Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
104 Cooper Drive Santee, SC 104 Cooper Drive is a beautiful custom-built 4br 3+ba home set on a larger lot overlooking...	4 beds \| 4 baths \| 3,316 sq.ft.	$434,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.94% Airbnb Rental Income: $null Traditional Rental Income: $3300 Airbnb ROI: N/A Traditional ROI: 5.94%
370 Chapel Creek Drive Santee, SC Welcome to luxury at it's finest ! Located within Santee National Golf Course, and the Cha...	4 beds \| 4 baths \| 3,720 sq.ft.	$570,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.66% Airbnb Rental Income: $null Traditional Rental Income: $3957 Airbnb ROI: N/A Traditional ROI: 5.66%
161 Ballard Lane Santee, SC Welcome to 161 Ballard Point, a 2-bedroom, 2-bathroom condo offering stunning lakefront vi...	2 beds \| 2 baths \| 1,251 sq.ft.	$225,500	Airbnb cash on cash: 2.29% Traditional cash on cash: 5.88% Airbnb Rental Income: $1617 Traditional Rental Income: $1925 Airbnb ROI: 2.29% Traditional ROI: 5.88%
119 Wateree Drive Santee, SC GOLFER'S DREAM. FISHERMAN'S DREAM. LOCATED IN SANTEE COOPER RESORT, A GATED, WATERFRONT AN...	3 beds \| 2 baths \| 1,766 sq.ft.	$315,000	Airbnb cash on cash: 0.01% Traditional cash on cash: 4.96% Airbnb Rental Income: $996 Traditional Rental Income: $2107 Airbnb ROI: 0.01% Traditional ROI: 4.96%
143 Ballard Lane Santee, SC Relaxation and Style on Lake Marion! Fully furnished 2-bedroom, 2-bath waterfront condo wi...	2 beds \| 2 baths \| 1,298 sq.ft.	$210,000	Airbnb cash on cash: 2.57% Traditional cash on cash: 5.89% Airbnb Rental Income: $1617 Traditional Rental Income: $1821 Airbnb ROI: 2.57% Traditional ROI: 5.89%
127 William Clark Boulevard Santee, SC As you enter this beautiful home, a welcoming hallway greets you. To the right is a full b...	3 beds \| 3 baths \| 2,482 sq.ft.	$355,000	Airbnb cash on cash: -0.07% Traditional cash on cash: 5.42% Airbnb Rental Income: $996 Traditional Rental Income: $2469 Airbnb ROI: -0.07% Traditional ROI: 5.42%
130 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$341,400	Airbnb cash on cash: 0.14% Traditional cash on cash: 4.38% Airbnb Rental Income: $996 Traditional Rental Income: $2000 Airbnb ROI: 0.14% Traditional ROI: 4.38%
145 William Clark Boulevard Santee, SC Center Pointe is conveniently located in the heart of Santee, South Carolina, only minutes...	3 beds \| 3 baths \| 1,774 sq.ft.	$349,965	Airbnb cash on cash: 0.1% Traditional cash on cash: 4.26% Airbnb Rental Income: $996 Traditional Rental Income: $2009 Airbnb ROI: 0.1% Traditional ROI: 4.26%
116 William Clark Boulevard Santee, SC Spacious 4-bedroom, 2-bath home located in the front of the neighborhood--just one block f...	4 beds \| 2 baths \| 1,774 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 5.76% Airbnb Rental Income: $null Traditional Rental Income: $2366 Airbnb ROI: N/A Traditional ROI: 5.76%
1041 Huran Lane Santee, SC JUST REDUCED ANOTHER $5k ! Welcome to this waterfront home on Chapel Branch cove across fr...	2 beds \| 2 baths \| 1,050 sq.ft.	$334,000	Airbnb cash on cash: 2.16% Traditional cash on cash: 3.15% Airbnb Rental Income: $1617 Traditional Rental Income: $1470 Airbnb ROI: 2.16% Traditional ROI: 3.15%
415 Santee Drive Santee, SC Spacious waterfront brick home is located in Santee Cooper Resort a gated waterfront and g...	4 beds \| 4 baths \| 3,201 sq.ft.	$799,000	Airbnb cash on cash: N/A Traditional cash on cash: 1.39% Airbnb Rental Income: $null Traditional Rental Income: $2243 Airbnb ROI: N/A Traditional ROI: 1.39%
106 Broad River Drive Santee, SC PROPOSED CONSTRUCTION on DEEP WATER. Vacant Land/Lot also listed as MLS# 23018200. S...	4 beds \| 3 baths \| 2,600 sq.ft.	$744,075	Airbnb cash on cash: N/A Traditional cash on cash: 2.49% Airbnb Rental Income: $null Traditional Rental Income: $2903 Airbnb ROI: N/A Traditional ROI: 2.49%
120 Wateree Drive Santee, SC DREAM BRICK RANCH HOME IN GATED, GOLF COURSE, WATERFRONT COMMUNITY ON LAKE MARION! Fish fr...	3 beds \| 2 baths \| 2,014 sq.ft.	$329,000	Airbnb cash on cash: -0.28% Traditional cash on cash: 4.57% Airbnb Rental Income: $996 Traditional Rental Income: $2141 Airbnb ROI: -0.28% Traditional ROI: 4.57%
472 Santee Drive Santee, SC Beautiful home with in ground pool and on the 17th. Fairway of Santee Cooper Golf Course. ...	5 beds \| 4 baths \| 4,046 sq.ft.	$625,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.11% Airbnb Rental Income: $null Traditional Rental Income: $3558 Airbnb ROI: N/A Traditional ROI: 4.11%
213 Myrtlewood Drive Santee, SC Act now to secure this stunning new-build ranch in Chapel Creek Plantation, set for comple...	3 beds \| 2 baths \| 1,610 sq.ft.	$360,000	Airbnb cash on cash: 0.01% Traditional cash on cash: 3.82% Airbnb Rental Income: $996 Traditional Rental Income: $1926 Airbnb ROI: 0.01% Traditional ROI: 3.82%
780 Striped Bass Court Santee, SC READY NOW! Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2...	3 beds \| 2 baths \| 1,183 sq.ft.	$245,900	Airbnb cash on cash: 0.89% Traditional cash on cash: 5.52% Airbnb Rental Income: $996 Traditional Rental Income: $1716 Airbnb ROI: 0.89% Traditional ROI: 5.52%
681 Perch Lane Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: 0.91% Traditional cash on cash: 6.42% Airbnb Rental Income: $996 Traditional Rental Income: $1905 Airbnb ROI: 0.91% Traditional ROI: 6.42%
740 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$269,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.69% Airbnb Rental Income: $null Traditional Rental Income: $1905 Airbnb ROI: N/A Traditional ROI: 5.69%
905 Bream Circle Santee, SC Newly Released! Looking for that spacious backyard? This lot with the Brandon floorplan ha...	3 beds \| 3 baths \| 1,518 sq.ft.	$293,120	Airbnb cash on cash: 0.59% Traditional cash on cash: 5.27% Airbnb Rental Income: $996 Traditional Rental Income: $1933 Airbnb ROI: 0.59% Traditional ROI: 5.27%
752 Striped Bass Court Santee, SC Newly Released! Looking for a home with a nice view? This lot with the Brandon floorplan h...	3 beds \| 3 baths \| 1,518 sq.ft.	$288,120	Airbnb cash on cash: 0.62% Traditional cash on cash: 5.41% Airbnb Rental Income: $996 Traditional Rental Income: $1942 Airbnb ROI: 0.62% Traditional ROI: 5.41%
125 Cooper Drive Santee, SC Your Lakeside Retreat Awaits - 125 Cooper Drive, Santee, SC Welcome to 125 Cooper Drive-ne...	3 beds \| 3 baths \| 2,674 sq.ft.	$460,000	Airbnb cash on cash: -0.44% Traditional cash on cash: 3.93% Airbnb Rental Income: $996 Traditional Rental Income: $2520 Airbnb ROI: -0.44% Traditional ROI: 3.93%
158 William Clark Boulevard Santee, SC HUGE PRICE REDUCTION Skip the stress of moving! This furnished 3 bedroom, 3 bath home is...	3 beds \| 3 baths \| 2,209 sq.ft.	$300,000	Airbnb cash on cash: 0.2% Traditional cash on cash: 6.32% Airbnb Rental Income: $996 Traditional Rental Income: $2369 Airbnb ROI: 0.2% Traditional ROI: 6.32%
1060 Chapel Branch Road Santee, SC Discover the perfect blend of comfort and convenience in this move-in-ready, recently remo...	3 beds \| 3 baths \| 2,258 sq.ft.	$345,900	Airbnb cash on cash: 0.03% Traditional cash on cash: 4.93% Airbnb Rental Income: $996 Traditional Rental Income: $2230 Airbnb ROI: 0.03% Traditional ROI: 4.93%
900 Bream Circle Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$249,850	Airbnb cash on cash: 0.86% Traditional cash on cash: 5.45% Airbnb Rental Income: $996 Traditional Rental Income: $1725 Airbnb ROI: 0.86% Traditional ROI: 5.45%
753 Striped Bass Court Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$247,850	Airbnb cash on cash: 0.88% Traditional cash on cash: 5.51% Airbnb Rental Income: $996 Traditional Rental Income: $1725 Airbnb ROI: 0.88% Traditional ROI: 5.51%
908 Bream Circle Santee, SC Welcome home to the Helena, a beautifully designed one-story home nested in the cul-de-sac...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,615	Airbnb cash on cash: N/A Traditional cash on cash: 5.42% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.42%
733 Striped Bass Court Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$282,115	Airbnb cash on cash: N/A Traditional cash on cash: 5.43% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.43%
729 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$293,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.66% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.66%
625 Perch Lane Santee, SC Welcome to this gorgeous ranch-style Sullivan floorplan featuring 3 bedrooms, 2 baths and ...	3 beds \| 2 baths \| 1,183 sq.ft.	$242,850	Airbnb cash on cash: 0.91% Traditional cash on cash: 5.64% Airbnb Rental Income: $996 Traditional Rental Income: $1725 Airbnb ROI: 0.91% Traditional ROI: 5.64%
728 Striped Bass Court Santee, SC D.R. Horton's best-selling Cali floorplan! This single-story home captures the essence of ...	4 beds \| 2 baths \| 1,774 sq.ft.	$289,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.75% Airbnb Rental Income: $null Traditional Rental Income: $2046 Airbnb ROI: N/A Traditional ROI: 5.75%
657 Perch Lane Santee, SC Welcome to single-story living at its best! This 4 bedroom, 2 bath Helena floorplan offers...	4 beds \| 2 baths \| 1,482 sq.ft.	$264,850	Airbnb cash on cash: N/A Traditional cash on cash: 5.84% Airbnb Rental Income: $null Traditional Rental Income: $1911 Airbnb ROI: N/A Traditional ROI: 5.84%
748 Striped Bass Court Santee, SC Welcome to the Rachel! This home offers everything you're looking for in a functional two-...	3 beds \| 3 baths \| 1,360 sq.ft.	$279,900	Airbnb cash on cash: 0.67% Traditional cash on cash: 5.28% Airbnb Rental Income: $996 Traditional Rental Income: $1858 Airbnb ROI: 0.67% Traditional ROI: 5.28%
102 Cooper Drive Santee, SC REDUCED! A beautiful brick, ranch, golf course home has many updates and is located in San...	3 beds \| 2 baths \| 2,369 sq.ft.	$499,000	Airbnb cash on cash: -0.78% Traditional cash on cash: 2.49% Airbnb Rental Income: $996 Traditional Rental Income: $2169 Airbnb ROI: -0.78% Traditional ROI: 2.49%
111 Santee Cooper Santee, SC MAKE EVERY DAY A VACATION DAY! LOCATED IN SANTEE COOPER RESORT, A GATED, WATERFRONT AND GO...	4 beds \| 3 baths \| 1,908 sq.ft.	$330,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.18% Airbnb Rental Income: $null Traditional Rental Income: $2285 Airbnb ROI: N/A Traditional ROI: 4.18%
202 Trillium Court Santee, SC Waterfront condo, 2 bedrooms, 2 baths, overlooking the Santee State Park & Lake Marion the...	2 beds \| 2 baths \| 1,328 sq.ft.	$245,000	Airbnb cash on cash: -0.53% Traditional cash on cash: 2.9% Airbnb Rental Income: $1617 Traditional Rental Income: $1953 Airbnb ROI: -0.53% Traditional ROI: 2.9%
406 Santee Drive Santee, SC Welcome to vibrant lake living in the gated Santee Cooper Resort! This charming 3BR/2BA br...	3 beds \| 2 baths \| 1,890 sq.ft.	$315,000	Airbnb cash on cash: -1% Traditional cash on cash: 3.96% Airbnb Rental Income: $996 Traditional Rental Income: $2112 Airbnb ROI: -1% Traditional ROI: 3.96%
119 Saluda Drive Santee, SC Live the lake and golf life at 119 Saluda Drive, located in the prestigious Santee Cooper ...	3 beds \| 3 baths \| 3,056 sq.ft.	$499,900	Airbnb cash on cash: -0.81% Traditional cash on cash: 3.09% Airbnb Rental Income: $996 Traditional Rental Income: $2466 Airbnb ROI: -0.81% Traditional ROI: 3.09%

Real Estate investment in Santee, SC

There are 43 properties for sale in the city of Santee . The median list price in Santee is $329,000 and the average price per square foot is $162. In September 2025, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $2,086.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 43 investment properties available for sale in Santee.

In 2025, the best neighborhood to buy investment property is Santee.

The ROI for Short-Term is higher than the Long-Term in Santee with average rental income of $996.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

104 Cooper Drive

Santee, SC

4 beds | 4 baths | 3,316 sq.ft.

$434,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.94%

Airbnb Rental Income: $null

Traditional Rental Income: $3300

Airbnb ROI: N/A

Traditional ROI: 5.94%

370 Chapel Creek Drive

Santee, SC

4 beds | 4 baths | 3,720 sq.ft.

$570,000

Airbnb cash on cash: N/A

Traditional cash on cash: 5.66%

Airbnb Rental Income: $null

Traditional Rental Income: $3957

Airbnb ROI: N/A

Traditional ROI: 5.66%

161 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,251 sq.ft.

$225,500

Airbnb cash on cash: 2.29%

Traditional cash on cash: 5.88%

Airbnb Rental Income: $1617

Traditional Rental Income: $1925

Airbnb ROI: 2.29%

Traditional ROI: 5.88%

119 Wateree Drive

Santee, SC

3 beds | 2 baths | 1,766 sq.ft.

$315,000

Airbnb cash on cash: 0.01%

Traditional cash on cash: 4.96%

Airbnb Rental Income: $996

Traditional Rental Income: $2107

Airbnb ROI: 0.01%

Traditional ROI: 4.96%

143 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$210,000

Airbnb cash on cash: 2.57%

Traditional cash on cash: 5.89%

Airbnb Rental Income: $1617

Traditional Rental Income: $1821

Airbnb ROI: 2.57%

Traditional ROI: 5.89%

127 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 2,482 sq.ft.

$355,000

Airbnb cash on cash: -0.07%

Traditional cash on cash: 5.42%

Airbnb Rental Income: $996

Traditional Rental Income: $2469

Airbnb ROI: -0.07%

Traditional ROI: 5.42%

130 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 1,774 sq.ft.

$341,400

Airbnb cash on cash: 0.14%

Traditional cash on cash: 4.38%

Airbnb Rental Income: $996

Traditional Rental Income: $2000

Airbnb ROI: 0.14%

Traditional ROI: 4.38%

145 William Clark Boulevard

Santee, SC

3 beds | 3 baths | 1,774 sq.ft.

$349,965

Airbnb cash on cash: 0.1%

Traditional cash on cash: 4.26%

Airbnb Rental Income: $996

Traditional Rental Income: $2009

Airbnb ROI: 0.1%