Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
448 Santee Dr Santee, SC Live where every day feels like a getaway--gated luxury, Lake Marion fun, golf at your doo...	4 beds \| 2 baths \| 2,784 sq.ft.	$470,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.13% Airbnb Rental Income: $null Traditional Rental Income: $2753 Airbnb ROI: N/A Traditional ROI: 4.13%
104 Cooper Dr Santee, SC In Santee Cooper Resort, you purchase more than a home, you purchase a lifestyle. Nothing ...	4 beds \| 3 baths \| 3,316 sq.ft.	$375,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.16% Airbnb Rental Income: $null Traditional Rental Income: $3300 Airbnb ROI: N/A Traditional ROI: 6.16%
126 Wateree Dr Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 2 baths \| 3,204 sq.ft.	$575,000	Airbnb cash on cash: -1.59% Traditional cash on cash: 1.18% Airbnb Rental Income: $824 Traditional Rental Income: $1986 Airbnb ROI: -1.59% Traditional ROI: 1.18%
125 Ballard Ln Santee, SC Enjoy lake-area living just minutes from Lake Marion in the heart of Santee. This top-floo...	2 beds \| 2 baths \| 1,298 sq.ft.	$220,000	Airbnb cash on cash: 0.6% Traditional cash on cash: 4.6% Airbnb Rental Income: $1235 Traditional Rental Income: $1675 Airbnb ROI: 0.6% Traditional ROI: 4.6%
116 William Clark Blvd Santee, SC Spacious 4-bedroom, 2-bath home located in the front of the neighborhood--just one block f...	4 beds \| 2 baths \| 1,774 sq.ft.	$320,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.83% Airbnb Rental Income: $null Traditional Rental Income: $2366 Airbnb ROI: N/A Traditional ROI: 5.83%
302 Santee Dr Santee, SC Welcome to the highly sought-after, gated Santee Cooper Resort, where luxury meets lakesid...	4 beds \| 2 baths \| 2,481 sq.ft.	$450,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.33% Airbnb Rental Income: $null Traditional Rental Income: $1879 Airbnb ROI: N/A Traditional ROI: 2.33%
106 Broad River Dr Santee, SC Easy home build process. PROPOSED CONSTRUCTION on DEEP WATER. ** Vacant Land/Lot also list...	4 beds \| 3 baths \| 2,600 sq.ft.	$743,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.49% Airbnb Rental Income: $null Traditional Rental Income: $2903 Airbnb ROI: N/A Traditional ROI: 2.49%
125 Congaree Ct Santee, SC Come Fall in love with this beautiful move-in-ready 2023-built home offering three bedroom...	3 beds \| 2 baths \| 1,183 sq.ft.	$229,000	Airbnb cash on cash: 0.08% Traditional cash on cash: 5.23% Airbnb Rental Income: $824 Traditional Rental Income: $1615 Airbnb ROI: 0.08% Traditional ROI: 5.23%
472 Santee Dr Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 3 baths \| 4,046 sq.ft.	$599,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.34% Airbnb Rental Income: $null Traditional Rental Income: $3558 Airbnb ROI: N/A Traditional ROI: 4.34%
780 Striped Bass Court Santee, SC READY NOW! Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2...	3 beds \| 2 baths \| 1,183 sq.ft.	$245,900	Airbnb cash on cash: 0.27% Traditional cash on cash: 5.52% Airbnb Rental Income: $824 Traditional Rental Income: $1716 Airbnb ROI: 0.27% Traditional ROI: 5.52%
740 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$269,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $1905 Airbnb ROI: N/A Traditional ROI: 5.69%
752 Striped Bass Court Santee, SC Newly Released! Looking for a home with a nice view? This lot with the Brandon floorplan h...	3 beds \| 3 baths \| 1,518 sq.ft.	$288,120	Airbnb cash on cash: 0.09% Traditional cash on cash: 5.41% Airbnb Rental Income: $824 Traditional Rental Income: $1942 Airbnb ROI: 0.09% Traditional ROI: 5.41%
900 Bream Cir Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$249,850	Airbnb cash on cash: 0.25% Traditional cash on cash: 5.45% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.25% Traditional ROI: 5.45%
753 Striped Bass Ct Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$247,850	Airbnb cash on cash: 0.26% Traditional cash on cash: 5.51% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.26% Traditional ROI: 5.51%
908 Bream Cir Santee, SC Welcome home to the Helena, a beautifully designed one-story home nested in the cul-de-sac...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,615	Airbnb cash on cash: N/A Traditional cash on cash: 5.42% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.42%
733 Striped Bass Ct Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,115	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.43%
729 Striped Bass Ct Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$293,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.66% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.66%
625 Perch Ln Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: 0.29% Traditional cash on cash: 5.64% Airbnb Rental Income: $824 Traditional Rental Income: $1725 Airbnb ROI: 0.29% Traditional ROI: 5.64%
728 Striped Bass Ct Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$289,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.75% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.75%
657 Perch Ln Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$264,850	Airbnb cash on cash: N/A Traditional cash on cash: 5.84% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.84%
748 Striped Bass Ct Santee, SC Welcome to the Rachel! This home offers everything you're looking for in a functional two-...	3 beds \| 2 baths \| 1,360 sq.ft.	$279,900	Airbnb cash on cash: 0.12% Traditional cash on cash: 5.28% Airbnb Rental Income: $824 Traditional Rental Income: $1858 Airbnb ROI: 0.12% Traditional ROI: 5.28%
102 Cooper Dr Santee, SC Welcome to 102 Cooper Drive, a beautifully maintained Southern-style brick ranch tucked aw...	3 beds \| 2 baths \| 2,369 sq.ft.	$459,800	Airbnb cash on cash: -1.05% Traditional cash on cash: 2.83% Airbnb Rental Income: $824 Traditional Rental Income: $2169 Airbnb ROI: -1.05% Traditional ROI: 2.83%
111 Santee Cooper Santee, SC MAKE EVERY DAY A VACATION DAY! LOCATED IN SANTEE COOPER RESORT, A GATED, WATERFRONT AND GO...	4 beds \| 3 baths \| 1,908 sq.ft.	$305,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.6% Airbnb Rental Income: $null Traditional Rental Income: $2285 Airbnb ROI: N/A Traditional ROI: 4.6%
202 Trillium Ct Santee, SC Waterfront condo, 2 bedrooms, 2 baths, overlooking the Santee State Park & Lake Marion the...	2 beds \| 2 baths \| 1,328 sq.ft.	$225,000	Airbnb cash on cash: -1.92% Traditional cash on cash: 3.08% Airbnb Rental Income: $1235 Traditional Rental Income: $1953 Airbnb ROI: -1.92% Traditional ROI: 3.08%
119 Saluda Dr Santee, SC Experience the ultimate lake and golf lifestyle at 119 Saluda Drive, located in the sought...	4 beds \| 2 baths \| 3,055 sq.ft.	$499,900	Airbnb cash on cash: -1.12% Traditional cash on cash: 3.09% Airbnb Rental Income: $824 Traditional Rental Income: $2466 Airbnb ROI: -1.12% Traditional ROI: 3.09%
457 Santee Dr Santee, SC Welcome to luxury living on Lake Marion! Situated on the serene shores of Lake Marion this...	4 beds \| 2 baths \| 3,778 sq.ft.	$1,450,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.22% Airbnb Rental Income: $null Traditional Rental Income: $4006 Airbnb ROI: N/A Traditional ROI: 1.22%
343 Pinewood Dr Santee, SC Welcome to 343 Pinewood Dr, Santee, SC 29142 your gateway to lakeside living in the heart ...	4 beds \| 2 baths \| 2,322 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.13% Airbnb Rental Income: $null Traditional Rental Income: $2690 Airbnb ROI: N/A Traditional ROI: 6.13%
756 Santee River Rd Santee, SC Country life is waiting! 2.2 acres 10 minutes from town! This estate sale home is 3/2. Ope...	3 beds \| 2 baths \| 1,782 sq.ft.	$225,000	Airbnb cash on cash: 0.84% Traditional cash on cash: 5.83% Airbnb Rental Income: $824 Traditional Rental Income: $1582 Airbnb ROI: 0.84% Traditional ROI: 5.83%
230 Oak Hollow Dr Santee, SC Your Lake Home Near Lake Marion! Embrace the perfect blend of comfort, and nature with thi...	3 beds \| 2 baths \| 1,792 sq.ft.	$230,000	Airbnb cash on cash: 0.77% Traditional cash on cash: 7.31% Airbnb Rental Income: $824 Traditional Rental Income: $1921 Airbnb ROI: 0.77% Traditional ROI: 7.31%
130 2nd St Santee, SC Steps to Lake Marion! This fully renovated 3-bedroom, 2-bath ranch offers turnkey living i...	3 beds \| 2 baths \| 1,580 sq.ft.	$240,000	Airbnb cash on cash: 0.33% Traditional cash on cash: 5.95% Airbnb Rental Income: $824 Traditional Rental Income: $1772 Airbnb ROI: 0.33% Traditional ROI: 5.95%
612 Santee Dr Santee, SC Don't miss an opportunity to view this immaculate second row home in gated Santee Cooper R...	3 beds \| 2 baths \| 2,019 sq.ft.	$415,000	Airbnb cash on cash: -1.06% Traditional cash on cash: 2.98% Airbnb Rental Income: $824 Traditional Rental Income: $2071 Airbnb ROI: -1.06% Traditional ROI: 2.98%
130 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$341,400	Airbnb cash on cash: -0.31% Traditional cash on cash: 4.38% Airbnb Rental Income: $824 Traditional Rental Income: $2000 Airbnb ROI: -0.31% Traditional ROI: 4.38%
145 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$349,965	Airbnb cash on cash: -0.34% Traditional cash on cash: 4.26% Airbnb Rental Income: $824 Traditional Rental Income: $2009 Airbnb ROI: -0.34% Traditional ROI: 4.26%
905 Bream Circle Santee, SC Newly Released! Looking for that spacious backyard? This lot with the Brandon floorplan ha...	3 beds \| 3 baths \| 1,518 sq.ft.	$293,120	Airbnb cash on cash: 0.07% Traditional cash on cash: 5.27% Airbnb Rental Income: $824 Traditional Rental Income: $1933 Airbnb ROI: 0.07% Traditional ROI: 5.27%
175 William Clark Boulevard Santee, SC Experience modern comfort and convenience in this gorgeous home located in the sought-afte...	3 beds \| 3 baths \| 2,482 sq.ft.	$256,500	Airbnb cash on cash: 0.1% Traditional cash on cash: 8.28% Airbnb Rental Income: $824 Traditional Rental Income: $2479 Airbnb ROI: 0.1% Traditional ROI: 8.28%
689 Planters Trace Road Santee, SC Charming Country Living Awaits You! Welcome to this delightful three-bedroom, two-bathroom...	3 beds \| 2 baths \| 1,272 sq.ft.	$249,900	Airbnb cash on cash: 0.56% Traditional cash on cash: 5.68% Airbnb Rental Income: $824 Traditional Rental Income: $1707 Airbnb ROI: 0.56% Traditional ROI: 5.68%

Real Estate investment in Santee, SC

There are 116 properties for sale in the city of Santee . The median list price in Santee is $569,500 and the average price per square foot is $371. In February 2026, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $1,942.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 116 investment properties available for sale in Santee.

In 2026, the best neighborhood to buy investment property is Santee.

The ROI for Short-Term is higher than the Long-Term in Santee with average rental income of $824.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

448 Santee Dr

Santee, SC

4 beds | 2 baths | 2,784 sq.ft.

$470,000

Airbnb cash on cash: N/A

Traditional cash on cash: 4.13%

Airbnb Rental Income: $null

Traditional Rental Income: $2753

Airbnb ROI: N/A

Traditional ROI: 4.13%

104 Cooper Dr

Santee, SC

4 beds | 3 baths | 3,316 sq.ft.

$375,000

Airbnb cash on cash: N/A

Traditional cash on cash: 6.16%

Airbnb Rental Income: $null

Traditional Rental Income: $3300

Airbnb ROI: N/A

Traditional ROI: 6.16%

126 Wateree Dr

Santee, SC

3 beds | 2 baths | 3,204 sq.ft.

$575,000

Airbnb cash on cash: -1.59%

Traditional cash on cash: 1.18%

Airbnb Rental Income: $824

Traditional Rental Income: $1986

Airbnb ROI: -1.59%

Traditional ROI: 1.18%

125 Ballard Ln

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$220,000

Airbnb cash on cash: 0.6%

Traditional cash on cash: 4.6%

Airbnb Rental Income: $1235

Traditional Rental Income: $1675

Airbnb ROI: 0.6%

Traditional ROI: 4.6%

116 William Clark Blvd

Santee, SC

4 beds | 2 baths | 1,774 sq.ft.

$320,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.83%

Airbnb Rental Income: $null

Traditional Rental Income: $2366

Airbnb ROI: N/A

Traditional ROI: 5.83%

302 Santee Dr

Santee, SC

4 beds | 2 baths | 2,481 sq.ft.

$450,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.33%

Airbnb Rental Income: $null

Traditional Rental Income: $1879

Airbnb ROI: N/A

Traditional ROI: 2.33%

106 Broad River Dr

Santee, SC

4 beds | 3 baths | 2,600 sq.ft.

$743,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.49%

Airbnb Rental Income: $null

Traditional Rental Income: $2903

Airbnb ROI: N/A

Traditional ROI: 2.49%

125 Congaree Ct

Santee, SC

3 beds | 2 baths | 1,183 sq.ft.

$229,000

Airbnb cash on cash: 0.08%

Traditional cash on cash: 5.23%

Airbnb Rental Income: $824

Traditional Rental Income: $1615

Airbnb ROI: 0.08%