renovated home ...	3 beds \| 3 baths \| N/A	$319,900	Airbnb cash on cash: -1.41% Traditional cash on cash: 4.25% Airbnb Rental Income: $539 Traditional Rental Income: $1962 Airbnb ROI: -1.41% Traditional ROI: 4.25%
1132 Pollard Plaza Sikeston, MO Welcome to this beautifully built 2024 home in Sikeston offering the perfect blend of mode...	4 beds \| 2 baths \| 2,004 sq.ft.	$340,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.11% Airbnb Rental Income: $null Traditional Rental Income: $1394 Airbnb ROI: N/A Traditional ROI: 2.11%
119 Depro Sikeston, MO Set on a spacious 0.72-acre corner lot just outside Sikeston, this property features a bra...	3 beds \| 3 baths \| 1,492 sq.ft.	$250,000	Airbnb cash on cash: -1.25% Traditional cash on cash: 6.14% Airbnb Rental Income: $539 Traditional Rental Income: $2006 Airbnb ROI: -1.25% Traditional ROI: 6.14%
312 Hardin Street Sikeston, MO Completely remodeled and ready to move into! Located near the center of Sikeston, close t...	3 beds \| 1 baths \| 1,296 sq.ft.	$175,000	Airbnb cash on cash: -0.26% Traditional cash on cash: 9.26% Airbnb Rental Income: $539 Traditional Rental Income: $1846 Airbnb ROI: -0.26% Traditional ROI: 9.26%
106 Jennings Lane Sikeston, MO Experience elevated living in this beautifully crafted 3,770-square-foot residence ideally...	4 beds \| 3 baths \| 3,770 sq.ft.	$549,995	Airbnb cash on cash: N/A Traditional cash on cash: 3.74% Airbnb Rental Income: $null Traditional Rental Income: $2760 Airbnb ROI: N/A Traditional ROI: 3.74%
303 Dorothy Street Sikeston, MO Hereâs the corrected version with it listed as a 4 bedroom: Welcome to 303 Dorthy, an am...	4 beds \| 2 baths \| 3,495 sq.ft.	$265,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.32% Airbnb Rental Income: $null Traditional Rental Income: $2713 Airbnb ROI: N/A Traditional ROI: 9.32%
406 Broadway Street Sikeston, MO Charming and well-maintained 3-bedroom, 2-bath home with thoughtful updates and versatile ...	3 beds \| 2 baths \| 1,434 sq.ft.	$175,000	Airbnb cash on cash: -0.43% Traditional cash on cash: 11.03% Airbnb Rental Income: $539 Traditional Rental Income: $2170 Airbnb ROI: -0.43% Traditional ROI: 11.03%
805 Sikes Avenue Sikeston, MO If space and functionality are at the top of your list, this is the one. This expansive 5...	5 beds \| 4 baths \| 4,387 sq.ft.	$355,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.91% Airbnb Rental Income: $null Traditional Rental Income: $4580 Airbnb ROI: N/A Traditional ROI: 11.91%
1300 N Main Street #319 Sikeston, MO Maingate Condominiums: A Gated Community Living with All-Inclusive Amenities This refined...	2 beds \| 2 baths \| 1,364 sq.ft.	$187,900	Airbnb cash on cash: N/A Traditional cash on cash: 6.57% Airbnb Rental Income: $null Traditional Rental Income: $1944 Airbnb ROI: N/A Traditional ROI: 6.57%
858 Cambridge Drive Sikeston, MO First time on the market! Proudly offered by the original owner and builder, this excepti...	5 beds \| 3 baths \| 3,230 sq.ft.	$275,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.63% Airbnb Rental Income: $null Traditional Rental Income: $3230 Airbnb ROI: N/A Traditional ROI: 10.63%
2008 Oklahoma Street Sikeston, MO Come take a look at this freshly painted 3 bedroom home. Home offers open floor plan, 3 be...	3 beds \| 1 baths \| 945 sq.ft.	$149,000	Airbnb cash on cash: -0.78% Traditional cash on cash: 8.79% Airbnb Rental Income: $539 Traditional Rental Income: $1625 Airbnb ROI: -0.78% Traditional ROI: 8.79%
225 N Ridge Road Sikeston, MO	4 beds \| 4 baths \| 2,700 sq.ft.	$610,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.62% Airbnb Rental Income: $null Traditional Rental Income: $3013 Airbnb ROI: N/A Traditional ROI: 3.62%
210 Sherrie Drive Sikeston, MO Welcome home to 210 Sherrie Drive! This beautifully remodeled ranch home offers 2,121 squa...	3 beds \| 2 baths \| 2,121 sq.ft.	$249,900	Airbnb cash on cash: -0.67% Traditional cash on cash: 8.72% Airbnb Rental Income: $539 Traditional Rental Income: $2476 Airbnb ROI: -0.67% Traditional ROI: 8.72%
107 Summer Drive Sikeston, MO	4 beds \| 3 baths \| 3,365 sq.ft.	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.36% Airbnb Rental Income: $null Traditional Rental Income: $3031 Airbnb ROI: N/A Traditional ROI: 8.36%
921 Bucklin Circle Sikeston, MO Don't wait to see this great family home with amazing curb appeal, located on a low-t...	3 beds \| 2 baths \| 1,701 sq.ft.	$245,000	Airbnb cash on cash: -0.84% Traditional cash on cash: 7.68% Airbnb Rental Income: $539 Traditional Rental Income: $2234 Airbnb ROI: -0.84% Traditional ROI: 7.68%

Real Estate investment in Sikeston, MO

There are 28 properties for sale in the city of Sikeston . The median list price in Sikeston is $194,883 and the average price per square foot is $112. In July 2026, the average monthly cash on cash return in Sikeston is 10.00%. The average monthly rental income in Sikeston is $2,173.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 28 investment properties available for sale in Sikeston.

In 2026, the best neighborhood to buy investment property is Sikeston.

The ROI for Long-Term is higher than the Short-Term in Sikeston with average rental income of $2,173.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

1811 State Highway Z

Sikeston, MO

3 beds | 3 baths | 1,774 sq.ft.

$259,900

Airbnb cash on cash: -0.57%

Traditional cash on cash: 9.06%

Airbnb Rental Income: $539

Traditional Rental Income: $2621

Airbnb ROI: -0.57%

Traditional ROI: 9.06%

604 Park Avenue

Sikeston, MO

3 beds | 2 baths | 2,048 sq.ft.

$199,000

Airbnb cash on cash: -0.77%

Traditional cash on cash: 11.62%

Airbnb Rental Income: $539

Traditional Rental Income: $2600

Airbnb ROI: -0.77%

Traditional ROI: 11.62%

1011 N Ranney Street

Sikeston, MO

4 beds | 7 baths | 7,356 sq.ft.

$670,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.11%

Airbnb Rental Income: $null

Traditional Rental Income: $4300

Airbnb ROI: N/A

Traditional ROI: 5.11%

1300 N Main

Sikeston, MO

3 beds | 3 baths | N/A

$225,000

Airbnb cash on cash: -1.18%

Traditional cash on cash: 9.62%

Airbnb Rental Income: $539

Traditional Rental Income: $2559

Airbnb ROI: -1.18%

Traditional ROI: 9.62%

126 Bradley Drive

Sikeston, MO

3 beds | 2 baths | 1,828 sq.ft.

$259,000

Airbnb cash on cash: -0.79%

Traditional cash on cash: 8.16%

Airbnb Rental Income: $539

Traditional Rental Income: $2449

Airbnb ROI: -0.79%

Traditional ROI: 8.16%

1201 Yosemite

Sikeston, MO

3 beds | 2 baths | 1,800 sq.ft.

$309,500

Airbnb cash on cash: -1.25%

Traditional cash on cash: 6.14%

Airbnb Rental Income: $539

Traditional Rental Income: $2410

Airbnb ROI: -1.25%

Traditional ROI: 6.14%

133 Larue Lane

Sikeston, MO

3 beds | 3 baths | N/A

$319,900

Airbnb cash on cash: -1.41%

Traditional cash on cash: 4.25%

Airbnb Rental Income: $539

Traditional Rental Income: $1962

Airbnb ROI: -1.41%

Traditional ROI: 4.25%

1132 Pollard Plaza

Sikeston, MO

4 beds | 2 baths | 2,004 sq.ft.

$340,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.11%

Airbnb Rental Income: $null

Traditional Rental Income: $1394

Airbnb ROI: N/A