Real Estate Investment Properties for Sale in Chillicothe, OH

Looking for investment property in Chillicothe, OH with high ROI ?

Explore a variety of short-term homes & houses in Chillicothe, OH. Invest wisely with VRBO & Chillicothe, OH Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Chillicothe, OH

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
1303 SANDY RD Chillicothe, OH Invest with success and buy through Auction.com. This bank-owned investment property is a ...	3 beds \| 2 baths \| 1,728 sq.ft.	$174,000	Airbnb cash on cash: 1.74% Traditional cash on cash: 9.48% Airbnb Rental Income: $1028 Traditional Rental Income: $1950 Airbnb ROI: 1.74% Traditional ROI: 9.48%
5 Shawnee Drive Chillicothe, OH Featuring a fully remodeled kitchen (2026) with new appliances, this move-in ready Brewer ...	3 beds \| 2 baths \| 1,607 sq.ft.	$365,000	Airbnb cash on cash: -0.06% Traditional cash on cash: 3.06% Airbnb Rental Income: $1028 Traditional Rental Income: $1735 Airbnb ROI: -0.06% Traditional ROI: 3.06%
191 Sullivan Road Chillicothe, OH UNIQUE CONTAINER HOME RETREAT - This is more than a home, it is an experience! Crafted fr...	3 beds \| 2 baths \| 1,488 sq.ft.	$350,000	Airbnb cash on cash: -0.8% Traditional cash on cash: 2.32% Airbnb Rental Income: $1028 Traditional Rental Income: $1692 Airbnb ROI: -0.8% Traditional ROI: 2.32%
1011 Lee Hollow Road Chillicothe, OH Very unique opportunity! Log cabin in the woods, on about 2.5 acress (3 parcels), PLUS a s...	1 beds \| 1 baths \| 728 sq.ft.	$150,000	Airbnb cash on cash: 0.21% Traditional cash on cash: 8.56% Airbnb Rental Income: $558 Traditional Rental Income: $1474 Airbnb ROI: 0.21% Traditional ROI: 8.56%
623 Glencroft Avenue Chillicothe, OH Welcome to 623 Glencoft Avenue! This brand-new, single-level home offers 3 bedrooms and 1 ...	3 beds \| 1 baths \| 1,056 sq.ft.	$145,000	Airbnb cash on cash: 3.04% Traditional cash on cash: 7.87% Airbnb Rental Income: $1028 Traditional Rental Income: $1339 Airbnb ROI: 3.04% Traditional ROI: 7.87%
485 Springer Road Chillicothe, OH Picture this... A real LOG CABIN, nestled at the back of 5 acres surrounded by woods and p...	3 beds \| 1 baths \| 632 sq.ft.	$250,000	Airbnb cash on cash: 1.33% Traditional cash on cash: 3.44% Airbnb Rental Income: $1028 Traditional Rental Income: $1168 Airbnb ROI: 1.33% Traditional ROI: 3.44%
4557 State Route 159 Chillicothe, OH Public Remarks: Here is your chance at a rare opp. to own 5.12 acres in Green Twp with NO ...	3 beds \| 3 baths \| 3,909 sq.ft.	$425,000	Airbnb cash on cash: -0.1% Traditional cash on cash: 3.57% Airbnb Rental Income: $1028 Traditional Rental Income: $2129 Airbnb ROI: -0.1% Traditional ROI: 3.57%
7178 State Route 159 Chillicothe, OH Cozy 3 bedroom, 1 full bath home nestled on 6 beautiful acres, offering both privacy and c...	3 beds \| 1 baths \| 1,304 sq.ft.	$250,000	Airbnb cash on cash: 0.86% Traditional cash on cash: 4.08% Airbnb Rental Income: $1028 Traditional Rental Income: $1427 Airbnb ROI: 0.86% Traditional ROI: 4.08%
20702 N US Highway 23 Chillicothe, OH One-of-a-Kind Estate Featuring Ohio's Largest Private Indoor Pool! Welcome to 20702 US Hig...	2 beds \| 5 baths \| 8,195 sq.ft.	$1,200,000	Airbnb cash on cash: -1.64% Traditional cash on cash: 1.32% Airbnb Rental Income: $915 Traditional Rental Income: $3876 Airbnb ROI: -1.64% Traditional ROI: 1.32%
14996 Pleasant Valley Road lot: 53 Chillicothe, OH Built in 2022 and meticulously cared for, this 3-bedroom, 2-bath manufactured home in the ...	3 beds \| 2 baths \| 1,120 sq.ft.	$85,000	Airbnb cash on cash: -1.75% Traditional cash on cash: 9.54% Airbnb Rental Income: $1028 Traditional Rental Income: $1609 Airbnb ROI: -1.75% Traditional ROI: 9.54%
1667 Stone Rd lot: 59 Chillicothe, OH Wow-so much space! This newer doublewide features 5 bedrooms and 3 full baths with an open...	5 beds \| 3 baths \| 2,040 sq.ft.	$239,900	Airbnb cash on cash: N/A Traditional cash on cash: 7.81% Airbnb Rental Income: $null Traditional Rental Income: $2524 Airbnb ROI: N/A Traditional ROI: 7.81%
90 2ND ST Chillicothe, OH Step back in time with this stunning Victorian gem in the heart of downtown Chillicothe. T...	4 beds \| 2 baths \| 3,720 sq.ft.	$400,000	Airbnb cash on cash: 0.21% Traditional cash on cash: 3.87% Airbnb Rental Income: $966 Traditional Rental Income: $1990 Airbnb ROI: 0.21% Traditional ROI: 3.87%
222 Saint Claire Drive Chillicothe, OH Experience easy living in this turn-key, three-story condo featuring two spacious bedrooms...	2 beds \| 2 baths \| 1,382 sq.ft.	$189,400	Airbnb cash on cash: -1.24% Traditional cash on cash: 5.34% Airbnb Rental Income: $915 Traditional Rental Income: $1757 Airbnb ROI: -1.24% Traditional ROI: 5.34%
35 Pickett Court Chillicothe, OH Welcome to your BRAND NEW sanctuary! This stunning 3-bed, 2-bath haven in a vibrant commun...	3 beds \| 2 baths \| 1,484 sq.ft.	$369,900	Airbnb cash on cash: -0.89% Traditional cash on cash: 2.92% Airbnb Rental Income: $1028 Traditional Rental Income: $1989 Airbnb ROI: -0.89% Traditional ROI: 2.92%
1071 Marietta Road Chillicothe, OH Come and visit the opportunity of a lifetime with this beautifully kept rustic barn that w...	4 beds \| 5 baths \| 2,550 sq.ft.	$550,000	Airbnb cash on cash: -0.28% Traditional cash on cash: 3.69% Airbnb Rental Income: $966 Traditional Rental Income: $2654 Airbnb ROI: -0.28% Traditional ROI: 3.69%
1271 Porter Dr. Chillicothe, OH Recently updated & available for immediate occupancy! Be sure to see this well-located 3 ...	3 beds \| 2 baths \| 1,390 sq.ft.	$269,000	Airbnb cash on cash: 0.45% Traditional cash on cash: 4.93% Airbnb Rental Income: $1028 Traditional Rental Income: $1803 Airbnb ROI: 0.45% Traditional ROI: 4.93%
24 Leggett Avenue Chillicothe, OH Looking for a great investment property or a perfect owner-occupied rental. This duplex of...	2 beds \| N/A baths \| N/A	$124,900	Airbnb cash on cash: 2% Traditional cash on cash: 7.39% Airbnb Rental Income: $915 Traditional Rental Income: $1222 Airbnb ROI: 2% Traditional ROI: 7.39%
4 Becky Lane Chillicothe, OH Welcome to this well-maintained 2-bedroom, 2-bath condo in the desirable Rosewood Villas s...	2 beds \| 2 baths \| 1,324 sq.ft.	$244,000	Airbnb cash on cash: -1.66% Traditional cash on cash: 1.25% Airbnb Rental Income: $915 Traditional Rental Income: $1244 Airbnb ROI: -1.66% Traditional ROI: 1.25%
1295 Randall Court Chillicothe, OH 3-Bedroom 3-Full Bath Bi-Level home offering 1440 Sq Ft and a full basement/lower level th...	3 beds \| 4 baths \| 1,440 sq.ft.	$269,900	Airbnb cash on cash: 0.36% Traditional cash on cash: 4.28% Airbnb Rental Income: $1028 Traditional Rental Income: $1667 Airbnb ROI: 0.36% Traditional ROI: 4.28%
53 Fruithill Drive Chillicothe, OH Private Pool. Five Bedrooms. Zero Ordinary. Welcome to a home that refuses to blend in. Tu...	5 beds \| 3 baths \| 2,763 sq.ft.	$459,900	Airbnb cash on cash: N/A Traditional cash on cash: 2.03% Airbnb Rental Income: $null Traditional Rental Income: $1797 Airbnb ROI: N/A Traditional ROI: 2.03%
1041 Edgewood Drive Chillicothe, OH Welcome to this beautifully updated 3-bedroom, 3 full bath home offering 1,568 sq ft of co...	3 beds \| 3 baths \| 1,568 sq.ft.	$335,000	Airbnb cash on cash: -0.72% Traditional cash on cash: 2.49% Airbnb Rental Income: $1028 Traditional Rental Income: $1678 Airbnb ROI: -0.72% Traditional ROI: 2.49%
161 Lana Lane Chillicothe, OH This 3-bedroom, 2-bath bi-level home offers the perfect blend of space, scenery, and poten...	3 beds \| 2 baths \| 1,752 sq.ft.	$259,000	Airbnb cash on cash: -0.19% Traditional cash on cash: 5.2% Airbnb Rental Income: $1028 Traditional Rental Income: $1986 Airbnb ROI: -0.19% Traditional ROI: 5.2%
1000 Crouse Chapel Road Chillicothe, OH Welcome to 1000 Crouse Chapel Rd in the highly sought-after Zane Trace School District. Bu...	4 beds \| 4 baths \| 2,700 sq.ft.	$465,000	Airbnb cash on cash: -0.91% Traditional cash on cash: 4.24% Airbnb Rental Income: $966 Traditional Rental Income: $2861 Airbnb ROI: -0.91% Traditional ROI: 4.24%
593 Franklin Circle Chillicothe, OH : Welcome to 593 Franklin Circle! This home was built in 1999 by the reputable Moody Homes...	3 beds \| 4 baths \| 1,388 sq.ft.	$280,000	Airbnb cash on cash: 0.31% Traditional cash on cash: 5.29% Airbnb Rental Income: $1028 Traditional Rental Income: $1983 Airbnb ROI: 0.31% Traditional ROI: 5.29%
601 Cherokee Rd Chillicothe, OH This is a very special mid-century home. It has been well-maintained throughout its life, ...	2 beds \| 1 baths \| 1,376 sq.ft.	$234,900	Airbnb cash on cash: -0.37% Traditional cash on cash: 3.2% Airbnb Rental Income: $915 Traditional Rental Income: $1368 Airbnb ROI: -0.37% Traditional ROI: 3.2%
20 Buckeye Trail Chillicothe, OH Immaculate 1.5 story home with vaulted ceilings, open floor plan and wood floors throughou...	3 beds \| 3 baths \| 2,636 sq.ft.	$425,000	Airbnb cash on cash: -0.36% Traditional cash on cash: 4.43% Airbnb Rental Income: $1028 Traditional Rental Income: $2577 Airbnb ROI: -0.36% Traditional ROI: 4.43%
1031 Dayton Street Chillicothe, OH Adorable Ranch-Style home nestled on a quaint side street close to downtown that's been we...	1 beds \| 1 baths \| 660 sq.ft.	$89,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 7.87% Airbnb Rental Income: $558 Traditional Rental Income: $888 Airbnb ROI: 0.84% Traditional ROI: 7.87%
1445 Lake Drive Chillicothe, OH Beautiful 3 bedroom, 2 bath home on a spacious lot with private setting and scenic views. ...	3 beds \| 2 baths \| 1,572 sq.ft.	$335,900	Airbnb cash on cash: 0.32% Traditional cash on cash: 4.19% Airbnb Rental Income: $1028 Traditional Rental Income: $1888 Airbnb ROI: 0.32% Traditional ROI: 4.19%
4700 Black Run Road Chillicothe, OH Nestled on 18.49 mostly wooded acres, this beautifully fully remodeled 2-bedroom, 2-bath h...	2 beds \| 2 baths \| 1,344 sq.ft.	$384,900	Airbnb cash on cash: -0.34% Traditional cash on cash: 2.85% Airbnb Rental Income: $915 Traditional Rental Income: $1725 Airbnb ROI: -0.34% Traditional ROI: 2.85%

Real Estate investment in Chillicothe, OH

There are 36 properties for sale in the city of Chillicothe . The median list price in Chillicothe is $239,900 and the average price per square foot is $143. In April 2026, the average monthly cash on cash return in Chillicothe is 4.00%. The average monthly rental income in Chillicothe is $1,800.

Chillicothe, OH Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 36 investment properties available for sale in Chillicothe.

In 2026, the best neighborhood to buy investment property is Chillicothe.

The ROI for Short-Term is higher than the Long-Term in Chillicothe with average rental income of $1,028.

Your search for investment property begins and ends here

Investment Property for Sale in Chillicothe, OH

1303 SANDY RD

Chillicothe, OH

3 beds | 2 baths | 1,728 sq.ft.

$174,000

Airbnb cash on cash: 1.74%

Traditional cash on cash: 9.48%

Airbnb Rental Income: $1028

Traditional Rental Income: $1950

Airbnb ROI: 1.74%

Traditional ROI: 9.48%

5 Shawnee Drive

Chillicothe, OH

3 beds | 2 baths | 1,607 sq.ft.

$365,000

Airbnb cash on cash: -0.06%

Traditional cash on cash: 3.06%

Airbnb Rental Income: $1028

Traditional Rental Income: $1735

Airbnb ROI: -0.06%

Traditional ROI: 3.06%

191 Sullivan Road

Chillicothe, OH

3 beds | 2 baths | 1,488 sq.ft.

$350,000

Airbnb cash on cash: -0.8%

Traditional cash on cash: 2.32%

Airbnb Rental Income: $1028

Traditional Rental Income: $1692

Airbnb ROI: -0.8%

Traditional ROI: 2.32%

1011 Lee Hollow Road

Chillicothe, OH

1 beds | 1 baths | 728 sq.ft.

$150,000

Airbnb cash on cash: 0.21%

Traditional cash on cash: 8.56%

Airbnb Rental Income: $558

Traditional Rental Income: $1474

Airbnb ROI: 0.21%

Traditional ROI: 8.56%

623 Glencroft Avenue

Chillicothe, OH

3 beds | 1 baths | 1,056 sq.ft.

$145,000

Airbnb cash on cash: 3.04%

Traditional cash on cash: 7.87%

Airbnb Rental Income: $1028

Traditional Rental Income: $1339

Airbnb ROI: 3.04%

Traditional ROI: 7.87%

485 Springer Road

Chillicothe, OH

3 beds | 1 baths | 632 sq.ft.

$250,000

Airbnb cash on cash: 1.33%

Traditional cash on cash: 3.44%

Airbnb Rental Income: $1028

Traditional Rental Income: $1168

Airbnb ROI: 1.33%

Traditional ROI: 3.44%

4557 State Route 159

Chillicothe, OH

3 beds | 3 baths | 3,909 sq.ft.

$425,000

Airbnb cash on cash: -0.1%

Traditional cash on cash: 3.57%

Airbnb Rental Income: $1028

Traditional Rental Income: $2129

Airbnb ROI: -0.1%

Traditional ROI: 3.57%

7178 State Route 159

Chillicothe, OH

3 beds | 1 baths | 1,304 sq.ft.

$250,000

Airbnb cash on cash: 0.86%

Traditional cash on cash: 4.08%

Airbnb Rental Income: $1028

Traditional Rental Income: $1427

Airbnb ROI: 0.86%