Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
448 Santee Drive Santee, SC Enjoy life by the lake in this beautiful home located on the 16th hole of the historic San...	4 beds \| 3 baths \| 2,784 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.13% Airbnb Rental Income: $null Traditional Rental Income: $2753 Airbnb ROI: N/A Traditional ROI: 4.13%
104 Cooper Drive Santee, SC In Santee Cooper Resort, you purchase more than a home, you purchase a lifestyle. Nothing ...	4 beds \| 4 baths \| 3,316 sq.ft.	$420,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.19% Airbnb Rental Income: $null Traditional Rental Income: $3300 Airbnb ROI: N/A Traditional ROI: 6.19%
143 Ballard Lane Santee, SC Relaxation and Style on Lake Marion! Fully furnished 2-bedroom, 2-bath waterfront condo wi...	2 beds \| 2 baths \| 1,298 sq.ft.	$200,000	Airbnb cash on cash: 1.09% Traditional cash on cash: 6.26% Airbnb Rental Income: $1235 Traditional Rental Income: $1821 Airbnb ROI: 1.09% Traditional ROI: 6.26%
126 Wateree Drive Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 2 baths \| 3,204 sq.ft.	$575,000	Airbnb cash on cash: -1.31% Traditional cash on cash: 1.46% Airbnb Rental Income: $824 Traditional Rental Income: $1986 Airbnb ROI: -1.31% Traditional ROI: 1.46%
130 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$341,400	Airbnb cash on cash: -0.31% Traditional cash on cash: 4.38% Airbnb Rental Income: $824 Traditional Rental Income: $2000 Airbnb ROI: -0.31% Traditional ROI: 4.38%
145 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$349,965	Airbnb cash on cash: -0.34% Traditional cash on cash: 4.26% Airbnb Rental Income: $824 Traditional Rental Income: $2009 Airbnb ROI: -0.34% Traditional ROI: 4.26%
116 William Clark Boulevard Santee, SC Spacious 4-bedroom, 2-bath home located in the front of the neighborhood--just one block f...	4 beds \| 2 baths \| 1,774 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.76% Airbnb Rental Income: $null Traditional Rental Income: $2366 Airbnb ROI: N/A Traditional ROI: 5.76%
106 Broad River Drive Santee, SC PROPOSED CONSTRUCTION on DEEP WATER. Vacant Land/Lot also listed as MLS# 23018200. S...	4 beds \| 3 baths \| 2,600 sq.ft.	$744,075	Airbnb cash on cash: N/A Traditional cash on cash: 2.49% Airbnb Rental Income: $null Traditional Rental Income: $2903 Airbnb ROI: N/A Traditional ROI: 2.49%
472 Santee Drive Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 4 baths \| 4,046 sq.ft.	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.34% Airbnb Rental Income: $null Traditional Rental Income: $3558 Airbnb ROI: N/A Traditional ROI: 4.34%
780 Striped Bass Court Santee, SC READY NOW! Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2...	3 beds \| 2 baths \| 1,183 sq.ft.	$245,900	Airbnb cash on cash: 0.27% Traditional cash on cash: 5.52% Airbnb Rental Income: $824 Traditional Rental Income: $1716 Airbnb ROI: 0.27% Traditional ROI: 5.52%
681 Perch Lane Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: 0.29% Traditional cash on cash: 6.42% Airbnb Rental Income: $824 Traditional Rental Income: $1905 Airbnb ROI: 0.29% Traditional ROI: 6.42%
740 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$269,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $1905 Airbnb ROI: N/A Traditional ROI: 5.69%
905 Bream Circle Santee, SC Newly Released! Looking for that spacious backyard? This lot with the Brandon floorplan ha...	3 beds \| N/A baths \| 1,518 sq.ft.	$293,120	Airbnb cash on cash: 0.07% Traditional cash on cash: 5.27% Airbnb Rental Income: $824 Traditional Rental Income: $1933 Airbnb ROI: 0.07% Traditional ROI: 5.27%
752 Striped Bass Court Santee, SC Newly Released! Looking for a home with a nice view? This lot with the Brandon floorplan h...	3 beds \| N/A baths \| 1,518 sq.ft.	$288,120	Airbnb cash on cash: 0.09% Traditional cash on cash: 5.41% Airbnb Rental Income: $824 Traditional Rental Income: $1942 Airbnb ROI: 0.09% Traditional ROI: 5.41%
900 Bream Circle Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$249,850	Airbnb cash on cash: 0.25% Traditional cash on cash: 5.45% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.25% Traditional ROI: 5.45%
753 Striped Bass Court Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$247,850	Airbnb cash on cash: 0.26% Traditional cash on cash: 5.51% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.26% Traditional ROI: 5.51%
908 Bream Circle Santee, SC Welcome home to the Helena, a beautifully designed one-story home nested in the cul-de-sac...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,615	Airbnb cash on cash: N/A Traditional cash on cash: 5.42% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.42%
733 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,115	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.43%
729 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$293,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.66% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.66%
625 Perch Lane Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: 0.29% Traditional cash on cash: 5.64% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.29% Traditional ROI: 5.64%
728 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$289,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.75% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.75%
657 Perch Lane Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$264,850	Airbnb cash on cash: N/A Traditional cash on cash: 5.84% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.84%
748 Striped Bass Court Santee, SC Welcome to the Rachel! This home offers everything you're looking for in a functional two-...	3 beds \| N/A baths \| 1,360 sq.ft.	$279,900	Airbnb cash on cash: 0.12% Traditional cash on cash: 5.28% Airbnb Rental Income: $824 Traditional Rental Income: $1858 Airbnb ROI: 0.12% Traditional ROI: 5.28%
102 Cooper Drive Santee, SC Welcome to 102 Cooper Drive, a beautifully maintained Southern-style brick ranch tucked aw...	3 beds \| 2 baths \| 2,369 sq.ft.	$459,900	Airbnb cash on cash: -1.05% Traditional cash on cash: 2.83% Airbnb Rental Income: $824 Traditional Rental Income: $2169 Airbnb ROI: -1.05% Traditional ROI: 2.83%
111 Santee Cooper Santee, SC MAKE EVERY DAY A VACATION DAY! LOCATED IN SANTEE COOPER RESORT, A GATED, WATERFRONT AND GO...	4 beds \| N/A baths \| 1,908 sq.ft.	$305,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.6% Airbnb Rental Income: $null Traditional Rental Income: $2285 Airbnb ROI: N/A Traditional ROI: 4.6%
202 Trillium Court Santee, SC Waterfront condo, 2 bedrooms, 2 baths, overlooking the Santee State Park & Lake Marion the...	2 beds \| 2 baths \| 1,328 sq.ft.	$235,000	Airbnb cash on cash: -1.93% Traditional cash on cash: 3.08% Airbnb Rental Income: $1235 Traditional Rental Income: $1953 Airbnb ROI: -1.93% Traditional ROI: 3.08%
119 Saluda Drive Santee, SC Live the lake and golf life at 119 Saluda Drive, located in the prestigious Santee Cooper ...	3 beds \| 2 baths \| 3,056 sq.ft.	$499,900	Airbnb cash on cash: -1.12% Traditional cash on cash: 3.09% Airbnb Rental Income: $824 Traditional Rental Income: $2466 Airbnb ROI: -1.12% Traditional ROI: 3.09%
461 Chapel Creek Drive Santee, SC Beautiful Custom Home on Nearly Half an Acre - Golf Course Frontage!Welcome to your dream ...	3 beds \| 3 baths \| 2,485 sq.ft.	$440,000	Airbnb cash on cash: -0.62% Traditional cash on cash: 3.85% Airbnb Rental Income: $824 Traditional Rental Income: $2337 Airbnb ROI: -0.62% Traditional ROI: 3.85%
457 Santee Drive Santee, SC Welcome to luxury living on Lake Marion! Situated on the serene shores of Lake Marion thi...	4 beds \| 4 baths \| 3,778 sq.ft.	$1,649,000	Airbnb cash on cash: N/A Traditional cash on cash: 0.96% Airbnb Rental Income: $null Traditional Rental Income: $4006 Airbnb ROI: N/A Traditional ROI: 0.96%
343 Pinewood Drive Santee, SC Welcome to 343 Pinewood Dr, Santee, SC 29142 your gateway to lakeside living in the heart ...	4 beds \| 3 baths \| 2,322 sq.ft.	$345,100	Airbnb cash on cash: N/A Traditional cash on cash: 5.82% Airbnb Rental Income: $null Traditional Rental Income: $2690 Airbnb ROI: N/A Traditional ROI: 5.82%
175 William Clark Boulevard Santee, SC Experience modern comfort and convenience in this gorgeous home located in the sought-afte...	3 beds \| 3 baths \| 2,482 sq.ft.	$285,000	Airbnb cash on cash: -0.06% Traditional cash on cash: 7.32% Airbnb Rental Income: $824 Traditional Rental Income: $2479 Airbnb ROI: -0.06% Traditional ROI: 7.32%

Real Estate investment in Santee, SC

There are 31 properties for sale in the city of Santee . The median list price in Santee is $293,120 and the average price per square foot is $146. In December 2025, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $2,000.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 31 investment properties available for sale in Santee.

In 2025, the best neighborhood to buy investment property is Santee.

The ROI for Short-Term is higher than the Long-Term in Santee with average rental income of $824.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

448 Santee Drive

Santee, SC

4 beds | 3 baths | 2,784 sq.ft.

$499,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.13%

Airbnb Rental Income: $null

Traditional Rental Income: $2753

Airbnb ROI: N/A

Traditional ROI: 4.13%

104 Cooper Drive

Santee, SC

4 beds | 4 baths | 3,316 sq.ft.

$420,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.19%

Airbnb Rental Income: $null

Traditional Rental Income: $3300

Airbnb ROI: N/A

Traditional ROI: 6.19%

143 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$200,000

Airbnb cash on cash: 1.09%

Traditional cash on cash: 6.26%

Airbnb Rental Income: $1235

Traditional Rental Income: $1821

Airbnb ROI: 1.09%

Traditional ROI: 6.26%

126 Wateree Drive

Santee, SC

3 beds | 2 baths | 3,204 sq.ft.

$575,000

Airbnb cash on cash: -1.31%

Traditional cash on cash: 1.46%

Airbnb Rental Income: $824

Traditional Rental Income: $1986

Airbnb ROI: -1.31%

Traditional ROI: 1.46%

130 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 1,774 sq.ft.

$341,400

Airbnb cash on cash: -0.31%

Traditional cash on cash: 4.38%

Airbnb Rental Income: $824

Traditional Rental Income: $2000

Airbnb ROI: -0.31%

Traditional ROI: 4.38%

145 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 1,774 sq.ft.

$349,965

Airbnb cash on cash: -0.34%

Traditional cash on cash: 4.26%

Airbnb Rental Income: $824

Traditional Rental Income: $2009

Airbnb ROI: -0.34%

Traditional ROI: 4.26%

116 William Clark Boulevard

Santee, SC

4 beds | 2 baths | 1,774 sq.ft.

$330,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.76%

Airbnb Rental Income: $null

Traditional Rental Income: $2366

Airbnb ROI: N/A

Traditional ROI: 5.76%

106 Broad River Drive

Santee, SC

4 beds | 3 baths | 2,600 sq.ft.

$744,075

Airbnb cash on cash: N/A

Traditional cash on cash: 2.49%

Airbnb Rental Income: $null

Traditional Rental Income: $2903

Airbnb ROI: N/A