Real Estate Investment Properties for Sale in Sikeston, MO

Looking for investment property in Sikeston, MO with high ROI ?

Explore a variety of short-term homes & houses in Sikeston, MO. Invest wisely with VRBO & Sikeston, MO Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Sikeston, MO

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
132 Autumn Dr Sikeston, MO Step inside this brick, 3-bed, 2.5-bathroom, ranch-style home offering both character and ...	3 beds \| 3 baths \| 1,856 sq.ft.	$209,900	Airbnb cash on cash: N/A Traditional cash on cash: 10.17% Airbnb Rental Income: $null Traditional Rental Income: $2506 Airbnb ROI: N/A Traditional ROI: 10.17%
522 Tanglewood Avenue Sikeston, MO This beautiful home is one youâll want to see in person. The curb appeal is picture-perf...	3 beds \| 4 baths \| 5,394 sq.ft.	$535,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.87% Airbnb Rental Income: $null Traditional Rental Income: $3281 Airbnb ROI: N/A Traditional ROI: 4.87%
907 Taylor Street Sikeston, MO Welcome to 907 Taylor St in Sikeston â a spacious 3-bedroom, 2-bath brick home offering ...	3 beds \| 2 baths \| 2,113 sq.ft.	$279,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.92% Airbnb Rental Income: $null Traditional Rental Income: $2522 Airbnb ROI: N/A Traditional ROI: 7.92%
208 Foust Drive Sikeston, MO GREAT 4 bedroom home located in Sikeston's north end! Beautifully remodeled eat-in kitche...	4 beds \| 3 baths \| 1,736 sq.ft.	$235,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.53% Airbnb Rental Income: $null Traditional Rental Income: $2311 Airbnb ROI: N/A Traditional ROI: 8.53%
212 Melissa Sikeston, MO New to the market, this ranch home is ideally situated on a large lot just minutes from to...	3 beds \| 2 baths \| 1,330 sq.ft.	$195,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.08% Airbnb Rental Income: $null Traditional Rental Income: $2029 Airbnb ROI: N/A Traditional ROI: 9.08%
1304 William Street Sikeston, MO This 3 bedroom, 1 bath home has a spacious back yard for entertaining, BBQs or enjoying an...	3 beds \| 1 baths \| 1,100 sq.ft.	$110,000	Airbnb cash on cash: N/A Traditional cash on cash: 8.83% Airbnb Rental Income: $null Traditional Rental Income: $1177 Airbnb ROI: N/A Traditional ROI: 8.83%
605 N. Ranney Street Sikeston, MO Don't miss out on this unique home located in Sikeston's Historic Downtown Distr...	3 beds \| 2 baths \| N/A	$197,500	Airbnb cash on cash: N/A Traditional cash on cash: 9.54% Airbnb Rental Income: $null Traditional Rental Income: $2250 Airbnb ROI: N/A Traditional ROI: 9.54%
1205 Northfield Ct. Sikeston, MO Welcome to your dream home! This beautiful brick two-story residence features an inviting ...	3 beds \| 4 baths \| N/A	$360,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.49% Airbnb Rental Income: $null Traditional Rental Income: $3287 Airbnb ROI: N/A Traditional ROI: 7.49%
3 Bel Air Sikeston, MO Welcome to this well-maintained two-story home nestled in a peaceful circle, featuring a b...	4 beds \| 3 baths \| N/A	$299,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.97% Airbnb Rental Income: $null Traditional Rental Income: $3451 Airbnb ROI: N/A Traditional ROI: 9.97%
721 Mimosa Dr Sikeston, MO NEW PRICE!!!<br> <br> Great quiet location! This 3 bedroom 2 bath brick home has 1485 sf ...	3 beds \| 2 baths \| 2,970 sq.ft.	$219,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.72% Airbnb Rental Income: $null Traditional Rental Income: $2516 Airbnb ROI: N/A Traditional ROI: 9.72%
108 Jennings Lane Sikeston, MO This 5-bedroom, 4-bath home offers 3,822 sq ft of thoughtfully designed living space on a ...	5 beds \| 4 baths \| 3,822 sq.ft.	$500,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.79% Airbnb Rental Income: $null Traditional Rental Income: $3474 Airbnb ROI: N/A Traditional ROI: 5.79%
243 N Ridge Road Sikeston, MO Tucked at the edge of town in a quiet, well-kept neighborhood, this home has the kind of s...	3 beds \| 5 baths \| 5,296 sq.ft.	$515,000	Airbnb cash on cash: N/A Traditional cash on cash: 7.04% Airbnb Rental Income: $null Traditional Rental Income: $4243 Airbnb ROI: N/A Traditional ROI: 7.04%
840 Delta Pine Lane Sikeston, MO Welcome to this beautifully maintained two-story home, located in one of the areaâs most...	3 beds \| 3 baths \| 2,808 sq.ft.	$224,900	Airbnb cash on cash: N/A Traditional cash on cash: 11.71% Airbnb Rental Income: $null Traditional Rental Income: $2917 Airbnb ROI: N/A Traditional ROI: 11.71%
850 Cambridge Dr Sikeston, MO Completely renovated 3-bedroom, 2-bath home in Sikeston city limits. This beautifully upda...	3 beds \| 2 baths \| 2,871 sq.ft.	$205,000	Airbnb cash on cash: N/A Traditional cash on cash: 10.69% Airbnb Rental Income: $null Traditional Rental Income: $2469 Airbnb ROI: N/A Traditional ROI: 10.69%
1010 Pine Street Sikeston, MO Meticulously maintained and move-in ready, this home offers comfort, style, and plenty of ...	3 beds \| 2 baths \| 1,594 sq.ft.	$234,900	Airbnb cash on cash: N/A Traditional cash on cash: 8.42% Airbnb Rental Income: $null Traditional Rental Income: $2304 Airbnb ROI: N/A Traditional ROI: 8.42%
901 Moore Avenue Sikeston, MO Do you like both indoor and outdoor space? This is the one for you. This home includes a...	3 beds \| 3 baths \| 6,536 sq.ft.	$370,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.85% Airbnb Rental Income: $null Traditional Rental Income: $2964 Airbnb ROI: N/A Traditional ROI: 6.85%
866 Auburn Drive Sikeston, MO Welcome to your dream home in the heart of Sikeston on a corner lot. This beautifully upda...	4 beds \| 3 baths \| 3,610 sq.ft.	$329,000	Airbnb cash on cash: N/A Traditional cash on cash: 9.25% Airbnb Rental Income: $null Traditional Rental Income: $3417 Airbnb ROI: N/A Traditional ROI: 9.25%
325 Daniel Street Sikeston, MO Welcome to this gorgeous and beautifully remodeled home where all the hard work has been d...	3 beds \| 2 baths \| 1,232 sq.ft.	$165,000	Airbnb cash on cash: N/A Traditional cash on cash: 11.86% Airbnb Rental Income: $null Traditional Rental Income: $2134 Airbnb ROI: N/A Traditional ROI: 11.86%

Real Estate investment in Sikeston, MO

There are 21 properties for sale in the city of Sikeston . The median list price in Sikeston is $136,250 and the average price per square foot is $68. In September 2025, the average monthly cash on cash return in Sikeston is 12.00%. The average monthly rental income in Sikeston is $2,192.

Sikeston, MO Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 21 investment properties available for sale in Sikeston.

The ROI for Short-Term is higher than the Long-Term in Sikeston with average rental income of $N/A.

Your search for investment property begins and ends here

Investment Property for Sale in Sikeston, MO

132 Autumn Dr

Sikeston, MO

3 beds | 3 baths | 1,856 sq.ft.

$209,900

Airbnb cash on cash: N/A

Traditional cash on cash: 10.17%

Airbnb Rental Income: $null

Traditional Rental Income: $2506

Airbnb ROI: N/A

Traditional ROI: 10.17%

522 Tanglewood Avenue

Sikeston, MO

3 beds | 4 baths | 5,394 sq.ft.

$535,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.87%

Airbnb Rental Income: $null

Traditional Rental Income: $3281

Airbnb ROI: N/A

Traditional ROI: 4.87%

907 Taylor Street

Sikeston, MO

3 beds | 2 baths | 2,113 sq.ft.

$279,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.92%

Airbnb Rental Income: $null

Traditional Rental Income: $2522

Airbnb ROI: N/A

Traditional ROI: 7.92%

208 Foust Drive

Sikeston, MO

4 beds | 3 baths | 1,736 sq.ft.

$235,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.53%

Airbnb Rental Income: $null

Traditional Rental Income: $2311

Airbnb ROI: N/A

Traditional ROI: 8.53%

212 Melissa

Sikeston, MO

3 beds | 2 baths | 1,330 sq.ft.

$195,000

Airbnb cash on cash: N/A

Traditional cash on cash: 9.08%

Airbnb Rental Income: $null

Traditional Rental Income: $2029

Airbnb ROI: N/A

Traditional ROI: 9.08%

1304 William Street

Sikeston, MO

3 beds | 1 baths | 1,100 sq.ft.

$110,000

Airbnb cash on cash: N/A

Traditional cash on cash: 8.83%

Airbnb Rental Income: $null

Traditional Rental Income: $1177

Airbnb ROI: N/A

Traditional ROI: 8.83%

605 N. Ranney Street

Sikeston, MO

3 beds | 2 baths | N/A

$197,500

Airbnb cash on cash: N/A

Traditional cash on cash: 9.54%

Airbnb Rental Income: $null

Traditional Rental Income: $2250

Airbnb ROI: N/A

Traditional ROI: 9.54%

1205 Northfield Ct.

Sikeston, MO

3 beds | 4 baths | N/A

$360,000

Airbnb cash on cash: N/A

Traditional cash on cash: 7.49%

Airbnb Rental Income: $null

Traditional Rental Income: $3287

Airbnb ROI: N/A