Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1811 State Highway Z Sikeston, MO This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience....	3 beds \| 3 baths \| 1,774 sq.ft.	$259,900	Airbnb cash on cash: 1.04% Traditional cash on cash: 9.06% Airbnb Rental Income: $1013 Traditional Rental Income: $2621 Airbnb ROI: 1.04% Traditional ROI: 9.06%
2011 State Highway H Sikeston, MO This one checks a LOT of boxes! 3 beds. 2 baths. Kelly School District. Updated kitchen. F...	3 beds \| 2 baths \| 2,147 sq.ft.	$275,000	Airbnb cash on cash: 0.89% Traditional cash on cash: 6.51% Airbnb Rental Income: $1013 Traditional Rental Income: $2112 Airbnb ROI: 0.89% Traditional ROI: 6.51%
819 E Kathleen Street Sikeston, MO Great opportunity for investors! This 2-bedroom property offers solid potential as a renta...	2 beds \| 1 baths \| 884 sq.ft.	$69,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.9% Airbnb Rental Income: $null Traditional Rental Income: $1023 Airbnb ROI: N/A Traditional ROI: 11.9%
303 Greer Avenue Sikeston, MO Are you ready for a small home in Sikeston? You can sit on the covered, front porch and e...	3 beds \| 1 baths \| 1,335 sq.ft.	$99,900	Airbnb cash on cash: 3.83% Traditional cash on cash: 6.9% Airbnb Rental Income: $1013 Traditional Rental Income: $953 Airbnb ROI: 3.83% Traditional ROI: 6.9%
911 S Prairie Street Sikeston, MO Welcome home to this charming ranch-style gem that perfectly balances cozy comfort with in...	3 beds \| 2 baths \| 1,600 sq.ft.	$145,000	Airbnb cash on cash: 2.22% Traditional cash on cash: 9.9% Airbnb Rental Income: $1013 Traditional Rental Income: $1722 Airbnb ROI: 2.22% Traditional ROI: 9.9%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$188,900	Airbnb cash on cash: 1.17% Traditional cash on cash: 10.05% Airbnb Rental Income: $1013 Traditional Rental Income: $2250 Airbnb ROI: 1.17% Traditional ROI: 10.05%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$344,500	Airbnb cash on cash: 0.29% Traditional cash on cash: 7.43% Airbnb Rental Income: $1013 Traditional Rental Income: $2964 Airbnb ROI: 0.29% Traditional ROI: 7.43%
8 Elizabeth Road Sikeston, MO Very motivated seller !!!!! Just outside of Sikeston, this 3-bedroom, 2-bathroom home sit...	3 beds \| 2 baths \| 1,592 sq.ft.	$224,900	Airbnb cash on cash: 1.31% Traditional cash on cash: 9.4% Airbnb Rental Income: $1013 Traditional Rental Income: $2378 Airbnb ROI: 1.31% Traditional ROI: 9.4%
205 E Beech Street Sikeston, MO Step into charm and character with this beautifully maintained 2-bedroom, 1-bath Folk Vict...	2 beds \| 1 baths \| 980 sq.ft.	$124,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.59% Airbnb Rental Income: $null Traditional Rental Income: $1637 Airbnb ROI: N/A Traditional ROI: 11.59%
1611 State Highway Z Sikeston, MO Surrounded by picturesque farmland, this beautifully maintained home offers the ultimate i...	3 beds \| 3 baths \| 2,015 sq.ft.	$229,900	Airbnb cash on cash: 1.18% Traditional cash on cash: 9.98% Airbnb Rental Income: $1013 Traditional Rental Income: $2569 Airbnb ROI: 1.18% Traditional ROI: 9.98%
1201 Yosemite Sikeston, MO Welcome to this stunning 2023-built home offering the perfect blend of modern design, func...	3 beds \| 2 baths \| 1,800 sq.ft.	$309,500	Airbnb cash on cash: 0.11% Traditional cash on cash: 6.14% Airbnb Rental Income: $1013 Traditional Rental Income: $2410 Airbnb ROI: 0.11% Traditional ROI: 6.14%
133 Larue Lane Sikeston, MO Need space for family and pets in the Kelly School District? This totally renovated home ...	3 beds \| 3 baths \| N/A	$319,900	Airbnb cash on cash: -0.09% Traditional cash on cash: 4.25% Airbnb Rental Income: $1013 Traditional Rental Income: $1962 Airbnb ROI: -0.09% Traditional ROI: 4.25%
719 N West Street Sikeston, MO Nice brick home with a family room added on the back. Wood burning fireplace. Huge walk ...	3 beds \| 2 baths \| 1,985 sq.ft.	$188,900	Airbnb cash on cash: 1.44% Traditional cash on cash: 11% Airbnb Rental Income: $1013 Traditional Rental Income: $2372 Airbnb ROI: 1.44% Traditional ROI: 11%
106 Holmes Drive Sikeston, MO Spacious, modern, updated, extremely well appointed. Enter into a large living room plus a...	3 beds \| 2 baths \| 2,034 sq.ft.	$250,999	Airbnb cash on cash: 0.68% Traditional cash on cash: 7.91% Airbnb Rental Income: $1013 Traditional Rental Income: $2369 Airbnb ROI: 0.68% Traditional ROI: 7.91%
103 Powers Sikeston, MO Charming 3-Bedroom All-Brick Home in Sikestonâs North End â 1,764 Sq Ft + 1.650 Sq Ft....	3 beds \| 3 baths \| N/A	$248,000	Airbnb cash on cash: 0.44% Traditional cash on cash: 7.83% Airbnb Rental Income: $1013 Traditional Rental Income: $2387 Airbnb ROI: 0.44% Traditional ROI: 7.83%
119 Depro Sikeston, MO Newly remodeled and move-in ready just outside Sikeston! Sitting on a spacious corner lot ...	3 beds \| 3 baths \| 1,492 sq.ft.	$250,000	Airbnb cash on cash: 0.42% Traditional cash on cash: 6.14% Airbnb Rental Income: $1013 Traditional Rental Income: $2006 Airbnb ROI: 0.42% Traditional ROI: 6.14%
312 Hardin Street Sikeston, MO Completely remodeled and ready to move into! Located near the center of Sikeston, close t...	3 beds \| 1 baths \| 1,296 sq.ft.	$199,000	Airbnb cash on cash: 1.75% Traditional cash on cash: 8.05% Airbnb Rental Income: $1013 Traditional Rental Income: $1846 Airbnb ROI: 1.75% Traditional ROI: 8.05%
112 N 6th Street Sikeston, MO Step inside to find a bright and airy living space featuring a freshly painted interior an...	3 beds \| 2 baths \| 1,421 sq.ft.	$195,000	Airbnb cash on cash: 1.78% Traditional cash on cash: 8.39% Airbnb Rental Income: $1013 Traditional Rental Income: $1880 Airbnb ROI: 1.78% Traditional ROI: 8.39%
106 Jennings Lane Sikeston, MO Experience elevated living in this beautifully crafted 3,770-square-foot residence ideally...	4 beds \| 3 baths \| 3,770 sq.ft.	$549,995	Airbnb cash on cash: N/A Traditional cash on cash: 3.74% Airbnb Rental Income: $null Traditional Rental Income: $2760 Airbnb ROI: N/A Traditional ROI: 3.74%
628 Moore Avenue Sikeston, MO This charming bungalow in Sikeston's historic district has been beautifully updated and is...	2 beds \| 1 baths \| 910 sq.ft.	$127,500	Airbnb cash on cash: N/A Traditional cash on cash: 8.35% Airbnb Rental Income: $null Traditional Rental Income: $1281 Airbnb ROI: N/A Traditional ROI: 8.35%
10 Dement Road Sikeston, MO This 3 bedroom, 1 & 3/4 bath home features a split bedroom floor plan and an eat-in kitche...	3 beds \| 2 baths \| 1,382 sq.ft.	$172,900	Airbnb cash on cash: 2.03% Traditional cash on cash: 8.97% Airbnb Rental Income: $1013 Traditional Rental Income: $1798 Airbnb ROI: 2.03% Traditional ROI: 8.97%
209 Aletha Drive Sikeston, MO Looking for a home outside the city limits in a great neighborhood? This property offers t...	4 beds \| 2 baths \| 2,347 sq.ft.	$255,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.38% Airbnb Rental Income: $null Traditional Rental Income: $2196 Airbnb ROI: N/A Traditional ROI: 7.38%
2012 Ables Road Sikeston, MO Welcome to this cozy and inviting 2-bedroom, 1-bath home in Sikeston. It features a comfo...	2 beds \| 1 baths \| 1,002 sq.ft.	$120,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.26% Airbnb Rental Income: $null Traditional Rental Income: $1447 Airbnb ROI: N/A Traditional ROI: 10.26%
303 Dorothy Street Sikeston, MO Welcome to 303 Dorthy an amazing Victorian-style home full of character and historical cha...	5 beds \| 2 baths \| 3,495 sq.ft.	$279,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.78% Airbnb Rental Income: $null Traditional Rental Income: $2713 Airbnb ROI: N/A Traditional ROI: 8.78%
904 Crescent Drive Sikeston, MO Welcome to this newly renovated 3-bedroom, 1 bath home offering 1113 square feet of comfor...	3 beds \| 1 baths \| 1,113 sq.ft.	$175,000	Airbnb cash on cash: 1.9% Traditional cash on cash: 8.26% Airbnb Rental Income: $1013 Traditional Rental Income: $1716 Airbnb ROI: 1.9% Traditional ROI: 8.26%

Real Estate investment in Sikeston, MO

There are 28 properties for sale in the city of Sikeston . The median list price in Sikeston is $136,250 and the average price per square foot is $103. In April 2026, the average monthly cash on cash return in Sikeston is 10.00%. The average monthly rental income in Sikeston is $1,984.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 28 investment properties available for sale in Sikeston.

In 2026, the best neighborhood to buy investment property is Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $1,013.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

1811 State Highway Z

Sikeston, MO

3 beds | 3 baths | 1,774 sq.ft.

$259,900

Airbnb cash on cash: 1.04%

Traditional cash on cash: 9.06%

Airbnb Rental Income: $1013

Traditional Rental Income: $2621

Airbnb ROI: 1.04%

Traditional ROI: 9.06%

2011 State Highway H

Sikeston, MO

3 beds | 2 baths | 2,147 sq.ft.

$275,000

Airbnb cash on cash: 0.89%

Traditional cash on cash: 6.51%

Airbnb Rental Income: $1013

Traditional Rental Income: $2112

Airbnb ROI: 0.89%

Traditional ROI: 6.51%

819 E Kathleen Street

Sikeston, MO

2 beds | 1 baths | 884 sq.ft.

$69,900

Airbnb cash on cash: N/A

Traditional cash on cash: 11.9%

Airbnb Rental Income: $null

Traditional Rental Income: $1023

Airbnb ROI: N/A

Traditional ROI: 11.9%

303 Greer Avenue

Sikeston, MO

3 beds | 1 baths | 1,335 sq.ft.

$99,900

Airbnb cash on cash: 3.83%

Traditional cash on cash: 6.9%

Airbnb Rental Income: $1013

Traditional Rental Income: $953

Airbnb ROI: 3.83%

Traditional ROI: 6.9%

911 S Prairie Street

Sikeston, MO

3 beds | 2 baths | 1,600 sq.ft.

$145,000

Airbnb cash on cash: 2.22%

Traditional cash on cash: 9.9%

Airbnb Rental Income: $1013

Traditional Rental Income: $1722

Airbnb ROI: 2.22%

Traditional ROI: 9.9%

605 N. Ranney Street

Sikeston, MO

3 beds | 2 baths | N/A

$188,900

Airbnb cash on cash: 1.17%

Traditional cash on cash: 10.05%

Airbnb Rental Income: $1013

Traditional Rental Income: $2250

Airbnb ROI: 1.17%

Traditional ROI: 10.05%

3 Bel Air

Sikeston, MO

4 beds | 3 baths | N/A

$299,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.97%

Airbnb Rental Income: $null

Traditional Rental Income: $3451

Airbnb ROI: N/A

Traditional ROI: 9.97%

901 Moore Avenue

Sikeston, MO

3 beds | 3 baths | 6,536 sq.ft.

$344,500

Airbnb cash on cash: 0.29%

Traditional cash on cash: 7.43%

Airbnb Rental Income: $1013

Traditional Rental Income: $2964

Airbnb ROI: 0.29%