Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
520 Trillium Court Santee, SC Lake life is calling! Owning a Lake Marion condo puts you in the sweet spot of low-mainten...	3 beds \| 2 baths \| 1,720 sq.ft.	$300,000	Airbnb cash on cash: -3.51% Traditional cash on cash: 3.02% Airbnb Rental Income: $711 Traditional Rental Income: $2248 Airbnb ROI: -3.51% Traditional ROI: 3.02%
370 Chapel Creek Drive Santee, SC Exquisite Custom Home with Golf and Pond Views in Desirable Chapel Creek. Welcome to 370 C...	4 beds \| 4 baths \| 3,720 sq.ft.	$585,500	Airbnb cash on cash: 1.57% Traditional cash on cash: 5.47% Airbnb Rental Income: $2419 Traditional Rental Income: $3957 Airbnb ROI: 1.57% Traditional ROI: 5.47%
126 Wateree Drive Santee, SC This beautiful brick home is perfectly situated on the scenic Santee Cooper Golf Course, o...	3 beds \| 3 baths \| 3,204 sq.ft.	$559,000	Airbnb cash on cash: -1.79% Traditional cash on cash: 1.24% Airbnb Rental Income: $711 Traditional Rental Income: $1986 Airbnb ROI: -1.79% Traditional ROI: 1.24%
121 Ballard Lane Santee, SC Welcome to lakefront living at its finest in Ballards Pointe II on Lake Marion. This beaut...	3 beds \| 3 baths \| 1,689 sq.ft.	$295,375	Airbnb cash on cash: -0.45% Traditional cash on cash: 4.67% Airbnb Rental Income: $711 Traditional Rental Income: $1827 Airbnb ROI: -0.45% Traditional ROI: 4.67%
164 William Clark Boulevard Santee, SC Conveniently located just an hour from Charleston, Santee is a quaint community surrounded...	3 beds \| 3 baths \| 2,388 sq.ft.	$300,000	Airbnb cash on cash: -0.64% Traditional cash on cash: 4.82% Airbnb Rental Income: $711 Traditional Rental Income: $1946 Airbnb ROI: -0.64% Traditional ROI: 4.82%
116 William Clark Boulevard Santee, SC Spacious 4-bedroom, 2-bath home located in the front of the neighborhood--just one block f...	4 beds \| 2 baths \| 1,774 sq.ft.	$320,000	Airbnb cash on cash: 4.04% Traditional cash on cash: 5.83% Airbnb Rental Income: $2419 Traditional Rental Income: $2366 Airbnb ROI: 4.04% Traditional ROI: 5.83%
105 Ballard Lane Santee, SC Turnkey waterfront condo overlooking Lake Marion--South Carolina's largest lake with acces...	2 beds \| 2 baths \| 1,298 sq.ft.	$279,000	Airbnb cash on cash: -2.39% Traditional cash on cash: 3.44% Airbnb Rental Income: $507 Traditional Rental Income: $1768 Airbnb ROI: -2.39% Traditional ROI: 3.44%
302 Santee Drive Santee, SC Welcome to the highly sought-after, gated Santee Cooper Resort, where luxury meets lakesid...	4 beds \| 3 baths \| 2,481 sq.ft.	$450,000	Airbnb cash on cash: 2.39% Traditional cash on cash: 2.51% Airbnb Rental Income: $2419 Traditional Rental Income: $1879 Airbnb ROI: 2.39% Traditional ROI: 2.51%
106 Broad River Drive Santee, SC Easy home build process. PROPOSED CONSTRUCTION on DEEP WATER. ** Vacant Land/Lot also list...	4 beds \| N/A baths \| 2,600 sq.ft.	$743,000	Airbnb cash on cash: 0.94% Traditional cash on cash: 2.49% Airbnb Rental Income: $2419 Traditional Rental Income: $2903 Airbnb ROI: 0.94% Traditional ROI: 2.49%
125 Congaree Court Santee, SC This home is a short sale! Come Fall in love with this beautiful move-in-ready 2023-built ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,000	Airbnb cash on cash: -0.42% Traditional cash on cash: 4.88% Airbnb Rental Income: $711 Traditional Rental Income: $1615 Airbnb ROI: -0.42% Traditional ROI: 4.88%
472 Santee Drive Santee, SC This custom-designed brick home is truly one-of-a-kind, offering more bells and whistles t...	5 beds \| 4 baths \| 4,046 sq.ft.	$599,900	Airbnb cash on cash: -0.86% Traditional cash on cash: 4.34% Airbnb Rental Income: $996 Traditional Rental Income: $3558 Airbnb ROI: -0.86% Traditional ROI: 4.34%
900 Bream Circle Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$249,850	Airbnb cash on cash: -0.15% Traditional cash on cash: 5.45% Airbnb Rental Income: $711 Traditional Rental Income: $1725 Airbnb ROI: -0.15% Traditional ROI: 5.45%
753 Striped Bass Court Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$247,850	Airbnb cash on cash: -0.14% Traditional cash on cash: 5.51% Airbnb Rental Income: $711 Traditional Rental Income: $1725 Airbnb ROI: -0.14% Traditional ROI: 5.51%
908 Bream Circle Santee, SC Welcome home to the Helena, a beautifully designed one-story home nested in the cul-de-sac...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,615	Airbnb cash on cash: 5.1% Traditional cash on cash: 5.42% Airbnb Rental Income: $2419 Traditional Rental Income: $1911 Airbnb ROI: 5.1% Traditional ROI: 5.42%
733 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,115	Airbnb cash on cash: 5.11% Traditional cash on cash: 5.43% Airbnb Rental Income: $2419 Traditional Rental Income: $1911 Airbnb ROI: 5.11% Traditional ROI: 5.43%
729 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$293,900	Airbnb cash on cash: 4.87% Traditional cash on cash: 5.66% Airbnb Rental Income: $2419 Traditional Rental Income: $2046 Airbnb ROI: 4.87% Traditional ROI: 5.66%
625 Perch Lane Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: -0.12% Traditional cash on cash: 5.64% Airbnb Rental Income: $711 Traditional Rental Income: $1725 Airbnb ROI: -0.12% Traditional ROI: 5.64%
728 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$289,900	Airbnb cash on cash: 4.95% Traditional cash on cash: 5.75% Airbnb Rental Income: $2419 Traditional Rental Income: $2046 Airbnb ROI: 4.95% Traditional ROI: 5.75%
657 Perch Lane Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$264,850	Airbnb cash on cash: 5.5% Traditional cash on cash: 5.84% Airbnb Rental Income: $2419 Traditional Rental Income: $1911 Airbnb ROI: 5.5% Traditional ROI: 5.84%
748 Striped Bass Court Santee, SC Welcome to the Rachel! This home offers everything you're looking for in a functional two-...	3 beds \| 2 baths \| 1,360 sq.ft.	$279,900	Airbnb cash on cash: -0.24% Traditional cash on cash: 5.28% Airbnb Rental Income: $711 Traditional Rental Income: $1858 Airbnb ROI: -0.24% Traditional ROI: 5.28%
102 Cooper Drive Santee, SC Now offering a $5,000 Closing Cost Credit with receipt of an acceptable Offer Welcome to...	3 beds \| N/A baths \| 2,369 sq.ft.	$459,800	Airbnb cash on cash: -1.27% Traditional cash on cash: 2.83% Airbnb Rental Income: $711 Traditional Rental Income: $2169 Airbnb ROI: -1.27% Traditional ROI: 2.83%
202 Trillium Court Santee, SC Waterfront condo, 2 bedrooms, 2 baths, overlooking the Santee State Park & Lake Marion the...	2 beds \| 2 baths \| 1,328 sq.ft.	$235,000	Airbnb cash on cash: -4.65% Traditional cash on cash: 3.08% Airbnb Rental Income: $507 Traditional Rental Income: $1953 Airbnb ROI: -4.65% Traditional ROI: 3.08%
461 Chapel Creek Drive Santee, SC Set along the 10th fairway of the Santee National Golf Club, this custom-built home offers...	3 beds \| 3 baths \| 2,819 sq.ft.	$405,000	Airbnb cash on cash: -1.19% Traditional cash on cash: 3.91% Airbnb Rental Income: $711 Traditional Rental Income: $2337 Airbnb ROI: -1.19% Traditional ROI: 3.91%
457 Santee Drive Santee, SC Welcome to luxury living on Lake Marion! Situated on the serene shores of Lake Marion this...	4 beds \| N/A baths \| 3,778 sq.ft.	$1,450,000	Airbnb cash on cash: -0.39% Traditional cash on cash: 1.22% Airbnb Rental Income: $2419 Traditional Rental Income: $4006 Airbnb ROI: -0.39% Traditional ROI: 1.22%
220 Green Street Santee, SC Welcome to this charming manufactured home offering comfort, style, and modern upgrades. F...	3 beds \| 2 baths \| 1,375 sq.ft.	$215,000	Airbnb cash on cash: 0.2% Traditional cash on cash: 6.3% Airbnb Rental Income: $711 Traditional Rental Income: $1646 Airbnb ROI: 0.2% Traditional ROI: 6.3%
756 Santee River Road Santee, SC Country life is waiting! 202 acres and only 10 minutes from town. This estate sale home is...	3 beds \| 2 baths \| 1,782 sq.ft.	$225,000	Airbnb cash on cash: 0.44% Traditional cash on cash: 5.98% Airbnb Rental Income: $711 Traditional Rental Income: $1582 Airbnb ROI: 0.44% Traditional ROI: 5.98%
230 Oak Hollow Drive Santee, SC Your Lake Home Near Lake Marion! Embrace the perfect blend of comfort, and nature with thi...	3 beds \| 2 baths \| N/A	$230,000	Airbnb cash on cash: 0.33% Traditional cash on cash: 7.31% Airbnb Rental Income: $711 Traditional Rental Income: $1921 Airbnb ROI: 0.33% Traditional ROI: 7.31%
130 2nd Street Santee, SC Steps to Lake Marion! This fully renovated 3-bedroom, 2-bath ranch offers turnkey living i...	3 beds \| 2 baths \| 1,580 sq.ft.	$240,000	Airbnb cash on cash: -0.09% Traditional cash on cash: 5.95% Airbnb Rental Income: $711 Traditional Rental Income: $1772 Airbnb ROI: -0.09% Traditional ROI: 5.95%
612 Santee Drive Santee, SC PRICE REDUCTION! Don't miss an opportunity to view this immaculate second row home in gate...	3 beds \| 3 baths \| 2,019 sq.ft.	$395,000	Airbnb cash on cash: -1.75% Traditional cash on cash: 2.75% Airbnb Rental Income: $711 Traditional Rental Income: $2071 Airbnb ROI: -1.75% Traditional ROI: 2.75%
23 Peter Collinson Road Santee, SC Charming 3-bedroom, 2-bath ranch in the quiet, gated 55+ community of Bradford Village. Th...	3 beds \| 2 baths \| 2,276 sq.ft.	$289,900	Airbnb cash on cash: -0.19% Traditional cash on cash: 6.17% Airbnb Rental Income: $711 Traditional Rental Income: $2140 Airbnb ROI: -0.19% Traditional ROI: 6.17%
613 Ballard Lane Santee, SC Beautiful Waterfront 2nd floor furnished condo overlooking the Big Waters of Lake Marion. ...	2 beds \| 2 baths \| 1,232 sq.ft.	$219,000	Airbnb cash on cash: -1.67% Traditional cash on cash: 7.1% Airbnb Rental Income: $507 Traditional Rental Income: $2053 Airbnb ROI: -1.67% Traditional ROI: 7.1%
130 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$341,400	Airbnb cash on cash: -0.6% Traditional cash on cash: 4.38% Airbnb Rental Income: $711 Traditional Rental Income: $2000 Airbnb ROI: -0.6% Traditional ROI: 4.38%
145 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$349,965	Airbnb cash on cash: -0.62% Traditional cash on cash: 4.26% Airbnb Rental Income: $711 Traditional Rental Income: $2009 Airbnb ROI: -0.62% Traditional ROI: 4.26%
905 Bream Circle Santee, SC Newly Released! Looking for that spacious backyard? This lot with the Brandon floorplan ha...	3 beds \| 3 baths \| 1,518 sq.ft.	$293,120	Airbnb cash on cash: -0.27% Traditional cash on cash: 5.27% Airbnb Rental Income: $711 Traditional Rental Income: $1933 Airbnb ROI: -0.27% Traditional ROI: 5.27%
111 Santee Cooper Santee, SC MAKE EVERY DAY A VACATION DAY! LOCATED IN SANTEE COOPER RESORT, A GATED, WATERFRONT AND GO...	4 beds \| 2 baths \| 1,908 sq.ft.	$305,000	Airbnb cash on cash: 3.01% Traditional cash on cash: 4.6% Airbnb Rental Income: $2419 Traditional Rental Income: $2285 Airbnb ROI: 3.01% Traditional ROI: 4.6%
175 William Clark Boulevard Santee, SC Experience modern comfort and convenience in this gorgeous home located in the sought-afte...	3 beds \| 3 baths \| 2,482 sq.ft.	$256,500	Airbnb cash on cash: -0.29% Traditional cash on cash: 8.28% Airbnb Rental Income: $711 Traditional Rental Income: $2479 Airbnb ROI: -0.29% Traditional ROI: 8.28%

Real Estate investment in Santee, SC

There are 36 properties for sale in the city of Santee . The median list price in Santee is $569,500 and the average price per square foot is $362. In April 2026, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $1,953.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 36 investment properties available for sale in Santee.

In 2026, the best neighborhood to buy investment property is Santee.

The ROI for Short-Term is higher than the Long-Term in Santee with average rental income of $711.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

520 Trillium Court

Santee, SC

3 beds | 2 baths | 1,720 sq.ft.

$300,000

Airbnb cash on cash: -3.51%

Traditional cash on cash: 3.02%

Airbnb Rental Income: $711

Traditional Rental Income: $2248

Airbnb ROI: -3.51%

Traditional ROI: 3.02%

370 Chapel Creek Drive

Santee, SC

4 beds | 4 baths | 3,720 sq.ft.

$585,500

Airbnb cash on cash: 1.57%

Traditional cash on cash: 5.47%

Airbnb Rental Income: $2419

Traditional Rental Income: $3957

Airbnb ROI: 1.57%

Traditional ROI: 5.47%

126 Wateree Drive

Santee, SC

3 beds | 3 baths | 3,204 sq.ft.

$559,000

Airbnb cash on cash: -1.79%

Traditional cash on cash: 1.24%

Airbnb Rental Income: $711

Traditional Rental Income: $1986

Airbnb ROI: -1.79%

Traditional ROI: 1.24%

121 Ballard Lane

Santee, SC

3 beds | 3 baths | 1,689 sq.ft.

$295,375

Airbnb cash on cash: -0.45%

Traditional cash on cash: 4.67%

Airbnb Rental Income: $711

Traditional Rental Income: $1827

Airbnb ROI: -0.45%

Traditional ROI: 4.67%

164 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 2,388 sq.ft.

$300,000

Airbnb cash on cash: -0.64%

Traditional cash on cash: 4.82%

Airbnb Rental Income: $711

Traditional Rental Income: $1946

Airbnb ROI: -0.64%

Traditional ROI: 4.82%

116 William Clark Boulevard

Santee, SC

4 beds | 2 baths | 1,774 sq.ft.

$320,000

Airbnb cash on cash: 4.04%

Traditional cash on cash: 5.83%

Airbnb Rental Income: $2419

Traditional Rental Income: $2366

Airbnb ROI: 4.04%

Traditional ROI: 5.83%

105 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$279,000

Airbnb cash on cash: -2.39%

Traditional cash on cash: 3.44%

Airbnb Rental Income: $507

Traditional Rental Income: $1768

Airbnb ROI: -2.39%

Traditional ROI: 3.44%

302 Santee Drive

Santee, SC

4 beds | 3 baths | 2,481 sq.ft.

$450,000

Airbnb cash on cash: 2.39%

Traditional cash on cash: 2.51%

Airbnb Rental Income: $2419

Traditional Rental Income: $1879

Airbnb ROI: 2.39%