Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
287 Santee Dr Santee, SC Waterfront home w/dock built in 2016 is located in Santee Cooper Resort, a gated waterfron...	4 beds \| 3 baths \| 2,786 sq.ft.	$849,900	Airbnb cash on cash: 2.72% Traditional cash on cash: 1.69% Airbnb Rental Income: $4603 Traditional Rental Income: $2829 Airbnb ROI: 2.72% Traditional ROI: 1.69%
370 Chapel Creek Dr Santee, SC Welcome to 370 Chapel Creek Drive in Santee, SC, where golf, lake living, and Lowcountry c...	4 beds \| 4 baths \| 3,720 sq.ft.	$570,000	Airbnb cash on cash: 5.08% Traditional cash on cash: 5.66% Airbnb Rental Income: $4603 Traditional Rental Income: $3957 Airbnb ROI: 5.08% Traditional ROI: 5.66%
106 Wateree Dr Santee, SC PRICED REDUCED!!!If you love boating, golfing, fishing make this house in Santee Cooper Re...	3 beds \| 2 baths \| 2,228 sq.ft.	$379,900	Airbnb cash on cash: -0.4% Traditional cash on cash: 2.84% Airbnb Rental Income: $1028 Traditional Rental Income: $1822 Airbnb ROI: -0.4% Traditional ROI: 2.84%
126 Wateree Dr Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 2 baths \| 3,204 sq.ft.	$549,000	Airbnb cash on cash: -1.29% Traditional cash on cash: 1.28% Airbnb Rental Income: $1028 Traditional Rental Income: $1986 Airbnb ROI: -1.29% Traditional ROI: 1.28%
440 Chapel Creek Dr Santee, SC PRICED TO SELL! The beautiful home is located on a lake at Chapel Creek Plantation, the h...	4 beds \| 2 baths \| 2,920 sq.ft.	$585,777	Airbnb cash on cash: 4.15% Traditional cash on cash: 1.69% Airbnb Rental Income: $4603 Traditional Rental Income: $2296 Airbnb ROI: 4.15% Traditional ROI: 1.69%
127 Cooper Cir Santee, SC Located in Santee Cooper Resort on Lake Marion. This home has 14 rooms (laundry room, uti...	4 beds \| 3 baths \| 3,386 sq.ft.	$499,900	Airbnb cash on cash: 4.19% Traditional cash on cash: 1.51% Airbnb Rental Income: $4603 Traditional Rental Income: $2394 Airbnb ROI: 4.19% Traditional ROI: 1.51%
109 Birdie Ct Santee, SC Well maintained brick home in Chapel Creek Plantation within Santee National Golf Club is ...	2 beds \| 2 baths \| 1,444 sq.ft.	$325,000	Airbnb cash on cash: 0.64% Traditional cash on cash: 3.53% Airbnb Rental Income: $1073 Traditional Rental Income: $1589 Airbnb ROI: 0.64% Traditional ROI: 3.53%
216 Broad River Dr Santee, SC Waterfront home in Santee Cooper Resort, a gated waterfront & golf course community locate...	3 beds \| 2 baths \| 2,492 sq.ft.	$649,900	Airbnb cash on cash: -0.55% Traditional cash on cash: 2.58% Airbnb Rental Income: $1028 Traditional Rental Income: $2570 Airbnb ROI: -0.55% Traditional ROI: 2.58%
133 Saluda Dr Santee, SC Beautiful home in Santee Cooper Resort, a gated golf and water, Lake Marion Community. Thi...	3 beds \| 2 baths \| 2,748 sq.ft.	$512,000	Airbnb cash on cash: -0.77% Traditional cash on cash: 2.17% Airbnb Rental Income: $1028 Traditional Rental Income: $2075 Airbnb ROI: -0.77% Traditional ROI: 2.17%
403 Ballard Ln Santee, SC Imagine waking up to stunning Lake Marion views in this first-floor, 3-bedroom, 3-bathroom...	3 beds \| 3 baths \| 1,498 sq.ft.	$299,000	Airbnb cash on cash: -1.22% Traditional cash on cash: 3.9% Airbnb Rental Income: $1028 Traditional Rental Income: $2110 Airbnb ROI: -1.22% Traditional ROI: 3.9%
116 William Clark Blvd Santee, SC Spacious 4-bedroom, 2-bath home located in the front of the neighborhood--just one block f...	4 beds \| 2 baths \| 1,768 sq.ft.	$325,000	Airbnb cash on cash: 9.91% Traditional cash on cash: 5.72% Airbnb Rental Income: $4603 Traditional Rental Income: $2366 Airbnb ROI: 9.91% Traditional ROI: 5.72%
105 Ballard Ln Santee, SC Turnkey waterfront condo overlooking Lake Marion--South Carolina's largest lake with acces...	2 beds \| 2 baths \| 1,298 sq.ft.	$260,000	Airbnb cash on cash: -0.57% Traditional cash on cash: 3.76% Airbnb Rental Income: $1073 Traditional Rental Income: $1768 Airbnb ROI: -0.57% Traditional ROI: 3.76%
8495 Old Number Six Hwy Santee, SC Half Acre Charming Lake Retreat Near Golf & Santee State Park! Don't miss this opportunity...	2 beds \| 1 baths \| 800 sq.ft.	$209,900	Airbnb cash on cash: 1.51% Traditional cash on cash: 5.65% Airbnb Rental Income: $1073 Traditional Rental Income: $1530 Airbnb ROI: 1.51% Traditional ROI: 5.65%
106 Broad River Dr Santee, SC Easy home build process. PROPOSED CONSTRUCTION on DEEP WATER. ** Vacant Land/Lot also list...	4 beds \| 3 baths \| 2,600 sq.ft.	$743,000	Airbnb cash on cash: 3.57% Traditional cash on cash: 2.49% Airbnb Rental Income: $4603 Traditional Rental Income: $2903 Airbnb ROI: 3.57% Traditional ROI: 2.49%
472 Santee Dr Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 3 baths \| 4,046 sq.ft.	$550,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.88% Airbnb Rental Income: $null Traditional Rental Income: $3558 Airbnb ROI: N/A Traditional ROI: 4.88%
119 Saluda Dr Santee, SC Experience the ultimate lake and golf lifestyle at 119 Saluda Drive, located in the sought...	4 beds \| 2 baths \| 3,055 sq.ft.	$499,900	Airbnb cash on cash: 5.62% Traditional cash on cash: 3.09% Airbnb Rental Income: $4603 Traditional Rental Income: $2466 Airbnb ROI: 5.62% Traditional ROI: 3.09%
457 Santee Dr Santee, SC Welcome to luxury living on Lake Marion! Situated on the serene shores of Lake Marion this...	4 beds \| 3 baths \| 3,778 sq.ft.	$1,150,000	Airbnb cash on cash: 1.46% Traditional cash on cash: 1.8% Airbnb Rental Income: $4603 Traditional Rental Income: $4006 Airbnb ROI: 1.46% Traditional ROI: 1.8%
208 Avocada Dr Santee, SC NO HOA with a FRONT AND BACK YARD.3 bedroom , 2 bathroom with a front porch followed by a ...	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 1.19% Traditional cash on cash: 5.97% Airbnb Rental Income: $1028 Traditional Rental Income: $1774 Airbnb ROI: 1.19% Traditional ROI: 5.97%
107 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton This is a limit...	3 beds \| 2 baths \| 1,473 sq.ft.	$269,000	Airbnb cash on cash: 0.24% Traditional cash on cash: 4.25% Airbnb Rental Income: $1028 Traditional Rental Income: $1687 Airbnb ROI: 0.24% Traditional ROI: 4.25%
109 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton This is a limit...	3 beds \| 2 baths \| 1,524 sq.ft.	$278,000	Airbnb cash on cash: 0.63% Traditional cash on cash: 4.32% Airbnb Rental Income: $1028 Traditional Rental Income: $1636 Airbnb ROI: 0.63% Traditional ROI: 4.32%
192 Avocada Dr Santee, SC 192 Avocada Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$260,000	Airbnb cash on cash: 0.77% Traditional cash on cash: 3.65% Airbnb Rental Income: $1028 Traditional Rental Income: $1375 Airbnb ROI: 0.77% Traditional ROI: 3.65%
190 Avocada Drive Dr Santee, SC 190 Avocada Drive Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 0.92% Traditional cash on cash: 3.97% Airbnb Rental Income: $1028 Traditional Rental Income: $1375 Airbnb ROI: 0.92% Traditional ROI: 3.97%
214 Avocada Dr Santee, SC 214 Avocada Dr, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,200 sq.ft.	$244,999	Airbnb cash on cash: 0.92% Traditional cash on cash: 3.97% Airbnb Rental Income: $1028 Traditional Rental Income: $1375 Airbnb ROI: 0.92% Traditional ROI: 3.97%
Spruce Plan Santee, SC Spruce Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,296 sq.ft.	$246,990	Airbnb cash on cash: 0.9% Traditional cash on cash: 3.74% Airbnb Rental Income: $1028 Traditional Rental Income: $1331 Airbnb ROI: 0.9% Traditional ROI: 3.74%
Fairview Plan Santee, SC Fairview Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 1,910 sq.ft.	$292,990	Airbnb cash on cash: 0.52% Traditional cash on cash: 4.37% Airbnb Rental Income: $1028 Traditional Rental Income: $1732 Airbnb ROI: 0.52% Traditional ROI: 4.37%
Tupelo Plan Santee, SC Tupelo Plan, Santee, SC 29142 \| Single Family Residential	3 beds \| 2 baths \| 1,517 sq.ft.	$267,990	Airbnb cash on cash: 0.71% Traditional cash on cash: 3.8% Airbnb Rental Income: $1028 Traditional Rental Income: $1449 Airbnb ROI: 0.71% Traditional ROI: 3.8%
106 Santee Cooper Anx Santee, SC 106 Santee Cooper Anx, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 2,771 sq.ft.	$440,000	Airbnb cash on cash: -0.63% Traditional cash on cash: 2.89% Airbnb Rental Income: $1028 Traditional Rental Income: $2116 Airbnb ROI: -0.63% Traditional ROI: 2.89%
156 William Clark Blvd Santee, SC Welcome to Center Pointe, where golf, fishing, and lake life are just minutes away! Conven...	5 beds \| 3 baths \| 2,646 sq.ft.	$349,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.1% Airbnb Rental Income: $null Traditional Rental Income: $2327 Airbnb ROI: N/A Traditional ROI: 5.1%
342 Picard Loop Santee, SC 342 Picard Loop, Santee, SC 29142 \| Townhouse	3 beds \| 2 baths \| 1,625 sq.ft.	$218,500	Airbnb cash on cash: 0.27% Traditional cash on cash: 4.76% Airbnb Rental Income: $1028 Traditional Rental Income: $1598 Airbnb ROI: 0.27% Traditional ROI: 4.76%
118 William Clark Blvd Santee, SC 118 William Clark Blvd, Santee, SC 29142 \| Single Family Residential	3 beds \| 3 baths \| 2,507 sq.ft.	$350,000	Airbnb cash on cash: -1.56% Traditional cash on cash: 2.97% Airbnb Rental Income: $1028 Traditional Rental Income: $2155 Airbnb ROI: -1.56% Traditional ROI: 2.97%
724 Striped Bass Ct Santee, SC Spacious New Home Near Lake Marion Welcome home to 724 Striped Bass Court, located in the ...	3 beds \| 2 baths \| 1,517 sq.ft.	$245,900	Airbnb cash on cash: 0.7% Traditional cash on cash: 4.57% Airbnb Rental Income: $1028 Traditional Rental Income: $1567 Airbnb ROI: 0.7% Traditional ROI: 4.57%
122 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Welcome to Mari...	3 beds \| 2 baths \| 1,524 sq.ft.	$273,000	Airbnb cash on cash: 0.66% Traditional cash on cash: 4.18% Airbnb Rental Income: $1028 Traditional Rental Income: $1573 Airbnb ROI: 0.66% Traditional ROI: 4.18%
126 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Don't miss this...	3 beds \| 2 baths \| 1,524 sq.ft.	$276,000	Airbnb cash on cash: 0.64% Traditional cash on cash: 4.12% Airbnb Rental Income: $1028 Traditional Rental Income: $1573 Airbnb ROI: 0.64% Traditional ROI: 4.12%
116 Cypress Hollow Way Santee, SC Don't miss this limited opportunity to own an end-unit townhome in Marion Village, one of ...	3 beds \| 2 baths \| 1,473 sq.ft.	$269,000	Airbnb cash on cash: 0.7% Traditional cash on cash: 4.11% Airbnb Rental Income: $1028 Traditional Rental Income: $1533 Airbnb ROI: 0.7% Traditional ROI: 4.11%
120 Cypress Hollow Way Santee, SC Townhomes for Sale with Lake Marion Access \| Marion Village by D.R. Horton Welcome to Mari...	3 beds \| 2 baths \| 1,473 sq.ft.	$258,000	Airbnb cash on cash: 0.79% Traditional cash on cash: 4.34% Airbnb Rental Income: $1028 Traditional Rental Income: $1533 Airbnb ROI: 0.79% Traditional ROI: 4.34%
SULLIVAN Plan Santee, SC	3 beds \| 2 baths \| 1,183 sq.ft.	$208,580	Airbnb cash on cash: 1.34% Traditional cash on cash: 4.52% Airbnb Rental Income: $1028 Traditional Rental Income: $1297 Airbnb ROI: 1.34% Traditional ROI: 4.52%
BRANDON Plan Santee, SC	3 beds \| 2 baths \| 1,518 sq.ft.	$244,370	Airbnb cash on cash: 0.92% Traditional cash on cash: 4.3% Airbnb Rental Income: $1028 Traditional Rental Income: $1449 Airbnb ROI: 0.92% Traditional ROI: 4.3%
0 Ellexlee Rd Santee, SC 0 Ellexlee Rd, Santee, SC 29142 \| Other	N/A beds \| N/A baths \| N/A	$150,000	Airbnb cash on cash: 8.06% Traditional cash on cash: 1.22% Airbnb Rental Income: $1996 Traditional Rental Income: $493 Airbnb ROI: 8.06% Traditional ROI: 1.22%
9387 Old Number Six Hwy Santee, SC 9387 Old Number Six Hwy, Santee, SC 29142 \| Other	N/A beds \| N/A baths \| N/A	$624,900	Airbnb cash on cash: 0.8% Traditional cash on cash: -0.88% Airbnb Rental Income: $1996 Traditional Rental Income: $493 Airbnb ROI: 0.8% Traditional ROI: -0.88%
0 State Dr Santee, SC 0 State Dr, Santee, SC 29142 \| Other	N/A beds \| N/A baths \| N/A	$1,250,000	Airbnb cash on cash: -0.38% Traditional cash on cash: -1.24% Airbnb Rental Income: $1996 Traditional Rental Income: $476 Airbnb ROI: -0.38% Traditional ROI: -1.24%

Real Estate investment in Santee, SC

There are 106 properties for sale in the city of Santee . The median list price in Santee is $294,024 and the average price per square foot is $180. In August 2026, the average monthly cash on cash return in Santee is 4.00%. The average monthly rental income in Santee is $1,588.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 106 investment properties available for sale in Santee.

In 2026, the best neighborhood to buy investment property is Santee.

The ROI for Long-Term is higher than the Short-Term in Santee with average rental income of $1,588.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

287 Santee Dr

Santee, SC

4 beds | 3 baths | 2,786 sq.ft.

$849,900

Airbnb cash on cash: 2.72%

Traditional cash on cash: 1.69%

Airbnb Rental Income: $4603

Traditional Rental Income: $2829

Airbnb ROI: 2.72%

Traditional ROI: 1.69%

370 Chapel Creek Dr

Santee, SC

4 beds | 4 baths | 3,720 sq.ft.

$570,000

Airbnb cash on cash: 5.08%

Traditional cash on cash: 5.66%

Airbnb Rental Income: $4603

Traditional Rental Income: $3957

Airbnb ROI: 5.08%

Traditional ROI: 5.66%

106 Wateree Dr

Santee, SC

3 beds | 2 baths | 2,228 sq.ft.

$379,900

Airbnb cash on cash: -0.4%

Traditional cash on cash: 2.84%

Airbnb Rental Income: $1028

Traditional Rental Income: $1822

Airbnb ROI: -0.4%

Traditional ROI: 2.84%

126 Wateree Dr

Santee, SC

3 beds | 2 baths | 3,204 sq.ft.

$549,000

Airbnb cash on cash: -1.29%

Traditional cash on cash: 1.28%

Airbnb Rental Income: $1028

Traditional Rental Income: $1986

Airbnb ROI: -1.29%

Traditional ROI: 1.28%

440 Chapel Creek Dr

Santee, SC

4 beds | 2 baths | 2,920 sq.ft.

$585,777

Airbnb cash on cash: 4.15%

Traditional cash on cash: 1.69%

Airbnb Rental Income: $4603

Traditional Rental Income: $2296

Airbnb ROI: 4.15%

Traditional ROI: 1.69%

127 Cooper Cir

Santee, SC

4 beds | 3 baths | 3,386 sq.ft.

$499,900

Airbnb cash on cash: 4.19%

Traditional cash on cash: 1.51%

Airbnb Rental Income: $4603

Traditional Rental Income: $2394

Airbnb ROI: 4.19%

Traditional ROI: 1.51%

109 Birdie Ct

Santee, SC

2 beds | 2 baths | 1,444 sq.ft.

$325,000

Airbnb cash on cash: 0.64%

Traditional cash on cash: 3.53%

Airbnb Rental Income: $1073

Traditional Rental Income: $1589

Airbnb ROI: 0.64%

Traditional ROI: 3.53%

216 Broad River Dr

Santee, SC

3 beds | 2 baths | 2,492 sq.ft.

$649,900

Airbnb cash on cash: -0.55%

Traditional cash on cash: 2.58%

Airbnb Rental Income: $1028

Traditional Rental Income: $2570

Airbnb ROI: -0.55%