Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
132 Autumn Dr Sikeston, MO Step inside this brick, 3-bed, 2.5-bathroom, ranch-style home offering both character and ...	3 beds \| 3 baths \| 1,856 sq.ft.	$209,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.17% Airbnb Rental Income: $null Traditional Rental Income: $2506 Airbnb ROI: N/A Traditional ROI: 10.17%
907 Taylor Street Sikeston, MO Welcome to 907 Taylor St in Sikeston â a spacious 3-bedroom, 2-bath brick home offering ...	3 beds \| 2 baths \| 2,113 sq.ft.	$279,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.92% Airbnb Rental Income: $null Traditional Rental Income: $2522 Airbnb ROI: N/A Traditional ROI: 7.92%
208 Foust Drive Sikeston, MO GREAT 4 bedroom home located in Sikeston's north end! Beautifully remodeled eat-in kitche...	4 beds \| 3 baths \| 1,736 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.53% Airbnb Rental Income: $null Traditional Rental Income: $2311 Airbnb ROI: N/A Traditional ROI: 8.53%
104 Ashley Drive Sikeston, MO Beautiful 3BR/2BA ranch in a quiet neighborhood on a corner lot! Bright open floor plan, u...	3 beds \| 2 baths \| 1,715 sq.ft.	$188,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.08% Airbnb Rental Income: $null Traditional Rental Income: $2337 Airbnb ROI: N/A Traditional ROI: 11.08%
123 Holmes Drive Sikeston, MO This ALL BRICK home has many upgrades and is MOVE-IN-READY. The home has 3 bedrooms & 2 1/...	3 beds \| 3 baths \| 1,798 sq.ft.	$245,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.7% Airbnb Rental Income: $null Traditional Rental Income: $2439 Airbnb ROI: N/A Traditional ROI: 8.7%
1304 William Street Sikeston, MO This 3 bedroom, 1 bath home has a spacious back yard for entertaining, BBQs or enjoying an...	3 beds \| 1 baths \| 1,100 sq.ft.	$110,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $1177 Airbnb ROI: N/A Traditional ROI: 8.83%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$197,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.54% Airbnb Rental Income: $null Traditional Rental Income: $2250 Airbnb ROI: N/A Traditional ROI: 9.54%
1205 Northfield Ct. Sikeston, MO Welcome to your dream home! This beautiful brick two-story residence features an inviting ...	3 beds \| 4 baths \| N/A	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.49% Airbnb Rental Income: $null Traditional Rental Income: $3287 Airbnb ROI: N/A Traditional ROI: 7.49%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
701 Sikes Avenue Sikeston, MO	3 beds \| 2 baths \| 1,702 sq.ft.	$175,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.96% Airbnb Rental Income: $null Traditional Rental Income: $2322 Airbnb ROI: N/A Traditional ROI: 11.96%
721 Mimosa Dr Sikeston, MO NEW PRICE!!!<br> <br> Great quiet location! This 3 bedroom 2 bath brick home has 1485 sf ...	3 beds \| 2 baths \| 2,970 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.72% Airbnb Rental Income: $null Traditional Rental Income: $2516 Airbnb ROI: N/A Traditional ROI: 9.72%
243 N Ridge Road Sikeston, MO Tucked at the edge of town in a quiet, well-kept neighborhood, this home has the kind of s...	3 beds \| 5 baths \| 5,296 sq.ft.	$515,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.04% Airbnb Rental Income: $null Traditional Rental Income: $4243 Airbnb ROI: N/A Traditional ROI: 7.04%
840 Delta Pine Lane Sikeston, MO Welcome to this beautifully maintained two-story home, located in one of the areaâs most...	3 beds \| 3 baths \| 2,808 sq.ft.	$219,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.99% Airbnb Rental Income: $null Traditional Rental Income: $2917 Airbnb ROI: N/A Traditional ROI: 11.99%
850 Cambridge Dr Sikeston, MO Completely renovated 3-bedroom, 2-bath home in Sikeston city limits. This beautifully upda...	3 beds \| 2 baths \| 2,871 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.69% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 10.69%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$370,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.85% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 6.85%
866 Auburn Drive Sikeston, MO Welcome to your dream home in the heart of Sikeston on a corner lot. This beautifully upda...	4 beds \| 3 baths \| 3,610 sq.ft.	$329,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.25% Airbnb Rental Income: $null Traditional Rental Income: $3417 Airbnb ROI: N/A Traditional ROI: 9.25%
8 Elizabeth Road Sikeston, MO Just outside of Sikeston, this 3-bedroom, 2-bathroom home sits on a spacious half-acre lot...	3 beds \| 2 baths \| 1,592 sq.ft.	$250,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.38% Airbnb Rental Income: $null Traditional Rental Income: $2378 Airbnb ROI: N/A Traditional ROI: 8.38%
2163 County Highway 450 Sikeston, MO This home is in Kelly School District and sits on one acre with the possibility of extra a...	3 beds \| 2 baths \| N/A	$259,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.47% Airbnb Rental Income: $null Traditional Rental Income: $1910 Airbnb ROI: N/A Traditional ROI: 5.47%

Real Estate investment in Sikeston, MO

There are 22 properties for sale in the city of Sikeston . The median list price in Sikeston is $135,750 and the average price per square foot is $72. In October 2025, the average monthly cash on cash return in Sikeston is 13.00%. The average monthly rental income in Sikeston is $2,134.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 22 investment properties available for sale in Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

132 Autumn Dr

Sikeston, MO

3 beds | 3 baths | 1,856 sq.ft.

$209,900

Airbnb cash on cash: N/A

Traditional cash on cash: 10.17%

Airbnb Rental Income: $null

Traditional Rental Income: $2506

Airbnb ROI: N/A

Traditional ROI: 10.17%

907 Taylor Street

Sikeston, MO

3 beds | 2 baths | 2,113 sq.ft.

$279,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.92%

Airbnb Rental Income: $null

Traditional Rental Income: $2522

Airbnb ROI: N/A

Traditional ROI: 7.92%

208 Foust Drive

Sikeston, MO

4 beds | 3 baths | 1,736 sq.ft.

$235,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.53%

Airbnb Rental Income: $null

Traditional Rental Income: $2311

Airbnb ROI: N/A

Traditional ROI: 8.53%

104 Ashley Drive

Sikeston, MO

3 beds | 2 baths | 1,715 sq.ft.

$188,000

Airbnb cash on cash: N/A

Traditional cash on cash: 11.08%

Airbnb Rental Income: $null

Traditional Rental Income: $2337

Airbnb ROI: N/A

Traditional ROI: 11.08%

123 Holmes Drive

Sikeston, MO

3 beds | 3 baths | 1,798 sq.ft.

$245,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.7%

Airbnb Rental Income: $null

Traditional Rental Income: $2439

Airbnb ROI: N/A

Traditional ROI: 8.7%

1304 William Street

Sikeston, MO

3 beds | 1 baths | 1,100 sq.ft.

$110,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.83%

Airbnb Rental Income: $null

Traditional Rental Income: $1177

Airbnb ROI: N/A

Traditional ROI: 8.83%

605 N. Ranney Street

Sikeston, MO

3 beds | 2 baths | N/A

$197,500

Airbnb cash on cash: N/A

Traditional cash on cash: 9.54%

Airbnb Rental Income: $null

Traditional Rental Income: $2250

Airbnb ROI: N/A

Traditional ROI: 9.54%

1205 Northfield Ct.

Sikeston, MO

3 beds | 4 baths | N/A

$360,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.49%

Airbnb Rental Income: $null

Traditional Rental Income: $3287

Airbnb ROI: N/A